Index matching to improve optical coherence tomography imaging through blood.

Abstract:

BACKGROUND:Most myocardial infarctions are caused by the rupture of small rather than large plaques in the arteries of the heart that are beyond the detection limit of current technologies. METHODS AND RESULTS:Recently, optical coherence tomography (OCT) has demonstrated considerable potential as a method for high-resolution assessment of vulnerable plaque. However, intravascular OCT imaging is complicated by the need to remove blood from the imaging field because blood results in substantial signal attenuation. This work examines index matching as a method for increasing penetration. Index matching is based on the hypothesis that the predominant source of scattering in blood is the difference in refractive index between the cytoplasm of erythrocytes and serum. By increasing the refractive index of serum to a value near that of the cytoplasm, or index matching, scattering can be substantially reduced. The concept was tested with a system that pumped blood in vitro through transparent tubing. The test compounds, dextran and intravenous contrast agent, both led to significant improvements in penetration (69+/-12% and 45+/-4%). No significant effect was seen with the saline control. For dextran, the effect could not be attributed to reductions of red cell number or volume because changes in these parameters were not different from the control. In the case of intravenous contrast, a small but significant relative reduction in red cell volume was seen. CONCLUSIONS:This study demonstrates the feasibility of index matching for improving OCT imaging through blood. Future studies are required to identify compounds for effective index matching in vivo.

journal_name

Circulation

journal_title

Circulation

authors

Brezinski M,Saunders K,Jesser C,Li X,Fujimoto J

doi

10.1161/01.cir.103.15.1999

subject

Has Abstract

pub_date

2001-04-17 00:00:00

pages

1999-2003

issue

15

eissn

0009-7322

issn

1524-4539

journal_volume

103

pub_type

杂志文章
  • Adverse intrauterine conditions diminish the fetal defense against acute hypoxia by increasing nitric oxide activity.

    abstract:BACKGROUND:The incidence of perinatal morbidity arising from birth hypoxia or asphyxia has not changed significantly in recent years despite marked improvements in labor management. Perinatal mortality in these circumstances may therefore reflect antenatal compromise and subsequent alteration of the fetal capacity to r...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000033827.48974.c8

    authors: Gardner DS,Fowden AL,Giussani DA

    更新日期:2002-10-22 00:00:00

  • A new method for quantitation of mitral regurgitation based on color flow Doppler imaging of flow convergence proximal to regurgitant orifice.

    abstract:BACKGROUND:Imaging of the flow convergence region (FCR) proximal to a regurgitant orifice has been shown to provide a method for quantifying the regurgitant flow rate. According to the continuity principle, the FCR is constituted by concentric hemispheric isovelocity surfaces centered at the orifice. The flow rate is c...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.84.4.1481

    authors: Bargiggia GS,Tronconi L,Sahn DJ,Recusani F,Raisaro A,De Servi S,Valdes-Cruz LM,Montemartini C

    更新日期:1991-10-01 00:00:00

  • Long-term prognostic value of dobutamine-atropine stress echocardiography in 1737 patients with known or suspected coronary artery disease: A single-center experience.

    abstract:BACKGROUND:The purpose of this study was to assess the long-term value of dobutamine-atropine stress echocardiography (DSE) for prediction of late cardiac events in patients with proven or suspected coronary artery disease. METHODS AND RESULTS:Clinical data and DSE results were analyzed in 1734 consecutive patients un...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.99.6.757

    authors: Poldermans D,Fioretti PM,Boersma E,Bax JJ,Thomson IR,Roelandt JR,Simoons ML

    更新日期:1999-02-16 00:00:00

  • Rosiglitazone and outcomes for patients with diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.

    abstract:BACKGROUND:Rosiglitazone improves glycemic control for patients with type 2 diabetes mellitus, but there remains controversy regarding an observed association with cardiovascular hazard. The cardiovascular effects of rosiglitazone for patients with coronary artery disease remain unknown. METHODS AND RESULTS:To examine...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.112.000678

    authors: Bach RG,Brooks MM,Lombardero M,Genuth S,Donner TW,Garber A,Kennedy L,Monrad ES,Pop-Busui R,Kelsey SF,Frye RL,BARI 2D Investigators.

    更新日期:2013-08-20 00:00:00

  • Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms.

    abstract:BACKGROUND:The pathogenesis of impaired endothelium-dependent coronary vasodilation in angina pectoris and normal coronary arteriograms (microvascular angina pectoris) is not known. We examined whether supplementation with L-arginine, a precursor of endothelium-derived nitric oxide, improves endothelium-dependent coron...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.2.130

    authors: Egashira K,Hirooka Y,Kuga T,Mohri M,Takeshita A

    更新日期:1996-07-15 00:00:00

  • Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration.

    abstract:BACKGROUND:Previous studies have established that bone marrow-derived endothelial progenitor cells (EPCs) are present in the systemic circulation. In the current study, we investigated the hypothesis that gene transfer can be used to achieve phenotypic modulation of EPCs. METHODS AND RESULTS:In vitro, ex vivo murine v...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc0602.103673

    authors: Iwaguro H,Yamaguchi J,Kalka C,Murasawa S,Masuda H,Hayashi S,Silver M,Li T,Isner JM,Asahara T

    更新日期:2002-02-12 00:00:00

  • Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension.

    abstract:BACKGROUND:We previously reported that administration of elastase inhibitors reverses fatal pulmonary arterial hypertension (PAH) in rats by inducing smooth muscle cell (SMC) apoptosis. We showed in pulmonary artery (PA) organ culture that the mechanism by which elastase inhibitors induce SMC apoptosis involves repress...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.540542

    authors: Merklinger SL,Jones PL,Martinez EC,Rabinovitch M

    更新日期:2005-07-19 00:00:00

  • Congenital heart block in newborns of mothers with connective tissue disease.

    abstract::Of 22 children with congenital complete heart block (CCHB) available for study, 14 (63.6%) were born to 11 mothers with clinical or laboratory evidence of connective tissue disease, primarily lupus erythematosus (LE). Seven mothers had both clinical and laboratory evidence of disease while four had only positive labor...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.56.1.82

    authors: McCue CM,Mantakas ME,Tingelstad JB,Ruddy S

    更新日期:1977-07-01 00:00:00

  • Applications of percutaneous transluminal coronary angioplasty in cardiac transplantation. Preliminary results in five patients.

    abstract::Atherosclerotic coronary artery disease is the major cause of late cardiac transplant failure secondary to silent ischemia and infarction. To increase the longevity of cardiac homografts, we performed percutaneous transluminal coronary angioplasty (PTCA) in five male patients (aged 45 +/- 7 years, mean +/- SEM); 17 le...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Vetrovec GW,Cowley MJ,Newton CM,Lewis SA,DiSciascio G,Thompson JA,Hastillo A,Lower R,Hess M

    更新日期:1988-11-01 00:00:00

  • Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease.

    abstract:BACKGROUND:Q waves on a 12-lead ECG are markers of a prior myocardial infarction (MI). However, they may regress or even disappear over time, and there is no specific ECG sign of a non-Q-wave MI. Fragmented QRS complexes (fQRSs), which include various RSR' patterns, without a typical bundle-branch block are markers of ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.595892

    authors: Das MK,Khan B,Jacob S,Kumar A,Mahenthiran J

    更新日期:2006-05-30 00:00:00

  • Lowering LDL cholesterol: questions from recent meta-analyses and subset analyses of clinical trial DataIssues from the Interdisciplinary Council on Reducing the Risk for Coronary Heart Disease, ninth Council meeting.

    abstract::The benefit of cholesterol-lowering therapy in the prevention of coronary heart disease (CHD) is well established. The secondary prevention Scandinavian Simvastatin Survival Study (4S) and the primary prevention West of Scotland Coronary Prevention Study (WOSCOPS) demonstrated that lipid lowering with a statin can dra...

    journal_title:Circulation

    pub_type:

    doi:10.1161/01.cir.99.8.e1

    authors: Gotto AM Jr,Grundy SM

    更新日期:1999-03-02 00:00:00

  • Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model.

    abstract:BACKGROUND:Considerable controversy exists regarding impairment of cardiac function in diabetes mellitus (DM). We investigated the serial changes in left ventricular (LV) histopathology and LV filling dynamics in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which have been established as an animal model of type II D...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.101.8.899

    authors: Mizushige K,Yao L,Noma T,Kiyomoto H,Yu Y,Hosomi N,Ohmori K,Matsuo H

    更新日期:2000-02-29 00:00:00

  • Valve replacement for aortic stenosis in patients with poor left ventricular function: comparison of early changes with stented and stentless valves.

    abstract:BACKGROUND:Long-standing aortic stenosis causes significant left ventricular (LV) dysfunction, which may progress irreversibly. In many cases, LV function can be salvaged by aortic valve surgery, although debate exists regarding the best valve prosthesis to use. METHODS AND RESULTS:We studied 33 patients retrospective...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.suppl_2.ii-1

    authors: Collinson J,Henein M,Flather M,Pepper JR,Gibson DG

    更新日期:1999-11-09 00:00:00

  • Myocardial perfusion after aortocoronary bypass surgery: measurements at rest and after administration of isoproterenol.

    abstract::This study examined quantitative regional myocardial perfusion (RMP) measured by the washout of 133Xe at rest and after an isoproterenol challenge in 50 patients (group I) studied 8 to 14 days after they underwent saphenous vein bypass grafting to the left coronary artery, and compared this with RMP measured in the na...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.71.4.767

    authors: Schmidt DH,Blau FM,Hendrix LJ,Kamath ML,Ray G

    更新日期:1985-04-01 00:00:00

  • Endothelial Cell-Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production.

    abstract:BACKGROUND:Ischemia reperfusion injury (IRI) predisposes to the formation of donor-specific antibodies, a factor contributing to chronic rejection and late allograft loss. METHODS:We describe a mechanism underlying the correlative association between IRI and donor-specific antibodies by using humanized models and pati...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.042501

    authors: Liu L,Fang C,Fu W,Jiang B,Li G,Qin L,Rosenbluth J,Gong G,Xie CB,Yoo P,Tellides G,Pober JS,Jane-Wit D

    更新日期:2020-02-11 00:00:00

  • Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome.

    abstract:BACKGROUND:Mutations in the gene G4.5 result in a wide spectrum of severe infantile cardiomyopathic phenotypes, including isolated left ventricular noncompaction (LVNC), as well as Barth syndrome (BTHS) with dilated cardiomyopathy (DCM). The purpose of this study was to investigate patients with LVNC or BTHS for mutati...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.103.9.1256

    authors: Ichida F,Tsubata S,Bowles KR,Haneda N,Uese K,Miyawaki T,Dreyer WJ,Messina J,Li H,Bowles NE,Towbin JA

    更新日期:2001-03-06 00:00:00

  • Patient and hospital differences underlying racial variation in outcomes after coronary artery bypass graft surgery.

    abstract:BACKGROUND:Few studies have examined the association of race and outcomes after coronary artery bypass graft (CABG) surgery while controlling for both patient and hospital effects. METHODS AND RESULTS:We retrospectively analyzed data on a cohort of 566,785 white and 24,354 black Medicare beneficiaries 65 years old and...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000157728.49918.9F

    authors: Konety SH,Vaughan Sarrazin MS,Rosenthal GE

    更新日期:2005-03-15 00:00:00

  • Exaggerated endothelin release in high-altitude pulmonary edema.

    abstract:BACKGROUND:Exaggerated pulmonary hypertension is thought to play an important part in the pathogenesis of high-altitude pulmonary edema (HAPE). Endothelin-1 is a potent pulmonary vasoconstrictor peptide that also augments microvascular permeability. METHODS AND RESULTS:We measured endothelin-1 plasma levels and pulmon...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.99.20.2665

    authors: Sartori C,Vollenweider L,Löffler BM,Delabays A,Nicod P,Bärtsch P,Scherrer U

    更新日期:1999-05-25 00:00:00

  • Platelet nitric oxide and superoxide release during the development of nitrate tolerance: effect of supplemental ascorbate.

    abstract:BACKGROUND:The therapeutic benefits that accompany the continuous administration of organic nitrates are attenuated by the development of tolerance to the compounds. Altered superoxide production and NO bioavailability have been implicated in contributing to the development of tolerance, an effect that may be ameliorat...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.0000021600.84149.78

    authors: McVeigh GE,Hamilton P,Wilson M,Hanratty CG,Leahey WJ,Devine AB,Morgan DG,Dixon LJ,McGrath LT

    更新日期:2002-07-09 00:00:00

  • Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells.

    abstract:BACKGROUND:Doxycycline has been shown to effectively inhibit aneurysm formation in animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix metalloproteinase-9 inhibition, such an effect is unclear in human studies. We reevaluated the effect of doxycycline on aortic wall protease content i...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.108.806505

    authors: Lindeman JH,Abdul-Hussien H,van Bockel JH,Wolterbeek R,Kleemann R

    更新日期:2009-04-28 00:00:00

  • Coronary sinus morphology in patients with atrioventricular junctional reentry tachycardia and other supraventricular tachyarrhythmias.

    abstract:BACKGROUND:Coronary sinus access by electrode catheters is easier in patients with atrioventricular junctional reentry tachycardia (AVJRT) than in patients with other supraventricular tachyarrhythmias. The reason for this has not been addressed. METHODS AND RESULTS:The size and shape of the proximal coronary sinus wer...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.3.436

    authors: Doig JC,Saito J,Harris L,Downar E

    更新日期:1995-08-01 00:00:00

  • Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART).

    abstract:BACKGROUND:The future risk of myocardial infarction is commonly assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenosis severity. We assessed whether noncalcified low-attenuation plaque burden on coronary CT angiography (CCTA) might be a better predictor of the future risk ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.044720

    authors: Williams MC,Kwiecinski J,Doris M,McElhinney P,D'Souza MS,Cadet S,Adamson PD,Moss AJ,Alam S,Hunter A,Shah ASV,Mills NL,Pawade T,Wang C,Weir McCall J,Bonnici-Mallia M,Murrills C,Roditi G,van Beek EJR,Shaw LJ,Nicol E

    更新日期:2020-05-05 00:00:00

  • Coronary stenting with a new, radiopaque, balloon-expandable endoprosthesis in pigs.

    abstract:BACKGROUND:Intracoronary stents may be effective when used as "bail-out" devices for acute complications after percutaneous transluminal coronary angioplasty. Furthermore, preliminary reports have demonstrated some promising results with stents with regard to the reduction of restenosis. Several stent devices are avail...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.83.5.1788

    authors: van der Giessen WJ,Serruys PW,van Beusekom HM,van Woerkens LJ,van Loon H,Soei LK,Strauss BH,Beatt KJ,Verdouw PD

    更新日期:1991-05-01 00:00:00

  • Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: a science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions,

    abstract::Dual antiplatelet therapy with aspirin and a thienopyridine has been shown to reduce cardiac events after coronary stenting. However, many patients and healthcare providers prematurely discontinue dual antiplatelet therapy, which greatly increases the risk of stent thrombosis, myocardial infarction, and death. This ad...

    journal_title:Circulation

    pub_type: 杂志文章,实务指引

    doi:10.1161/CIRCULATIONAHA.106.180944

    authors: Grines CL,Bonow RO,Casey DE Jr,Gardner TJ,Lockhart PB,Moliterno DJ,O'Gara P,Whitlow P,American Heart Association.,American College of Cardiology.,Society for Cardiovascular Angiography and Interventions.,American College of Surgeon

    更新日期:2007-02-13 00:00:00

  • Endogenous cell seeding. Remnant endothelium after stenting enhances vascular repair.

    abstract:BACKGROUND:Endothelial integrity is essential for maintaining vascular homeostasis, and endothelial denudation results in neointimal thickening. Balloon-expandable endovascular stents provide a luminal scaffolding within atherosclerotic arteries with minimal direct contact between balloon and endothelium. We wondered w...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.11.2909

    authors: Rogers C,Parikh S,Seifert P,Edelman ER

    更新日期:1996-12-01 00:00:00

  • Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease.

    abstract:BACKGROUND:High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. The impact of lack of prebiotic fiber and the associated mechanisms that lead to higher ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.043081

    authors: Kaye DM,Shihata WA,Jama HA,Tsyganov K,Ziemann M,Kiriazis H,Horlock D,Vijay A,Giam B,Vinh A,Johnson C,Fiedler A,Donner D,Snelson M,Coughlan MT,Phillips S,Du XJ,El-Osta A,Drummond G,Lambert GW,Spector TD,Valdes AM

    更新日期:2020-04-28 00:00:00

  • Direct evidence for a crucial role of the arterial wall in control of atherosclerosis susceptibility.

    abstract:BACKGROUND:Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerosis susceptibility. We sought to determine whether the difference in atherosclerosis susceptibility resides at the level of arterial walls. METHODS AND RESULTS:Thoracic aortic segments from 8-week-old female B6 an...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.640185

    authors: Pei H,Wang Y,Miyoshi T,Zhang Z,Matsumoto AH,Helm GA,Tellides G,Shi W

    更新日期:2006-11-28 00:00:00

  • Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes.

    abstract:BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) is a chemokine responsible for the recruitment of monocytes to sites of inflammation. MCP-1 appears to play a critical role at multiple stages in atherosclerosis, including the initiation of the fatty streak, promotion of plaque instability, and remodeling after myo...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.cir.0000049742.68848.99

    authors: de Lemos JA,Morrow DA,Sabatine MS,Murphy SA,Gibson CM,Antman EM,McCabe CH,Cannon CP,Braunwald E

    更新日期:2003-02-11 00:00:00

  • Attenuated progression of coronary artery disease after 6 years of multifactorial risk intervention: role of physical exercise.

    abstract:BACKGROUND:It was the aim of this study to assess the long-term effects of physical exercise and low-fat diet on the progression of coronary artery disease. At the beginning of the study, 113 male patients with coronary artery disease were randomized to an intervention group (n=56) or a control group (n=57); 90 patient...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.96.8.2534

    authors: Niebauer J,Hambrecht R,Velich T,Hauer K,Marburger C,Kälberer B,Weiss C,von Hodenberg E,Schlierf G,Schuler G,Zimmermann R,Kübler W

    更新日期:1997-10-21 00:00:00

  • Association between visceral and subcutaneous adipose depots and incident cardiovascular disease risk factors.

    abstract:BACKGROUND:Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) vary in volume and quality. We evaluated whether fat volume or attenuation (indirect measure of quality) predicts metabolic risk factor changes. METHODS AND RESULTS:Framingham Heart Study Multi-detector Computed Tomography Substudy particip...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.114.015000

    authors: Abraham TM,Pedley A,Massaro JM,Hoffmann U,Fox CS

    更新日期:2015-10-27 00:00:00