A hemodynamically responsive antitachycardia system. Development and basis for design in humans.

abstract：BACKGROUND:Genetic testing for long-QT syndrome (LQTS) has diagnostic, prognostic, and therapeutic implications. Hundreds of causative mutations in 12 known LQTS-susceptibility genes have been identified. Genetic testing that includes the 3 most commonly mutated genes is available clinically. Distinguishing pathogenic ...

journal_title：Circulation

authors： Kapa S,Tester DJ,Salisbury BA,Harris-Kerr C,Pungliya MS,Alders M,Wilde AA,Ackerman MJ

更新日期：2009-11-03 00:00:00

abstract：BACKGROUND:Epidemiological studies have identified clinical and echocardiographic factors associated with increased stroke risk in atrial fibrillation (AF), but mechanisms linking these factors to stroke in AF are incompletely understood. We hypothesized that stroke risk factors may be associated with increased endothe...

journal_title：Circulation

authors： Conway DS,Pearce LA,Chin BS,Hart RG,Lip GY

更新日期：2002-10-08 00:00:00

abstract：:The Persantine-Aspirin Reinfarction Study (PARIS) was a randomized, controlled, double-blind study of dipyridamole (Persantine) and aspirin in secondary prevention of coronary heart disease. Two thousand twenty-six men and women with myocardial infarction (MI) documented by electrocardiographic findings, clinical hist...

journal_title：Circulation

authors：

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:Fetal tachyarrhythmia may result in low cardiac output and death. Consequently, antiarrhythmic treatment is offered in most affected pregnancies. We compared 3 drugs commonly used to control supraventricular tachycardia (SVT) and atrial flutter (AF). METHODS AND RESULTS:We reviewed 159 consecutive referrals...

journal_title：Circulation

authors： Jaeggi ET,Carvalho JS,De Groot E,Api O,Clur SA,Rammeloo L,McCrindle BW,Ryan G,Manlhiot C,Blom NA

更新日期：2011-10-18 00:00:00

abstract：BACKGROUND:This study sought to evaluate the clinical impact of angiographic complete revascularization (CR) after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary disease. METHODS AND RESULTS:A total of 1914 consecutive patients with multivessel coronary disease undergo...

journal_title：Circulation

authors： Kim YH,Park DW,Lee JY,Kim WJ,Yun SC,Ahn JM,Song HG,Oh JH,Park JS,Kang SJ,Lee SW,Lee CW,Park SW,Park SJ

更新日期：2011-05-31 00:00:00

abstract：BACKGROUND:An effect of diet in determining blood pressure is suggested by epidemiological studies, but the role of specific nutrients is still unsettled. METHODS AND RESULTS:The relation of various nutritional factors with hypertension was examined prospectively among 30,681 predominantly white US male health profess...

journal_title：Circulation

authors： Ascherio A,Rimm EB,Giovannucci EL,Colditz GA,Rosner B,Willett WC,Sacks F,Stampfer MJ

更新日期：1992-11-01 00:00:00

abstract：:Postoperative angiographic studies were carried out at 1 month, 1 year, and 10 years in two groups of patients: 238 patients with saphenous vein (SV) grafts and 40 patients with internal mammary artery (IMA) grafts. Cumulative patency was better in IMA grafts, both at 1 year (88.5% vs 76.4%) and at 10 years (84.1% vs ...

journal_title：Circulation

authors： Grondin CM,Campeau L,Lespérance J,Enjalbert M,Bourassa MG

更新日期：1984-09-01 00:00:00

abstract：:Oral flecainide acetate was administered to 34 patients with documented symptomatic paroxysmal supraventricular tachycardia (PSVT) with a double-blind, placebo-controlled, 8-week crossover trial design. PSVT was defined as a regular tachycardia of at least 120 beats/min without evidence of atrioventricular dissociatio...

journal_title：Circulation

authors： Henthorn RW,Waldo AL,Anderson JL,Gilbert EM,Alpert BL,Bhandari AK,Hawkinson RW,Pritchett EL

更新日期：1991-01-01 00:00:00

abstract：:Threshold bipolar pacing was performed from one of 12 selected atrial sites with temporary implanted electrodes in 69 patients following open-heart surgery in order to study P wave polarity and morphology and the P-R interval during paced ectopic atrial rhythms. A negative P wave was recorded in lead I only with paci...

journal_title：Circulation

authors： MacLean WA,Karp RB,Kouchoukos NT,James TN,Waldo AL

更新日期：1975-09-01 00:00:00

abstract：:We recorded direct-current extracellular electrograms simultaneously from 60 left ventricular epicardial sites in 38 alpha-chloralose-anesthetized dogs during repeated, 5 min coronary arterial occlusions. In each dog recordings made during control occlusions were compared with those made in occlusions after, or during...

journal_title：Circulation

authors： Janse MJ,Schwartz PJ,Wilms-Schopman F,Peters RJ,Durrer D

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) is associated with an impairment in exercise performance and muscle function that is not fully explained by the reduced leg blood flow during exercise. This study characterized the effects of PAD on muscle function, histology, and metabolism. METHODS AND RESULTS:Twenty-six ...

journal_title：Circulation

authors： Regensteiner JG,Wolfel EE,Brass EP,Carry MR,Ringel SP,Hargarten ME,Stamm ER,Hiatt WR

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Morbidity and mortality after conventional repair of thoracoabdominal aneurysms remain high. Alternative techniques have been proposed and are the subject of this report. METHODS AND RESULTS:Endovascular grafts that have a means of incorporating the visceral vessels into the aortic repair were divided into ...

journal_title：Circulation

authors： Greenberg RK,Lytle B

更新日期：2008-04-29 00:00:00

abstract：BACKGROUND:A role for myeloperoxidase (MPO) as a mediator of coronary artery disease and acute coronary syndromes has recently received considerable attention. Although active MPO and hypochlorite-modified proteins and peptides have been detected in human atherosclerotic lesions, detection of novel chlorinated oxidized...

journal_title：Circulation

authors： Thukkani AK,McHowat J,Hsu FF,Brennan ML,Hazen SL,Ford DA

更新日期：2003-12-23 00:00:00

abstract：:In seven patients who underwent Fontan procedures but in whom no valves were inserted, dynamics of right heart flow were evaluated with the use of a catheter-tipped velocity transducer, pulsed Doppler echocardiography, and angiocardiography. Right atrial (RA) contraction caused a forward flow to the pulmonary artery (...

journal_title：Circulation

authors： Nakazawa M,Nakanishi T,Okuda H,Satomi G,Nakae S,Imai Y,Takao A

更新日期：1984-02-01 00:00:00

abstract：:Normal right ventricular muscles and similar preparations obtained from cats with signs of subacute right ventricular failure (RVF) (3 to 14 days after pressure overload induced by pulmonary artery coarctation) were studied during stimulation (at 0.5 Hz) and exposure to high-K+ Tyrode's solution. Twitch force, rate of...

journal_title：Circulation

authors： Gaide MS,Kimura S,Lodge NJ,Cameron JS,Kozlovskis PL,Myerburg RJ,Bassett AL

更新日期：1986-03-01 00:00:00

abstract：:Although evidence suggests that primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy in the majority of patients with ST-segment-elevation myocardial infarction (STEMI), only a minority of patients with STEMI are treated with primary PCI, and of those, only a minority receive the trea...

journal_title：Circulation

authors： Jacobs AK,Antman EM,Ellrodt G,Faxon DP,Gregory T,Mensah GA,Moyer P,Ornato J,Peterson ED,Sadwin L,Smith SC,American Heart Association's Acute Myocardial Infarction Advisory Working Group.

更新日期：2006-05-02 00:00:00

abstract：BACKGROUND:Whether reperfusion can cause necrosis of previously viable myocytes (lethal reperfusion injury) remains controversial. Numerous studies examined the ability of various agents to prevent or limit reperfusion injury, but the results were contradictory. In a single-canine-heart model of ischemia-reperfusion, w...

journal_title：Circulation

authors： Zahger D,Yano J,Chaux A,Fishbein MC,Ganz W

更新日期：1995-06-15 00:00:00

abstract：BACKGROUND:Glycoprotein (GP) IIb/IIIa inhibitors are beneficial in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS); their safe use in women, however, remains a concern. The contribution of dosing to the observed sex-related differences in bleeding is unknown. METHODS AND RESULTS:We explored ...

journal_title：Circulation

authors： Alexander KP,Chen AY,Newby LK,Schwartz JB,Redberg RF,Hochman JS,Roe MT,Gibler WB,Ohman EM,Peterson ED,CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC\/

更新日期：2006-09-26 00:00:00

abstract：BACKGROUND:Several recent studies attempted to classify plaques as those prone to cause clinical manifestations (vulnerable, atheromatous plaques) or those less frequently associated with acute thrombotic complication (stable, fibrous plaques). Defining the cellular and molecular mechanisms that underlie these morpholo...

journal_title：Circulation

authors： Sukhova GK,Schönbeck U,Rabkin E,Schoen FJ,Poole AR,Billinghurst RC,Libby P

更新日期：1999-05-18 00:00:00

abstract：:Optimal electrode position for long-term transvenous cardiac pacing is in the apex of the right ventricle. Intracardiac electrograms, surface electrocardiograms, frontal fluoroscopy, lateral roentgenograms, and pacing threshold levels were studied in two groups of patients: One group was comprised of five patients wit...

journal_title：Circulation

authors： Gulotta SJ

更新日期：1970-10-01 00:00:00

abstract：BACKGROUND:Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. METHODS:ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcom...

journal_title：Circulation

authors： Steg PG,Szarek M,Bhatt DL,Bittner VA,Brégeault MF,Dalby AJ,Diaz R,Edelberg JM,Goodman SG,Hanotin C,Harrington RA,Jukema JW,Lecorps G,Mahaffey KW,Moryusef A,Ostadal P,Parkhomenko A,Pordy R,Roe MT,Tricoci P,Vogel R

更新日期：2019-07-09 00:00:00

abstract：BACKGROUND:Vascular events during initial reperfusion after a period of hypothermic cardioplegic ischemia may play an important role in the recovery of mechanical function. Prior studies have shown (1) that dysfunction of the postischemic myocardium after normothermic ischemia can be ameliorated by vasodilation and (2)...

journal_title：Circulation

authors： Kawata H,Aoki M,Mayer JE Jr

更新日期：1993-11-01 00:00:00

abstract：:Patients with systemic morphological right ventricles (RVs), including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries with a Mustard or Senning atrial baffle repair, have a high likelihood of developing systemic ventricular dysfunction. Unfortunately, there ar...

journal_title：Circulation

authors： Zaragoza-Macias E,Zaidi AN,Dendukuri N,Marelli A

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Gene-nutrient interactions affecting high-density lipoprotein cholesterol (HDL-C) concentrations may contribute to the interindividual variability of the cardiovascular disease risk associated with dietary fat intake. Hepatic lipase (HL) is a key determinant of HDL metabolism. Four polymorphisms in linkage d...

journal_title：Circulation

authors： Ordovas JM,Corella D,Demissie S,Cupples LA,Couture P,Coltell O,Wilson PW,Schaefer EJ,Tucker KL

更新日期：2002-10-29 00:00:00

abstract：:Variations in the frequency of ventricular premature depolarizations (VPDs) were evaluated with three consecutive 24-hour long-term electrocardiography monitor recordings from 15 clinically stable patients with various cardiac disorders. Mean hourly VPD frequencies ranged from 37--1,801 per hour. Data were subjected t...

journal_title：Circulation

authors： Morganroth J,Michelson EL,Horowitz LN,Josephson ME,Pearlman AS,Dunkman WB

更新日期：1978-09-01 00:00:00

abstract：:Our experimental studies since 1972 show that the heart is preserved best during cardiopulmonary bypass when it is in the beating, nonworking state. Results after mitral valve replacement (MVR) from 1968 to 1974 using various techniques of cardiac preservation were compared. In group I were 47 patients (1968 to 1972) ...

journal_title：Circulation

authors： Maloney JV Jr,Cooper N,Mulder DG,Buckberg GD

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Out-of-hospital cardiac arrest (OHCA) commonly presents with nonshockable rhythms (asystole and pulseless electric activity). It is unknown whether antiarrhythmic drugs are safe and effective when nonshockable rhythms evolve to shockable rhythms (ventricular fibrillation/pulseless ventricular tachycardia [VF...

journal_title：Circulation

authors： Kudenchuk PJ,Leroux BG,Daya M,Rea T,Vaillancourt C,Morrison LJ,Callaway CW,Christenson J,Ornato JP,Dunford JV,Wittwer L,Weisfeldt ML,Aufderheide TP,Vilke GM,Idris AH,Stiell IG,Colella MR,Kayea T,Egan D,Desvigne-Nick

更新日期：2017-11-28 00:00:00

abstract：:From 1962-1977, 99 patients, mean age 65 +/- 0.5 years (range 60-81 years) underwent valve replacement for severe calcific aortic valve stenosis. Ninety-three percent of the patients were in New York Heart Association functional class III or IV. The aortic valve gradient was 76 +/- 3 mm Hg and the aortic valve area in...

journal_title：Circulation

authors： Murphy ES,Lawson RM,Starr A,Rahimtoola SH

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Myocardial infarction, stroke, and sudden death undergo diurnal variation. Although genes relevant to hemostasis and vascular integrity undergo circadian oscillation, the role of the molecular clock in thrombotic events remains to be established. METHODS AND RESULTS:A diurnal variation in the time to thromb...

journal_title：Circulation

authors： Westgate EJ,Cheng Y,Reilly DF,Price TS,Walisser JA,Bradfield CA,FitzGerald GA

更新日期：2008-04-22 00:00:00

abstract：BACKGROUND:Isoprostanes (iPs) are free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Several iPs exert biological effects in vitro and may contribute to the functional consequences of oxidant stress. For example, iPF(2alpha)-III (8-iso PGF(2alpha)) and iPE(2)-III modulate plate...

journal_title：Circulation

authors： Audoly LP,Rocca B,Fabre JE,Koller BH,Thomas D,Loeb AL,Coffman TM,FitzGerald GA

更新日期：2000-06-20 00:00:00