Abstract:
:Thirteen patients with proven Q fever endocarditis and three additional patients with probable endocarditis are reviewed. The most helpful diagnostic test is the demonstration of a high complement fixing antibody titre to Phase 1 antigen of Coxiella burneti. The macroscopic pathology of the aortic valve is described and includes aneurysmal pockets in the aortic wall and valve annulus which are demonstrable angiographically. Evidence is presented that the infection may be controlled by prolonged tetracycline therapy and that this is accompanied by a falling antibody titre to Phase 1 antigen. Valve replacement is undertaken only for symptomatic and hemodynamic indications. The combined tetracycline therapy and valve replacement have produced a fall in titres with eradication of infection and palliation of the cardiac disability in all patients followed for long periods.
journal_name
Circulationjournal_title
Circulationauthors
Wilson HG,Neilson GH,Galea EG,Stafford G,O'Brien MFdoi
10.1161/01.cir.53.4.680subject
Has Abstractpub_date
1976-04-01 00:00:00pages
680-4issue
4eissn
0009-7322issn
1524-4539journal_volume
53pub_type
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