Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages.

abstract：BACKGROUND:A growing body of evidence from animal studies supports the hypothesis that oxidative stress-mediated mechanisms play a central role in early atherogenesis. In contrast, clinical trials with antioxidant vitamins have not produced consistent results in humans with established atherosclerosis. METHODS AND RES...

journal_title：Circulation

authors： Cyrus T,Yao Y,Rokach J,Tang LX,Praticò D

更新日期：2003-02-04 00:00:00

abstract：:Resting hemodynamics improve during vasodilator administration in patients, with congestive heart failure (CHF), but the effects of these agents on exercise is unknown. Twenty-two patients with class II or III CHF performed bicycle exercise to symptomatic maximum before and 90 minutes after random double-blind adminis...

journal_title：Circulation

authors： Franciosa JA,Cohn JN

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:In patients with severe congestive heart failure (CHF), short-term administration of dobutamine exerts sustained clinical benefits that are partially mediated by a training-like effect on skeletal muscle. Recently, physical training has been shown to enhance endothelial function in the skeletal muscle vascul...

journal_title：Circulation

authors： Patel MB,Kaplan IV,Patni RN,Levy D,Strom JA,Shirani J,LeJemtel TH

更新日期：1999-01-05 00:00:00

abstract：:Digoxin, in a common clinical dose and at a low serum level, brought out severe manifestations of sinus node dysfunction in a patient who had previously undergone successful mitral valve replacement. This report presents the results of extensive clinical and electrophysiologic studies of this patient before and after ...

journal_title：Circulation

authors： Margolis JR,Strauss HC,Miller HC,Gilbert M,Wallace AG

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:Anthracyclines are the most effective drugs available in the treatment of neoplastic diseases; however, they have profound consequences on the structure and function of the heart, which over time cause a cardiomyopathy that leads to congestive heart failure. METHODS AND RESULTS:Administration of doxorubicin...

journal_title：Circulation

authors： De Angelis A,Piegari E,Cappetta D,Marino L,Filippelli A,Berrino L,Ferreira-Martins J,Zheng H,Hosoda T,Rota M,Urbanek K,Kajstura J,Leri A,Rossi F,Anversa P

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:Thoracic endovascular aortic repair offers a less invasive approach for the treatment of ruptured descending thoracic aortic aneurysms (rDTAA). Due to the low incidence of this life-threatening condition, little is known about the outcomes of endovascular repair of rDTAA and the factors that affect these out...

journal_title：Circulation

authors： Jonker FH,Verhagen HJ,Lin PH,Heijmen RH,Trimarchi S,Lee WA,Moll FL,Athamneh H,Muhs BE

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide (BNP), as a cardiac hormone, is expressed together with atrial natriuretic peptide (ANP) in the ventricles in congestive heart failure. However, the ventricular expression of BNP in hypertrophic cardiomyopathy (HCM) with normal systolic function is still unclear. METHODS AND RESULT...

journal_title：Circulation

authors： Hasegawa K,Fujiwara H,Doyama K,Miyamae M,Fujiwara T,Suga S,Mukoyama M,Nakao K,Imura H,Sasayama S

更新日期：1993-08-01 00:00:00

abstract：:The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction ("stunning"), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-...

journal_title：Circulation

authors： Moore CA,Cannon J,Watson DD,Kaul S,Beller GA

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Isoprostanes (iPs) are free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Several iPs exert biological effects in vitro and may contribute to the functional consequences of oxidant stress. For example, iPF(2alpha)-III (8-iso PGF(2alpha)) and iPE(2)-III modulate plate...

journal_title：Circulation

authors： Audoly LP,Rocca B,Fabre JE,Koller BH,Thomas D,Loeb AL,Coffman TM,FitzGerald GA

更新日期：2000-06-20 00:00:00

abstract：BACKGROUND:It is not known whether progression of aortic arch (AA) atheroma is associated with vascular events in patients with stroke or transient ischemic attack (TIA). METHODS AND RESULTS:AA atheroma was detected on baseline transesophageal echocardiogram in 167 consecutive patients who had prevalent stroke or TIA....

journal_title：Circulation

authors： Sen S,Hinderliter A,Sen PK,Simmons J,Beck J,Offenbacher S,Ohman EM,Oppenheimer SM

更新日期：2007-08-21 00:00:00

abstract：BACKGROUND:We investigated whether L-arginine induces regression of preexisting atheromatous lesions and reversal of endothelial dysfunction in hypercholesterolemic rabbits, whether similar effects can be obtained by cholesterol-lowering therapy with lovastatin, and which mechanism leads to these effects. METHODS AND ...

journal_title：Circulation

authors： Böger RH,Bode-Böger SM,Brandes RP,Phivthong-ngam L,Böhme M,Nafe R,Mügge A,Frölich JC

更新日期：1997-08-19 00:00:00

abstract：:Novel compounds that induce or inhibit platelet aggregation and constrict or dilate blood vessels were recently discovered. These compounds are all derivatives of arachidonic acid and include prostaglandin endoperoxides, thromboxane A2, prostaglandin E2, prostaglandin D2 and prostacyclin. Thromboxane A2 (TxA2) could b...

journal_title：Circulation

authors： Smith JB,Araki H,Lefer AM

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:Despite intensive investigation, how DNA methylation influences endothelial function remains poorly understood. We used methyl-CpG-binding domain protein 2 (MBD2), an interpreter for DNA methylome-encoded information, to dissect the impact of DNA methylation on endothelial function in both physiological and ...

journal_title：Circulation

authors： Rao X,Zhong J,Zhang S,Zhang Y,Yu Q,Yang P,Wang MH,Fulton DJ,Shi H,Dong Z,Wang D,Wang CY

更新日期：2011-06-28 00:00:00

abstract：BACKGROUND:Although beta-adrenergic receptor (AR) blockade therapy is beneficial in the treatment of heart failure, little is known regarding the transcriptional mechanisms underlying this salutary action. METHODS AND RESULTS:In the present study, we screened mice overexpressing Gsalpha, beta1AR, beta2AR, or protein k...

journal_title：Circulation

authors： Gaussin V,Tomlinson JE,Depre C,Engelhardt S,Antos CL,Takagi G,Hein L,Topper JN,Liggett SB,Olson EN,Lohse MJ,Vatner SF,Vatner DE

更新日期：2003-12-09 00:00:00

abstract：BACKGROUND:Major gender-based differences in the incidence of ventricular tachyarrhythmia after myocardial infarction have been shown in humans. Although the underlying mechanisms are unclear, earlier studies suggest that estrogen receptor-mediated effects play a major role in this process. METHODS AND RESULTS:We exam...

journal_title：Circulation

authors： Korte T,Fuchs M,Arkudas A,Geertz S,Meyer R,Gardiwal A,Klein G,Niehaus M,Krust A,Chambon P,Drexler H,Fink K,Grohé C

更新日期：2005-05-10 00:00:00

abstract：BACKGROUND:Mutations in the ryanodine 2 receptor (RyR2) gene have been identified in patients with catecholaminergic polymorphic ventricular tachycardia. We examined the cellular basis for the ECG features and arrhythmia mechanisms using low-dose caffeine to mimic the defective calcium homeostasis encountered under the...

journal_title：Circulation

authors： Nam GB,Burashnikov A,Antzelevitch C

更新日期：2005-05-31 00:00:00

abstract：BACKGROUND:To assess the long-term results of the edge-to-edge mitral repair performed without annuloplasty in degenerative mitral regurgitation (MR). METHODS AND RESULTS:From 1993 to 2002, 61 patients with degenerative MR were treated with an isolated edge-to-edge suture without any annuloplasty. Annuloplasty was omi...

journal_title：Circulation

authors： De Bonis M,Lapenna E,Maisano F,Barili F,La Canna G,Buzzatti N,Pappalardo F,Calabrese M,Nisi T,Alfieri O

更新日期：2014-09-09 00:00:00

abstract：BACKGROUND:Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown. METHODS AND RESULTS:We studied the effect of diet restriction-induced weight loss ...

journal_title：Circulation

authors： Verreth W,De Keyzer D,Pelat M,Verhamme P,Ganame J,Bielicki JK,Mertens A,Quarck R,Benhabilès N,Marguerie G,Mackness B,Mackness M,Ninio E,Herregods MC,Balligand JL,Holvoet P

更新日期：2004-11-16 00:00:00

abstract：BACKGROUND:The role of endothelial nitric oxide synthase (eNOS) in ischemic preconditioning (PC) and cardioprotection is poorly understood. We addressed this issue using a genetic, rather than pharmacological, approach. METHODS AND RESULTS:In the nonpreconditioned state, eNOS-/- mice exhibited infarct sizes similar to...

journal_title：Circulation

authors： Xuan YT,Guo Y,Zhu Y,Wang OL,Rokosh G,Bolli R

更新日期：2007-07-31 00:00:00

abstract：:Cerebral neurons can tolerate at least 20 min of normothermic ischemic anoxia. Cerebral recovery from more than 5 min of cardiac arrest is hampered by complex secondary derangements of multiple organ systems after reperfusion. There is increasing support of our hypothesis that this "postresuscitation syndrome" include...

journal_title：Circulation

authors： Safar P

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Familial polymorphic ventricular tachycardia is an autosomal-dominant, inherited disease with a relatively early onset and a mortality rate of approximately 30% by the age of 30 years. Phenotypically, it is characterized by salvoes of bidirectional and polymorphic ventricular tachycardias in response to vigo...

journal_title：Circulation

authors： Laitinen PJ,Brown KM,Piippo K,Swan H,Devaney JM,Brahmbhatt B,Donarum EA,Marino M,Tiso N,Viitasalo M,Toivonen L,Stephan DA,Kontula K

更新日期：2001-01-30 00:00:00

abstract：BACKGROUND:Reduction in cardiovascular death and hospitalization for heart failure (HHF) was recently reported with the sodium-glucose cotransporter-2 inhibitor (SGLT-2i) empagliflozin in patients with type 2 diabetes mellitus who have atherosclerotic cardiovascular disease. We compared HHF and death in patients newly ...

journal_title：Circulation

authors： Kosiborod M,Cavender MA,Fu AZ,Wilding JP,Khunti K,Holl RW,Norhammar A,Birkeland KI,Jørgensen ME,Thuresson M,Arya N,Bodegård J,Hammar N,Fenici P,CVD-REAL Investigators and Study Group*.

更新日期：2017-07-18 00:00:00

abstract：:BACKGROUND-We determined whether repeated caffeine administration at different dosages and for different periods of time (400 or 600 mg/d for 1 week or 400 mg/d for 2 weeks) upregulates human platelet adenosine A(2A) receptors and is accompanied by increases in cAMP accumulation and decreases in aggregation and calciu...

journal_title：Circulation

authors： Varani K,Portaluppi F,Gessi S,Merighi S,Ongini E,Belardinelli L,Borea PA

更新日期：2000-07-18 00:00:00

abstract：:A series of 252 isolated aortic homograft valves in 248 patients have been followed for 9 to 16.5 years (mean 10.8). The valves were sterilized in antibiotic solution and stored in a nutrient medium at 4 degrees C and were nonvital. There were 15 in-hospital deaths (6%) and a mortality of 2.7% in patients undergoing a...

journal_title：Circulation

authors： Barratt-Boyes BG,Roche AH,Subramanyan R,Pemberton JR,Whitlock RM

更新日期：1987-04-01 00:00:00

abstract：:The effects of therapeutic levels of quinidine were studied in an ischemic gap preparation of reflected reentry. The preparation consisted of a Purkinje fiber mounted in a three-compartment chamber. A narrow central compartment was perfused with a solution prepared to mimic the extracellular milieu at a site of ischem...

journal_title：Circulation

authors： Shen XT,Antzelevitch C

更新日期：1986-06-01 00:00:00

abstract：:A case history of a 46-year-old Negro male was presented with rheumatic aortic insufficiency, angina pectoris, and possible subacute bacterial endocarditis. While hospitalized, the patient developed angina pectoris associated with micturition. This was not accompanied by a change in blood pressure, pulse, or increase ...

journal_title：Circulation

authors： Morris JJ,McIntosh HD

更新日期：1963-01-01 00:00:00

abstract：BACKGROUND:The therapeutic effects of nonspecific beta-blockers are limited by vasoconstriction, thus justifying the interest in molecules with ancillary vasodilating properties. Nebivolol is a selective beta1-adrenoreceptor antagonist that releases nitric oxide (NO) through incompletely characterized mechanisms. We id...

journal_title：Circulation

authors： Dessy C,Saliez J,Ghisdal P,Daneau G,Lobysheva II,Frérart F,Belge C,Jnaoui K,Noirhomme P,Feron O,Balligand JL

更新日期：2005-08-23 00:00:00

abstract：BACKGROUND:The main goal of the initial treatment of ST-segment elevation myocardial infarction is prompt reperfusion of the infarct-related artery. The value of pretreatment with clopidogrel before primary percutaneous coronary intervention is currently unclear. METHODS AND RESULTS:Studies were retrieved through MEDL...

journal_title：Circulation

authors： Vlaar PJ,Svilaas T,Damman K,de Smet BJ,Tijssen JG,Hillege HL,Zijlstra F

更新日期：2008-10-28 00:00:00

abstract：BACKGROUND:Prenatal surgery for congenital anomalies can prevent fetal demise or alter the course of organ development, resulting in a more favorable condition at birth. The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system...

journal_title：Circulation

authors： Rychik J,Tian Z,Cohen MS,Ewing SG,Cohen D,Howell LJ,Wilson RD,Johnson MP,Hedrick HL,Flake AW,Crombleholme TM,Adzick NS

更新日期：2004-09-21 00:00:00

abstract：BACKGROUND:Ultrasonic angioplasty was recently shown to ablate thrombi and atherosclerotic plaques in vitro and to recanalize occluded arteries in experimental animal models. The goal of the present study was to examine the clinical feasibility of ultrasonic angioplasty. METHODS AND RESULTS:Intraoperative ultrasonic a...

journal_title：Circulation

authors： Rosenschein U,Rozenszajn LA,Kraus L,Marboe CC,Watkins JF,Rose EA,David D,Cannon PJ,Weinstein JS

更新日期：1991-06-01 00:00:00