Flecainide acetate prevents recurrence of symptomatic paroxysmal supraventricular tachycardia. The Flecainide Supraventricular Tachycardia Study Group.


:Oral flecainide acetate was administered to 34 patients with documented symptomatic paroxysmal supraventricular tachycardia (PSVT) with a double-blind, placebo-controlled, 8-week crossover trial design. PSVT was defined as a regular tachycardia of at least 120 beats/min without evidence of atrioventricular dissociation. The study required considerable patient cooperation. Patients first entered a 4-week qualifying phase followed by a 3-week, open label, flecainide dose-ranging phase. They were then randomized in a blind fashion to receive either placebo or tolerated flecainide dose for an 8-week treatment period and then crossed over after four symptomatic documented episodes of PSVT or at the end of the treatment period. By all efficacy parameters analyzed, flecainide was superior to placebo. Flecainide was associated with an actuarial 79% freedom from symptomatic PSVT events compared with only 15% on placebo at 60 days (p less than 0.001). Of the 34 patients, 29 had recurrence of symptomatic PSVT at least once during the placebo phase; only eight patients had a recurrence during the flecainide phase (p less than 0.001). The median time to the first symptomatic PSVT event was 11 days in the placebo group and greater than 55 days in the flecainide group (p less than 0.001). Likewise, the interval between attacks was a median of 12 days on placebo compared with more than 55 days on flecainide (p less than 0.001). Finally, the flecainide slowed symptomatic PSVT heart rates to 143 +/- 12 beats/min from 178 +/- 12 on placebo (p less than 0.02) in the seven patients who had events in the placebo and flecainide treatment phases.(ABSTRACT TRUNCATED AT 250 WORDS)






Henthorn RW,Waldo AL,Anderson JL,Gilbert EM,Alpert BL,Bhandari AK,Hawkinson RW,Pritchett EL




Has Abstract


1991-01-01 00:00:00












  • Implantable left ventricular assist device. Approaching an alternative for end-stage heart failure. Implantable LVAD Study Group.

    abstract:BACKGROUND:The implantable left ventricular assist device (LVAD) was designed to provide circulatory support as an alternative to heart transplantation or to continued medical therapy of end-stage heart failure. Initial experience with the implantable LVAD used as a bridge to heart transplantation provides a clinical o...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: McCarthy PM,James KB,Savage RM,Vargo R,Kendall K,Harasaki H,Hobbs RE,Pashkow FJ

    更新日期:1994-11-01 00:00:00

  • The risk of coronary bypass surgery for patients with postinfarction angina.

    abstract::Three hundred consecutive patients who developed unstable postinfarction angina requiring isolated coronary artery bypass from 1982 through 1987 were analyzed. Hospital mortality was 5%; 15 (5.5%) additional late deaths occurred during the 69-month follow-up period (mean follow-up, 23.3 months). Significant independen...


    pub_type: 杂志文章


    authors: Gardner TJ,Stuart RS,Greene PS,Baumgartner WA

    更新日期:1989-06-01 00:00:00

  • Interindividual heterogeneity in the hypoxic regulation of VEGF: significance for the development of the coronary artery collateral circulation.

    abstract:BACKGROUND:The coronary artery collateral circulation may be beneficial in protecting against myocardial ischemia and necrosis. However, there is a tremendous interindividual variability in the degree of new collateral formation in patients with coronary artery disease. The basis for this interindividual heterogeneity ...


    pub_type: 杂志文章


    authors: Schultz A,Lavie L,Hochberg I,Beyar R,Stone T,Skorecki K,Lavie P,Roguin A,Levy AP

    更新日期:1999-08-03 00:00:00

  • Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine.

    abstract:BACKGROUND:Hyperhomocysteinemia is an independent risk factor for coronary heart disease (CHD). Dietary supplementation with B vitamins lowers plasma homocysteine by up to 30%. However, little is known about the potential beneficial effects of homocysteine lowering on vascular function in patients with CHD. METHODS AN...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chambers JC,Ueland PM,Obeid OA,Wrigley J,Refsum H,Kooner JS

    更新日期:2000-11-14 00:00:00

  • Clinical correlates of atrial tachyarrhythmias after valve replacement for aortic stenosis.

    abstract::One hundred eighteen consecutive patients undergoing valve replacement for aortic stenosis were analyzed to determine the incidence of and predisposing factors to postoperative atrial tachyarrhythmias. Univariate and multivariate analyses were performed on 70 clinical, hemodynamic, radiographic, electrocardiographic, ...


    pub_type: 杂志文章


    authors: Douglas PS,Hirshfeld JW Jr,Edmunds LH Jr

    更新日期:1985-09-01 00:00:00

  • Reentry within the atrioventricular node: surgical cure with preservation of atrioventricular conduction.

    abstract::Paroxysmal supraventricular tachycardia (PSVT) is commonly caused by reentry within the atrioventricular (AV) node. This arrhythmia was abolished by operative dissection of the AV junction in a patient with disabling tachycardia that was not controlled by drugs. The operation was intended to create complete AV block, ...


    pub_type: 杂志文章


    authors: Pritchett EL,Anderson RW,Benditt DG,Kasell J,Harrison L,Wallace AG,Sealy WC,Gallagher JJ

    更新日期:1979-08-01 00:00:00

  • Nexilin Is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation.

    abstract:BACKGROUND:Membrane contact sites are fundamental for transmission and translation of signals in multicellular organisms. The junctional membrane complexes in the cardiac dyads, where transverse (T) tubules are juxtaposed to the sarcoplasmic reticulum, are a prime example. T-tubule uncoupling and remodeling are well-kn...


    pub_type: 杂志文章


    authors: Liu C,Spinozzi S,Chen JY,Fang X,Feng W,Perkins G,Cattaneo P,Guimarães-Camboa N,Dalton ND,Peterson KL,Wu T,Ouyang K,Fu XD,Evans SM,Chen J

    更新日期:2019-07-02 00:00:00

  • Characterization of spatial patterns of flow within the reperfused myocardium by myocardial contrast echocardiography. Implications in determining extent of myocardial salvage.

    abstract:BACKGROUND:Since myocardial blood flow changes dynamically after reperfusion and since both hyperemia and impairment in microvascular function exist within the acutely reperfused bed, we sought to investigate the role of myocardial contrast echocardiography (MCE) in (1) defining the temporal variability in perfusion pa...


    pub_type: 杂志文章


    authors: Villanueva FS,Glasheen WP,Sklenar J,Kaul S

    更新日期:1993-12-01 00:00:00

  • Response of blood pressure, cardiac output, peripheral resistance, and exercise performance to substitution of calcium blocker for beta-blocker plus thiazide diuretic therapy in patients with both systemic hypertension and mild stable angina.

    abstract::We studied 14 patients to determine whether sustained-release diltiazem is a satisfactory long-term substitute for the combination of propranolol plus hydrochlorothiazide (HCTZ), control phase, in the treatment of systemic hypertension with coexisting chronic stable angina pectoris. All patients had either one- or two...


    pub_type: 杂志文章


    authors: Kawanishi DT,Reid CL,Gonzales A,O'Rourke RA,Rahimtoola SH

    更新日期:1989-12-01 00:00:00

  • Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure.

    abstract:BACKGROUND:The purpose of this study was to investigate the prevalence of skeletal muscle atrophy and its relation to exercise intolerance and abnormal muscle metabolism in patients with heart failure (HF). METHODS AND RESULTS:Peak VO2, percent ideal body weight (% IBW), 24-hour urine creatinine (Cr), and anthropometr...


    pub_type: 杂志文章


    authors: Mancini DM,Walter G,Reichek N,Lenkinski R,McCully KK,Mullen JL,Wilson JR

    更新日期:1992-04-01 00:00:00

  • Thrombogenic properties of murine anti-cardiolipin antibodies induced by beta 2 glycoprotein 1 and human immunoglobulin G antiphospholipid antibodies.

    abstract:BACKGROUND:Recurrent arterial thrombosis and venous thrombosis are frequent complications of the antiphospholipid syndrome (APS). Patients produce anti-cardiolipin antibodies, but the role of these antibodies in thrombus formation is uncertain. This study used a unique CD-1 mouse model of thrombosis to determine whethe...


    pub_type: 杂志文章


    authors: Pierangeli SS,Liu SW,Anderson G,Barker JH,Harris EN

    更新日期:1996-10-01 00:00:00

  • Edge-to-edge mitral valve repair without ring annuloplasty for acute ischemic mitral regurgitation.

    abstract:BACKGROUND:Alfieri edge-to-edge mitral repair has been used clinically with ring annuloplasty to correct ischemic mitral regurgitation (IMR), but its efficacy without concomitant ring annuloplasty has not been described in this setting. METHODS:Seventeen sheep underwent implantation of 9 radiopaque markers on the left...


    pub_type: 杂志文章


    authors: Timek TA,Nielsen SL,Lai DT,Tibayan FA,Liang D,Rodriguez F,Daughters GT,Ingels NB Jr,Miller DC

    更新日期:2003-09-09 00:00:00

  • Effect of pulse separation between two sequential biphasic shocks given over different lead configurations on ventricular defibrillation efficacy.

    abstract:BACKGROUND:Two sequential biphasic shocks delivered over separate lead configurations markedly improve defibrillation efficacy compared with a single shock alone. We investigated the effect of varying the intershock interval between sequential biphasic shocks on defibrillation. METHODS AND RESULTS:Defibrillation thres...


    pub_type: 杂志文章


    authors: Johnson EE,Alferness CA,Wolf PD,Smith WM,Ideker RE

    更新日期:1992-06-01 00:00:00

  • Long-term outcome of patients with depressed left ventricular function undergoing percutaneous transluminal coronary angioplasty. The NHLBI PTCA Registry.

    abstract:BACKGROUND:Coronary revascularization with bypass has been shown to improve survival in patients with coronary artery disease and left ventricular dysfunction. In these patients, use of nonsurgical revascularization with percutaneous transluminal coronary angioplasty (PTCA) is increasing, although their long-term outco...


    pub_type: 杂志文章


    authors: Holmes DR Jr,Detre KM,Williams DO,Kent KM,King SB 3rd,Yeh W,Steenkiste A

    更新日期:1993-01-01 00:00:00

  • KB-R7943 block of Ca(2+) influx via Na(+)/Ca(2+) exchange does not alter twitches or glycoside inotropy but prevents Ca(2+) overload in rat ventricular myocytes.

    abstract:BACKGROUND:The Na(+)/Ca(2+) exchange (NCX) extrudes Ca(2+) from cardiac myocytes, but it can also mediate Ca(2+) influx, load the sarcoplasmic reticulum with Ca(2+), and trigger Ca(2+) release from the sarcoplasmic reticulum. In ischemia/reperfusion or digitalis toxicity, increased levels of intracellular [Na(+)] ([Na(...


    pub_type: 杂志文章


    authors: Satoh H,Ginsburg KS,Qing K,Terada H,Hayashi H,Bers DM

    更新日期:2000-03-28 00:00:00

  • Radiofrequency catheter modification of the sinus node for "inappropriate" sinus tachycardia.

    abstract:BACKGROUND:Radiofrequency catheter ablation is the treatment of choice for patients with paroxysmal supraventricular tachycardias refractory to medical therapy. However, in symptomatic patients with inappropriate sinus tachycardia resistant to drug therapy, catheter ablation of the His' bundle with permanent pacemaker ...


    pub_type: 杂志文章


    authors: Lee RJ,Kalman JM,Fitzpatrick AP,Epstein LM,Fisher WG,Olgin JE,Lesh MD,Scheinman MM

    更新日期:1995-11-15 00:00:00

  • Sex differences in perioperative and long-term cardiac event-free survival in vascular surgery patients. An analysis of clinical and scintigraphic variables.

    abstract:BACKGROUND:Little information is available regarding the occurrence of perioperative and late cardiac events in women with vascular disease. The current study was performed to examine whether sex-specific differences exist in these outcomes in a large population of vascular surgery patients and to determine the value o...


    pub_type: 杂志文章


    authors: Hendel RC,Chen MH,L'Italien GJ,Newell JB,Paul SD,Eagle KA,Leppo JA

    更新日期:1995-02-15 00:00:00

  • Immediate effect of expiratory loading on left ventricular stroke volume.

    abstract::While the steady-state effects of positive pleural pressure on the circulation have been extensively studied, less is known about the immediate effects of positive intrathoracic pressure on cardiac dynamics. Therefore, we performed electrocardiographically gated radionuclide ventriculography with a respiratory gating ...


    pub_type: 杂志文章


    authors: Natarajan TK,Wise RA,Karam M,Permutt S,Wagner HN Jr

    更新日期:1987-01-01 00:00:00

  • Pharmacodynamics and pharmacokinetics of eptifibatide in patients with acute coronary syndromes: prospective analysis from PURSUIT.

    abstract:BACKGROUND:Platelet deposition and aggregation are central to the pathogenesis of ischemic complications of acute coronary syndromes (ACS). Pharmacodynamic effects of the platelet glycoprotein IIb/IIIa antagonist eptifibatide have been delineated in healthy subjects but not in patients with ACS. We assessed effects of ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tardiff BE,Jennings LK,Harrington RA,Gretler D,Potthoff RF,Vorchheimer DA,Eisenberg PR,Lincoff AM,Labinaz M,Joseph DM,McDougal MF,Kleiman NS,PERIGEE Investigators.

    更新日期:2001-07-24 00:00:00

  • Randomized trial of warfarin, aspirin, and clopidogrel in patients with chronic heart failure: the Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) trial.

    abstract:BACKGROUND:Chronic heart failure remains a major cause of mortality and morbidity. The role of antithrombotic therapy in patients with chronic heart failure has long been debated. The objective of this study was to determine the optimal antithrombotic agent for heart failure patients with reduced ejection fractions who...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Massie BM,Collins JF,Ammon SE,Armstrong PW,Cleland JG,Ezekowitz M,Jafri SM,Krol WF,O'Connor CM,Schulman KA,Teo K,Warren SR,WATCH Trial Investigators.

    更新日期:2009-03-31 00:00:00

  • Thallium 201 kinetics in stunned myocardium characterized by severe postischemic systolic dysfunction.

    abstract::The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction ("stunning"), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-...


    pub_type: 杂志文章


    authors: Moore CA,Cannon J,Watson DD,Kaul S,Beller GA

    更新日期:1990-05-01 00:00:00

  • Anatomic features in victims of sudden coronary death. Coronary artery pathology.

    abstract::Study of the detailed pathology of the myocardium and coronary arteries in ambulatory subjects dying suddenly of coronary heart disease shows that they can be divided into two groups. In one group, there is atherosclerosis with a new vascular event involving coronary thrombosis, which initiates acute myocardial ischem...


    pub_type: 杂志文章,评审


    authors: Davies MJ

    更新日期:1992-01-01 00:00:00

  • Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association.

    abstract::Spontaneous coronary artery dissection (SCAD) has emerged as an important cause of acute coronary syndrome, myocardial infarction, and sudden death, particularly among young women and individuals with few conventional atherosclerotic risk factors. Patient-initiated research has spurred increased awareness of SCAD, and...


    pub_type: 杂志文章,实务指引,评审


    authors: Hayes SN,Kim ESH,Saw J,Adlam D,Arslanian-Engoren C,Economy KE,Ganesh SK,Gulati R,Lindsay ME,Mieres JH,Naderi S,Shah S,Thaler DE,Tweet MS,Wood MJ,American Heart Association Council on Peripheral Vascular Disease; Council on

    更新日期:2018-05-08 00:00:00

  • Differential response to right and left ansae subclaviae stimulation of early afterdepolarizations and ventricular tachycardia induced by cesium in dogs.

    abstract::Early afterdepolarizations (EADs) are depolarizing potentials that occur before complete repolarization. They may be important in the acquired and possibly the idiopathic long QT syndrome and associated ventricular tachycardia (VT). The purpose of these experiments was to study in 20 open-chest dogs the effects of sym...


    pub_type: 杂志文章


    authors: Ben-David J,Zipes DP

    更新日期:1988-11-01 00:00:00

  • Effects of inhaled nitric oxide and oxygen in high-altitude pulmonary edema.

    abstract:BACKGROUND:High-altitude pulmonary edema (HAPE) is characterized by pulmonary hypertension, increased pulmonary capillary permeability, and hypoxemia. Treatment is limited to descent to lower altitude and administration of oxygen. METHODS AND RESULTS:We studied the acute effects of inhaled nitric oxide (NO), 50% oxyge...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Anand IS,Prasad BA,Chugh SS,Rao KR,Cornfield DN,Milla CE,Singh N,Singh S,Selvamurthy W

    更新日期:1998-12-01 00:00:00

  • Prognostic value of bisoprolol-induced hemodynamic effects in heart failure during the Cardiac Insufficiency BIsoprolol Study (CIBIS).

    abstract:BACKGROUND:To further evaluate the mechanism of beta-blocker-induced benefits in heart failure, the relationships between bisoprolol-induced hemodynamic effects and survival were studied during the Cardiac Insufficiency BIsoprolol Study (CIBIS). METHODS AND RESULTS:In 557 patients studied, bisoprolol significantly red...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Lechat P,Escolano S,Golmard JL,Lardoux H,Witchitz S,Henneman JA,Maisch B,Hetzel M,Jaillon P,Boissel JP,Mallet A

    更新日期:1997-10-07 00:00:00

  • High-volume continuous hemofiltration during cardiopulmonary bypass attenuates pulmonary dysfunction in neonatal lambs after deep hypothermic circulatory arrest.

    abstract:BACKGROUND:Cardiopulmonary bypass (CPB) induces an inflammatory reaction that activates neutrophils and releases free radicals in tissue. Ischemia-reperfusion further aggravates inflammation. Hemofiltration (HF) could potentially remove inflammatory mediators and reduce injury. This study assessed the effect of continu...


    pub_type: 杂志文章


    authors: Nagashima M,Shin'oka T,Nollert G,Shum-Tim D,Rader CM,Mayer JE Jr

    更新日期:1998-11-10 00:00:00

  • Assessment of the treatment effect of enoxaparin for unstable angina/non-Q-wave myocardial infarction. TIMI 11B-ESSENCE meta-analysis.

    abstract:BACKGROUND:Two phase III trials of enoxaparin for unstable angina/non-Q-wave myocardial infarction have shown it to be superior to unfractionated heparin for preventing a composite of death and cardiac ischemic events. A prospectively planned meta-analysis was performed to provide a more precise estimate of the effects...


    pub_type: 临床试验,杂志文章,meta分析,多中心研究


    authors: Antman EM,Cohen M,Radley D,McCabe C,Rush J,Premmereur J,Braunwald E

    更新日期:1999-10-12 00:00:00

  • A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees.

    abstract:BACKGROUND:Functional benefit in heart failure due to idiopathic dilated cardiomyopathy has been observed after beta-blockade, but improvement in survival has not been established in a large-scale randomized trial. This was the main objective of the Cardiac Insufficiency Bisoprolol Study (CIBIS). METHODS AND RESULTS:S...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验



    更新日期:1994-10-01 00:00:00

  • Transmembrane potential properties at the core of functional reentrant wave fronts in isolated canine right atria.

    abstract:BACKGROUND:The characteristics of transmembrane potential (TMP) at the core of functional reentry in the atrium are not well understood. METHODS AND RESULTS:In protocol 1 (11 dogs), isolated perfused canine right atria were mapped from the endocardial surface while simultaneous TMPs were recorded from the epicardial s...


    pub_type: 杂志文章


    authors: Athill CA,Ikeda T,Kim YH,Wu TJ,Fishbein MC,Karagueuzian HS,Chen PS

    更新日期:1998-10-13 00:00:00