Tripling survival from sudden cardiac arrest via early defibrillation without traditional education in cardiopulmonary resuscitation.

Abstract:

BACKGROUND:Early defibrillation is the most important intervention affecting survival from sudden cardiac arrest (SCA). To improve public access to early defibrillation, we established Piacenza Progetto Vita (PPV), the first system of out-of-hospital early defibrillation by first-responder volunteers. METHODS AND RESULTS:The system serves a population of 173 114 residents in the Piacenza region of Italy. Equipment for the system comprises 39 semiautomatic external biphasic defibrillators (AEDs): 12 placed in high-risk locations, 12 in lay-staffed ambulances, and 15 in police cars; 1285 lay volunteers trained in use of the AED, without traditional education in cardiac pulmonary resuscitation, responded to all cases of suspected SCA, in coordination with the Emergency Medical System (EMS). During the first 22 months, 354 SCA occurred (72+/-12 years, 73% witnessed). The PPV volunteers treated 143 SCA cases (40.4%), with an EMS call-to-arrival time of 4.8+/-1.2 minutes (versus 6.2+/-2.3 minutes for EMS, P=0.05). Overall survival rate to hospital discharge was tripled from 3.3% (7 of 211) for EMS intervention to 10.5% (15 of 143) for PPV intervention (P=0.006). The survival rate for witnessed SCA was tripled by PPV: 15.5% versus 4.3% in the EMS-treated group (P=0.002). A "shockable" rhythm was present in 23.8% (34 of 143) of the PPV patients versus 15.6% (33 of 211) of the EMS patients (P=0.055). The survival rate from shockable dysrhythmias was higher for PPV versus EMS: 44.1% (15 of 34) versus 21.2% (7 of 33), P=0.046. The neurologically intact survival rate was higher in PPV-treated versus EMS-treated patients: 8.4% (12 of 143) versus 2.4% (5 of 211), P=0.009. CONCLUSIONS:Broad dissemination of AEDs for use by nonmedical volunteers enabled early defibrillation and tripled the survival rate for out-of-hospital SCA.

journal_name

Circulation

journal_title

Circulation

authors

Capucci A,Aschieri D,Piepoli MF,Bardy GH,Iconomu E,Arvedi M

doi

10.1161/01.cir.0000028148.62305.69

subject

Has Abstract

pub_date

2002-08-27 00:00:00

pages

1065-70

issue

9

eissn

0009-7322

issn

1524-4539

journal_volume

106

pub_type

杂志文章
  • Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus.

    abstract:BACKGROUND:Postprandial hyperglycemia may be a risk factor for cardiovascular disease. We compared the effects of two insulin secretagogues, repaglinide and glyburide, known to have different efficacy on postprandial hyperglycemia, on carotid intima-media thickness (CIMT) and markers of systemic vascular inflammation i...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.CIR.0000134501.57864.66

    authors: Esposito K,Giugliano D,Nappo F,Marfella R,Campanian Postprandial Hyperglycemia Study Group.

    更新日期:2004-07-13 00:00:00

  • Absence of lethal reperfusion injury after 3 hours of reperfusion. A study in a single-canine-heart model of ischemia-reperfusion.

    abstract:BACKGROUND:Whether reperfusion can cause necrosis of previously viable myocytes (lethal reperfusion injury) remains controversial. Numerous studies examined the ability of various agents to prevent or limit reperfusion injury, but the results were contradictory. In a single-canine-heart model of ischemia-reperfusion, w...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.91.12.2989

    authors: Zahger D,Yano J,Chaux A,Fishbein MC,Ganz W

    更新日期:1995-06-15 00:00:00

  • Slow breathing increases arterial baroreflex sensitivity in patients with chronic heart failure.

    abstract:BACKGROUND:It is well established that a depressed baroreflex sensitivity may adversely influence the prognosis in patients with chronic heart failure (CHF) and in those with previous myocardial infarction. METHODS AND RESULTS:We tested whether a slow breathing rate (6 breaths/min) could modify the baroreflex sensitiv...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/hc0202.103311

    authors: Bernardi L,Porta C,Spicuzza L,Bellwon J,Spadacini G,Frey AW,Yeung LY,Sanderson JE,Pedretti R,Tramarin R

    更新日期:2002-01-15 00:00:00

  • Repeat coronary revascularization after coronary artery bypass surgery in older adults: the Society of Thoracic Surgeons' national experience, 1991-2007.

    abstract:BACKGROUND:A major advantage of coronary artery bypass graft surgery (CABG) relative to percutaneous coronary intervention is its durability, yet there is a paucity of information on rates and predictors of repeat coronary revascularization after CABG in the modern era. METHODS AND RESULTS:We included patients ≥65 yea...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.113.001882

    authors: Fosbøl EL,Zhao Y,Shahian DM,Grover FL,Edwards FH,Peterson ED

    更新日期:2013-04-23 00:00:00

  • Attenuation of exercise-induced myocardial ischemia in dogs with recruitment of coronary vasodilator reserve by nifedipine.

    abstract::There is now evidence that under resting conditions coronary vasodilator reserve exists even in the presence of myocardial ischemia. Therefore, we tested the hypothesis that a vasodilator reserve may exist during exercise so that during exercise-induced ischemia a reduction in coronary constrictor tone can be produced...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.75.2.482

    authors: Heusch G,Guth BD,Seitelberger R,Ross J Jr

    更新日期:1987-02-01 00:00:00

  • Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice.

    abstract:BACKGROUND:Fat inflammation may play an important role in comorbidities associated with obesity such as atherosclerosis. METHODS AND RESULTS:To first establish feasibility of fat transplantation, epididymal fat pads were harvested from wild-type C57BL/6J mice and transplanted into leptin-deficient (Lep(ob/ob)) mice. F...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.717595

    authors: Ohman MK,Shen Y,Obimba CI,Wright AP,Warnock M,Lawrence DA,Eitzman DT

    更新日期:2008-02-12 00:00:00

  • Acute effect of intravenous dipyridamole on regional coronary hemodynamics and metabolism.

    abstract::The acute coronary hemodynamic and metabolic effects of intravenous dipyridamole were studied in 13 patients. Total left ventricular (LV), anterior (supplied by the left anterior descending coronary artery) and inferior (supplied by circumflex and right coronary arteries) regional flows and metabolic responses were as...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.64.2.333

    authors: Feldman RL,Nichols WW,Pepine CJ,Conti CR

    更新日期:1981-08-01 00:00:00

  • Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability.

    abstract:BACKGROUND:Studies have implicated a role for prostaglandin (PG) E(2)-dependent matrix metalloproteinase (MMP) biosynthesis in the rupture of atherosclerotic plaque. Cyclooxygenase-2 (COX-2) and PGE synthase (PGES) are coregulated in nucleated cells by inflammatory stimuli. The aim of this study was to characterize the...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc3401.093152

    authors: Cipollone F,Prontera C,Pini B,Marini M,Fazia M,De Cesare D,Iezzi A,Ucchino S,Boccoli G,Saba V,Chiarelli F,Cuccurullo F,Mezzetti A

    更新日期:2001-08-21 00:00:00

  • In vivo visualization of cardiac allograft rejection and trafficking passenger leukocytes using bioluminescence imaging.

    abstract:BACKGROUND:We investigated the feasibility of bioluminescence imaging (BLI) for the in vivo assessment of cardiac allograft viability and visualization of passenger leukocytes during the course of acute rejection. METHODS AND RESULTS:Hearts of FVB (H-2q) luciferase-green fluorescent protein transgenic mice (beta-actin...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.104.524777

    authors: Tanaka M,Swijnenburg RJ,Gunawan F,Cao YA,Yang Y,Caffarelli AD,de Bruin JL,Contag CH,Robbins RC

    更新日期:2005-08-30 00:00:00

  • Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation.

    abstract:BACKGROUND:Functional mitral regurgitation (MR) is caused by systolic traction on the mitral leaflets related to ventricular distortion. Little is known about whether chronic tethering causes the mitral leaflet area to adapt to the geometric needs imposed by tethering, in part because of inability to reconstruct leafle...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.749440

    authors: Chaput M,Handschumacher MD,Tournoux F,Hua L,Guerrero JL,Vlahakes GJ,Levine RA

    更新日期:2008-08-19 00:00:00

  • Minnesota ALG. Safe and effective immunosuppression for cardiac transplantation.

    abstract::Fifty-six patients undergoing orthotopic cardiac transplantation were given Minnesota ALG prophylactically or therapeutically for acute cardiac rejection. During a follow-up period of 0-28 months (mean follow-up period, 11.9 months), the actuarial survival for the entire group was 96% and 86% at 30 days and 1 year, re...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Keith FM,Magilligan DJ Jr,Lakier JB,Drost CJ

    更新日期:1988-11-01 00:00:00

  • Sympathoinhibitory effects of atrial natriuretic factor in normal humans.

    abstract::In rats, atrial natriuretic factor (ANF) reduces sympathetic nerve activity (SNA) reflexively by sensitizing cardiac mechanoreceptors with inhibitory vagal afferents. We performed three series of experiments in 26 normal young men to document whether ANF inhibits SNA in humans and if so, to determine potential mechani...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.81.6.1860

    authors: Floras JS

    更新日期:1990-06-01 00:00:00

  • Transmembrane potential properties at the core of functional reentrant wave fronts in isolated canine right atria.

    abstract:BACKGROUND:The characteristics of transmembrane potential (TMP) at the core of functional reentry in the atrium are not well understood. METHODS AND RESULTS:In protocol 1 (11 dogs), isolated perfused canine right atria were mapped from the endocardial surface while simultaneous TMPs were recorded from the epicardial s...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.98.15.1556

    authors: Athill CA,Ikeda T,Kim YH,Wu TJ,Fishbein MC,Karagueuzian HS,Chen PS

    更新日期:1998-10-13 00:00:00

  • Staged carotid angioplasty and stenting followed by cardiac surgery in patients with severe asymptomatic carotid artery stenosis: early and long-term results.

    abstract:BACKGROUND:The strategy for treating patients with severe asymptomatic carotid artery stenosis and cardiac disease remains unresolved. Staged or combined carotid endarterectomy in these patients offers the potential benefit of decreased neurological morbidity during and after cardiac surgery; however, in high-risk pati...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.658625

    authors: Van der Heyden J,Suttorp MJ,Bal ET,Ernst JM,Ackerstaff RG,Schaap J,Kelder JC,Schepens M,Plokker HW

    更新日期:2007-10-30 00:00:00

  • Comparison of ascending aorta versus femoral artery cannulation for acute aortic dissection type A.

    abstract:BACKGROUND:The site of cannulation for repair of ascending aortic dissection remains controversial. We present our experience with ascending aortic cannulation for acute aortic dissection type A. METHODS AND RESULTS:From January 1988 to September 2007, we operated on 242 patients for acute aortic dissection type A. Me...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.108.844480

    authors: Kamiya H,Kallenbach K,Halmer D,Ozsöz M,Ilg K,Lichtenberg A,Karck M

    更新日期:2009-09-15 00:00:00

  • Alternative Strategies to Achieve Cardiovascular Mortality Goals in China and India: A Microsimulation of Target- Versus Risk-Based Blood Pressure Treatment.

    abstract:BACKGROUND:The World Health Organization aims to reduce mortality from chronic diseases including cardiovascular disease (CVD) by 25% by 2025. High blood pressure is a leading CVD risk factor. We sought to compare 3 strategies for treating blood pressure in China and India: a treat-to-target (TTT) strategy emphasizing ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.115.019985

    authors: Basu S,Yudkin JS,Sussman JB,Millett C,Hayward RA

    更新日期:2016-03-01 00:00:00

  • Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo.

    abstract:BACKGROUND:The alpha(v)beta3 integrin plays a critical role in cell proliferation and migration. We hypothesized that vascular cell proliferation, a hallmark of injury-induced remodeling, can be tracked by targeting alpha(v)beta3 integrin expression in vivo. METHODS AND RESULTS:RP748, a novel 111In-labeled alpha(v)bet...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000133319.84326.70

    authors: Sadeghi MM,Krassilnikova S,Zhang J,Gharaei AA,Fassaei HR,Esmailzadeh L,Kooshkabadi A,Edwards S,Yalamanchili P,Harris TD,Sinusas AJ,Zaret BL,Bender JR

    更新日期:2004-07-06 00:00:00

  • Late thrombosis of saphenous vein coronary bypass grafts related to risk factors.

    abstract::In 72% of 143 patients undergoing a second coronary bypass grafting, mural or occlusive late thrombosis was observed histologically in 69% of 173 resected grafts. Late thrombosis was particularly prevalent in atherosclerotic grafts (80.2% vs. 40.4% in nonatherosclerotic grafts) and was always noted in 16 grafts with a...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Solymoss BC,Nadeau P,Millette D,Campeau L

    更新日期:1988-09-01 00:00:00

  • Effect of tachycardia heart failure on the restitution of left ventricular function in closed-chest dogs.

    abstract:BACKGROUND:Cardiac mechanical restitution and relaxation restitution are thought to be physiological correlates of the recovery kinetics of Ca2+ release mechanisms and sequestration capacity of the sarcoplasmic reticulum (SR). Since congestive heart failure is characterized by abnormal intracellular Ca2+ handling, we s...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.91.1.176

    authors: Prabhu SD,Freeman GL

    更新日期:1995-01-01 00:00:00

  • Trans-fatty acids intake and risk of myocardial infarction.

    abstract:BACKGROUND:Concern that trans-fatty acids formed in the partial hydrogenation of vegetable oils may increase the risk of coronary disease has existed for several decades, but direct evidence on this relation in humans is limited. METHODS AND RESULTS:With a case-control design, we studied the association between intake...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.1.94

    authors: Ascherio A,Hennekens CH,Buring JE,Master C,Stampfer MJ,Willett WC

    更新日期:1994-01-01 00:00:00

  • Autoimmunity in idiopathic dilated cardiomyopathy. Characterization of antibodies against the beta 1-adrenoceptor with positive chronotropic effect.

    abstract:BACKGROUND:Autoantibodies against the beta 1-adrenoceptor have been detected in the sera of patients with idiopathic dilated cardiomyopathy (DCM). The mechanisms by which these autoantibodies can alter normal receptor function are investigated, and the results are interpreted in the light of the beneficial effects of b...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.6.2760

    authors: Magnusson Y,Wallukat G,Waagstein F,Hjalmarson A,Hoebeke J

    更新日期:1994-06-01 00:00:00

  • Ticagrelor versus clopidogrel in acute coronary syndromes in relation to renal function: results from the Platelet Inhibition and Patient Outcomes (PLATO) trial.

    abstract:BACKGROUND:Reduced renal function is associated with a poorer prognosis and increased bleeding risk in patients with acute coronary syndromes and may therefore alter the risk-benefit ratio with antiplatelet therapies. In the Platelet Inhibition and Patient Outcomes (PLATO) trial, ticagrelor compared with clopidogrel re...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.109.933796

    authors: James S,Budaj A,Aylward P,Buck KK,Cannon CP,Cornel JH,Harrington RA,Horrow J,Katus H,Keltai M,Lewis BS,Parikh K,Storey RF,Szummer K,Wojdyla D,Wallentin L

    更新日期:2010-09-14 00:00:00

  • Selective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer.

    abstract:BACKGROUND:We tested the hypothesis that combined cyclooxygenase-1 (COX-1) and prostacyclin synthase (PGIS) gene transfer selectively augments prostacyclin production without a concurrent overproduction of other prostanoids. METHODS AND RESULTS:ECV304 cells were transfected with bicistronic pCOX-1/PGIS versus pCOX-1 o...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.103.16.2090

    authors: Shyue SK,Tsai MJ,Liou JY,Willerson JT,Wu KK

    更新日期:2001-04-24 00:00:00

  • Extent of clinical improvement after surgical treatment of hypertrophic obstructive cardiomyopathy.

    abstract:BACKGROUND:A subgroup of patients with hypertrophic obstructive cardiomyopathy remain severely symptomatic despite optimal medical therapy. Septal myectomy reduces or eliminates left ventricular outflow obstruction and produces marked symptomatic improvement. With the recent advent of alternative methods for treatment ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.3.467

    authors: McCully RB,Nishimura RA,Tajik AJ,Schaff HV,Danielson GK

    更新日期:1996-08-01 00:00:00

  • Long-term safety and efficacy of percutaneous coronary intervention with stenting and coronary artery bypass surgery for multivessel coronary artery disease: a meta-analysis with 5-year patient-level data from the ARTS, ERACI-II, MASS-II, and SoS trials.

    abstract:BACKGROUND:Randomized trials that studied clinical outcomes after percutaneous coronary intervention (PCI) with bare metal stenting versus coronary artery bypass grafting (CABG) are underpowered to properly assess safety end points like death, stroke, and myocardial infarction. Pooling data from randomized controlled t...

    journal_title:Circulation

    pub_type: 杂志文章,meta分析

    doi:10.1161/CIRCULATIONAHA.107.752147

    authors: Daemen J,Boersma E,Flather M,Booth J,Stables R,Rodriguez A,Rodriguez-Granillo G,Hueb WA,Lemos PA,Serruys PW

    更新日期:2008-09-09 00:00:00

  • Noninvasive quantitative evaluation of the morphology of the major pulmonary artery branches in cyanotic congenital heart disease. Angiocardiographic and echocardiographic correlative study.

    abstract:BACKGROUND:Precise noninvasive evaluation of pulmonary artery (PA) morphology is extremely important for medical and surgical management of patients with cyanotic heart disease. In this study, the accuracy of two-dimensional echocardiography combined with color Doppler flow mapping to assess the size, stenosis, and atr...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.3.1306

    authors: Hiraishi S,Misawa H,Hirota H,Agata Y,Horiguchi Y,Fujino N,Yi LH,Yashiro K,Nakae S,Kawada M

    更新日期:1994-03-01 00:00:00

  • Loss of methyl-CpG-binding domain protein 2 enhances endothelial angiogenesis and protects mice against hind-limb ischemic injury.

    abstract:BACKGROUND:Despite intensive investigation, how DNA methylation influences endothelial function remains poorly understood. We used methyl-CpG-binding domain protein 2 (MBD2), an interpreter for DNA methylome-encoded information, to dissect the impact of DNA methylation on endothelial function in both physiological and ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.110.966408

    authors: Rao X,Zhong J,Zhang S,Zhang Y,Yu Q,Yang P,Wang MH,Fulton DJ,Shi H,Dong Z,Wang D,Wang CY

    更新日期:2011-06-28 00:00:00

  • Effect of septal myotomy and myectomy on left ventricular systolic function at rest and during exercise in patients with IHSS.

    abstract::Patients with idiopathic hypertrophic subaortic stenosis (IHSS) have supernormal left ventricular systolic function at rest. Septal myotomy/myectomy reduces outflow obstruction and symptoms. However, it has been proposed that operation causes myocardial damage, with consequent reduction in left ventricular function an...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.60.2.82

    authors: Borer JS,Bacharach SL,Green MV,Kent KM,Rosing DR,Seides SF,Morrow AG,Epstein SE

    更新日期:1979-08-01 00:00:00

  • Considerations in evaluating new antianginal drugs.

    abstract::Diseases that cause symptoms incompletely relieved by available modes of treatment stimulate search for new therapies. Chronic disease processes, in which interventions are palliative rather than curative provide a particular challenge in determining the value of therapeutic intervention. Management of patients with a...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Parisi AF,Strauss WE,McIntyre KM,Sasahara AA

    更新日期:1982-01-01 00:00:00

  • Coronary vasomotor effects of serotonin in patients with angina. Relation to coronary stenosis morphology.

    abstract:BACKGROUND:Previous experimental studies have shown that the effect of serotonin on a coronary stenosis depends on whether that stenosis is compliant or fixed. However, the relation between coronary stenosis morphology and the response to serotonin in patients with angina is not known. METHODS AND RESULTS:Using comput...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.88.4.1518

    authors: Tousoulis D,Davies G,McFadden E,Clarke J,Kaski JC,Maseri A

    更新日期:1993-10-01 00:00:00