Trans-fatty acids intake and risk of myocardial infarction.

abstract：BACKGROUND:The importance of clinical presentation and pretransplantation course on outcome in children with dilated cardiomyopathy listed for heart transplantation is not well defined. METHODS AND RESULTS:The impact of age, duration of illness, sex, race, ventricular geometry, and diagnosis of myocarditis on outcome ...

journal_title：Circulation

authors： Pietra BA,Kantor PF,Bartlett HL,Chin C,Canter CE,Larsen RL,Edens RE,Colan SD,Towbin JA,Lipshultz SE,Kirklin JK,Naftel DC,Hsu DT

更新日期：2012-08-28 00:00:00

abstract：BACKGROUND:Platelet aggregation plays a critical role in myocardial infarction and stroke; however, the role of platelet secretion in atherosclerotic vascular disease is poorly understood. Therefore, we examined the hypothesis that platelet dense-granule secretion modulates thrombosis, inflammation, and atherosclerotic...

journal_title：Circulation

authors： King SM,McNamee RA,Houng AK,Patel R,Brands M,Reed GL

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:After a cavopulmonary anastomosis, the superior vena caval flow, by virtue of being the effective pulmonary blood flow, is the most important factor influencing the systemic arterial saturation. Determination of the amount of this blood flow will allow a better understanding of the physiology of the circulat...

journal_title：Circulation

authors： Salim MA,DiSessa TG,Arheart KL,Alpert BS

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:In patients with atrial fibrillation (AF), the risk of thromboembolic events (TEs) is variable and is influenced by the presence and number of comorbid conditions. The effect of percutaneous left atrial radiofrequency ablation (LARFA) of AF on the risk of TEs is unclear. METHODS AND RESULTS:LARFA was perfor...

journal_title：Circulation

authors： Oral H,Chugh A,Ozaydin M,Good E,Fortino J,Sankaran S,Reich S,Igic P,Elmouchi D,Tschopp D,Wimmer A,Dey S,Crawford T,Pelosi F Jr,Jongnarangsin K,Bogun F,Morady F

更新日期：2006-08-22 00:00:00

abstract：BACKGROUND:Adriamycin (ADR) is an anticancer drug known to cause severe cardiac toxicity by generating free radicals. We investigated the role of a redox-regulating molecule, thioredoxin-1 (TRX1), in ADR-induced cardiotoxicity. METHODS AND RESULTS:The in vitro study showed that TRX1 was dose-dependently increased conc...

journal_title：Circulation

authors： Shioji K,Kishimoto C,Nakamura H,Masutani H,Yuan Z,Oka S,Yodoi J

更新日期：2002-09-10 00:00:00

abstract：BACKGROUND:Thrombus formation within a coronary vessel is the acute precipitating event in most acute coronary syndromes. Recently, constitutive nitric oxide synthase (cNOS) has been identified in human platelets, and platelet-derived nitric oxide has been shown to inhibit platelet recruitment after aggregation. Howeve...

journal_title：Circulation

authors： Freedman JE,Ting B,Hankin B,Loscalzo J,Keaney JF Jr,Vita JA

更新日期：1998-10-13 00:00:00

abstract：BACKGROUND:The pulmonary autograft procedure (Ross) is now considered the gold standard for aortic valve replacement. One of its advantages is the freedom from macroemboli without anticoagulation. Whether this holds true for circulating microemboli, detectable as high-intensity transient Doppler signals (HITS), has not...

journal_title：Circulation

authors： Nötzold A,Droste DW,Hagedorn G,Berndt S,Kaps M,Graf B,Sievers HH

更新日期：1997-09-16 00:00:00

abstract：BACKGROUND:One of the features of high-risk atherosclerotic plaques is a preponderance of macrophages. Experimental studies with hyperlipidemic rabbits have shown that ultrasmall superparamagnetic particles of iron oxide (USPIOs) accumulate in plaques with a high macrophage content and that this induces magnetic resona...

journal_title：Circulation

authors： Kooi ME,Cappendijk VC,Cleutjens KB,Kessels AG,Kitslaar PJ,Borgers M,Frederik PM,Daemen MJ,van Engelshoven JM

更新日期：2003-05-20 00:00:00

abstract：:Although the postoperative hemodynamic and echocardiographic features of idiopathic hypertrophic subaortic stenosis have been studied, the expected consistent postoperative thinning of the interventricular septum has not been reported. In this study, the short-term effects of septal myectomy were evaluated in 16 patie...

journal_title：Circulation

authors： Schapira JN,Stemple DR,Martin RP,Rakowski H,Stinson EB,Popp RL

更新日期：1978-11-01 00:00:00

abstract：:To evaluate the severity of heart failure, cardiopulmonary exercise testing was performed in 99 normal subjects and in 382 patients with cardiac disease. Anaerobic threshold, peak oxygen uptake, and the ratio of increase in oxygen uptake to work-rate increment were determined by ventilatory and gas exchange measuremen...

journal_title：Circulation

authors： Itoh H,Taniguchi K,Koike A,Doi M

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications. METHODS AND RESULTS:To test the hypothesis that optical molecular imaging with the use of an activatable near-infrared fluorescence (NIRF) p...

journal_title：Circulation

authors： Deguchi JO,Aikawa M,Tung CH,Aikawa E,Kim DE,Ntziachristos V,Weissleder R,Libby P

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Left ventricular (LV) mechanical dyssynchrony (LVMD) has emerged as a therapeutic target using cardiac resynchronization therapy (CRT) in selected patients with chronic heart failure. Current methods used to evaluate LVMD are technically difficult and do not assess LVMD of the whole LV simultaneously. We dev...

journal_title：Circulation

authors： Kapetanakis S,Kearney MT,Siva A,Gall N,Cooklin M,Monaghan MJ

更新日期：2005-08-16 00:00:00

abstract：BACKGROUND:Conventional x-ray angiography frequently underestimates the true burden of atherosclerosis. Although intravascular ultrasound allows for imaging of coronary plaque, this invasive technique is inappropriate for screening or serial examinations. We therefore sought to develop a noninvasive free-breathing MR t...

journal_title：Circulation

authors： Botnar RM,Stuber M,Kissinger KV,Kim WY,Spuentrup E,Manning WJ

更新日期：2000-11-21 00:00:00

abstract：BACKGROUND:Body fat distribution has been cross-sectionally associated with atherosclerotic disease risk factors, but the prospective relation with coronary heart disease remains uncertain. METHODS AND RESULTS:We examined the prospective relation between fat distribution indices and coronary heart disease among 24,508...

journal_title：Circulation

authors： Canoy D,Boekholdt SM,Wareham N,Luben R,Welch A,Bingham S,Buchan I,Day N,Khaw KT

更新日期：2007-12-18 00:00:00

abstract：:Exit block from a parasystolic focus is recognized when automatic discharges fail to become manifest during the excitable phase of the ventricular cycle. In the present study, an apparently complete exit block and a persistently concealed ventricular parasystole (VP) resulted from an exit refractory period (ExRP) long...

journal_title：Circulation

authors： Nau GJ,Aldariz AE,Acunzo RS,Chiale PA,Elizari MV,Rosenbaum MB

更新日期：1981-07-01 00:00:00

abstract：:Resting hemodynamics improve during vasodilator administration in patients, with congestive heart failure (CHF), but the effects of these agents on exercise is unknown. Twenty-two patients with class II or III CHF performed bicycle exercise to symptomatic maximum before and 90 minutes after random double-blind adminis...

journal_title：Circulation

authors： Franciosa JA,Cohn JN

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:We studied the effect of an antioxidant, the intracoronary infusion of vitamin C, on basal and dobutamine-stimulated left ventricular (LV) contractility. METHODS AND RESULTS:Nineteen patients with normal ventricular function participated in this study. A micromanometer-tipped catheter was inserted into the ...

journal_title：Circulation

authors： Mak S,Newton GE

更新日期：2001-02-13 00:00:00

abstract：BACKGROUND:Familial polymorphic ventricular tachycardia (FPVT) is characterized by exercise-induced arrhythmias and sudden cardiac death due to missense mutations in the cardiac ryanodine receptor (RyR2), an intracellular Ca2+ release channel required for excitation-contraction coupling in the heart. METHODS AND RESUL...

journal_title：Circulation

authors： Lehnart SE,Wehrens XH,Laitinen PJ,Reiken SR,Deng SX,Cheng Z,Landry DW,Kontula K,Swan H,Marks AR

更新日期：2004-06-29 00:00:00

abstract：BACKGROUND:A family history of premature coronary artery disease (CAD) in a first-degree relative is an independent risk factor for coronary disease. Both genetic and environmental influences are likely to be responsible and may interact, but their relative importance is unclear. METHODS AND RESULTS:We studied endothe...

journal_title：Circulation

authors： Clarkson P,Celermajer DS,Powe AJ,Donald AE,Henry RM,Deanfield JE

更新日期：1997-11-18 00:00:00

abstract：BACKGROUND:The aims of this study were to identify hibernating myocardium (hypocontractile, hypoperfused viable myocardium that regains contractility after revascularization) in the clinical setting and to predict functional outcome in patients with coronary artery disease after coronary revascularization. METHODS AND...

journal_title：Circulation

authors： Shivalkar B,Maes A,Borgers M,Ausma J,Scheys I,Nuyts J,Mortelmans L,Flameng W

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Drugs with negative inotropic effect are widely used to decrease obstruction in hypertrophic cardiomyopathy (HCM). However, the mechanism of therapeutic benefit has not been studied. METHODS AND RESULTS:We used M-mode, two-dimensional, and pulsed Doppler echocardiography to study 11 patients with obstructiv...

journal_title：Circulation

authors： Sherrid MV,Pearle G,Gunsburg DZ

更新日期：1998-01-06 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) activators, such as troglitazone (Tro), not only improve insulin resistance but also suppress the neointimal formation after balloon injury. However, the precise mechanisms have not been determined. Angiotensin II (Ang II) plays crucial roles in th...

journal_title：Circulation

authors： Takeda K,Ichiki T,Tokunou T,Funakoshi Y,Iino N,Hirano K,Kanaide H,Takeshita A

更新日期：2000-10-10 00:00:00

abstract：BACKGROUND:Nafamostat mesilate (FUT-175) is a protease inhibitor inactivating coagulation, fibrinolysis, and platelet aggregation. A prospective, randomized trial was performed to assess the efficacy of FUT-175 in the reduction of postoperative bleeding tendency. METHODS AND RESULTS:FUT-175 was infused at a rate of 40...

journal_title：Circulation

authors： Murase M,Usui A,Tomita Y,Maeda M,Koyama T,Abe T

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Oxidative stress activates endothelial innate immunity and disrupts endothelial functions, including endothelial nitric oxide synthase-derived nitric oxide bioavailability. Here, we postulated that oxidative stress induces sterol regulatory element-binding protein 2 (SREBP2) and microRNA-92a (miR-92a), which...

journal_title：Circulation

authors： Chen Z,Wen L,Martin M,Hsu CY,Fang L,Lin FM,Lin TY,Geary MJ,Geary GG,Zhao Y,Johnson DA,Chen JW,Lin SJ,Chien S,Huang HD,Miller YI,Huang PH,Shyy JY

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:In the congenital long-QT syndrome (LQTS), there can be a marked phenotypic heterogeneity. Founder effects, by which many individuals share a mutation identical by descent, represent a powerful tool to further understand the underlying mechanisms and to predict the natural history of mutation-associated effe...

journal_title：Circulation

authors： Brink PA,Crotti L,Corfield V,Goosen A,Durrheim G,Hedley P,Heradien M,Geldenhuys G,Vanoli E,Bacchini S,Spazzolini C,Lundquist AL,Roden DM,George AL Jr,Schwartz PJ

更新日期：2005-10-25 00:00:00

abstract：BACKGROUND:Posteroseptal ablation of the atrioventricular node (AVN) has been proposed as a means to slow the ventricular rate during atrial fibrillation (AF). The suggested mechanism is elimination of the AVN "slow pathway." On the basis of the unpredictable success of the procedure, we hypothesize that, in fact, the ...

journal_title：Circulation

authors： Garrigue S,Mowrey KA,Fahy G,Tchou PJ,Mazgalev TN

更新日期：1999-05-04 00:00:00

abstract：:Valve-related complications after Björk-Shiley mitral valve implantation (n = 475), aortic valve implantation (n = 424), or mitral-aortic valve implantation (n = 119) were compared with those after St. Jude Medical mitral valve replacement (n = 173), aortic valve replacement (n = 152), or mitral-aortic valve replaceme...

journal_title：Circulation

authors： Horstkotte D,Körfer R,Seipel L,Bircks W,Loogen F

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:Most myocardial infarctions are caused by the rupture of small rather than large plaques in the arteries of the heart that are beyond the detection limit of current technologies. METHODS AND RESULTS:Recently, optical coherence tomography (OCT) has demonstrated considerable potential as a method for high-res...

journal_title：Circulation

authors： Brezinski M,Saunders K,Jesser C,Li X,Fujimoto J

更新日期：2001-04-17 00:00:00

abstract：BACKGROUND:ATP-sensitive K+ channels are activated when the myocardium becomes ischemic. However, the role of the ATP-sensitive K+ current in the emergence of ECG ST changes during ischemia remained unclarified. METHODS AND RESULTS:The left anterior descending coronary artery (LAD) was cannulated and perfused with art...

journal_title：Circulation

authors： Kubota I,Yamaki M,Shibata T,Ikeno E,Hosoya Y,Tomoike H

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:The conjoint trait hypothesis proposes that combined low HDL cholesterol (HDL-C) and high triglyceride (TG) levels represent a single, inherited phenotype that adiposity may influence in an unspecified manner. We conducted formal statistical genetic tests of the conjoint trait hypothesis and the relation of ...

journal_title：Circulation

authors： Mahaney MC,Blangero J,Comuzzie AG,VandeBerg JL,Stern MP,MacCluer JW

更新日期：1995-12-01 00:00:00