Lifetime fruit and vegetable consumption and arterial pulse wave velocity in adulthood: the Cardiovascular Risk in Young Finns Study.


BACKGROUND:The relationships between childhood lifestyle risk factors and adulthood pulse wave velocity (PWV) have not been reported. We studied whether childhood and adulthood lifestyle risk factors are associated with PWV assessed in adulthood. METHODS AND RESULTS:The study cohort comprised 1622 subjects of the Cardiovascular Risk in Young Finns Study followed up for 27 years since baseline (1980; aged 3 to 18 years) with lifestyle risk factor data available since childhood. Arterial PWV was measured in 2007 by whole-body impedance cardiography device. Vegetable consumption in childhood was inversely associated with adulthood PWV (β=-0.06, P=0.02), and this association remained significant (β=-0.07, P=0.004) when adjusted for traditional risk factors (high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, systolic blood pressure, body mass index, and smoking). Vegetable consumption was also an independent predictor of PWV in adulthood when adjusted for lifestyle or traditional risk factors (β=-0.08, P=0.002 and β=-0.07, P=0.0007, respectively). Persistently high consumption of both fruits and vegetables from childhood to adulthood was associated with lower PWV compared with persistently low consumption (P=0.03 for both). The number of lifestyle risk factors (the lowest quintile for vegetable consumption, fruit consumption, physical activity, and smoking) in childhood was directly associated with PWV in adulthood (P=0.001). This association remained significant when adjusted for the number of lifestyle risk factors in adulthood (P=0.003). CONCLUSIONS:These findings suggest that lifetime lifestyle risk factors, with low consumption of fruits and vegetables in particular, are related to arterial stiffness in young adulthood.






Aatola H,Koivistoinen T,Hutri-Kähönen N,Juonala M,Mikkilä V,Lehtimäki T,Viikari JS,Raitakari OT,Kähönen M




Has Abstract


2010-12-14 00:00:00














  • De subitaneis mortibus. XV. Hereditary stenosis of the His bundle in Pug dogs.

    abstract::Syncope and sudden death occurs in certain purebred Pug dogs which have been found to have intermittent sinus pauses and paroxysmal second degree heart block on electrocardiographic (ECG) study. We have established a colony of such dogs to study this problem and here report the results of histological examination of t...


    pub_type: 杂志文章


    authors: James TN,Robertson BT,Waldo AL,Branch CE

    更新日期:1975-12-01 00:00:00

  • Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction.

    abstract:BACKGROUND:Myocardial infarction (MI) is an ischemic wound that recruits millions of leukocytes. MI-associated blood leukocytosis correlates inversely with patient survival, yet the signals driving heightened leukocyte production after MI remain incompletely understood. METHODS AND RESULTS:With the use of parabiosis s...


    pub_type: 杂志文章


    authors: Sager HB,Heidt T,Hulsmans M,Dutta P,Courties G,Sebas M,Wojtkiewicz GR,Tricot B,Iwamoto Y,Sun Y,Weissleder R,Libby P,Swirski FK,Nahrendorf M

    更新日期:2015-11-17 00:00:00

  • Late survival and symptoms after repair of tetralogy of Fallot.

    abstract::The long-term results of 414 patients who underwent repair of tetralogy of Fallot between 1967 and 1977 were studied and correlated with the results of others. There were nine late deaths (8-year actuarial survival 95.8%). Six of the deaths wee directly related to the malformation or its treatment. Eight patients (2.4...


    pub_type: 杂志文章


    authors: Katz NM,Blackstone EH,Kirklin JW,Pacifico AD,Bargeron LM Jr

    更新日期:1982-02-01 00:00:00

  • Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages.

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    pub_type: 杂志文章


    authors: Iwata H,Manabe I,Fujiu K,Yamamoto T,Takeda N,Eguchi K,Furuya A,Kuro-o M,Sata M,Nagai R

    更新日期:2010-11-16 00:00:00

  • Prevalence and risk factors for pulmonary arterial hypertension in a large group of β-thalassemia patients using right heart catheterization: a Webthal study.

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    pub_type: 杂志文章,多中心研究


    authors: Derchi G,Galanello R,Bina P,Cappellini MD,Piga A,Lai ME,Quarta A,Casu G,Perrotta S,Pinto V,Musallam KM,Forni GL,Webthal Pulmonary Arterial Hypertension Group*.

    更新日期:2014-01-21 00:00:00

  • Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats.

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    pub_type: 杂志文章


    authors: Auyeung Y,Sievers RE,Weng D,Barbosa V,Wolfe CL

    更新日期:1995-12-01 00:00:00

  • Regional Systems of Care Demonstration Project: American Heart Association Mission: Lifeline STEMI Systems Accelerator.

    abstract:BACKGROUND:Up to 50% of patients fail to meet ST-segment-elevation myocardial infarction (STEMI) guideline goals recommending a first medical contact-to-device time of <90 minutes for patients directly presenting to percutaneous coronary intervention-capable hospitals and <120 minutes for transferred patients. We sough...


    pub_type: 杂志文章


    authors: Jollis JG,Al-Khalidi HR,Roettig ML,Berger PB,Corbett CC,Dauerman HL,Fordyce CB,Fox K,Garvey JL,Gregory T,Henry TD,Rokos IC,Sherwood MW,Suter RE,Wilson BH,Granger CB,Mission: Lifeline STEMI Systems Accelerator Project.

    更新日期:2016-08-02 00:00:00

  • Ultrasonic tissue characterization of human hypertrophied hearts in vivo with cardiac cycle-dependent variation in integrated backscatter.

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    pub_type: 杂志文章


    authors: Masuyama T,St Goar FG,Tye TL,Oppenheim G,Schnittger I,Popp RL

    更新日期:1989-10-01 00:00:00

  • Phase-plane analysis of left ventricular chamber filling and midwall fiber lengthening in patients with left ventricular hypertrophy.

    abstract::Echocardiographic measurements of the left ventricle were used to define rates of circumferential fiber lengthening at the endocardium and midwall in 12 normal subjects and six patients with concentric left ventricular hypertrophy (wall thickness 11 to 16 mm). There was no difference in chamber size and systolic short...


    pub_type: 杂志文章


    authors: Shimizu G,Conrad CH,Gaasch WH

    更新日期:1987-01-01 00:00:00

  • Predictors of outcomes in low-flow, low-gradient aortic stenosis: results of the multicenter TOPAS Study.

    abstract:BACKGROUND:Patients with low-flow, low-gradient aortic stenosis have a poor prognosis with conservative therapy but a high operative mortality if treated surgically. Recently, we proposed a new index of aortic stenosis severity derived from dobutamine stress echocardiography, the projected aortic valve area at a normal...


    pub_type: 杂志文章,多中心研究


    authors: Clavel MA,Fuchs C,Burwash IG,Mundigler G,Dumesnil JG,Baumgartner H,Bergler-Klein J,Beanlands RS,Mathieu P,Magne J,Pibarot P

    更新日期:2008-09-30 00:00:00

  • Use of Administrative Claims to Assess Outcomes and Treatment Effect in Randomized Clinical Trials for Transcatheter Aortic Valve Replacement: Findings From the EXTEND Study.

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    pub_type: 杂志文章


    authors: Strom JB,Faridi KF,Butala NM,Zhao Y,Tamez H,Valsdottir LR,Brennan JM,Shen C,Popma JJ,Kazi DS,Yeh RW

    更新日期:2020-07-21 00:00:00

  • Echocardiographic assessment of the evolution of amyloid heart disease: a study with familial amyloid polyneuropathy.

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    pub_type: 杂志文章


    authors: Hongo M,Ikeda S

    更新日期:1986-02-01 00:00:00

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    abstract:BACKGROUND:Precise noninvasive evaluation of pulmonary artery (PA) morphology is extremely important for medical and surgical management of patients with cyanotic heart disease. In this study, the accuracy of two-dimensional echocardiography combined with color Doppler flow mapping to assess the size, stenosis, and atr...


    pub_type: 杂志文章


    authors: Hiraishi S,Misawa H,Hirota H,Agata Y,Horiguchi Y,Fujino N,Yi LH,Yashiro K,Nakae S,Kawada M

    更新日期:1994-03-01 00:00:00

  • Rapid heart rate increase at onset of exercise predicts adverse cardiac events in patients with coronary artery disease.

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    pub_type: 杂志文章


    authors: Falcone C,Buzzi MP,Klersy C,Schwartz PJ

    更新日期:2005-09-27 00:00:00

  • Thrombin facilitation of voltage-gated sodium channel activation in human cardiomyocytes: implications for ischemic sodium loading.

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    pub_type: 杂志文章


    authors: Pinet C,Le Grand B,John GW,Coulombe A

    更新日期:2002-10-15 00:00:00

  • Premortem assessment of myocardial area at risk with the use of intracoronary technetium macroaggregated albumin and gated nuclear imaging.

    abstract::The purpose of this study was to develop a clinically applicable system for quantifying premortem myocardial area at risk. Coronary artery occlusion was performed in 18 closed-chest dogs (11 left anterior descending and seven circumflex). 99mTc (15 mCi)-labeled macroaggregated albumin was then injected through an angi...


    pub_type: 杂志文章


    authors: Feiring AJ,Bruch P,Husayni TS,Kirchner PT,Marcus ML

    更新日期:1986-03-01 00:00:00

  • Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle.

    abstract:BACKGROUND:Endogenous adenosine can protect the overloaded heart against the development of hypertrophy and heart failure, but the contribution of A(1) receptors (A(1)R) and A(3) receptors (A(3)R) is not known. METHODS AND RESULTS:To test the hypothesis that A(1)R and A(3)R can protect the heart against systolic overl...


    pub_type: 杂志文章


    authors: Lu Z,Fassett J,Xu X,Hu X,Zhu G,French J,Zhang P,Schnermann J,Bache RJ,Chen Y

    更新日期:2008-10-21 00:00:00

  • Measurement of right and left ventricular systolic time intervals by echocardiography.

    abstract::One of the noninvasive methods of evaluating left ventricular performance is the measurement of left ventricular systolic time intervals (LVSTI). However, noninvasive measurement of right ventricular systole by this technique has been unreliable because of the inability to accurately time the onset of right ventricula...


    pub_type: 杂志文章


    authors: Hirschfeld S,Meyer R,Schwartz DC,Korfhagen J,Kaplan S

    更新日期:1975-02-01 00:00:00

  • Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin.

    abstract:BACKGROUND:Angiotensin-converting enzyme (ACE) inhibition potentiates the tissue-type plasminogen activator (t-PA) response to exogenous bradykinin. This study tested the hypothesis that ACE inhibition increases endothelial t-PA release through endogenous bradykinin. METHODS AND RESULTS:We measured the effect of intra...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pretorius M,Rosenbaum D,Vaughan DE,Brown NJ

    更新日期:2003-02-04 00:00:00

  • Coagulant activities of platelets in coronary artery disease.

    abstract::Platelets have been implicated in the pathogenesis of coronary artery disease, and a number of studies have examined platelet function and coagulation parameters in such patients. We have examined platelet coagulant activities, volumes, and aggregate ratios in 23 patients with chest pain, seven of whom had normal coro...


    pub_type: 杂志文章


    authors: Rao AK,Mintz PD,Lavine SJ,Bove AA,McDonough MT,Spann JF,Walsh PN

    更新日期:1984-01-01 00:00:00

  • Coronary artery surgery study (CASS): a randomized trial of coronary bypass surgery. Eight years follow-up and survival in patients with reduced ejection fraction.

    abstract::Survival data after 8 years of follow-up for all patients and after 7 years for certain subgroups are reported from CASS, a randomized trial of surgical or medical treatment assignment in patients with coronary artery disease who have less than severe angina or are asymptomatic after myocardial infarction. After 8 yea...


    pub_type: 临床试验,杂志文章


    authors: Killip T,Passamani E,Davis K

    更新日期:1985-12-01 00:00:00

  • Temporal Trends in Percutaneous Coronary Intervention Appropriateness: Insights From the Clinical Outcomes Assessment Program.

    abstract:BACKGROUND:It is unknown whether the appropriate use of percutaneous coronary intervention (PCI) has improved over time and whether trends in PCI appropriateness have been accompanied by changes in the use of PCI. METHODS AND RESULTS:We applied appropriate use criteria to determine the appropriateness of all 51 872 PC...


    pub_type: 杂志文章


    authors: Bradley SM,Bohn CM,Malenka DJ,Graham MM,Bryson CL,McCabe JM,Curtis JP,Lambert-Kerzner A,Maynard C

    更新日期:2015-07-07 00:00:00

  • Factors controlling the development of arterial lesions after injury.

    abstract::This review discusses the role of growth factors on the proliferation of smooth muscle cells (SMCs) in injured arteries. We have used a variety of procedures to injure rat carotid arteries and noted that removal of endothelium followed by platelet adherence does not always initiate SMC replication. Furthermore, thromb...


    pub_type: 杂志文章,评审


    authors: Reidy MA,Fingerle J,Lindner V

    更新日期:1992-12-01 00:00:00

  • Paradoxic decrease in ischemic mitral regurgitation with papillary muscle dysfunction: insights from three-dimensional and contrast echocardiography with strain rate measurement.

    abstract:BACKGROUND:Ischemic mitral regurgitation (MR) was first ascribed to papillary muscle (PM) contractile dysfunction. Current theories include apical leaflet tethering caused by left ventricular (LV) distortion, but PM dysfunction is still postulated and commonly diagnosed. PM contraction, however, parallels apical tether...


    pub_type: 杂志文章


    authors: Messas E,Guerrero JL,Handschumacher MD,Chow CM,Sullivan S,Schwammenthal E,Levine RA

    更新日期:2001-10-16 00:00:00

  • Risk of thromboembolic events after percutaneous left atrial radiofrequency ablation of atrial fibrillation.

    abstract:BACKGROUND:In patients with atrial fibrillation (AF), the risk of thromboembolic events (TEs) is variable and is influenced by the presence and number of comorbid conditions. The effect of percutaneous left atrial radiofrequency ablation (LARFA) of AF on the risk of TEs is unclear. METHODS AND RESULTS:LARFA was perfor...


    pub_type: 杂志文章


    authors: Oral H,Chugh A,Ozaydin M,Good E,Fortino J,Sankaran S,Reich S,Igic P,Elmouchi D,Tschopp D,Wimmer A,Dey S,Crawford T,Pelosi F Jr,Jongnarangsin K,Bogun F,Morady F

    更新日期:2006-08-22 00:00:00

  • Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis.

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    pub_type: 杂志文章


    authors: Eldrup N,Grønholdt ML,Sillesen H,Nordestgaard BG

    更新日期:2006-10-24 00:00:00

  • Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study.

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    pub_type: 杂志文章


    authors: Nakamura H,Kurokawa J,Bai CX,Asada K,Xu J,Oren RV,Zhu ZI,Clancy CE,Isobe M,Furukawa T

    更新日期:2007-12-18 00:00:00

  • Altered age-related blood pressure pattern in type 1 diabetes.

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    pub_type: 杂志文章


    authors: Rönnback M,Fagerudd J,Forsblom C,Pettersson-Fernholm K,Reunanen A,Groop PH,Finnish Diabetic Nephropathy (FinnDiane) Study Group.

    更新日期:2004-08-31 00:00:00

  • Relation of plasma lipoprotein(a) to infarct artery patency in survivors of myocardial infarction.

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    pub_type: 杂志文章


    authors: Moliterno DJ,Lange RA,Meidell RS,Willard JE,Leffert CC,Gerard RD,Boerwinkle E,Hobbs HH,Hillis LD

    更新日期:1993-09-01 00:00:00

  • Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica.

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    pub_type: 杂志文章


    authors: Baylin A,Kabagambe EK,Ascherio A,Spiegelman D,Campos H

    更新日期:2003-04-01 00:00:00