Persantine-aspirin reinfarction study. Design, methods and baseline results. By the persantine-aspirin reinfarction study research group.

abstract：BACKGROUND:Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice that overexpress HSP72 demonstrate improved functional recovery and decreased inf...

journal_title：Circulation

authors： Hutter JJ,Mestril R,Tam EK,Sievers RE,Dillmann WH,Wolfe CL

更新日期：1996-09-15 00:00:00

abstract：:We evaluated the effects of selective activation of H1 receptors on coronary hemodynamics in 16 patients divided into two groups: group A, 11 patients with atypical angina or valvular heart disease and normal coronary arteries, and group B, five patients with spontaneous angina, four of whom had significant (greater t...

journal_title：Circulation

authors： Vigorito C,Poto S,Picotti GB,Triggiani M,Marone G

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction may contribute to the risk of premature atherosclerosis in patients with diabetes. Endothelin (ET-1) may be involved in this process by activating smooth muscle cell mitogenesis and leukocyte adhesion. We sought to assess the activity of endogenous ET-1 in a group of patients with typ...

journal_title：Circulation

authors： Cardillo C,Campia U,Bryant MB,Panza JA

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:The relations of insulin sensitivity (IS) to hypertension incidence may vary according to baseline age, body mass index (BMI), and blood pressure (BP). METHODS AND RESULTS:We investigated the relations of IS (insulin sensitivity index, ISI(0,120)) to 4-year incidence of hypertension and BP progression in 19...

journal_title：Circulation

authors： Arnlöv J,Pencina MJ,Nam BH,Meigs JB,Fox CS,Levy D,D'Agostino RB,Vasan RS

更新日期：2005-09-20 00:00:00

abstract：:Lidocaine is a commonly used antiarrhythmic drug that causes use-dependent blockade of sodium channels in vitro and reduces conduction velocity in vitro and in vivo. According to the modulated receptor hypothesis of antiarrhythmic drug action, lidocaine has a low affinity for rested sodium channels but a high affinity...

journal_title：Circulation

authors： Davis J,Matsubara T,Scheinman MM,Katzung B,Hondeghem LH

更新日期：1986-07-01 00:00:00

abstract：:A Y-shaped lesion in the right atrium allows induction of atrial flutter in dogs. We recorded the activation sequence during this tachycardia from 96 endocardial bipolar electrodes using intracavitary electrode arrays during 12 separate episodes in three isolated perfused hearts. In each case a reentrant impulse circu...

journal_title：Circulation

authors： Frame LH,Page RL,Boyden PA,Fenoglio JJ Jr,Hoffman BF

更新日期：1987-11-01 00:00:00

abstract：:The effects of therapeutic levels of quinidine were studied in an ischemic gap preparation of reflected reentry. The preparation consisted of a Purkinje fiber mounted in a three-compartment chamber. A narrow central compartment was perfused with a solution prepared to mimic the extracellular milieu at a site of ischem...

journal_title：Circulation

authors： Shen XT,Antzelevitch C

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:An association of chronic Chlamydia pneumoniae infection to coronary heart disease has been suggested recently. In a recent study, we demonstrated circulating immune complexes containing chlamydial genus-specific lipopolysaccharide in patients with coronary heart disease. The objective of the present study w...

journal_title：Circulation

authors： Linnanmäki E,Leinonen M,Mattila K,Nieminen MS,Valtonen V,Saikku P

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia. Over the last 25 years, multiple genes have been reported to cause this condition and are routinely tested in patients. Because of dramatic changes in our understanding of human genetic variation, reappraisal of reported gen...

journal_title：Circulation

authors： Adler A,Novelli V,Amin AS,Abiusi E,Care M,Nannenberg EA,Feilotter H,Amenta S,Mazza D,Bikker H,Sturm AC,Garcia J,Ackerman MJ,Hershberger RE,Perez MV,Zareba W,Ware JS,Wilde AAM,Gollob MH

更新日期：2020-02-11 00:00:00

abstract：:Between July 1985 and September 1987, 25 patients underwent 26 carotid endarterectomies based on an abnormal duplex scan (B-mode ultrasonography and pulsed-Doppler sound spectral analysis) indicative of severe stenosis or ulceration. Arteriography was not performed because of severe unstable angina requiring coronary ...

journal_title：Circulation

authors： Marshall WG Jr,Kouchoukos NT,Murphy SF,Pelate C

更新日期：1988-09-01 00:00:00

abstract：:Thirteen patients with proven Q fever endocarditis and three additional patients with probable endocarditis are reviewed. The most helpful diagnostic test is the demonstration of a high complement fixing antibody titre to Phase 1 antigen of Coxiella burneti. The macroscopic pathology of the aortic valve is described a...

journal_title：Circulation

authors： Wilson HG,Neilson GH,Galea EG,Stafford G,O'Brien MF

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Recent data suggest that the Berlin Heart EXCOR Pediatric ventricular assist device is superior to extracorporeal membrane oxygenation for bridge to heart transplantation. Published data are limited to 1 in 4 children who received the device as part of the US clinical trial. We analyzed outcomes for all US c...

journal_title：Circulation

authors： Almond CS,Morales DL,Blackstone EH,Turrentine MW,Imamura M,Massicotte MP,Jordan LC,Devaney EJ,Ravishankar C,Kanter KR,Holman W,Kroslowitz R,Tjossem C,Thuita L,Cohen GA,Buchholz H,St Louis JD,Nguyen K,Niebler RA,Walt

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:We have reported that myocardial ischemia increases nitric oxide (NO) production. Several lines of evidence suggest that NO reduces myocardial contraction. Therefore, we tested whether endogenous NO decreases the inotropic response of the ischemic myocardium and whether endogenous NO is beneficial in the met...

journal_title：Circulation

authors： Node K,Kitakaze M,Kosaka H,Komamura K,Minamino T,Inoue M,Tada M,Hori M,Kamada T

更新日期：1996-01-15 00:00:00

abstract：BACKGROUND:During the development of heart failure (HF), the chief myocardial energy substrate switches from fatty acids to glucose. This metabolic switch, which recapitulates fetal cardiac energy substrate preferences, is thought to maintain aerobic energetic balance. The regulatory mechanisms involved in this metabol...

journal_title：Circulation

authors： Sack MN,Rader TA,Park S,Bastin J,McCune SA,Kelly DP

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Our purpose was to use multislice MRI for detection of reversible myocardial ischemia and assessment of the effect of revascularization on tissue perfusion in patients with coronary artery disease. METHODS AND RESULTS:Eleven patients with single-vessel proximal left anterior descending coronary artery disea...

journal_title：Circulation

authors： Lauerma K,Virtanen KS,Sipilä LM,Hekali P,Aronen HJ

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Fat inflammation may play an important role in comorbidities associated with obesity such as atherosclerosis. METHODS AND RESULTS:To first establish feasibility of fat transplantation, epididymal fat pads were harvested from wild-type C57BL/6J mice and transplanted into leptin-deficient (Lep(ob/ob)) mice. F...

journal_title：Circulation

authors： Ohman MK,Shen Y,Obimba CI,Wright AP,Warnock M,Lawrence DA,Eitzman DT

更新日期：2008-02-12 00:00:00

abstract：BACKGROUND:Hypercholesterolemia and sickle cell disease (SCD) impair endothelium-dependent vasodilation by dissimilar mechanisms. Hypercholesterolemia impairs vasodilation by a low-density lipoprotein (LDL)-dependent mechanism. SCD has been characterized as a chronic state of inflammation in which xanthine oxidase (XO)...

journal_title：Circulation

authors： Ou J,Ou Z,Jones DW,Holzhauer S,Hatoum OA,Ackerman AW,Weihrauch DW,Gutterman DD,Guice K,Oldham KT,Hillery CA,Pritchard KA Jr

更新日期：2003-05-13 00:00:00

abstract：BACKGROUND:In PTCA patients with multivessel coronary artery disease, incomplete revascularization (IR) is the result of both pre-PTCA strategy and initial lesion outcome. The unique contribution of these components on long-term patient outcome is uncertain. METHODS AND RESULTS:From the Bypass Angioplasty Revasculariz...

journal_title：Circulation

authors： Kip KE,Bourassa MG,Jacobs AK,Schwartz L,Feit F,Alderman EL,Weiner BH,Weiss MB,Kellett MA Jr,Sharaf BL,Dimas AP,Jones RH,Sopko G,Detre KM

更新日期：1999-08-31 00:00:00

abstract：BACKGROUND:Myocardial salvage is most likely to occur when thrombolytic therapy is administered within 4 to 6 hours of the onset of symptoms of myocardial infarction. The impact of delays within this early time period on final myocardial infarct size are unknown. The purpose of this study was to quantitate the relation...

journal_title：Circulation

authors： Raitt MH,Maynard C,Wagner GS,Cerqueira MD,Selvester RH,Weaver WD

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Glycoprotein (GP) IIb/IIIa inhibitors are beneficial in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS); their safe use in women, however, remains a concern. The contribution of dosing to the observed sex-related differences in bleeding is unknown. METHODS AND RESULTS:We explored ...

journal_title：Circulation

authors： Alexander KP,Chen AY,Newby LK,Schwartz JB,Redberg RF,Hochman JS,Roe MT,Gibler WB,Ohman EM,Peterson ED,CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC\/

更新日期：2006-09-26 00:00:00

abstract：BACKGROUND:We compared ischemic preconditioning (IP) induced with a single cycle of transient ischemia and reperfusion with that induced by multiple cycles in terms of (1) efficacy of protection against myocardial necrosis and (2) susceptibility to pharmacological blockade by inhibition of protein kinase C (PKC) or ele...

journal_title：Circulation

authors： Sandhu R,Diaz RJ,Mao GD,Wilson GJ

更新日期：1997-08-05 00:00:00

abstract：:The purpose of this study was to develop a clinically applicable system for quantifying premortem myocardial area at risk. Coronary artery occlusion was performed in 18 closed-chest dogs (11 left anterior descending and seven circumflex). 99mTc (15 mCi)-labeled macroaggregated albumin was then injected through an angi...

journal_title：Circulation

authors： Feiring AJ,Bruch P,Husayni TS,Kirchner PT,Marcus ML

更新日期：1986-03-01 00:00:00

abstract：:Retrograde coronary artery flow was observed angiographically in 43 patients with aortic stenosis and/or regurgitation. In the 24 patients with pure or predominant aortic stenosis, retrograde flow was seen in all 24 during end-systole. In the eight patients with pure aortic regurgitation, retrograde flow was seen main...

journal_title：Circulation

authors： Carroll RJ,Falsetti HL

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:Recently, it was reported that the degree of microvascular injury and left ventricular functional recovery during the chronic period can be predicted after treatment of the infarct-related artery based on the coronary flow velocity (CFV) pattern assessed using a Doppler guidewire. The aim of this prospective...

journal_title：Circulation

authors： Yamamuro A,Akasaka T,Tamita K,Yamabe K,Katayama M,Takagi T,Morioka S

更新日期：2002-12-10 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP), a well-recognized marker of atherosclerosis, has recently been suggested to have a direct proinflammatory effect. The constitutive expression of low levels of CRP in normal plasma suggests the likelihood that a natural factor exists to neutralize the effect of CRP. This factor(s) ha...

journal_title：Circulation

authors： Wadham C,Albanese N,Roberts J,Wang L,Bagley CJ,Gamble JR,Rye KA,Barter PJ,Vadas MA,Xia P

更新日期：2004-05-04 00:00:00

abstract：BACKGROUND:This study compared the efficacy of ischemic preconditioning (IPC) and sodium-hydrogen exchanger (NHE)-1 inhibition to reduce infarct size (IS) induced by a 90-minute ischemic insult and examined the interaction between NHE-1 inhibition and IPC. METHODS AND RESULTS:In a canine infarct model, either IPC, pro...

journal_title：Circulation

authors： Gumina RJ,Buerger E,Eickmeier C,Moore J,Daemmgen J,Gross GJ

更新日期：1999-12-21 00:00:00

abstract：BACKGROUND:The incidence, determinants, and outcome of postoperative atrial fibrillation (AF) after surgery for mitral regurgitation (MR) are poorly defined but may have important implications for timing of mitral valve surgery. METHODS AND RESULTS:In 762 patients in sinus rhythm with no AF history undergoing MR surgi...

journal_title：Circulation

authors： Kernis SJ,Nkomo VT,Messika-Zeitoun D,Gersh BJ,Sundt TM 3rd,Ballman KV,Scott CG,Schaff HV,Enriquez-Sarano M

更新日期：2004-10-19 00:00:00

abstract：BACKGROUND:approximately half of patients with heart failure die suddenly as a result of ventricular arrhythmias. Although abnormal Ca(2+) release from the sarcoplasmic reticulum through ryanodine receptors (RyR2) has been linked to arrhythmogenesis, the molecular mechanisms triggering release of arrhythmogenic Ca(2+) ...

journal_title：Circulation

authors： van Oort RJ,McCauley MD,Dixit SS,Pereira L,Yang Y,Respress JL,Wang Q,De Almeida AC,Skapura DG,Anderson ME,Bers DM,Wehrens XH

更新日期：2010-12-21 00:00:00

abstract：:The ability to quantify the quality of cardiovascular care critically depends on the translation of recommendations for high-quality care into the measurement of that care. As payers and regulatory agencies increasingly seek to quantify healthcare quality, the implications of the measurement process on practicing phys...

journal_title：Circulation

authors： Spertus JA,Eagle KA,Krumholz HM,Mitchell KR,Normand SL,American College of Cardiology.,American Heart Association Task Force on Performance Measures.

更新日期：2005-04-05 00:00:00

abstract：BACKGROUND:Cardiac Na/K-ATPase (NKA) regulates intracellular Na ([Na](i)), which in turn affects intracellular Ca and thus contractility via Na/Ca exchange. Recent evidence shows that phosphorylation of the NKA-associated small transmembrane protein phospholemman (PLM) mediates beta-adrenergic-induced NKA stimulation. ...

journal_title：Circulation

authors： Despa S,Tucker AL,Bers DM

更新日期：2008-04-08 00:00:00