Exercise echocardiography versus 201Tl single-photon emission computed tomography in evaluation of coronary artery disease. Analysis of 292 patients.

Abstract:

BACKGROUND:Exercise echocardiography (digital cine-loop technique) and 201Tl single-photon emission computed tomography (SPECT) were performed simultaneously in 292 patients being evaluated for coronary artery disease. METHODS AND RESULTS:Pretreadmill and posttreadmill echocardiographic images of diagnostic quality were obtained in 289 patients, and the left ventricle was divided into anterior, inferior, and lateral regions. Any wall motion or perfusion abnormality observed within each region was classified as totally reversible, fixed, or partially reversible. Exercise echocardiography and SPECT were normal in 137 patients and abnormal in 118 (88% agreement). Equal numbers of regional abnormalities were detected by one test when missed by the other. The two tests had an 82% agreement in detecting the same type of finding within the regions analyzed. SPECT detected more reversible abnormalities than echocardiography, whereas echocardiography detected more fixed abnormalities than SPECT: Regions with a fixed abnormality by echocardiography frequently showed partial reversibility of a perfusion defect by SPECT: Nearly one third of regions with fixed perfusion defects by SPECT demonstrated normal resting function or reversible abnormalities by echocardiography. Sensitivity for coronary artery disease by angiography (greater than or equal to 50% diameter stenosis) in 112 patients was similar for the two tests, ranging from 58% and 61% (echocardiography and SPECT, respectively) for one-vessel disease to 94% for three-vessel disease. The specificities for echocardiography and SPECT were 88% and 81%, respectively. CONCLUSIONS:Exercise echocardiography had a diagnostic accuracy comparable to that of SPECT for the detection of regional abnormalities produced by significant coronary artery disease. A greater number of abnormal regions were detected with the combined use of both tests.

journal_name

Circulation

journal_title

Circulation

authors

Quiñones MA,Verani MS,Haichin RM,Mahmarian JJ,Suarez J,Zoghbi WA

doi

10.1161/01.cir.85.3.1026

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

1026-31

issue

3

eissn

0009-7322

issn

1524-4539

journal_volume

85

pub_type

杂志文章
  • The natural history of regional dysfunction in a canine preparation of chronic infarction.

    abstract::We used a canine preparation of experimental infarction to study the natural course of echocardiographically defined regional wall motion abnormalities in the 6 weeks after acute coronary ligation. Eight dogs underwent serial short-axis echocardiographic evaluation and microsphere blood flow determinations at control,...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.71.2.394

    authors: Gibbons EF,Hogan RD,Franklin TD,Nolting M,Weyman AE

    更新日期:1985-02-01 00:00:00

  • Contrasting inotropic effects of endogenous endothelin in the normal and failing human heart: studies with an intracoronary ET(A) receptor antagonist.

    abstract:BACKGROUND:Endothelin-1 (ET-1) is a potent positive inotrope in vitro, but its physiological effects on intrinsic myocardial contractile function in humans in vivo are unknown. Plasma ET-1 levels are elevated in heart failure, and ET-1 may be involved in the pathophysiology of this condition. However, its effects on co...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.101.2.142

    authors: MacCarthy PA,Grocott-Mason R,Prendergast BD,Shah AM

    更新日期:2000-01-18 00:00:00

  • Effect of Alirocumab on Mortality After Acute Coronary Syndromes.

    abstract:BACKGROUND:Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. METHODS:ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcom...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.118.038840

    authors: Steg PG,Szarek M,Bhatt DL,Bittner VA,Brégeault MF,Dalby AJ,Diaz R,Edelberg JM,Goodman SG,Hanotin C,Harrington RA,Jukema JW,Lecorps G,Mahaffey KW,Moryusef A,Ostadal P,Parkhomenko A,Pordy R,Roe MT,Tricoci P,Vogel R

    更新日期:2019-07-09 00:00:00

  • Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range.

    abstract:BACKGROUND:Oral anticoagulation (OAC) therapy is effective in atrial fibrillation but requires vigilance to maintain the international normalized ratio in the therapeutic range. This report examines how differences in time in therapeutic range (TTR) between centers and between countries affect the outcomes of OAC thera...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.107.750000

    authors: Connolly SJ,Pogue J,Eikelboom J,Flaker G,Commerford P,Franzosi MG,Healey JS,Yusuf S,ACTIVE W Investigators.

    更新日期:2008-11-11 00:00:00

  • Efficacy of Long-Term β-Blocker Therapy for Secondary Prevention of Long-Term Outcomes After Coronary Artery Bypass Grafting Surgery.

    abstract:BACKGROUND:Conflicting results from recent observational studies have raised questions concerning the benefit of β-blockers for patients undergoing coronary artery bypass grafting (CABG). Furthermore, the efficacy of long-term β-blocker therapy in CABG patients after hospital discharge is uncertain. METHODS AND RESULT...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.114.014209

    authors: Zhang H,Yuan X,Zhang H,Chen S,Zhao Y,Hua K,Rao C,Wang W,Sun H,Hu S,Zheng Z

    更新日期:2015-06-23 00:00:00

  • Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults.

    abstract:BACKGROUND:Aging results in vascular stiffening and an increase in the velocity of the pressure wave as it travels down the aorta. Increased aortic pulse wave velocity (aPWV) has been associated with mortality in clinical but not general populations. The objective of this investigation was to determine whether aPWV is ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.104.483628

    authors: Sutton-Tyrrell K,Najjar SS,Boudreau RM,Venkitachalam L,Kupelian V,Simonsick EM,Havlik R,Lakatta EG,Spurgeon H,Kritchevsky S,Pahor M,Bauer D,Newman A,Health ABC Study.

    更新日期:2005-06-28 00:00:00

  • Dynamics of right heart flow in patients after Fontan procedure.

    abstract::In seven patients who underwent Fontan procedures but in whom no valves were inserted, dynamics of right heart flow were evaluated with the use of a catheter-tipped velocity transducer, pulsed Doppler echocardiography, and angiocardiography. Right atrial (RA) contraction caused a forward flow to the pulmonary artery (...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.69.2.306

    authors: Nakazawa M,Nakanishi T,Okuda H,Satomi G,Nakae S,Imai Y,Takao A

    更新日期:1984-02-01 00:00:00

  • Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats.

    abstract:BACKGROUND:Estrogen may increase the long-term survival of women who have suffered from a myocardial infarction (MI). We examined the acute and chronic influence of estrogen on MI in the rat left coronary artery ligation model. METHODS AND RESULTS:Female Sprague-Dawley rats (10 to 12 weeks, n=93), divided into 3 group...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.24.2983

    authors: Smith PJ,Ornatsky O,Stewart DJ,Picard P,Dawood F,Wen WH,Liu PP,Webb DJ,Monge JC

    更新日期:2000-12-12 00:00:00

  • Effects of dopamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure.

    abstract:BACKGROUND:Inhibition of dopamine beta-hydroxylase (DBH) results in a decrease in norepinephrine synthesis. The present study was a randomized, blinded, placebo-controlled investigation of the long-term effects of therapy with the DBH inhibitor nepicastat (NCT) on the progression of left ventricular (LV) dysfunction an...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.16.1990

    authors: Sabbah HN,Stanley WC,Sharov VG,Mishima T,Tanimura M,Benedict CR,Hegde S,Goldstein S

    更新日期:2000-10-17 00:00:00

  • Suprasternal notch echocardiography: a two-dimensional technique for evaluating congenital heart disease.

    abstract::Two-dimensional suprasternal notch echocardiography was performed in 1033 patients, ages 1 day to 18 years. For the long-axis suprasternal notch view, the transducer was positioned in the suprasternal notch and angled to obtain a plane passing between the right nipple and left scapular tip. In this view, the entire ao...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.63.1.165

    authors: Snider AR,Silverman NH

    更新日期:1981-01-01 00:00:00

  • Effect of intense angiotensin II suppression on the diuretic response to furosemide during chronic ACE inhibition.

    abstract:BACKGROUND:Contrary to expectation, most studies have demonstrated that initiation of an angiotensin-converting enzyme (ACE) inhibitor in conventional doses in patients with heart failure reduces the diuretic efficacy of furosemide. Recently, it has been suggested that single low doses (1 mg) but not high doses (25 mg)...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.90.1.220

    authors: Good JM,Brady AJ,Noormohamed FH,Oakley CM,Cleland JG

    更新日期:1994-07-01 00:00:00

  • Long-term prognostic value of dobutamine-atropine stress echocardiography in 1737 patients with known or suspected coronary artery disease: A single-center experience.

    abstract:BACKGROUND:The purpose of this study was to assess the long-term value of dobutamine-atropine stress echocardiography (DSE) for prediction of late cardiac events in patients with proven or suspected coronary artery disease. METHODS AND RESULTS:Clinical data and DSE results were analyzed in 1734 consecutive patients un...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.99.6.757

    authors: Poldermans D,Fioretti PM,Boersma E,Bax JJ,Thomson IR,Roelandt JR,Simoons ML

    更新日期:1999-02-16 00:00:00

  • Arterial reactivity is significantly impaired in normotensive young adults after successful repair of aortic coarctation in childhood.

    abstract:BACKGROUND:Despite successful repair of coarctation of the aorta in childhood, adult survivors often have hypertension at rest or on exercise, and their life expectancy is shorter than normal because of premature coronary and cerebrovascular disease. This may be related to persistent structural and functional arterial ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.4.1745

    authors: Gardiner HM,Celermajer DS,Sorensen KE,Georgakopoulos D,Robinson J,Thomas O,Deanfield JE

    更新日期:1994-04-01 00:00:00

  • Detection of lung rejection with indium-111-labeled lymphocytes in heterotopic rat heart-lung transplantation.

    abstract::To determine if acute lung rejection after heart-lung transplantation can be detected noninvasively with indium-111-labeled (111In) lymphocytes, we studied 33 allogeneic and 18 isogeneic heterotopic heart-lung transplants in rats. Twenty-four hours after injection of isogeneic splenic 111In-lymphocytes (75 +/- 2 micro...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Arai H,Yuda T,Goodgold HM,deMello DE,Hendershott L,Pennington DG

    更新日期:1991-11-01 00:00:00

  • Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).

    abstract:BACKGROUND:To date, the uptake of drugs into the human heart by transport proteins is poorly understood. A candidate protein is the organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent transport protein for carnitine. We investigated expression and localization of OCTN...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.586107

    authors: Grube M,Meyer zu Schwabedissen HE,Präger D,Haney J,Möritz KU,Meissner K,Rosskopf D,Eckel L,Böhm M,Jedlitschky G,Kroemer HK

    更新日期:2006-02-28 00:00:00

  • Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor.

    abstract:BACKGROUND:Z-Val-Ala-Asp(OMe)-CH2F (ZVAD-fmk), a tripeptide inhibitor of the caspase interleukin-1beta-converting enzyme family of cysteine proteases, may reduce myocardial reperfusion injury in vivo by attenuating cardiomyocyte apoptosis within the ischemic area at risk. METHODS AND RESULTS:Sprague-Dawley rats were s...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.97.3.276

    authors: Yaoita H,Ogawa K,Maehara K,Maruyama Y

    更新日期:1998-01-27 00:00:00

  • Coronary events after arterial switch operation for transposition of the great arteries.

    abstract:BACKGROUND:Transfer of the coronary arteries is a crucial step during the arterial switch operation (ASO) for transposition of the great arteries. This retrospective study aims to assess the incidence and risk factors of coronary events after ASO and sensitivity of noninvasive tests in the diagnosis of the coronary obs...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000087902.67220.2b

    authors: Legendre A,Losay J,Touchot-Koné A,Serraf A,Belli E,Piot JD,Lambert V,Capderou A,Planche C

    更新日期:2003-09-09 00:00:00

  • Physical training alters the pathogenesis of pacing-induced heart failure through endothelium-mediated mechanisms in awake dogs.

    abstract:BACKGROUND:Beneficial effects of exercise training on cardiovascular function in chronic heart failure (CHF) have been suggested previously, but the underlying mechanisms are unknown. We tested whether daily exercise training improves systemic hemodynamics and preserves endothelium-mediated vasodilator function during ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.96.8.2683

    authors: Wang J,Yi GH,Knecht M,Cai BL,Poposkis S,Packer M,Burkhoff D

    更新日期:1997-10-21 00:00:00

  • Oxidative stress induces NF-kappaB nuclear translocation without degradation of IkappaBalpha.

    abstract:BACKGROUND:Rel/NF-kappaB, an oxidative stress-responsive transcription factor, participates transiently in the control of gene expression. The cellular mechanisms that mediate NF-kappaB activation during ischemia (and during reperfusion in the course of treating ischemia) are not known. METHODS AND RESULTS:To investig...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.suppl_2.ii-361

    authors: Canty TG Jr,Boyle EM Jr,Farr A,Morgan EN,Verrier ED,Pohlman TH

    更新日期:1999-11-09 00:00:00

  • An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome.

    abstract:BACKGROUND:Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia. Over the last 25 years, multiple genes have been reported to cause this condition and are routinely tested in patients. Because of dramatic changes in our understanding of human genetic variation, reappraisal of reported gen...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.043132

    authors: Adler A,Novelli V,Amin AS,Abiusi E,Care M,Nannenberg EA,Feilotter H,Amenta S,Mazza D,Bikker H,Sturm AC,Garcia J,Ackerman MJ,Hershberger RE,Perez MV,Zareba W,Ware JS,Wilde AAM,Gollob MH

    更新日期:2020-02-11 00:00:00

  • A collaborative study of infective endocarditis in the 1970s. Emphasis on infections in patients who have undergone cardiovascular surgery.

    abstract::Twenty-six major cardiovascular centers participated in a cooperative study of all cases of infective endocarditis occurring during a single calendar year to obtain an overview of infective endocarditis. The study was designed to learn which patients appear to be at highest risk to develop this infection after palliat...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.59.2.327

    authors: Kaplan EL,Rich H,Gersony W,Manning J

    更新日期:1979-02-01 00:00:00

  • Reappraisal of Reported Genes for Sudden Arrhythmic Death: Evidence-Based Evaluation of Gene Validity for Brugada Syndrome.

    abstract:BACKGROUND:Implicit in the genetic evaluation of patients with suspected genetic diseases is the assumption that the genes evaluated are causative for the disease based on robust scientific and statistical evidence. However, in the past 20 years, considerable variability has existed in the study design and quality of e...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.118.035070

    authors: Hosseini SM,Kim R,Udupa S,Costain G,Jobling R,Liston E,Jamal SM,Szybowska M,Morel CF,Bowdin S,Garcia J,Care M,Sturm AC,Novelli V,Ackerman MJ,Ware JS,Hershberger RE,Wilde AAM,Gollob MH,National Institutes of Health C

    更新日期:2018-09-18 00:00:00

  • Regional myocardial oxygen consumption determined noninvasively in humans with [1-11C]acetate and dynamic positron tomography.

    abstract::Experimental studies of animals have previously demonstrated the validity of [1-11C]acetate as a tracer of oxidative metabolism for use with positron emission tomography. The present study was undertaken to define in normal human volunteers the relation between myocardial clearance kinetics of [1-11C]acetate, and the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.80.4.863

    authors: Armbrecht JJ,Buxton DB,Brunken RC,Phelps ME,Schelbert HR

    更新日期:1989-10-01 00:00:00

  • Quantification of incomplete revascularization and its association with five-year mortality in the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) trial validation of the residual SYNTAX score.

    abstract:BACKGROUND:The residual Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) Score is an objective measure of the degree and complexity of residual stenosis after percutaneous coronary intervention (PCI). METHODS AND RESULTS:In the randomized PCI cohort of the SYNTAX Trial (n=903)...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.113.001803

    authors: Farooq V,Serruys PW,Bourantas CV,Zhang Y,Muramatsu T,Feldman T,Holmes DR,Mack M,Morice MC,Ståhle E,Colombo A,de Vries T,Morel MA,Dawkins KD,Kappetein AP,Mohr FW

    更新日期:2013-07-09 00:00:00

  • Refining Prediction of Atrial Fibrillation-Related Stroke Using the P2-CHA2DS2-VASc Score.

    abstract:BACKGROUND:In people with atrial fibrillation (AF), periods of sinus rhythm present an opportunity to detect prothrombotic atrial remodeling through measurement of P-wave indices (PWIs)-prolonged P-wave duration, abnormal P-wave axis, advanced interatrial block, and abnormal P-wave terminal force in lead V1. We hypothe...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.118.035411

    authors: Maheshwari A,Norby FL,Roetker NS,Soliman EZ,Koene RJ,Rooney MR,O'Neal WT,Shah AM,Claggett BL,Solomon SD,Alonso A,Gottesman RF,Heckbert SR,Chen LY

    更新日期:2019-01-08 00:00:00

  • Tissue plasminogen activator and risk of myocardial infarction. The Rotterdam Study.

    abstract:BACKGROUND:Impaired fibrinolytic capacity, as assessed by euglobulin clot lysis time or plasma concentration of fibrinolytic parameters, has been associated with an increased risk of myocardial infarction (MI). We studied the association of a polymorphism in the gene for TPA and of plasma concentrations of TPA (antigen...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.95.12.2623

    authors: van der Bom JG,de Knijff P,Haverkate F,Bots ML,Meijer P,de Jong PT,Hofman A,Kluft C,Grobbee DE

    更新日期:1997-06-17 00:00:00

  • Hyperlipidemia and coronary disease. Correction of the increased thrombogenic potential with cholesterol reduction.

    abstract:BACKGROUND:Hypercholesterolemia is a risk factor for coronary disease, and platelet reactivity is increased with hypercholesterolemia, suggesting a prethrombotic risk. The aim of this study was to measure mural platelet thrombus formation on an injured arterial wall in a model simulating vessel stenosis and plaque rupt...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.11.3172

    authors: Lacoste L,Lam JY,Hung J,Letchacovski G,Solymoss CB,Waters D

    更新日期:1995-12-01 00:00:00

  • Ultrasonic echolucent carotid plaques predict future strokes.

    abstract:BACKGROUND:We tested prospectively the hypothesis that stroke development can be predicted by echolucency of carotid atherosclerotic plaques in previously symptomatic and asymptomatic patients. METHODS AND RESULTS:We followed incidence of ipsilateral ischemic strokes for 4.4 years in 111 asymptomatic and 135 symptomat...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/hc2601.091704

    authors: Grønholdt ML,Nordestgaard BG,Schroeder TV,Vorstrup S,Sillesen H

    更新日期:2001-07-03 00:00:00

  • Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.

    abstract:BACKGROUND:Patients with atrial fibrillation (AF) often take multiple medications. METHODS AND RESULTS:We examined characteristics and compared adjusted outcomes between rivaroxaban and warfarin according to number of concomitant baseline medications and the presence of combined cytochrome P450 3A4 and P-glycoprotein ...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.115.018544

    authors: Piccini JP,Hellkamp AS,Washam JB,Becker RC,Breithardt G,Berkowitz SD,Halperin JL,Hankey GJ,Hacke W,Mahaffey KW,Nessel CC,Singer DE,Fox KA,Patel MR

    更新日期:2016-01-26 00:00:00

  • Infarct size, myocardial hemorrhage, and recovery of function after mechanical versus pharmacological reperfusion: effects of lytic state and occlusion time.

    abstract:BACKGROUND:Whether myocardial reperfusion obtained with thrombolysis or primary angioplasty is associated with a similar recovery of function and with the same risk of hemorrhagic infarction is unknown. We evaluated the effects of mechanical and pharmacological reperfusion (with or without a plasma lytic state) on infa...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.96.2.659

    authors: Pislaru SV,Barrios L,Stassen T,Jun L,Pislaru C,Van de Werf F

    更新日期:1997-07-15 00:00:00