Effects of verapamil on ischemia-induced changes in extracellular K+, pH, and local activation in the pig.

abstract：BACKGROUND:Aortic counterpulsation has been observed to reduce the rate of reocclusion of the infarct-related artery after patency has been restored during acute myocardial infarction in observational studies. To evaluate the benefit-to-risk ratio of aortic counterpulsation during the early phase of myocardial infarcti...

journal_title：Circulation

authors： Ohman EM,George BS,White CJ,Kern MJ,Gurbel PA,Freedman RJ,Lundergan C,Hartmann JR,Talley JD,Frey MJ

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Coronary blood flow occurs mainly during the diastolic phase of each cardiac cycle and is mainly dependent on diastolic driving pressure, especially in the left anterior descending coronary artery (LAD). We hypothesized that calculation of the ratio of the diastolic driving pressure of a stenotic LAD to its ...

journal_title：Circulation

authors： Abe M,Tomiyama H,Yoshida H,Doba N

更新日期：2000-11-07 00:00:00

abstract：:We have recently demonstrated that exercise training can induce important hemodynamic and metabolic adaptations in patients with chronic heart failure due to severe left ventricular dysfunction. This study examines the accompanying changes in submaximal exercise performance and the ventilatory response to exercise in ...

journal_title：Circulation

authors： Sullivan MJ,Higginbotham MB,Cobb FR

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the adult heart experimentally. Moreover, whether these Ca(2+) release channels are present and play a critical role in human cardiomyocytes remains to be defined. IP3Rs may be activated after Gαq-protein-coupled receptor...

journal_title：Circulation

authors： Signore S,Sorrentino A,Ferreira-Martins J,Kannappan R,Shafaie M,Del Ben F,Isobe K,Arranto C,Wybieralska E,Webster A,Sanada F,Ogórek B,Zheng H,Liu X,Del Monte F,D'Alessandro DA,Wunimenghe O,Michler RE,Hosoda T,Goichb

更新日期：2013-09-17 00:00:00

abstract：:The Academic Research Consortium (ARC)-2 initiative revisited the clinical and angiographic end point definitions in coronary device trials, proposed in 2007, to make them more suitable for use in clinical trials that include increasingly complex lesion and patient populations and incorporate novel devices such as bio...

journal_title：Circulation

authors： Garcia-Garcia HM,McFadden EP,Farb A,Mehran R,Stone GW,Spertus J,Onuma Y,Morel MA,van Es GA,Zuckerman B,Fearon WF,Taggart D,Kappetein AP,Krucoff MW,Vranckx P,Windecker S,Cutlip D,Serruys PW,Academic Research Consortium

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:We examined the associations of a range of parental and early life characteristics with systolic blood pressure at 5 years of age. METHODS AND RESULTS:Information from 3864 children who were followed up prospectively from their mother's first antenatal clinic assessment was used. Maternal age, body mass ind...

journal_title：Circulation

authors： Lawlor DA,Najman JM,Sterne J,Williams GM,Ebrahim S,Davey Smith G

更新日期：2004-10-19 00:00:00

abstract：BACKGROUND:Although there is a statistically significant association between modestly raised baseline plasma C-reactive protein (CRP) values and future cardiovascular events, the debate is still unsettled in regard to whether CRP plays a causal role in the pathogenesis of atherosclerosis. METHODS AND RESULTS:We genera...

journal_title：Circulation

authors： Koike T,Kitajima S,Yu Y,Nishijima K,Zhang J,Ozaki Y,Morimoto M,Watanabe T,Bhakdi S,Asada Y,Chen YE,Fan J

更新日期：2009-11-24 00:00:00

abstract：BACKGROUND:It has been suggested that intracellular Ca2+ overload in cardiac myocytes leads to the development of diabetic cardiomyopathy. Troglitazone, an insulin-sensitizing agent, is a promising therapeutic agent for diabetes and has been shown to prevent diabetes-induced myocardial changes. To elucidate the underly...

journal_title：Circulation

authors： Nakajima T,Iwasawa K,Oonuma H,Imuta H,Hazama H,Asano M,Morita T,Nakamura F,Suzuki J,Suzuki S,Kawakami Y,Omata M,Okuda Y

更新日期：1999-06-08 00:00:00

abstract：BACKGROUND:Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are a promising source of cells for regenerating myocardium. However, several issues, especially the large-scale preparation of hiPS-CMs and elimination of undifferentiated iPS cells, must be resolved before hiPS cells can be used clinical...

journal_title：Circulation

authors： Kawamura M,Miyagawa S,Miki K,Saito A,Fukushima S,Higuchi T,Kawamura T,Kuratani T,Daimon T,Shimizu T,Okano T,Sawa Y

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies have not assessed relations of a comprehensive panel of stiffness measures to prognosis in the community. METHODS AND RESULTS:We used proportional hazards models to analyze first-onset...

journal_title：Circulation

authors： Mitchell GF,Hwang SJ,Vasan RS,Larson MG,Pencina MJ,Hamburg NM,Vita JA,Levy D,Benjamin EJ

更新日期：2010-02-02 00:00:00

abstract：BACKGROUND:Platelet-thrombus formation is a complication of arterial wall deep injury by balloon angioplasty that may lead to acute arterial occlusion and may contribute to restenosis. METHODS AND RESULTS:Because common platelet-inhibitor drugs with a heparin bolus (100 units/kg) may be effective in inhibiting platele...

journal_title：Circulation

authors： Lam JY,Chesebro JH,Steele PM,Heras M,Webster MW,Badimon L,Fuster V

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Guidelines for the management of patients with suspected coronary artery disease (CAD) rely on the age, sex, and angina typicality-based pretest probabilities of angiographically significant CAD derived from invasive coronary angiography (guideline probabilities). Reliability of guideline probabilities has n...

journal_title：Circulation

authors： Cheng VY,Berman DS,Rozanski A,Dunning AM,Achenbach S,Al-Mallah M,Budoff MJ,Cademartiri F,Callister TQ,Chang HJ,Chinnaiyan K,Chow BJ,Delago A,Gomez M,Hadamitzky M,Hausleiter J,Karlsberg RP,Kaufmann P,Lin FY,Maffei E

更新日期：2011-11-29 00:00:00

abstract：BACKGROUND:Data from single-center studies suggest that echocardiographic parameters of mechanical dyssynchrony may improve patient selection for cardiac resynchronization therapy (CRT). In a prospective, multicenter setting, the Predictors of Response to CRT (PROSPECT) study tested the performance of these parameters ...

journal_title：Circulation

authors： Chung ES,Leon AR,Tavazzi L,Sun JP,Nihoyannopoulos P,Merlino J,Abraham WT,Ghio S,Leclercq C,Bax JJ,Yu CM,Gorcsan J 3rd,St John Sutton M,De Sutter J,Murillo J

更新日期：2008-05-20 00:00:00

abstract：BACKGROUND:In recent decades, the rates of incident acute myocardial infarction (AMI) have declined in the United States, yet disparities by sex remain. In an integrated healthcare delivery system, we examined temporal trends in incident AMI among women and men. METHODS:We identified hospitalized AMI among members ≥35...

journal_title：Circulation

authors： Mefford MT,Li BH,Qian L,Reading SR,Harrison TN,Scott RD,Cavendish JJ,Jacobsen SJ,Kanter MH,Woodward M,Reynolds K

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Pharmacological ventricular rate control is an acceptable atrial fibrillation (AF) therapy limited by systemic toxicity. We postulate that focal catheter-based drug delivery into the atrioventricular nodal (AVN) region may effectively control ventricular rate during AF without systemic toxicity. This study e...

journal_title：Circulation

authors： Sigg DC,Hiniduma-Lokuge P,Coles JA Jr,Falkner P,Rose R,Urban JF,Ujhelyi MR

更新日期：2006-05-23 00:00:00

abstract：BACKGROUND:Inflammation and matrix degradation may play a pathogenic role in chronic heart failure (CHF), and therefore, we examined whether thalidomide, a drug with potential immunomodulating and matrix-stabilizing properties, could improve left ventricular (LV) function in patients with CHF secondary to idiopathic di...

journal_title：Circulation

authors： Gullestad L,Ueland T,Fjeld JG,Holt E,Gundersen T,Breivik K,Følling M,Hodt A,Skårdal R,Kjekshus J,Andreassen A,Kjekshus E,Wergeland R,Yndestad A,Frøland SS,Semb AG,Aukrust P

更新日期：2005-11-29 00:00:00

abstract：BACKGROUND:Intravascular irradiation with beta-emitters has been proposed for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. Previous studies have shown the effectiveness of gamma-radiation to prevent recurrent restenosis, even in the presence of an implanted stent. The l...

journal_title：Circulation

authors： Amols HI,Trichter F,Weinberger J

更新日期：1998-11-10 00:00:00

abstract：BACKGROUND:Although gender-specific criteria are common for defining cardiac traits such as left ventricular hypertrophy, left ventricular ejection fraction (LVEF) thresholds widely used in clinical practice have traditionally been the same for women and men, perhaps because it remains uncertain whether there is a syst...

journal_title：Circulation

authors： Chung AK,Das SR,Leonard D,Peshock RM,Kazi F,Abdullah SM,Canham RM,Levine BD,Drazner MH

更新日期：2006-03-28 00:00:00

abstract：BACKGROUND:Endothelial progenitor cells (EPCs) circulate in adult peripheral blood (PB) and contribute to neovascularization. However, little is known regarding whether EPCs and their putative precursor, CD34-positive mononuclear cells (MNC(CD34+)), are mobilized into PB in acute ischemic events in humans. METHODS AND...

journal_title：Circulation

authors： Shintani S,Murohara T,Ikeda H,Ueno T,Honma T,Katoh A,Sasaki K,Shimada T,Oike Y,Imaizumi T

更新日期：2001-06-12 00:00:00

abstract：BACKGROUND:Alteration of the circadian rhythm and increased vascular senescence are linked to cardiovascular disease. Per2, a circadian gene, is known to regulate endothelium-dependent vasomotion. However, the mechanism by which Per2 affects endothelial function is unknown. We hypothesize that endothelial dysfunction i...

journal_title：Circulation

authors： Wang CY,Wen MS,Wang HW,Hsieh IC,Li Y,Liu PY,Lin FC,Liao JK

更新日期：2008-11-18 00:00:00

abstract：:Although evidence suggests that primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy in the majority of patients with ST-segment-elevation myocardial infarction (STEMI), only a minority of patients with STEMI are treated with primary PCI, and of those, only a minority receive the trea...

journal_title：Circulation

authors： Jacobs AK,Antman EM,Ellrodt G,Faxon DP,Gregory T,Mensah GA,Moyer P,Ornato J,Peterson ED,Sadwin L,Smith SC,American Heart Association's Acute Myocardial Infarction Advisory Working Group.

更新日期：2006-05-02 00:00:00

abstract：:To determine the contribution of disopyramide's suggested opposing direct depressant and indirect acceleratory actions on sinus node function, we studied the effects of disopyramide, 1 x 10(-7) to 1 x 10(-4) M, on isolated rabbit sinus node preparations using standard microelectrode techniques. Transmembrane potential...

journal_title：Circulation

authors： Katoh T,Karagueuzian HS,Jordan J,Mandel WJ

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Early results of sirolimus-eluting stent implantation showed a nearly complete abolition of neointimal hyperplasia. The question remains, however, whether the early promising results will still be evident at long-term follow-up. The objective of our study was to evaluate the efficiency of sirolimus-eluting s...

journal_title：Circulation

authors： Degertekin M,Serruys PW,Foley DP,Tanabe K,Regar E,Vos J,Smits PC,van der Giessen WJ,van den Brand M,de Feyter P,Popma JJ

更新日期：2002-09-24 00:00:00

abstract：BACKGROUND:Trends in cardiovascular mortality across Europe demonstrate significant geographical variation, and an understanding of these trends has a central role in global public health. METHODS AND RESULTS:Ischemic heart disease and cerebrovascular disease age-standardized death rates (as per International Classifi...

journal_title：Circulation

authors： Hartley A,Marshall DC,Salciccioli JD,Sikkel MB,Maruthappu M,Shalhoub J

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. METHODS AND RESULTS:The study used the explanted hearts of five human cardiac transplant recipients. Three right and t...

journal_title：Circulation

authors： Ikeda T,Czer L,Trento A,Hwang C,Ong JJ,Hough D,Fishbein MC,Mandel WJ,Karagueuzian HS,Chen PS

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Sudden Unexplained Death Syndrome (SUDS) is the leading cause of death in young, healthy, Southeast Asian men. The role of an implantable cardioverter defibrillator (ICD) for mortality reduction in these patients remains unclear. METHODS AND RESULTS:The Defibrillator Versus beta-Blockers for Unexplained Dea...

journal_title：Circulation

authors： Nademanee K,Veerakul G,Mower M,Likittanasombat K,Krittayapong R,Bhuripanyo K,Sitthisook S,Chaothawee L,Lai MY,Azen SP

更新日期：2003-05-06 00:00:00

abstract：BACKGROUND:The first compounds considered for stent-based delivery, such as heparin, were chosen on the basis of promising tissue culture and animal experiments, and yet they have failed to stop restenosis clinically. More recent compounds, such as paclitaxel, are of a different sort, being hydrophobic in nature, and t...

journal_title：Circulation

authors： Hwang CW,Wu D,Edelman ER

更新日期：2001-07-31 00:00:00

abstract：BACKGROUND:Coconut oil is high in saturated fat and may, therefore, raise serum cholesterol concentrations, but beneficial effects on other cardiovascular risk factors have also been suggested. Therefore, we conducted a systematic review of the effect of coconut oil consumption on blood lipids and other cardiovascular ...

journal_title：Circulation

authors： Neelakantan N,Seah JYH,van Dam RM

更新日期：2020-03-10 00:00:00

abstract：BACKGROUND:Indications for surgical correction of aortic regurgitation have been established mostly in men and have not been validated in women. The outcome of this surgical correction in women is unknown. METHODS AND RESULTS:Baseline characteristics and postoperative outcomes were compared between 51 women and 198 me...

journal_title：Circulation

authors： Klodas E,Enriquez-Sarano M,Tajik AJ,Mullany CJ,Bailey KR,Seward JB

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic responses. Here, we investigated the role of Sirt7 in cardiovascular tissue repair process. METHODS AND RESULTS:In wild-type mice, Sirt7 expression increa...

journal_title：Circulation

authors： Araki S,Izumiya Y,Rokutanda T,Ianni A,Hanatani S,Kimura Y,Onoue Y,Senokuchi T,Yoshizawa T,Yasuda O,Koitabashi N,Kurabayashi M,Braun T,Bober E,Yamagata K,Ogawa H

更新日期：2015-09-22 00:00:00