Abstract:
BACKGROUND:The role of endothelial nitric oxide synthase (eNOS) in ischemic preconditioning (PC) and cardioprotection is poorly understood. We addressed this issue using a genetic, rather than pharmacological, approach. METHODS AND RESULTS:In the nonpreconditioned state, eNOS-/- mice exhibited infarct sizes similar to those of wild-type mice. A sequence of six 4-minute coronary occlusion/4-minute reperfusion cycles (ischemic PC) induced late PC in wild-type mice; genetic deletion of eNOS abrogated the cardioprotection induced by late PC. In wild-type mice, ischemic PC induced membranous translocation of protein kinase C (PKC) epsilon and an increase in pSer-MEK-1/2 and pTyr-p44/42 mitogen-activated protein kinase, nuclear pSer-signal transducers and activators of transcription (STAT)1 and pSer-STAT3, and nuclear STAT1/3 DNA binding activity, followed by upregulation of cyclooxygenase-2 protein and activity 24 hours later. All of these changes were abrogated in eNOS-/- mice. The NO donor diethylenetriamine/NO recapitulated the effects of ischemic PC. CONCLUSIONS:In contrast to previous reports, we found that basal eNOS activity does not modulate infarct size in the nonpreconditioned state. However, eNOS is obligatorily required for the development of the cardioprotective effects of late PC and acts as the trigger of this process by activating the PKC epsilon-MEK-1/2-p44/42 mitogen-activated protein kinase pathway, leading to Ser-727 phosphorylation of STAT1 and STAT3 and consequent upregulation of STAT-dependent genes such as cyclooxygenase-2. The effects of eNOS-derived NO are reproduced by exogenous NO (NO donors), implying that nitrates can upregulate cardiac cyclooxygenase-2.
journal_name
Circulationjournal_title
Circulationauthors
Xuan YT,Guo Y,Zhu Y,Wang OL,Rokosh G,Bolli Rdoi
10.1161/CIRCULATIONAHA.107.689471subject
Has Abstractpub_date
2007-07-31 00:00:00pages
535-44issue
5eissn
0009-7322issn
1524-4539pii
CIRCULATIONAHA.107.689471journal_volume
116pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::Eleven consecutive patients with idiopathic dilated cardiomyopathy and spontaneous, sustained ventricular tachycardia (VT) of uniform morphology underwent programmed ventricular stimulation and serial antiarrhythmic drug testing. The mean ejection fraction was 30 +/- 6.4%. Sustained VT was induced by programmed electr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.70.3.451
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:Symptomatic prolonged sinus pauses on termination of atrial fibrillation (AF) are an indication for pacemaker implantation. We evaluated sinus node function and clinical outcome in patients with prolonged sinus pauses on termination of arrhythmia who underwent ablation of paroxysmal AF. METHODS AND RESULTS:...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.CIR.0000090685.13169.07
更新日期:2003-09-09 00:00:00
abstract:BACKGROUND:Few data have evaluated physician adherence to cardiovascular disease (CVD) prevention guidelines according to physician specialty or patient characteristics, particularly gender. METHODS AND RESULTS:An online study of 500 randomly selected physicians (300 primary care physicians, 100 obstetricians/gynecolo...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000154568.43333.82
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Obstruction to left ventricular outflow can be seen after surgical repair of congenital heart disease in which a ventricular septal defect (VSD) is closed by means of a baffle to the systemic great artery arising from the right ventricle (Rastelli operation, intraventricular repair, for conotruncal anomaly)....
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Electrophysiological mechanisms by which adenosine may activate cardiac afferent neurons are unknown. Slow afterhyperpolarizations (AHPs) follow action potentials in a subset of vagal C afferents, rendering them inexcitable. The purpose of this study was to test the hypothesis that adenosine increases vagal ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.9.1325
更新日期:2001-03-06 00:00:00
abstract::The time of acute myocardial infarction was determined in all 1,741 patients of the ISAM (Intravenous Streptokinase in Acute Myocardial Infarction) Study, based on onset of clinical symptoms and evaluation of plasma CK-MB enzyme time-activity curves. The incidence of myocardial infarction was markedly increased betwee...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.80.4.853
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:In people with atrial fibrillation (AF), periods of sinus rhythm present an opportunity to detect prothrombotic atrial remodeling through measurement of P-wave indices (PWIs)-prolonged P-wave duration, abnormal P-wave axis, advanced interatrial block, and abnormal P-wave terminal force in lead V1. We hypothe...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.118.035411
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:Precise noninvasive evaluation of pulmonary artery (PA) morphology is extremely important for medical and surgical management of patients with cyanotic heart disease. In this study, the accuracy of two-dimensional echocardiography combined with color Doppler flow mapping to assess the size, stenosis, and atr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.3.1306
更新日期:1994-03-01 00:00:00
abstract::Four revolutions are transforming the cardiology of our day. The first is a social revolution. It has resulted in plummeting esteem for the medical profession reflecting disenchantment coupled with the rapid emergence of the recognition that health care is a right rather than a privilege. The second revolution, interv...
journal_title:Circulation
pub_type: 传,历史文章,杂志文章
doi:10.1161/01.cir.87.6.2047
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:In hypertrophic cardiomyopathy, a spectrum of mitral leaflet abnormalities has been related to the mechanism of mitral systolic anterior motion (SAM), which causes both subaortic obstruction and mitral regurgitation. In the individual patient, SAM and regurgitation vary in parallel; clinically, however, grea...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.9.856
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:While previous clinical studies have shown a possible beneficial effect of the reperfusion performed at a relatively late phase of acute myocardial infarction ("late reperfusion") in preventing left ventricular enlargement, the mechanism has not been clarified. METHODS AND RESULTS:Of 89 patients with an ini...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.88.6.2565
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:The excess risk of atherosclerosis among patients with non-insulin dependent diabetes mellitus (NIDDM) is well documented. However, the presence of conventional risk factors cannot fully account for this excess risk, and the underlying mechanism remains to be elucidated. The present study prospectively evalu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.7.1770
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Two phase III trials of enoxaparin for unstable angina/non-Q-wave myocardial infarction have shown it to be superior to unfractionated heparin for preventing a composite of death and cardiac ischemic events. A prospectively planned meta-analysis was performed to provide a more precise estimate of the effects...
journal_title:Circulation
pub_type: 临床试验,杂志文章,meta分析,多中心研究
doi:10.1161/01.cir.100.15.1602
更新日期:1999-10-12 00:00:00
abstract:BACKGROUND:We previously reported that administration of elastase inhibitors reverses fatal pulmonary arterial hypertension (PAH) in rats by inducing smooth muscle cell (SMC) apoptosis. We showed in pulmonary artery (PA) organ culture that the mechanism by which elastase inhibitors induce SMC apoptosis involves repress...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.540542
更新日期:2005-07-19 00:00:00
abstract:BACKGROUND:We studied in coronary conductance and resistance arteries the coronary vasodilator effects of the angiotensin-converting enzyme inhibitor ramiprilat and the contribution of nitric oxide, bradykinin, and prostaglandins to this vasodilation. METHODS AND RESEARCH:In seven anesthetized dogs, a Doppler guidewir...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.93.9.1734
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:We evaluated the prognosis of deferred and revascularized coronary stenoses after fractional flow reserve (FFR) measurement to assess its revascularization threshold in clinical practice. METHODS:The IRIS-FFR registry (Interventional Cardiology Research In-cooperation Society Fractional Flow Reserve) prospe...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.116.024433
更新日期:2017-06-06 00:00:00
abstract::Forty adult patients underwent Doppler and two-dimensional echocardiographic examination of the pulmonary artery from multiple views to determine the variability in the magnitude of Doppler-determined flow velocity and pulmonary arterial diameter from various echocardiographic windows. Flows were recorded from two or ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.74.5.1002
更新日期:1986-11-01 00:00:00
abstract::The indications for biventricular versus left ventricular mechanical circulatory support as a bridge to cardiac transplantation are not well established. In this study, 27 potential heart transplant candidates who were in imminent risk of dying before donor heart procurement were implanted with Thoratec prosthetic ven...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:This experiment sought to determine the effects of fish oil on superoxide anion production in the myocardium and coronary arteries of atherosclerotic monkeys. Recent evidence indicates that dietary supplementation with fish oil preserves normal vasomotion of atherosclerotic coronary arteries and reduces dama...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.4.1123
更新日期:1995-02-15 00:00:00
abstract:BACKGROUND:Arteriogenesis serves as an efficient mechanism for flow restoration after arterial occlusion. This process is associated with inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), although their role in arteriogenesis remains unclear. We hypothesized that arteriogenesis is reduced in mice ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000014987.32865.8e
更新日期:2002-04-09 00:00:00
abstract:BACKGROUND:According to the American Heart Association, passive smoking is an important risk factor for coronary heart disease (CHD), but the mechanisms underlying this association are not fully understood. We studied the acute effect of passive smoking on the factors that influence the development of CHD: the antioxid...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.97.20.2012
更新日期:1998-05-26 00:00:00
abstract:BACKGROUND:Less invasive methods are replacing traditional invasive means of measuring coronary flow reserve (CFR). Transesophageal echocardiography (TEE) is becoming a useful tool for evaluation of coronary artery disease and has recently been used to measure CFR. This has always been done using dipyridamole, but aden...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.92.2.190
更新日期:1995-07-15 00:00:00
abstract:BACKGROUND:Platelet aggregation plays a critical role in myocardial infarction and stroke; however, the role of platelet secretion in atherosclerotic vascular disease is poorly understood. Therefore, we examined the hypothesis that platelet dense-granule secretion modulates thrombosis, inflammation, and atherosclerotic...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.845461
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Although acute pericarditis is a common complication of beta-thalassemia major, the prevalence and consequences of myocarditis in this disease have not been investigated. METHODS AND RESULTS:A prospective 5-year follow-up study was carried out in all patients with beta-thalassemia major in whom the diagnosi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.1.66
更新日期:1995-01-01 00:00:00
abstract::The ameliorative effect of antiplatelet therapy on atherogenesis of vein grafts was assessed in autologous cephalic veins grafted into femoral arteries of 16 normolipemic and 11 hyperlipemic stump-tailed macaque monkeys. Before grafting, one half of each vein was distended at high pressure (700 mm Hg) and the other ha...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.66.2.338
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:Early defibrillation is the most important intervention affecting survival from sudden cardiac arrest (SCA). To improve public access to early defibrillation, we established Piacenza Progetto Vita (PPV), the first system of out-of-hospital early defibrillation by first-responder volunteers. METHODS AND RESU...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000028148.62305.69
更新日期:2002-08-27 00:00:00
abstract::In our approach to dynamic cardiomyoplasty, which consists of wrapping a skeletal muscle around the heart and stimulating the former in synchrony with heart contractions to augment ventricular contractility, we have transferred a latissimus dorsi muscle flap to the heart by way of a partial resection of the second rib...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1988-11-01 00:00:00
abstract::Amiloride, a widely used diuretic, has multiple pharmacological actions, including inhibition of the sodium-hydronium ion and the sodium-calcium exchanger in heart. In terms of cardiac electrophysiology, amiloride prolongs action potential duration without alteration in upstroke velocity of phase 0 in Purkinje fibers....
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.78.6.1469
更新日期:1988-12-01 00:00:00
abstract::We studied regional myocardial perfusion by scintigraphic computer-assisted analysis of initial distribution, washout rates, and residual activity of 133Xe injected into the left coronary artery of four patients with normal arteriograms and 14 patients with coronary stenosis. At rest, residual activity in poststenotic...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.3.423
更新日期:1977-03-01 00:00:00
abstract::In a study of aerobically perfused rat hearts, the in situ photoactivation (530-590 nm) of rose bengal (a process that leads to the production of singlet oxygen and superoxide) has been shown to lead to the rapid development of electrocardiographic abnormalities and arrhythmias. With rose bengal concentrations of 1,00...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.80.5.1432
更新日期:1989-11-01 00:00:00