Human C-reactive protein does not promote atherosclerosis in transgenic rabbits.

abstract：BACKGROUND:We compared ischemic preconditioning (IP) induced with a single cycle of transient ischemia and reperfusion with that induced by multiple cycles in terms of (1) efficacy of protection against myocardial necrosis and (2) susceptibility to pharmacological blockade by inhibition of protein kinase C (PKC) or ele...

journal_title：Circulation

authors： Sandhu R,Diaz RJ,Mao GD,Wilson GJ

更新日期：1997-08-05 00:00:00

abstract：:One hundred consecutive patients who underwent coronary artery bypass surgery at the Columbia-Presbyterian Medical Center from December 1972 through February 1975 were evaluated at surgery and then followed for as long as 4 1/2 years to study their postoperative psychosocial and behavioral course. One patient died dur...

journal_title：Circulation

authors： Kornfeld DS,Heller SS,Frank KA,Wilson SN,Malm JR

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The guidelines presented in this consensus statement are intended to serve researchers, clinicians, reviewers, and regulators in the selection of the most appropriate primary outcome for a clinical trial of cardiac arrest therapies. The American Heart Association guidelines for the treatment of c...

journal_title：Circulation

authors： Becker LB,Aufderheide TP,Geocadin RG,Callaway CW,Lazar RM,Donnino MW,Nadkarni VM,Abella BS,Adrie C,Berg RA,Merchant RM,O'Connor RE,Meltzer DO,Holm MB,Longstreth WT,Halperin HR,American Heart Association Emergency Cardiova

更新日期：2011-11-08 00:00:00

abstract：BACKGROUND:Previous evidence has shown that increased sympathetic tone enhances the cesium chloride (Cs)-induced early afterdepolarizations (EADs) and ventricular tachycardias (VTs). METHODS AND RESULTS:We assessed the effects of vagal stimulation on Cs-induced EADs and ventricular arrhythmias in the rabbit heart. Mon...

journal_title：Circulation

authors： Takahashi N,Ito M,Ishida S,Fujino T,Saikawa T,Arita M

更新日期：1992-12-01 00:00:00

abstract：:Aortic root motion was studied in 24 normal volunteers at rest and during the Valsalva maneuver, isometric exercise, and amyl nitrite inhalation. In addition root motion was correlated with the stroke volumes determined at cardiac catheterization in 24 patients. The root has distinct systolic movement, the amplitude a...

journal_title：Circulation

authors： Pratt RC,Parisi AF,Harrington JJ,Sasahara AA

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Basic fibroblast growth factor (bFGF) has been shown to reduce infarct size in canine acute myocardial infarction; however, the mechanism of tissue salvage remains uncertain. We evaluated the effect of bFGF on infarct size in a model of acute infarction in which coronary occlusion was followed by prolonged r...

journal_title：Circulation

authors： Horrigan MC,MacIsaac AI,Nicolini FA,Vince DG,Lee P,Ellis SG,Topol EJ

更新日期：1996-10-15 00:00:00

abstract：:Mitral valve closure during cardiopulmonary resuscitation may result from direct cardiac compression. An alternative hypothesis is that with a rise in intrathoracic pressure, mitral valve closure can occur but may be influenced by whether the lungs are inflated or deflated. To test this hypothesis, we placed a large-b...

journal_title：Circulation

authors： Halperin HR,Weiss JL,Guerci AD,Chandra N,Tsitlik JE,Brower R,Beattie C,Wurmb E,Cadden J,Weisfeldt ML

更新日期：1988-09-01 00:00:00

abstract：:The benefit of cholesterol-lowering therapy in the prevention of coronary heart disease (CHD) is well established. The secondary prevention Scandinavian Simvastatin Survival Study (4S) and the primary prevention West of Scotland Coronary Prevention Study (WOSCOPS) demonstrated that lipid lowering with a statin can dra...

journal_title：Circulation

authors： Gotto AM Jr,Grundy SM

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic responses. Here, we investigated the role of Sirt7 in cardiovascular tissue repair process. METHODS AND RESULTS:In wild-type mice, Sirt7 expression increa...

journal_title：Circulation

authors： Araki S,Izumiya Y,Rokutanda T,Ianni A,Hanatani S,Kimura Y,Onoue Y,Senokuchi T,Yoshizawa T,Yasuda O,Koitabashi N,Kurabayashi M,Braun T,Bober E,Yamagata K,Ogawa H

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Comprehensive data based on single-beat analysis of the ventricular activation sequence during sinus rhythm in infarcted hearts are currently not available. It was the aim of our study (1) to measure and analyze these activation sequences on the epicardial surface of the right and left ventricles and on the ...

journal_title：Circulation

authors： Hatala R,Savard P,Tremblay G,Pagé P,Cardinal R,Molin F,Kus T,Nadeau R

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Pregnant women with congenital heart disease (CHD) are susceptible to cardiovascular, obstetric, and offspring complications. In women with CHD, cardiac dysfunction may compromise uteroplacental flow and contribute to the increased incidence of obstetric and offspring events. METHODS AND RESULTS:We performe...

journal_title：Circulation

authors： Pieper PG,Balci A,Aarnoudse JG,Kampman MA,Sollie KM,Groen H,Mulder BJ,Oudijk MA,Roos-Hesselink JW,Cornette J,van Dijk AP,Spaanderman ME,Drenthen W,van Veldhuisen DJ,ZAHARA II investigators.

更新日期：2013-12-03 00:00:00

abstract：BACKGROUND:Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human cor...

journal_title：Circulation

authors： Wallner K,Li C,Shah PK,Fishbein MC,Forrester JS,Kaul S,Sharifi BG

更新日期：1999-03-16 00:00:00

abstract：:Proton (hydrogen-1) magnetic resonance imaging techniques have potential for the detection and characterization of changes associated with myocardial ischemia. Since image contrast is dependent on T1 and T2 relaxation times, we examined these parameters in a canine preparation of occlusion of the left anterior descend...

journal_title：Circulation

authors： Johnston DL,Brady TJ,Ratner AV,Rosen BR,Newell JB,Pohost GM,Okada RD

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:To simplify extensive primary repair of the thoracic aorta in acute type A aortic dissection, we developed the open triple-branched stent graft placement technique. The early results of this new technique are reported. METHODS AND RESULTS:Between June 2008 and November 2009, 30 patients with acute Stanford ...

journal_title：Circulation

authors： Chen LW,Dai XF,Lu L,Zhang GC,Cao H

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:Collaterals limit infarct size, preserve viability, and reduce mortality in patients with acute myocardial infarction. In patients with stable coronary disease, collaterals are associated with less angina and ischemia during angioplasty and fewer ischemic events during follow-up. The role of collaterals has ...

journal_title：Circulation

authors： Nathoe HM,Buskens E,Jansen EW,Suyker WJ,Stella PR,Lahpor JR,van Boven WJ,van Dijk D,Diephuis JC,Borst C,Moons KG,Grobbee DE,de Jaegere PP

更新日期：2004-09-28 00:00:00

abstract：BACKGROUND:The endothelium acts as the sensor of shear stress and as the mediator of flow-induced changes in vessel tone and structure. The purpose of this study was to delineate the signal transduction pathway of flow-induced release of endothelium-derived relaxing factor (EDRF). METHODS AND RESULTS:We used a shear s...

journal_title：Circulation

authors： Ohno M,Gibbons GH,Dzau VJ,Cooke JP

更新日期：1993-07-01 00:00:00

abstract：:Ventricular dysfunction, elevated pulmonary vascular resistance, and residual distal pulmonary artery distortion contribute to early mortality after a Fontan operation; they may be transient or reversible. A baffle fenestration, allowing right-to-left shunting, maintains cardiac output and limits right atrial pressure...

journal_title：Circulation

authors： Bridges ND,Lock JE,Castaneda AR

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Cardiac allograft arteriosclerosis is a complex process of alloimmune response, chronic inflammation, and smooth muscle cell proliferation that includes cross talk between cytokines and growth factors. METHODS AND RESULTS:Our results in rat cardiac allografts established alloimmune response as an alternativ...

journal_title：Circulation

authors： Lemström KB,Krebs R,Nykänen AI,Tikkanen JM,Sihvola RK,Aaltola EM,Häyry PJ,Wood J,Alitalo K,Ylä-Herttuala S,Koskinen PK

更新日期：2002-05-28 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (iNO) has been used to assess the vasodilator capacity of the pulmonary vascular bed in children with congenital heart disease and elevated pulmonary vascular resistance. Inhaled iloprost is a pulmonary vasodilator for the long-term treatment of pulmonary hypertension (PHT). Because thes...

journal_title：Circulation

authors： Rimensberger PC,Spahr-Schopfer I,Berner M,Jaeggi E,Kalangos A,Friedli B,Beghetti M

更新日期：2001-01-30 00:00:00

abstract：:Reactive oxygen species such as the superoxide anion (.O2-) have recently been implicated as important agents involved in causing cell death in the setting of myocardial ischemia and reperfusion. When superoxide anion is involved in ischemic injury the administration of superoxide dismutase (SOD) may limit infarct siz...

journal_title：Circulation

authors： Uraizee A,Reimer KA,Murry CE,Jennings RB

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Accessory pathways originating at the tricuspid annulus that exhibit decremental antegrade conduction properties (Mahaim-type preexcitation) are amenable to radiofrequency (RF) current catheter ablation. However, a reliable and reproducible strategy for mapping and ablation of these fibers is lacking. METHO...

journal_title：Circulation

authors： Cappato R,Schlüter M,Weiss C,Siebels J,Hebe J,Duckeck W,Mletzko RU,Kuck KH

更新日期：1994-07-01 00:00:00

abstract：:Disorders associated with the overproduction or delayed clearance of beta-very low density lipoprotein and low density lipoprotein (LDL) are strikingly related to premature coronary artery disease. There are five recognized classes of LDL-lowering drugs, each acting through different basic mechanisms. The increased pr...

journal_title：Circulation

authors： Levy RI,Troendle AJ,Fattu JM

更新日期：1993-04-01 00:00:00

abstract：:In response to the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, the Chinese Society of Cardiology (CSC) issued this consensus statement after consulting with 125 medical experts in the fields of cardiovascular disease and infectious disease. The over-arching principles laid out here are the followi...

journal_title：Circulation

authors： Han Y,Zeng H,Jiang H,Yang Y,Yuan Z,Cheng X,Jing Z,Liu B,Chen J,Nie S,Zhu J,Li F,Ma C

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:We compared the efficacy and safety of different dosages of a low-molecular-weight heparin, CY 216 D (Fraxiparine), in the treatment of submassive pulmonary embolism with unfractionated heparin in a prospective, randomized, dose-finding study. METHODS AND RESULTS:The primary outcome was the evolution of pul...

journal_title：Circulation

authors： Théry C,Simonneau G,Meyer G,Hélénon O,Bridey F,Armagnac C,d'Azemar P,Coquart JP

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Prolonged survival of xenografted neonatal cardiomyocytes was achieved by blocking the CD28/B7 costimulatory pathway via CTLA4-Ig gene transfer. We examined the long-term survival of xenografted neonatal cardiomyocytes by adenovirus-mediated CTLA4-Ig expression and transient CD40 blockade with anti-CD40L mon...

journal_title：Circulation

authors： Li TS,Ito H,Kajiwara K,Hamano K

更新日期：2003-10-07 00:00:00

abstract：:In patients with atrioventricular (A-V) nodal re-entrant paroxysmal supraventricular tachycardia (PSVT), atrial extrastimulus technique frequently reveals discontinuous A1-A2, H1-H2 curves suggestive of dual A-V nodal pathways. To further test the hypothesis that these curves in fact reflect dual A-V nodal pathways, a...

journal_title：Circulation

authors： Wu D,Denes P,Wyndham C,Amat-y-Leon F,Dhingra RC,Rosen KM

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND:Patients with low-flow, low-gradient aortic stenosis have a poor prognosis with conservative therapy but a high operative mortality if treated surgically. Recently, we proposed a new index of aortic stenosis severity derived from dobutamine stress echocardiography, the projected aortic valve area at a normal...

journal_title：Circulation

authors： Clavel MA,Fuchs C,Burwash IG,Mundigler G,Dumesnil JG,Baumgartner H,Bergler-Klein J,Beanlands RS,Mathieu P,Magne J,Pibarot P

更新日期：2008-09-30 00:00:00

abstract：BACKGROUND:Elevated levels of oxidized phospholipids (OxPLs) on apolipoprotein B-100 particles (OxPL/apoB) are associated with cardiovascular disease and predict new cardiovascular events. Elevated lipoprotein (a) [Lp(a)] levels are a risk factor for cardiovascular disease in whites and also in blacks if they carry sma...

journal_title：Circulation

authors： Tsimikas S,Clopton P,Brilakis ES,Marcovina SM,Khera A,Miller ER,de Lemos JA,Witztum JL

更新日期：2009-04-07 00:00:00

abstract：:Coronary occlusion in the dog results in irreversible myocardial cell injury which develops first in subendocardial areas of severe ischemica and subsequently spreads into mid and subepicardial areas of moderate ischemia. The effect of propranolol on this progression of ischemic injury was evaluated. Three groups of d...

journal_title：Circulation

authors： Rasmussen MM,Reimer KA,Kloner RA,Jennings RB

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:Patients with bicuspid aortic valve (AV) stenosis were excluded from the pivotal evaluations of transcatheter AV replacement (TAVR) devices. We sought to evaluate the outcomes of TAVR in patients with bicuspid AV stenosis in comparison with those with tricuspid AV stenosis. METHODS:We used data from the Soc...

journal_title：Circulation

authors： Halim SA,Edwards FH,Dai D,Li Z,Mack MJ,Holmes DR,Tuzcu EM,Thourani VH,Harrison JK,Brennan JM

更新日期：2020-03-31 00:00:00