HDL cholesterol and protective factors in atherosclerosis.

abstract：BACKGROUND:The prevalence, prognostic import, and impact of renal insufficiency on the benefits of ACE inhibitors and beta-blockers in community-dwelling patients with heart failure are uncertain. METHODS AND RESULTS:We analyzed data from a prospective cohort of 754 patients with heart failure who had ejection fractio...

journal_title：Circulation

authors： McAlister FA,Ezekowitz J,Tonelli M,Armstrong PW

更新日期：2004-03-02 00:00:00

abstract：:In experimental animals, the calcium channel-blocking agents lessen the arrhythmogenic, ionic, metabolic, and electrical changes that occur during acute myocardial ischemia. To date, these effects have been studied separately, and the effects of these agents on local activation have not been correlated with ionic or m...

journal_title：Circulation

authors： Fleet WF,Johnson TA,Graebner CA,Engle CL,Gettes LS

更新日期：1986-04-01 00:00:00

abstract：:To determine whether a ventricular (LV) end-systolic dimension (ESD) greater than or equal to 55 mm and LV left fractional shortening less than 25% are risk factors for aortic valve replacement (AVR) in patients with aortic insufficiency, we analyzed the clinical course and M-mode echocardiograms in 47 consecutive pat...

journal_title：Circulation

authors： Fioretti P,Roelandt J,Bos RJ,Meltzer RS,van Hoogenhuijze D,Serruys PW,Nauta J,Hugenholtz PG

更新日期：1983-01-01 00:00:00

abstract：:Current automatic implantable cardioverter-defibrillators detect tachyarrhythmias primarily by rate-only algorithms and cannot adequately distinguish hemodynamically stable from unstable tachyarrhythmias. The responses of right atrial (mean) and right ventricular pressures (mean, systolic, diastolic, and pulse) to 64 ...

journal_title：Circulation

authors： Cohen TJ,Liem LB

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:The lysyl oxidases are extracellular copper enzymes that initiate the crosslinking of collagens and elastin, 5 human isoenzymes having been characterized so far. The crosslinks formed provide the tensile strength and elastic properties for various extracellular matrices, including vascular walls. We studied ...

journal_title：Circulation

authors： Mäki JM,Räsänen J,Tikkanen H,Sormunen R,Mäkikallio K,Kivirikko KI,Soininen R

更新日期：2002-11-05 00:00:00

abstract：BACKGROUND:Long-standing aortic stenosis causes significant left ventricular (LV) dysfunction, which may progress irreversibly. In many cases, LV function can be salvaged by aortic valve surgery, although debate exists regarding the best valve prosthesis to use. METHODS AND RESULTS:We studied 33 patients retrospective...

journal_title：Circulation

authors： Collinson J,Henein M,Flather M,Pepper JR,Gibson DG

更新日期：1999-11-09 00:00:00

abstract：:Predictability of prognosis was analyzed in 630 patients who were alive 30 days after valve replacement (1965-1986) for aortic stenosis. Follow-up totaled 4,072 patient-years. During the operative periods of 1965-1971 (n = 62), 1972-1976 (n = 164), 1977-1981 (n = 158), and 1982-1986 (n = 246), decreases in cardiothora...

journal_title：Circulation

authors： Lund O

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Increased expression of osteopontin (OPN), fibroblast growth factors (FGFs), and their type-1 receptor (FGFR-1) is associated with neointima formation and atherosclerosis. This study tested the hypothesis that ligand activation of FGFR-1 stimulates OPN expression in rat aortic smooth muscle cells (RASMCs), e...

journal_title：Circulation

authors： Li G,Oparil S,Kelpke SS,Chen YF,Thompson JA

更新日期：2002-08-13 00:00:00

abstract：:To determine the effect of calcium-channel blockers on beta-adrenergic receptors, we studied the interactions of verapamil, diltiazem, and nifedipine with both human lymphocyte beta 2-adrenergic receptors and rat myocardial beta 1-adrenergic receptors by means of radioligand binding assays. We also determined the func...

journal_title：Circulation

authors： Feldman RD,Park GD,Lai CY

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:The mechanism and treatment of diastolic heart failure are poorly understood. We compared the effects of an ACE inhibitor, an angiotensin receptor blocker (ARB), and their combination on diastolic heart failure in Dahl salt-sensitive (DS) rats. METHODS AND RESULTS:DS rats fed an 8% NaCl diet from 7 weeks of...

journal_title：Circulation

authors： Kim S,Yoshiyama M,Izumi Y,Kawano H,Kimoto M,Zhan Y,Iwao H

更新日期：2001-01-02 00:00:00

abstract：BACKGROUND:Postprandial angina pectoris has been recognized for more than two centuries and can be identified in up to 10% of patients with chronic ischemic heart disease. Redistribution of myocardial blood flow, from a region supplied by a severely stenotic coronary artery to those supplied by less diseased or normal ...

journal_title：Circulation

authors： Baliga RR,Rosen SD,Camici PG,Kooner JS

更新日期：1998-03-31 00:00:00

abstract：BACKGROUND:Although several loci for familial dilated cardiomyopathy (DCM) have been mapped, the origin of a large percentage of DCM remains unclear. Mdm2, a p53-negative regulator, protects cardiomyocytes from ischemic and reperfusion-induced cell death. Mdm4, a homolog of Mdm2, inhibits p53 activity in numerous cell ...

journal_title：Circulation

authors： Xiong S,Van Pelt CS,Elizondo-Fraire AC,Fernandez-Garcia B,Lozano G

更新日期：2007-06-12 00:00:00

abstract：:Proton (hydrogen-1) magnetic resonance imaging techniques have potential for the detection and characterization of changes associated with myocardial ischemia. Since image contrast is dependent on T1 and T2 relaxation times, we examined these parameters in a canine preparation of occlusion of the left anterior descend...

journal_title：Circulation

authors： Johnston DL,Brady TJ,Ratner AV,Rosen BR,Newell JB,Pohost GM,Okada RD

更新日期：1985-03-01 00:00:00

abstract：:Integrated ultrasonic backscatter (IB) is a noninvasive measure of the acoustic properties of myocardium. Previous experimental studies have indicated that altered acoustic properties of the myocardium are reflected by the magnitude of variation of IB during the cardiac cycle. In our study, cardiac cycle-dependent var...

journal_title：Circulation

authors： Masuyama T,St Goar FG,Tye TL,Oppenheim G,Schnittger I,Popp RL

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:The use of balloon coarctation angioplasty instead of surgery as treatment for unoperated coarctation of the aorta is controversial. The efficacy and complications of the two procedures have not been studied before in a prospective fashion. METHODS AND RESULTS:Thirty-six patients were prospectively randomiz...

journal_title：Circulation

authors： Shaddy RE,Boucek MM,Sturtevant JE,Ruttenberg HD,Jaffe RB,Tani LY,Judd VE,Veasy LG,McGough EC,Orsmond GS

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:During the initial phase of an ischemic insult, left ventricular (LV) performance depends on the complex interaction between oxygen deprivation, vascular turgor, and accumulation of metabolites. In experimental preparations, low-flow ischemia decreases systolic shortening and increases diastolic LV distensib...

journal_title：Circulation

authors： De Bruyne B,Bronzwaer JG,Heyndrickx GR,Paulus WJ

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:The regional wall motion impairment and predisposition to arrhythmias in human ventricular hibernation may plausibly result from abnormal intercellular propagation of the depolarizing wave front. This study investigated the hypothesis that altered patterns of expression of connexin43, the principal gap junct...

journal_title：Circulation

authors： Kaprielian RR,Gunning M,Dupont E,Sheppard MN,Rothery SM,Underwood R,Pennell DJ,Fox K,Pepper J,Poole-Wilson PA,Severs NJ

更新日期：1998-02-24 00:00:00

abstract：:The relation between ventricular dysrhythmia during the first 20 hours after hospitalization for acute myocardial infarction and enzymatically estimated infarct size was studied prospectively. The duration of dyshythmia was measured by the total time during which the average premature ventricular depolarization (PVC) ...

journal_title：Circulation

authors： Cox JR Jr,Roberts R,Ambos HD,Oliver GC,Sobel BE

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction is associated with atherosclerosis and may contribute to ischemic syndromes. We assessed the contribution of endothelium-derived nitric oxide (NO) and vasodilator prostanoids to resting blood flow, metabolic vasodilation, and flow reserve in the human coronary circulation. METHODS AN...

journal_title：Circulation

authors： Duffy SJ,Castle SF,Harper RW,Meredith IT

更新日期：1999-11-09 00:00:00

abstract：:Atherosclerotic coronary artery disease is the major cause of late cardiac transplant failure secondary to silent ischemia and infarction. To increase the longevity of cardiac homografts, we performed percutaneous transluminal coronary angioplasty (PTCA) in five male patients (aged 45 +/- 7 years, mean +/- SEM); 17 le...

journal_title：Circulation

authors： Vetrovec GW,Cowley MJ,Newton CM,Lewis SA,DiSciascio G,Thompson JA,Hastillo A,Lower R,Hess M

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Current consensus statements maintain that endoscopic vein harvesting (EVH) should be standard care in coronary artery bypass graft surgery, but vein quality and clinical outcomes have been questioned. The VICO trial (Vein Integrity and Clinical Outcomes) was designed to assess the impact of different vein h...

journal_title：Circulation

authors： Krishnamoorthy B,Critchley WR,Thompson AJ,Payne K,Morris J,Venkateswaran RV,Caress AL,Fildes JE,Yonan N

更新日期：2017-10-31 00:00:00

abstract：BACKGROUND:Monocarboxylate transporters (MCTs) mediate lactate transport across the plasma membrane of cells. The molecular mechanisms regulating monocarboxylate transport in smooth muscle cells (SMCs) remain poorly characterized. The aim of this study was to investigate the effects of DNA methylation on MCT expression...

journal_title：Circulation

authors： Zhu S,Goldschmidt-Clermont PJ,Dong C

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:Exercise echocardiography (digital cine-loop technique) and 201Tl single-photon emission computed tomography (SPECT) were performed simultaneously in 292 patients being evaluated for coronary artery disease. METHODS AND RESULTS:Pretreadmill and posttreadmill echocardiographic images of diagnostic quality we...

journal_title：Circulation

authors： Quiñones MA,Verani MS,Haichin RM,Mahmarian JJ,Suarez J,Zoghbi WA

更新日期：1992-03-01 00:00:00

abstract：:The effects of abrupt withdrawal or continuation of beta-blockade therapy during acute myocardial infarction were evaluated in 326 patients participating in the Multicenter Investigation of the Limitation of Infarct Size (MILIS). Thirty-nine patients previously receiving a beta-blocker and randomly selected for withdr...

journal_title：Circulation

authors： Croft CH,Rude RE,Gustafson N,Stone PH,Poole WK,Roberts R,Strauss HW,Raabe DS Jr,Thomas LJ,Jaffe AS

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:The myocardial velocity gradient (MVG) is a recent index of regional myocardial function derived from endocardial and epicardial velocities obtained by tissue Doppler imaging (TDI). This index might be useful for discriminating between physiological and pathological left ventricular hypertrophy (LVH) and for...

journal_title：Circulation

authors： Derumeaux G,Mulder P,Richard V,Chagraoui A,Nafeh C,Bauer F,Henry JP,Thuillez C

更新日期：2002-04-02 00:00:00

abstract：BACKGROUND:Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease. The pathways that govern titin-dependent cardiac growth and contribute to disease are diverse and difficult to dissect. METHOD...

journal_title：Circulation

authors： Radke MH,Polack C,Methawasin M,Fink C,Granzier HL,Gotthardt M

更新日期：2019-04-09 00:00:00

abstract：BACKGROUND:Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its functional contribution to lesion development has not been evaluated. METHODS AND RESULTS:We studied the role of MIF on neointima lesion formation after ...

journal_title：Circulation

authors： Schober A,Bernhagen J,Thiele M,Zeiffer U,Knarren S,Roller M,Bucala R,Weber C

更新日期：2004-01-27 00:00:00

abstract：BACKGROUND:The diagnosis of long QT syndrome (LQTS) is rather straightforward. We were surprised by realizing that, despite long-standing experience, we were making occasional diagnostic errors by considering as affected subjects who, over time, resulted as not affected. These individuals were all actively practicing s...

journal_title：Circulation

authors： Dagradi F,Spazzolini C,Castelletti S,Pedrazzini M,Kotta MC,Crotti L,Schwartz PJ

更新日期：2020-12-22 00:00:00

abstract：:To investigate the electrocardiographic and hemodynamic changes in isolated right ventricular infarction, 0.25 ml or 0.5 ml of metallic mercury was injected into the right coronary artery of 14 closed-chest dogs. At autopsy, at least 60% of the right ventricle was necrotic in every dog. Hemodynamic observations were m...

journal_title：Circulation

authors： Chou TC,Fowler NO,Gabel M,van der Bel-Kahn J,Feltner EJ

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:The rate of coronary heart disease (CHD) mortality in eastern Finland has been the highest in the world. The official mortality statistics suggest, however, that is has declined by 60% during the past 20 years. The aim of the present study was to examine the contributions of incidence, recurrence, and case f...

journal_title：Circulation

authors： Salomaa V,Miettinen H,Kuulasmaa K,Niemelä M,Ketonen M,Vuorenmaa T,Lehto S,Palomäki P,Mähönen M,Immonen-Räihä P,Arstila M,Kaarsalo E,Mustaniemi H,Torppa J,Tuomilehto J,Puska P,Pyörälä K

更新日期：1996-12-15 00:00:00