Lifetime fruit and vegetable consumption and arterial pulse wave velocity in adulthood: the Cardiovascular Risk in Young Finns Study.


BACKGROUND:The relationships between childhood lifestyle risk factors and adulthood pulse wave velocity (PWV) have not been reported. We studied whether childhood and adulthood lifestyle risk factors are associated with PWV assessed in adulthood. METHODS AND RESULTS:The study cohort comprised 1622 subjects of the Cardiovascular Risk in Young Finns Study followed up for 27 years since baseline (1980; aged 3 to 18 years) with lifestyle risk factor data available since childhood. Arterial PWV was measured in 2007 by whole-body impedance cardiography device. Vegetable consumption in childhood was inversely associated with adulthood PWV (β=-0.06, P=0.02), and this association remained significant (β=-0.07, P=0.004) when adjusted for traditional risk factors (high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, systolic blood pressure, body mass index, and smoking). Vegetable consumption was also an independent predictor of PWV in adulthood when adjusted for lifestyle or traditional risk factors (β=-0.08, P=0.002 and β=-0.07, P=0.0007, respectively). Persistently high consumption of both fruits and vegetables from childhood to adulthood was associated with lower PWV compared with persistently low consumption (P=0.03 for both). The number of lifestyle risk factors (the lowest quintile for vegetable consumption, fruit consumption, physical activity, and smoking) in childhood was directly associated with PWV in adulthood (P=0.001). This association remained significant when adjusted for the number of lifestyle risk factors in adulthood (P=0.003). CONCLUSIONS:These findings suggest that lifetime lifestyle risk factors, with low consumption of fruits and vegetables in particular, are related to arterial stiffness in young adulthood.






Aatola H,Koivistoinen T,Hutri-Kähönen N,Juonala M,Mikkilä V,Lehtimäki T,Viikari JS,Raitakari OT,Kähönen M




Has Abstract


2010-12-14 00:00:00














  • Value of physical signs in the diagnosis of ventricular tachycardia.

    abstract:BACKGROUND:Although the use of physical signs for the diagnosis of ventricular tachycardia (VT) was described in the early 1900s, their value in this role has never been systematically assessed. METHODS AND RESULTS:Using a blinded, randomized protocol, we examined the ability of 26 clinicians to detect ventriculoatria...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Garratt CJ,Griffith MJ,Young G,Curzen N,Brecker S,Rickards AF,Camm AJ

    更新日期:1994-12-01 00:00:00

  • Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis.

    abstract:BACKGROUND:The uptake of oxidized low-density lipoprotein (OxLDL) by macrophage scavenger receptors is thought to be a key process in the formation of foam cells, the hallmark of early atherosclerotic lesions. CXCL16/scavenger receptor for phosphatidylserine and OxLDL is a multifunctional chemokine that exhibits scaven...


    pub_type: 杂志文章


    authors: Aslanian AM,Charo IF

    更新日期:2006-08-08 00:00:00

  • Dronedarone.

    abstract::Amiodarone is the most effective antiarrhythmic drug for maintaining sinus rhythm for patients with atrial fibrillation. Extra-cardiac side effects have been a limiting factor, especially during chronic use, and may offset its benefits. Dronedarone is a noniodinated benzofuran derivative of amiodarone that has been de...


    pub_type: 杂志文章,评审


    authors: Patel C,Yan GX,Kowey PR

    更新日期:2009-08-18 00:00:00

  • Improved preservation of saphenous vein grafts by the use of glyceryl trinitrate-verapamil solution during harvesting.

    abstract:BACKGROUND:High-pressure distension during harvesting damages the saphenous vein (SV) and may contribute to subsequent coronary artery bypass graft (CABG) occlusion. Application of vasodilator agents to the SV during harvesting may reduce the need for high-pressure distension and improve graft quality. We tested the ef...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Roubos N,Rosenfeldt FL,Richards SM,Conyers RA,Davis BB

    更新日期:1995-11-01 00:00:00

  • Factors contributing to perforations resulting from laser coronary angioplasty: observations in an intact human postmortem preparation of intraoperative laser coronary angioplasty.

    abstract::This investigation was designed to assess the potential use of laser coronary angioplasty as an intraoperative adjunct in the surgical treatment of ischemic heart disease. Among 17 postmortem hearts, simulated laser coronary angioplasty was performed at 53 sites with a No. 4F guiding catheter and 240 micron (200 micro...


    pub_type: 杂志文章


    authors: Isner JM,Donaldson RF,Funai JT,Deckelbaum LI,Pandian NG,Clarke RH,Konstam MA,Salem DN,Bernstein JS

    更新日期:1985-09-01 00:00:00

  • Noninvasive visualization of the dilated main coronary arteries in coronary artery fistulas by cross-sectional echocardiography.

    abstract::Real-time cross-sectional echocardiographic studies of the main coronary arteries were performed in 20 normal subjects, 12 patients with patent ductus arteriosus and 14 patients with coronary artery fistula in whom the diagnosis was established by angiography. In 12 patients, the coronary artery that formed the fistul...


    pub_type: 杂志文章


    authors: Yoshikawa J,Katao H,Yanagihara K,Takagi Y,Okumachi F,Yoshida K,Tomita Y,Fukaya T,Baba K

    更新日期:1982-03-01 00:00:00

  • Myocarditis in beta-thalassemia major. A cause of heart failure.

    abstract:BACKGROUND:Although acute pericarditis is a common complication of beta-thalassemia major, the prevalence and consequences of myocarditis in this disease have not been investigated. METHODS AND RESULTS:A prospective 5-year follow-up study was carried out in all patients with beta-thalassemia major in whom the diagnosi...


    pub_type: 杂志文章


    authors: Kremastinos DT,Tiniakos G,Theodorakis GN,Katritsis DG,Toutouzas PK

    更新日期:1995-01-01 00:00:00

  • A hemodynamically responsive antitachycardia system. Development and basis for design in humans.

    abstract::Current automatic implantable cardioverter-defibrillators detect tachyarrhythmias primarily by rate-only algorithms and cannot adequately distinguish hemodynamically stable from unstable tachyarrhythmias. The responses of right atrial (mean) and right ventricular pressures (mean, systolic, diastolic, and pulse) to 64 ...


    pub_type: 杂志文章


    authors: Cohen TJ,Liem LB

    更新日期:1990-08-01 00:00:00

  • The linearity of the end-systolic pressure-volume relationship in man and its sensitivity for assessment of left ventricular function.

    abstract::The linearity and sensitivity of the end-systolic pressure-volume (P-Ves) relation to the inotropic state of the left ventricle were investigated in 11 patients with coronary heart disease and one patient with congestive cardiomyopathy. To minimize autonomic reflex responses, propranolol, 0.15 mg/kg, and atropine, 1 m...


    pub_type: 杂志文章


    authors: Mehmel HC,Stockins B,Ruffmann K,von Olshausen K,Schuler G,Kübler W

    更新日期:1981-06-01 00:00:00

  • Destruction of contrast microbubbles by ultrasound: effects on myocardial function, coronary perfusion pressure, and microvascular integrity.

    abstract:BACKGROUND:Recent experimental data indicate that ultrasound-induced destruction of ultrasound contrast microbubbles can cause immediate rupture of the microvessels in which these microbubbles are located. METHODS AND RESULTS:To examine the functional and morphological significance of these findings in the heart, isol...


    pub_type: 杂志文章


    authors: Ay T,Havaux X,Van Camp G,Campanelli B,Gisellu G,Pasquet A,Denef JF,Melin JA,Vanoverschelde JL

    更新日期:2001-07-24 00:00:00

  • Reverse remodeling of sinus node function after catheter ablation of atrial fibrillation in patients with prolonged sinus pauses.

    abstract:BACKGROUND:Symptomatic prolonged sinus pauses on termination of atrial fibrillation (AF) are an indication for pacemaker implantation. We evaluated sinus node function and clinical outcome in patients with prolonged sinus pauses on termination of arrhythmia who underwent ablation of paroxysmal AF. METHODS AND RESULTS:...


    pub_type: 临床试验,杂志文章


    authors: Hocini M,Sanders P,Deisenhofer I,Jaïs P,Hsu LF,Scavée C,Weerasoriya R,Raybaud F,Macle L,Shah DC,Garrigue S,Le Metayer P,Clémenty J,Haïssaguerre M

    更新日期:2003-09-09 00:00:00

  • Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study.

    abstract:BACKGROUND:Although insulin resistance has been implicated in the pathogenesis of left ventricular (LV) hypertrophy, previous studies have yielded inconsistent results and are limited by referral bias. METHODS AND RESULTS:We examined the relations between echocardiographic LV measurements and glucose tolerance status ...


    pub_type: 杂志文章


    authors: Rutter MK,Parise H,Benjamin EJ,Levy D,Larson MG,Meigs JB,Nesto RW,Wilson PW,Vasan RS

    更新日期:2003-01-28 00:00:00

  • iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1.

    abstract:BACKGROUND:Production of NO by inducible NO synthase (iNOS) has been implicated in the pathology of spontaneous and antigen-induced autoimmune diseases, and iNOS is expressed in the myocardium of patients with heart failure. It is not clear whether inflammatory murine autoimmune heart disease, an experimental model for...


    pub_type: 杂志文章


    authors: Bachmaier K,Neu N,Pummerer C,Duncan GS,Mak TW,Matsuyama T,Penninger JM

    更新日期:1997-07-15 00:00:00

  • Elevated serum lipoprotein(a) is a risk factor for clinical recurrence after coronary balloon angioplasty.

    abstract:BACKGROUND:Elevated lipoprotein (Lp) (a) concentrations are associated with coronary artery disease and myocardial infarction. Lp(a) is structurally related to proteins involved in lipid transport, fibrinolysis, coagulation, and cellular mitogenesis and is known to have important physiological interactions with the coa...


    pub_type: 杂志文章


    authors: Desmarais RL,Sarembock IJ,Ayers CR,Vernon SM,Powers ER,Gimple LW

    更新日期:1995-03-01 00:00:00

  • Catheter ablation versus antiarrhythmic drugs for atrial fibrillation: the A4 study.

    abstract:BACKGROUND:The mainstay of treatment for atrial fibrillation (AF) remains pharmacological; however, catheter ablation has increasingly been used over the last decade. The relative merits of each strategy have not been extensively studied. METHODS AND RESULTS:We conducted a randomized multicenter comparison of these 2 ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Jaïs P,Cauchemez B,Macle L,Daoud E,Khairy P,Subbiah R,Hocini M,Extramiana F,Sacher F,Bordachar P,Klein G,Weerasooriya R,Clémenty J,Haïssaguerre M

    更新日期:2008-12-09 00:00:00

  • Chronic inflammation and impaired coronary vasoreactivity in patients with coronary risk factors.

    abstract:BACKGROUND:The goal of this study was to examine a possible association between systemic microinflammation, as reflected by C-reactive protein (CRP) serum levels, and coronary vasomotion in patients with coronary risk factors but with angiographically normal coronary arteries. METHODS AND RESULTS:Coronary vasomotor fu...


    pub_type: 杂志文章


    authors: Schindler TH,Nitzsche EU,Olschewski M,Magosaki N,Mix M,Prior JO,Facta AD,Solzbach U,Just H,Schelbert HR

    更新日期:2004-08-31 00:00:00

  • Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.

    abstract:BACKGROUND:Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates the metabo...


    pub_type: 杂志文章


    authors: Rashid S,Tavori H,Brown PE,Linton MF,He J,Giunzioni I,Fazio S

    更新日期:2014-07-29 00:00:00

  • Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study.

    abstract:BACKGROUND:Fe2+ released from tissue iron stores may accelerate lipid peroxidation by virtue of its pro-oxidant properties and thus promote early atherogenesis. METHODS AND RESULTS:The present prospective survey addresses the potential association between serum ferritin concentrations and the 5-year progression of car...


    pub_type: 杂志文章


    authors: Kiechl S,Willeit J,Egger G,Poewe W,Oberhollenzer F

    更新日期:1997-11-18 00:00:00

  • Mortality benefits and the implantable cardioverter-defibrillator.

    abstract::The automatic implantable cardioverter-defibrillator (ICD) is highly effective in reducing sudden death rates in patients with life-threatening ventricular tachyarrhythmias. However, the magnitude of the ability of the ICD to improve overall survival is less certain. Data supporting the contention that the ICD prolong...


    pub_type: 杂志文章,评审


    authors: Sweeney MO,Ruskin JN

    更新日期:1994-04-01 00:00:00

  • Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.

    abstract:BACKGROUND:Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell proliferation. The X-box binding protein 1 (XBP1) is believed to be a signal transducer in the endoplasmic reticulum stress response. It is unknown whether there is crosstalk between vascular endothel...


    pub_type: 杂志文章


    authors: Zeng L,Xiao Q,Chen M,Margariti A,Martin D,Ivetic A,Xu H,Mason J,Wang W,Cockerill G,Mori K,Li JY,Chien S,Hu Y,Xu Q

    更新日期:2013-04-23 00:00:00

  • Regional three-dimensional geometry and function of left ventricles with fibrous aneurysms. A cine-computed tomography study.

    abstract:BACKGROUND:To assess the extent and nature of the dysfunction surrounding aneurysms of the left ventricle (LV), we examined the parameters of local and global three-dimensional shape, size, and function of LVs of eight patients with histologically confirmed anterior fibrous aneurysms. METHODS AND RESULTS:Three-dimensi...


    pub_type: 杂志文章


    authors: Lessick J,Sideman S,Azhari H,Marcus M,Grenadier E,Beyar R

    更新日期:1991-09-01 00:00:00

  • Long-term treatment with N(omega)-nitro-L-arginine methyl ester causes arteriosclerotic coronary lesions in endothelial nitric oxide synthase-deficient mice.

    abstract:BACKGROUND:N(omega)-nitro-L-arginine methyl ester (l-NAME) is widely used to inhibit endothelial synthesis of NO in vivo. However, it is controversial whether the long-term vascular effects of l-NAME are mediated primarily by inhibition of endothelial NO synthesis. We addressed this point in mice that are deficient in ...


    pub_type: 杂志文章


    authors: Suda O,Tsutsui M,Morishita T,Tanimoto A,Horiuchi M,Tasaki H,Huang PL,Sasaguri Y,Yanagihara N,Nakashima Y

    更新日期:2002-09-24 00:00:00

  • TAXUS I: six- and twelve-month results from a randomized, double-blind trial on a slow-release paclitaxel-eluting stent for de novo coronary lesions.

    abstract:BACKGROUND:The TAXUS NIRx stent (Boston Scientific Corp) provides local delivery of paclitaxel via a slow-release polymer coating. The TAXUS I trial was the first in-human experience evaluating safety and feasibility of the TAXUS NIRx stent system compared with bare NIR stents (control) (Boston Scientific Corp) for tre...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Grube E,Silber S,Hauptmann KE,Mueller R,Buellesfeld L,Gerckens U,Russell ME

    更新日期:2003-01-07 00:00:00

  • Visceral adiposity and the prevalence of hypertension in Japanese Americans.

    abstract:BACKGROUND:Visceral adiposity is generally considered to play a key role in the metabolic syndrome, including hypertension. The purpose of this study was to evaluate cross-sectionally whether visceral adiposity is associated with prevalence of hypertension independent of other adipose depots and fasting plasma insulin....


    pub_type: 杂志文章


    authors: Hayashi T,Boyko EJ,Leonetti DL,McNeely MJ,Newell-Morris L,Kahn SE,Fujimoto WY

    更新日期:2003-10-07 00:00:00

  • KB-R7943 block of Ca(2+) influx via Na(+)/Ca(2+) exchange does not alter twitches or glycoside inotropy but prevents Ca(2+) overload in rat ventricular myocytes.

    abstract:BACKGROUND:The Na(+)/Ca(2+) exchange (NCX) extrudes Ca(2+) from cardiac myocytes, but it can also mediate Ca(2+) influx, load the sarcoplasmic reticulum with Ca(2+), and trigger Ca(2+) release from the sarcoplasmic reticulum. In ischemia/reperfusion or digitalis toxicity, increased levels of intracellular [Na(+)] ([Na(...


    pub_type: 杂志文章


    authors: Satoh H,Ginsburg KS,Qing K,Terada H,Hayashi H,Bers DM

    更新日期:2000-03-28 00:00:00

  • Effects of reperfusion on ischemic right ventricular dysfunction. Disparate mechanisms of benefit related to duration of ischemia.

    abstract:BACKGROUND:Right ventricular free wall (RVFW) ischemia impairs global RV performance and may result in acute hemodynamic compromise. However, RV function and hemodynamic performance typically improve spontaneously over time. This study was designed to determine whether reperfusion facilitates recovery of function in th...


    pub_type: 杂志文章


    authors: Laster SB,Ohnishi Y,Saffitz JE,Goldstein JA

    更新日期:1994-09-01 00:00:00

  • Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction.

    abstract:BACKGROUND:Myocardial infarction (MI) is an ischemic wound that recruits millions of leukocytes. MI-associated blood leukocytosis correlates inversely with patient survival, yet the signals driving heightened leukocyte production after MI remain incompletely understood. METHODS AND RESULTS:With the use of parabiosis s...


    pub_type: 杂志文章


    authors: Sager HB,Heidt T,Hulsmans M,Dutta P,Courties G,Sebas M,Wojtkiewicz GR,Tricot B,Iwamoto Y,Sun Y,Weissleder R,Libby P,Swirski FK,Nahrendorf M

    更新日期:2015-11-17 00:00:00

  • Relationship between plasma lipid concentrations and coronary artery disease in 496 patients.

    abstract::The relationship between fasting plasma cholesterol and triglyceride concentrations and the frequency and extensiveness of coronary artery disease (CAD) was studied in 496 subjects evaluated for chest pain by coronary arteriography at The Methodist Hospital. One hundred six of the patients had no CAD while 390 had 25%...


    pub_type: 杂志文章


    authors: Gotto AM,Gorry GA,Thompson JR,Cole JS,Trost R,Yeshurun D,DeBakey ME

    更新日期:1977-11-01 00:00:00

  • Prevention of iatrogenic atrial tachycardia after ablation of atrial fibrillation: a prospective randomized study comparing circumferential pulmonary vein ablation with a modified approach.

    abstract:BACKGROUND:Circumferential pulmonary vein ablation (CPVA) is effective in curing atrial fibrillation (AF), but new-onset left atrial tachycardia (AT) is a potential complication. We evaluated whether a modified CPVA approach including additional ablation lines on posterior wall and the mitral isthmus would reduce the i...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pappone C,Manguso F,Vicedomini G,Gugliotta F,Santinelli O,Ferro A,Gulletta S,Sala S,Sora N,Paglino G,Augello G,Agricola E,Zangrillo A,Alfieri O,Santinelli V

    更新日期:2004-11-09 00:00:00

  • Noninvasive quantitative evaluation of the morphology of the major pulmonary artery branches in cyanotic congenital heart disease. Angiocardiographic and echocardiographic correlative study.

    abstract:BACKGROUND:Precise noninvasive evaluation of pulmonary artery (PA) morphology is extremely important for medical and surgical management of patients with cyanotic heart disease. In this study, the accuracy of two-dimensional echocardiography combined with color Doppler flow mapping to assess the size, stenosis, and atr...


    pub_type: 杂志文章


    authors: Hiraishi S,Misawa H,Hirota H,Agata Y,Horiguchi Y,Fujino N,Yi LH,Yashiro K,Nakae S,Kawada M

    更新日期:1994-03-01 00:00:00