Abstract:
BACKGROUND:Sympathetic activation and respiratory abnormalities may each be implicated in the pathophysiology of congestive heart failure (CHF). Chemoreflexes are an important mechanism regulating both sympathetic drive and breathing. We therefore tested the hypothesis that chemoreflex function is altered in CHF. METHODS AND RESULTS:We compared ventilatory, sympathetic, heart rate, and blood pressure responses to hypoxia, hypercapnia, and the cold pressor test in 9 patients with CHF and 9 control subjects matched for age and body mass index. Baseline muscle sympathetic nerve activity (MSNA) was higher in the patients with CHF compared with control subjects (47+/-8 versus 23+/-3 bursts per minute, P<0.01). During hypercapnia, patients with CHF had greater increases in minute ventilation (6.7+/-1.4 versus 2.7+/-0.9 L/min, P=0.03) and heart rate (7.0+/-2.1 versus 0.6+/-1.2 bpm, P=0.02). Despite higher ventilation, which inhibits sympathetic activity, the MSNA increase in patients with CHF was also greater than that in control subjects (58+/-12% versus 21+/-9%, P=0.03). Ventilatory, autonomic, and blood pressure responses to hypoxia and the cold pressor test in CHF patients were not different from those in control subjects. CONCLUSIONS:Chronic heart failure is characterized by a selective potentiation of ventilatory and sympathetic responses to central chemoreceptor activation by hypercapnia.
journal_name
Circulationjournal_title
Circulationauthors
Narkiewicz K,Pesek CA,van de Borne PJ,Kato M,Somers VKdoi
10.1161/01.cir.100.3.262subject
Has Abstractpub_date
1999-07-20 00:00:00pages
262-7issue
3eissn
0009-7322issn
1524-4539journal_volume
100pub_type
临床试验,杂志文章相关文献
CIRCULATION文献大全abstract::To study the determinants of smooth muscle injury during balloon angioplasty, we conducted a series of experiments to examine the effects of degree of arterial stretching, duration of balloon inflation, and arterial precontraction on smooth muscle injury after balloon angioplasty in isolated, perfused whole-vessel seg...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.82.6.2170
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Two different techniques have been developed for radiofrequency catheter ablation of typical atrioventricular nodal reentry (AVNRT). Lesions made anteriorly near the apex of the triangle of Koch usually eliminate fast pathway function, whereas lesions made posteriorly near the ostium of the coronary sinus se...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.87.5.1551
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Bradycardia and sinus node dysfunction are common causes of early postoperative morbidity in orthotopic heart transplant recipients and frequently require the use of chronotropic drugs or permanent pacemakers. Several causes have been postulated, including surgical trauma to the sinus node and its blood supp...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:We recently reported that arterial superoxide (O2-) is augmented by increased endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-salt hypertension, a model of low renin hypertension. Tetrahydrobiopterin (BH4), a potent reducing molecule with antioxidant properties and an essential cofactor for endothe...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000089082.40285.C3
更新日期:2003-09-09 00:00:00
abstract:BACKGROUND:Preconditioning protects the myocardium from ischemia and may be a potent means of endogenous cardioprotection during cardioplegic arrest and rewarming. However, fundamental mechanisms that potentially contribute to the beneficial effects of preconditioning during cardioplegic arrest and rewarming remain unc...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:The coexistence of atrial fibrillation (AF) and atrial flutter (AFL) is well recognized. AF precedes the onset of AFL in almost all instances. We evaluated the effect of 2 ablation strategies in patients with paroxysmal AF (PAF) and AFL. METHODS AND RESULTS:Ninety-eight patients with PAF/AFL were prospectiv...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/CIRCULATIONAHA.107.711622
更新日期:2007-12-11 00:00:00
abstract:BACKGROUND:Hypercholesterolemia and sickle cell disease (SCD) impair endothelium-dependent vasodilation by dissimilar mechanisms. Hypercholesterolemia impairs vasodilation by a low-density lipoprotein (LDL)-dependent mechanism. SCD has been characterized as a chronic state of inflammation in which xanthine oxidase (XO)...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000070589.61860.A9
更新日期:2003-05-13 00:00:00
abstract::In a placebo-controlled, randomized, cross-over, double-blind study of 12 patients with stable exertional angina, we measured at rest and during bicycle exercise the effects of 20 mg of nifedipine administered sublingually on hemodynamics and systemic and regional oxygen extraction and metabolism. Nifedipine decreased...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.71.4.787
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:The myocardial velocity gradient (MVG) is a recent index of regional myocardial function derived from endocardial and epicardial velocities obtained by tissue Doppler imaging (TDI). This index might be useful for discriminating between physiological and pathological left ventricular hypertrophy (LVH) and for...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000012943.91101.d7
更新日期:2002-04-02 00:00:00
abstract::We performed a 15 year follow-up of 748 patients undergoing bypass surgery, comparing 532 patients with one or two internal mammary artery grafts with or without additional saphenous vein grafts to 216 patients with saphenous vein grafts alone. During the 15 years of follow-up the 532 patients with at least one intern...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Intimal smooth muscle cells (SMCs) contribute to the foam cell population in arterial plaque, and express lower levels of the cholesterol exporter ATP-binding cassette transporter A1 (ABCA1) in comparison with medial arterial SMCs. The relative contribution of SMCs to the total foam cell population and their...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.005015
更新日期:2014-04-15 00:00:00
abstract::In the United States each year, >5.3 million patients present to emergency departments with chest discomfort and related symptoms. Ultimately, >1.4 million individuals are hospitalized for unstable angina and non-ST-segment elevation myocardial infarction. For emergency physicians and cardiologists alike, these patien...
journal_title:Circulation
pub_type: 杂志文章,实务指引
doi:10.1161/01.CIR.0000165556.44271.BE
更新日期:2005-05-24 00:00:00
abstract::The two-dimensional echocardiographic features of three patients with congenital aneurysms of the left atrium are described. The aneurysm arose from the left atrial appendage in two patients and from the posterior left atrial wall in one. The aneurysms were characterized by their origin from an otherwise normal left a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.66.5.1065
更新日期:1982-11-01 00:00:00
abstract::Echocardiographic and cardiac catheterization findings were compared in 61 patients with mitral stenosis without other significant lesions in an attempt to determine the clinical usefulness of echocardiography in the assessment of such patients. There was a poor correlation between the E-F slope on the echocardiogram ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.52.4.664
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:Coronary artery bypass grafting in patients with chronic ischemic cardiomyopathy is increasing in frequency, as is reoperative bypass. However, there exist very little data on early outcomes of patients with severe left ventricular dysfunction undergoing reoperation. Hence, we tested the following hypotheses...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-11-04 00:00:00
abstract::Relationships between enzyme estimates (EE) and histologic measurements of infarct size (HIS) were analyzed in 14 conscious dogs with permanent occlusion of the circumflex coronary artery. EE were derived from serial CPK, CPK-MM, CPK-MB, and CPK-BB. Estimates were obtained using methods of Shell et al., Norris et al.,...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.3.438
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND:Although patients with heart failure express elevated circulating levels of tumor necrosis factor-alpha (TNF-alpha) in their peripheral circulation, the structural and functional effects of circulating levels of pathophysiologically relevant concentrations of TNF-alpha on the heart are not known. METHODS AN...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.97.14.1382
更新日期:1998-04-14 00:00:00
abstract:BACKGROUND:Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI). METHODS AND RESULTS:BM-MSCs were obtained from rat bone marrow, expanded in vitro to a purity of >50%, an...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000084828.50310.6A
更新日期:2003-08-19 00:00:00
abstract:BACKGROUND:Heart rate (HR) variability is a marker of tonic cardiac autonomic activity and contributes in assessing risk for sudden death after myocardial infarction. Recent clinical observations have indicated that attenuation of HR variability, which occurs after myocardial infarction, may be transient. This study ad...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.2.976
更新日期:1994-08-01 00:00:00
abstract::Myocardial lactate production indicates anaerobic metabolism resulting from hypoxia or anoxia. Clinically, myocardial lactate extraction of less than 10% has also been used as an indicator of ischemia. Sixteen healthy young male volunteers underwent coronary sinus and aterial catheterization. A coronary sinus pacing c...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.61.2.256
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:Development of left ventricular hypertrophy in aortic stenosis (AS) is accompanied by coronary microcirculatory dysfunction, demonstrated by an impaired coronary vasodilator reserve (CVR). However, evidence for regional abnormalities in myocardial blood flow (MBF) and the potential mechanisms is limited. The...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/hc0402.102931
更新日期:2002-01-29 00:00:00
abstract:BACKGROUND:Despite successful surgical correction, morbidity of patients with coarctation of the aorta is increased. It is well known that these patients have impaired elastic properties of the prestenotic arteries. To find out whether these abnormalities are primarily present or develop later, we studied 17 newborns b...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.529792
更新日期:2005-06-21 00:00:00
abstract::Despite a 2% to 3% prevalence of echocardiographically defined mitral valve prolapse (MVP) in the general population, the actual burden, risk stratification, and treatment of the so-called arrhythmic MVP are unknown. The clinical profile is characterized by a patient, usually female, with mostly bileaflet myxomatous d...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.118.034075
更新日期:2019-09-10 00:00:00
abstract:BACKGROUND:Vascular inflammation and subsequent matrix degradation play an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipose-specific plasma protein, accumulated to the injured artery and attenuated vascular inflammatory response. Clinically, high plasma adiponect...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000127953.98131.ED
更新日期:2004-05-04 00:00:00
abstract:BACKGROUND:Several nonpharmacological interventions, including exercise, are recommended in primary prevention of hypertension and other cardiovascular diseases in which the pathogenetic role of endothelial dysfunction has been suggested. We studied the effects of long-term aerobic exercise on endothelial function in p...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.100.11.1194
更新日期:1999-09-14 00:00:00
abstract:BACKGROUND:Perioperative management of patients with complete mixing of pulmonary and systemic blood centers on approximately equating pulmonary (Qp) and systemic (Qs) blood flow (Qp/Qs approximately 1). This empirically derived target is opposed by theoretical studies advocating a target Qp/Qs well below 1. We studied...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.21.2198
更新日期:1999-11-23 00:00:00
abstract:BACKGROUND:Inhaled nitric oxide (iNO) has been used to assess the vasodilator capacity of the pulmonary vascular bed in children with congenital heart disease and elevated pulmonary vascular resistance. Inhaled iloprost is a pulmonary vasodilator for the long-term treatment of pulmonary hypertension (PHT). Because thes...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.103.4.544
更新日期:2001-01-30 00:00:00
abstract:BACKGROUND:Cerebral protection during surgery for acute aortic dissection type A relies on hypothermic circulatory arrest, either alone or in conjunction with cerebral perfusion. METHODS AND RESULTS:The perioperative and intraoperative conditions of 1558 patients submitted from 44 cardiac surgery centers in German-spe...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.009282
更新日期:2011-07-26 00:00:00
abstract::The Academic Research Consortium (ARC)-2 initiative revisited the clinical and angiographic end point definitions in coronary device trials, proposed in 2007, to make them more suitable for use in clinical trials that include increasingly complex lesion and patient populations and incorporate novel devices such as bio...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.117.029289
更新日期:2018-06-12 00:00:00
abstract:BACKGROUND:The pathogenesis of sodium and water accumulation in chronic constrictive pericarditis is not well understood and may differ from that in patients with chronic congestive heart failure due to myocardial disease. This study was undertaken to investigate some of the mechanisms. METHODS AND RESULTS:Using stand...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.83.6.1880
更新日期:1991-06-01 00:00:00