当前位置： SCI文献检索 > CIRCULATION期刊下所有文献 > Association between visceral and subcutaneous adipose depots and incident cardiovascular disease risk factors.

Association between visceral and subcutaneous adipose depots and incident cardiovascular disease risk factors.

Abstract：

BACKGROUND:Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) vary in volume and quality. We evaluated whether fat volume or attenuation (indirect measure of quality) predicts metabolic risk factor changes. METHODS AND RESULTS:Framingham Heart Study Multi-detector Computed Tomography Substudy participants (n=1730, 45% women) were followed up over a mean of 6.2 years. Baseline VAT and SAT volume (in cm(3)) and attenuation (in Hounsfield units) were assessed. Outcomes included blood pressure, lipids, and glucose. We constructed multivariable regression models predicting change from baseline to follow-up. Baseline VAT was associated with metabolic risk factors at follow-up. Per 500-cm(3) increase in baseline VAT, glucose was 2.34 mg/dL higher (95% confidence interval, 1.71-2.97) and high-density lipoprotein was 1.62 mg/dL lower (95% confidence interval, 0.97-2.28) in women (P<0.0001 for both). These findings remained significant after adjustment for body mass index. Results for SAT were similar although less striking. Lower (more negative) fat attenuation was associated with more adverse metabolic profiles at follow-up. For example, per 5-unit decrease in baseline VAT Hounsfield units, log triglycerides increased by 0.08 mg/dL (95% confidence interval, 0.05-0.12; P=0.005), which remained significant after adjustment for baseline VAT. Among men, VAT and SAT Hounsfield units were associated with changes in cardiovascular disease risk factors but were mostly attenuated after baseline volume adjustment. CONCLUSIONS:VAT volume and SAT volume are associated with incident metabolic risk factors beyond overall adiposity. Decreases in fat attenuation are also associated with incident risk factors. These findings suggest that both volume and quality of VAT and SAT contribute to metabolic risk.

journal_name

Circulation

journal_title

Circulation

authors

Abraham TM,Pedley A,Massaro JM,Hoffmann U,Fox CS

doi

10.1161/CIRCULATIONAHA.114.015000

subject

Has Abstract

pub_date

2015-10-27 00:00:00

pages

1639-47

issue

17

eissn

0009-7322

issn

1524-4539

pii

CIRCULATIONAHA.114.015000

journal_volume

132

pub_type

杂志文章

相关文献

CIRCULATION文献大全
  • The St. Jude valve. Thrombolysis as the first line of therapy for cardiac valve thrombosis.

    abstract：BACKGROUND:Thrombolytic therapy is a promising alternative to valve replacement in the management of prosthetic valve thrombosis. We sought to determine the short- and long-term results of treating thrombosed St. Jude heart valves with thrombolytic therapy as the primary treatment modality. METHODS AND RESULTS:Between...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.87.1.30

    authors： Silber H,Khan SS,Matloff JM,Chaux A,DeRobertis M,Gray R

    更新日期：1993-01-01 00:00:00

  • Research related to medical treatment of cardiovascular disease.

    abstract：:Medical treatment of heart disease has improved significantly in the past 30 years. The spectacular change in the natural history of rheumatic heart disease is apparent from a 1948 article that reported that 42% of children with rheumatic heart disease died of rheumatic infection or bacterial endocarditis. Antibiotics...

    journal_title：Circulation

    pub_type： 临床试验,历史文章,杂志文章

    doi：10.1161/01.cir.60.7.1609

    authors： Ross RS

    更新日期：1979-12-01 00:00:00

  • Prognostic Implications of Magnetic Resonance-Derived Quantification in Asymptomatic Patients With Organic Mitral Regurgitation: Comparison With Doppler Echocardiography-Derived Integrative Approach.

    abstract：BACKGROUND:Magnetic resonance imaging (MRI) is an accurate method for the quantitative assessment of organic mitral regurgitation (OMR). The aim of the present study was to compare the discriminative power of MRI quantification and the recommended Doppler echocardiography (ECHO)-derived integrative approach to identify...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.117.029332

    authors： Penicka M,Vecera J,Mirica DC,Kotrc M,Kockova R,Van Camp G

    更新日期：2018-03-27 00:00:00

  • Cyclic elevation of intrathoracic pressure can close the mitral valve during cardiac arrest in dogs.

    abstract：:Mitral valve closure during cardiopulmonary resuscitation may result from direct cardiac compression. An alternative hypothesis is that with a rise in intrathoracic pressure, mitral valve closure can occur but may be influenced by whether the lungs are inflated or deflated. To test this hypothesis, we placed a large-b...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.78.3.754

    authors： Halperin HR,Weiss JL,Guerci AD,Chandra N,Tsitlik JE,Brower R,Beattie C,Wurmb E,Cadden J,Weisfeldt ML

    更新日期：1988-09-01 00:00:00

  • Low-density lipoprotein postsecretory modification, monocyte function, and circulating adhesion molecules in type 2 diabetic patients with and without macrovascular complications: the effect of alpha-tocopherol supplementation.

    abstract：BACKGROUND:Although diabetes confers an increased propensity toward accelerated atherogenesis, data are lacking on monocyte activity in type 2 diabetic patients with (DM2-MV) and without (DM2) macrovascular disease compared with control subjects. Thus, we tested whether (1) postsecretory modifications of LDL (glycation...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.102.2.191

    authors： Devaraj S,Jialal I

    更新日期：2000-07-11 00:00:00

  • Lifetime fruit and vegetable consumption and arterial pulse wave velocity in adulthood: the Cardiovascular Risk in Young Finns Study.

    abstract：BACKGROUND:The relationships between childhood lifestyle risk factors and adulthood pulse wave velocity (PWV) have not been reported. We studied whether childhood and adulthood lifestyle risk factors are associated with PWV assessed in adulthood. METHODS AND RESULTS:The study cohort comprised 1622 subjects of the Card...

    journal_title：Circulation

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/CIRCULATIONAHA.110.969279

    authors： Aatola H,Koivistoinen T,Hutri-Kähönen N,Juonala M,Mikkilä V,Lehtimäki T,Viikari JS,Raitakari OT,Kähönen M

    更新日期：2010-12-14 00:00:00

  • Asymptomatic Cardiac Ischemia Pilot (ACIP) Study. Improvement of cardiac ischemia at 1 year after PTCA and CABG.

    abstract：BACKGROUND:Cardiac ischemia on the ambulatory ECG (AECG) and/or on the exercise treadmill test (ETT) is associated with an increased risk of adverse outcome. Myocardial revascularization more often suppresses cardiac ischemia than does medical management alone. However, few studies have compared the effects of percutan...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1161/01.cir.92.9.1

    authors： Bourassa MG,Knatterud GL,Pepine CJ,Sopko G,Rogers WJ,Geller NL,Dyrda I,Forman SA,Chaitman BR,Sharaf B

    更新日期：1995-11-01 00:00:00

  • Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium.

    abstract：BACKGROUND:Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics in patients with congestive heart failure. We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-st...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/hc0202.102238

    authors： Hasenfuss G,Maier LS,Hermann HP,Lüers C,Hünlich M,Zeitz O,Janssen PM,Pieske B

    更新日期：2002-01-15 00:00:00

  • Inaccuracy of estimated resting oxygen uptake in the clinical setting.

    abstract：BACKGROUND:The Fick principle (cardiac output = oxygen uptake ( O2)/systemic arterio-venous oxygen difference) is used to determine cardiac output in numerous clinical situations. However, estimated rather than measured O2 is commonly used because of complexities of the measurement, though the accuracy of estimation re...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.113.003334

    authors： Narang N,Thibodeau JT,Levine BD,Gore MO,Ayers CR,Lange RA,Cigarroa JE,Turer AT,de Lemos JA,McGuire DK

    更新日期：2014-01-14 00:00:00

  • Recombinant staphylokinase variants with altered immunoreactivity. II: Thrombolytic properties and antibody induction.

    abstract：BACKGROUND:The substitution variants K35A,E38A,K74A, E75A,R77A (SakSTAR.M38) and K74A,E75A,R77A,E80A, D82A (SakSTAR.M89) of recombinant staphylokinase (SakSTAR) with reduced antibody reactivity were assayed for thrombolytic potency and antibody induction in animal models and in patients. METHODS AND RESULTS:In a 125I-...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.94.2.207

    authors： Collen D,Moreau H,Stockx L,Vanderschueren S

    更新日期：1996-07-15 00:00:00

  • Coronary arterial spasm and Prinzmetal's variant form of angina induced by hyperventilation and Tris-buffer infusion.

    abstract：:Vigorous hyperventilation was induced for five minutes immediately after a five-minute infusion of 100 ml of Tris-buffer (pH 10) in nine patients with Prinzmetal's variant angina. In eight of the patients, chest pain with ischemic changes in the electrocardiogram occurred during this procedure or within five minutes a...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.58.1.56

    authors： Yasue H,Nagao M,Omote S,Takizawa A,Miwa K,Tanaka S

    更新日期：1978-07-01 00:00:00

  • Gap junction blockers decrease defibrillation thresholds without changes in ventricular refractoriness in isolated rabbit hearts.

    abstract：BACKGROUND:The maintenance and termination of reentry arrhythmias are determined by tissue properties such as refractoriness and conduction velocity. Although the effects of Na(+) and K(+) channel block on electrophysiological properties and defibrillation threshold (DFT) have been studied, little is known about the ef...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/hc3801.095587

    authors： Qi X,Varma P,Newman D,Dorian P

    更新日期：2001-09-25 00:00:00

  • Decrease in forces responsible for diastolic suction during acute coronary occlusion.

    abstract：BACKGROUND:The production of left ventricular (LV) restoring forces generated during contraction, which are responsible for diastolic suction, is dependent on end-systolic volume (ESV) and systolic transmural and 3D deformation. We tested the hypothesis that acute coronary occlusion would result in loss of forces that ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.96.7.2348

    authors： Bell SP,Fabian J,Watkins MW,LeWinter MM

    更新日期：1997-10-07 00:00:00

  • Interleukin-8 mediates downregulation of tissue inhibitor of metalloproteinase-1 expression in cholesterol-loaded human macrophages: relevance to stability of atherosclerotic plaque.

    abstract：BACKGROUND:The accumulation of macrophage-derived foam cells in atherosclerotic lesions correlates with increased local release of matrix-degrading metalloproteinases (MMPs) and a thin fibrous cap. The activity of these enzymes is controlled by specific tissue inhibitors of metalloproteinases (TIMPs). METHODS AND RESU...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.99.3.420

    authors： Moreau M,Brocheriou I,Petit L,Ninio E,Chapman MJ,Rouis M

    更新日期：1999-01-26 00:00:00

  • Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium.

    abstract：BACKGROUND:We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection. METHODS AND RESULTS:In one series, 129/SvJ-derived mouse ESCs (ES-D3 line) were transplanted by direct myocardial injection (1 x 10(6) c...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.104.525824

    authors： Swijnenburg RJ,Tanaka M,Vogel H,Baker J,Kofidis T,Gunawan F,Lebl DR,Caffarelli AD,de Bruin JL,Fedoseyeva EV,Robbins RC

    更新日期：2005-08-30 00:00:00

  • Environmental tobacco smoke and coronary heart disease in the American Cancer Society CPS-II cohort.

    abstract：BACKGROUND:Thirteen of 14 epidemiological studies have shown an increased risk of approximately 20% for coronary heart disease (CHD) for never-smokers exposed to environmental tobacco smoke (ETS), but this association remains controversial. If true, ETS might account for an estimated 35,000 to 40,000 heart disease deat...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.94.4.622

    authors： Steenland K,Thun M,Lally C,Heath C Jr

    更新日期：1996-08-15 00:00:00

  • Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control.

    abstract：BACKGROUND:In the preterm newborn, a patent ductus arteriosus is in large part a result of the increased sensitivity of the immature ductus to prostaglandin E2 (PGE2). PGE2 acts through 3 G protein-coupled receptors (EP2, EP3, and EP4) that activate both adenyl cyclase and K(ATP) channels. We explored these pathways to...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.CIR.0000145159.16637.5D

    authors： Waleh N,Kajino H,Marrache AM,Ginzinger D,Roman C,Seidner SR,Moss TJ,Fouron JC,Vazquez-Tello A,Chemtob S,Clyman RI

    更新日期：2004-10-19 00:00:00

  • Platelet activation by emotional stress in patients with coronary artery disease.

    abstract：:We studied the effects of experimentally induced emotional stress (mental arithmetic) on different hemodynamic parameters, catecholamine levels, and serum and platelet function tests in 25 postinfarction patients and in 10 apparently healthy, age-matched control subjects. Mental stress (10 minutes) induced significant...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：

    authors： Grignani G,Soffiantino F,Zucchella M,Pacchiarini L,Tacconi F,Bonomi E,Pastoris A,Sbaffi A,Fratino P,Tavazzi L

    更新日期：1991-04-01 00:00:00

  • From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II.

    abstract：:Atherosclerotic cardiovascular disease results in >19 million deaths annually, and coronary heart disease accounts for the majority of this toll. Despite major advances in treatment of coronary heart disease patients, a large number of victims of the disease who are apparently healthy die suddenly without prior sympto...

    journal_title：Circulation

    pub_type： 共识发展会议,杂志文章,评审

    doi：10.1161/01.CIR.0000087481.55887.C9

    authors： Naghavi M,Libby P,Falk E,Casscells SW,Litovsky S,Rumberger J,Badimon JJ,Stefanadis C,Moreno P,Pasterkamp G,Fayad Z,Stone PH,Waxman S,Raggi P,Madjid M,Zarrabi A,Burke A,Yuan C,Fitzgerald PJ,Siscovick DS,de Korte CL

    更新日期：2003-10-14 00:00:00

  • Simultaneous autologous transplantation of cocultured mesenchymal stem cells and skeletal myoblasts improves ventricular function in a murine model of Chagas disease.

    abstract：BACKGROUND:Cellular transplantation is emerging as a promising strategy for the treatment of postinfarction ventricular dysfunction. Whether its beneficial effects can be extended to other cardiomyopathies remains an unexplored question. We evaluated the histological and functional effects of simultaneous autologous tr...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.105.000646

    authors： Guarita-Souza LC,Carvalho KA,Woitowicz V,Rebelatto C,Senegaglia A,Hansen P,Miyague N,Francisco JC,Olandoski M,Faria-Neto JR,Brofman P

    更新日期：2006-07-04 00:00:00

  • Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial.

    abstract：BACKGROUND:Restenosis after percutaneous coronary intervention (PCI) is a major problem affecting 15% to 30% of patients after stent placement. No oral agent has shown a beneficial effect on restenosis or on associated major adverse cardiovascular events. In limited trials, the oral agent tranilast has been shown to de...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1161/01.cir.0000028335.31300.da

    authors： Holmes DR Jr,Savage M,LaBlanche JM,Grip L,Serruys PW,Fitzgerald P,Fischman D,Goldberg S,Brinker JA,Zeiher AM,Shapiro LM,Willerson J,Davis BR,Ferguson JJ,Popma J,King SB 3rd,Lincoff AM,Tcheng JE,Chan R,Granett JR,P

    更新日期：2002-09-03 00:00:00

  • Calcineurin splicing variant calcineurin Aβ1 improves cardiac function after myocardial infarction without inducing hypertrophy.

    abstract：BACKGROUND:Calcineurin is a calcium-regulated phosphatase that plays a major role in cardiac hypertrophy. We previously described that alternative splicing of the calcineurin Aβ (CnAβ) gene generates the CnAβ1 isoform, with a unique C-terminal region that is different from the autoinhibitory domain present in all other...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.110.012211

    authors： Felkin LE,Narita T,Germack R,Shintani Y,Takahashi K,Sarathchandra P,López-Olañeta MM,Gómez-Salinero JM,Suzuki K,Barton PJ,Rosenthal N,Lara-Pezzi E

    更新日期：2011-06-21 00:00:00

  • Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia.

    abstract：BACKGROUND:Lung hypoplasia and persistent pulmonary hypertension of the newborn limit survival in congenital diaphragmatic hernia (CDH). Unlike other diseases resulting in persistent pulmonary hypertension of the newborn, infants with CDH are refractory to inhaled nitric oxide (NO). Nitric oxide mediates pulmonary vaso...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.108.845909

    authors： Luong C,Rey-Perra J,Vadivel A,Gilmour G,Sauve Y,Koonen D,Walker D,Todd KG,Gressens P,Kassiri Z,Nadeem K,Morgan B,Eaton F,Dyck JR,Archer SL,Thébaud B

    更新日期：2011-05-17 00:00:00

  • Transluminal angioplasty: correlation of morphologic and angiographic findings in an experimental model.

    abstract：:The morphologic consequences of transluminal angioplasty of stenotic atherosclerotic coronary arteries are unknown. This study describes the production of aortoiliac atherosclerosis in rabbits and reports the morphologic changes after transluminal angioplasty of stenotic arterial lesions. Atherosclerotic lesions were ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.61.4.778

    authors： Block PC,Baughman KL,Pasternak RC,Fallon JT

    更新日期：1980-04-01 00:00:00

  • Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes.

    abstract：BACKGROUND:Apoptotic microparticles are responsible for almost all tissue factor activity of the plaque lipid core. We hypothesized that elevated levels of procoagulant microparticles could also circulate in the peripheral blood of patients with recent clinical signs of plaque disruption and thrombosis. METHODS AND RE...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.101.8.841

    authors： Mallat Z,Benamer H,Hugel B,Benessiano J,Steg PG,Freyssinet JM,Tedgui A

    更新日期：2000-02-29 00:00:00

  • Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries.

    abstract：BACKGROUND:Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a puzzling clinical entity with no previous evaluation of the literature. This systematic review aims to (1) quantify the prevalence, risk factors, and 12-month prognosis in patients with MINOCA, and (2) evaluate potential pathophysiolog...

    journal_title：Circulation

    pub_type： 杂志文章,meta分析,评审

    doi：10.1161/CIRCULATIONAHA.114.011201

    authors： Pasupathy S,Air T,Dreyer RP,Tavella R,Beltrame JF

    更新日期：2015-03-10 00:00:00

  • Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn Study.

    abstract：BACKGROUND:Type 2 diabetes (DM-2) and impaired glucose metabolism (IGM) are associated with an increased cardiovascular disease risk. In nondiabetic individuals, increased arterial stiffness is an important cause of cardiovascular disease. Associations between DM-2 and IGM and arterial stiffness have not been systemati...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.CIR.0000065222.34933.FC

    authors： Henry RM,Kostense PJ,Spijkerman AM,Dekker JM,Nijpels G,Heine RJ,Kamp O,Westerhof N,Bouter LM,Stehouwer CD,Hoorn Study.

    更新日期：2003-04-29 00:00:00

  • Differences in the effect of metabolic inhibition on action potentials and calcium currents in endocardial and epicardial cells.

    abstract：BACKGROUND:Ischemia-induced electrophysiological changes are more prominent in epicardial cells than in endocardial cells. Epicardial action potentials shorten more than endocardial action potentials during ischemia. Since the L-type Ca2+ current plays an important role in the maintenance of action potential duration, ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.84.2.768

    authors： Kimura S,Bassett AL,Furukawa T,Furukawa N,Myerburg RJ

    更新日期：1991-08-01 00:00:00

  • Endocardial catheter mapping: wire skeleton technique for representation of computed arrhythmogenic sites compared with intraoperative mapping.

    abstract：:Guiding surgical therapy of ventricular tachycardia by preoperative endocardial catheter mapping necessitates improvement of the accuracy of localization of the arrhythmogenic site. We therefore used a new mathematical cineradiographic method during catheter mapping to compute the position of left ventricular arrhythm...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.74.6.1346

    authors： Hauer RN,de Zwart MT,de Bakker JM,Hitchcock JF,Penn OC,Nijsen-Karelse M,Robles de Medina EO

    更新日期：1986-12-01 00:00:00

  • Endovascular repair of thoracoabdominal aneurysms.

    abstract：BACKGROUND:Morbidity and mortality after conventional repair of thoracoabdominal aneurysms remain high. Alternative techniques have been proposed and are the subject of this report. METHODS AND RESULTS:Endovascular grafts that have a means of incorporating the visceral vessels into the aortic repair were divided into ...

    journal_title：Circulation

    pub_type： 杂志文章,评审

    doi：10.1161/CIRCULATIONAHA.107.716134

    authors： Greenberg RK,Lytle B

    更新日期：2008-04-29 00:00:00