Induction of meandering functional reentrant wave front in isolated human atrial tissues.

abstract：BACKGROUND:Supply of sulfhydryl groups with the administration of N-acetylcysteine (NAC) has been reported to reverse tolerance to nitroglycerin but not to isosorbide dinitrate (ISDN). Lack of interaction between NAC and ISDN was suggested as an explanation for these findings. The present study was therefore designed t...

journal_title：Circulation

authors： Mehra A,Shotan A,Ostrzega E,Hsueh W,Vasquez-Johnson J,Elkayam U

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Endothelin (ET)-1 and norepinephrine (NE) are involved in myocardial ischemia/reperfusion injury. We investigated the role of ET-1 in ischemia/reperfusion-induced NE overflow and cardiac dysfunction using a selective ET(A) receptor antagonist (ABT-627), a selective ET(B) receptor antagonist (A-192621), and t...

journal_title：Circulation

authors： Yamamoto S,Matsumoto N,Kanazawa M,Fujita M,Takaoka M,Gariepy CE,Yanagisawa M,Matsumura Y

更新日期：2005-01-25 00:00:00

abstract：:The International Liaison Committee on Resuscitation has initiated a near-continuous review of cardiopulmonary resuscitation science that replaces the previous 5-year cyclic batch-and-queue approach process. This is the first of an annual series of International Consensus on Cardiopulmonary Resuscitation and Emergency...

journal_title：Circulation

authors： Olasveengen TM,de Caen AR,Mancini ME,Maconochie IK,Aickin R,Atkins DL,Berg RA,Bingham RM,Brooks SC,Castrén M,Chung SP,Considine J,Couto TB,Escalante R,Gazmuri RJ,Guerguerian AM,Hatanaka T,Koster RW,Kudenchuk PJ,Lang

更新日期：2017-12-05 00:00:00

abstract：BACKGROUND:Activation of the sympathetic nervous system has important prognostic implications in chronic heart failure. Nonselective versus selective beta-adrenergic receptor antagonists may have differential effects on norepinephrine release from nerve terminals mediated by prejunctional beta(2)-adrenergic receptors. ...

journal_title：Circulation

authors： Azevedo ER,Kubo T,Mak S,Al-Hesayen A,Schofield A,Allan R,Kelly S,Newton GE,Floras JS,Parker JD

更新日期：2001-10-30 00:00:00

abstract：BACKGROUND:Coronary heart disease (CHD) mortality is rising in many developing countries. We examined how much of the increase in CHD mortality in Beijing, China, between 1984 and 1999 could be attributed to changes in major cardiovascular risk factors and assessed the impact of medical and surgical treatments. METHOD...

journal_title：Circulation

authors： Critchley J,Liu J,Zhao D,Wei W,Capewell S

更新日期：2004-09-07 00:00:00

abstract：BACKGROUND:Reports on outcome after the Ross procedure are limited by small study size and show variable durability results. A systematic review of evidence on outcome after the Ross procedure may improve insight into outcome and potential determinants. METHODS AND RESULTS:A systematic review of reports published from...

journal_title：Circulation

authors： Takkenberg JJ,Klieverik LM,Schoof PH,van Suylen RJ,van Herwerden LA,Zondervan PE,Roos-Hesselink JW,Eijkemans MJ,Yacoub MH,Bogers AJ

更新日期：2009-01-20 00:00:00

abstract：BACKGROUND:Candidates for cardiac resynchronization therapy (CRT) receive either a biventricular pacemaker or a biventricular pacemaker with an implantable cardioverter-defibrillator (CRT-D). Optimal device selection remains challenging because the benefit of implantable cardioverter-defibrillator therapy may not be un...

journal_title：Circulation

authors： Lindvall C,Chatterjee NA,Chang Y,Chernack B,Jackson VA,Singh JP,Metlay JP

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:The degree of protection provided to the right ventricle during retrograde continuous normothermic blood cardioplegia (RCNBC) remains controversial. The purpose of this study was to determine whether RCNBC is able to provide "adequate" nutritive flow to both ventricles to prevent ischemic metabolism in norma...

journal_title：Circulation

authors： Ye J,Sun J,Shen J,Gregorash L,Summers R,Salerno TA,Deslauriers R

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Uncoupling protein 2 (UCP2) regulates the production of reactive oxygen species in macrophages. However, its role in atherosclerosis is unknown. METHODS AND RESULTS:Irradiated low-density lipoprotein receptor deficient mice (LDLR-/-) were transplanted with bone marrow from either UCP2 deficient mice (Ucp2-/...

journal_title：Circulation

authors： Blanc J,Alves-Guerra MC,Esposito B,Rousset S,Gourdy P,Ricquier D,Tedgui A,Miroux B,Mallat Z

更新日期：2003-01-28 00:00:00

abstract：BACKGROUND:Anisotropic conduction properties may provide a substrate for reentrant arrhythmias. We investigated the age-dependent changes of structural and functional anisotropy in isolated right atria from infant (1 to 2 months), young (6 to 12 months), and old (6 to 10 years) dogs. METHODS AND RESULTS:The histology ...

journal_title：Circulation

authors： Koura T,Hara M,Takeuchi S,Ota K,Okada Y,Miyoshi S,Watanabe A,Shiraiwa K,Mitamura H,Kodama I,Ogawa S

更新日期：2002-04-30 00:00:00

abstract：BACKGROUND:The maintenance and termination of reentry arrhythmias are determined by tissue properties such as refractoriness and conduction velocity. Although the effects of Na(+) and K(+) channel block on electrophysiological properties and defibrillation threshold (DFT) have been studied, little is known about the ef...

journal_title：Circulation

authors： Qi X,Varma P,Newman D,Dorian P

更新日期：2001-09-25 00:00:00

abstract：:Originally described by Japanese authors in the 1990s, Takotsubo syndrome (TTS) generally presents as an acute myocardial infarction characterized by severe left ventricular dysfunction. TTS, however, differs from an acute coronary syndrome because patients have generally a normal coronary angiogram and left ventricul...

journal_title：Circulation

authors： Pelliccia F,Kaski JC,Crea F,Camici PG

更新日期：2017-06-13 00:00:00

abstract：BACKGROUND:Impaired fibrinolytic activity has been linked to the presence and severity of allograft vasculopathy (Tx CAD). This impairment may be associated with the presence of certain fibrinolytic protein gene polymorphisms. METHODS AND RESULTS:To investigate the relation between donor-specific fibrinolytic protein ...

journal_title：Circulation

authors： Benza RL,Grenett HE,Bourge RC,Kirklin JK,Naftel DC,Castro PF,McGiffin DC,George JF,Booyse FM

更新日期：1998-11-24 00:00:00

abstract：BACKGROUND:Nontranscriptional signaling through estrogen receptors (ERs) is important in the cardiovascular system. In particular, estrogen stimulates endothelial NO synthase (eNOS) via the phosphatidylinositol 3-kinase (PI3K) pathway. The selective estrogen receptor modulator (SERM) raloxifene is effective for the tre...

journal_title：Circulation

authors： Simoncini T,Genazzani AR,Liao JK

更新日期：2002-03-19 00:00:00

abstract：BACKGROUND:Automatic implantable cardioverter-defibrillator therapy is considered the only effective treatment for high-risk patients with Brugada syndrome. Quinidine depresses I(to) current, which may play an important role in the arrhythmogenesis of this disease. METHODS AND RESULTS:The effects of quinidine bisulfat...

journal_title：Circulation

authors： Belhassen B,Glick A,Viskin S

更新日期：2004-09-28 00:00:00

abstract：BACKGROUND:An inverse association between height and risk of coronary heart disease (CHD) has been reported in several case-control and cohort studies, but the reasons for the association remain uncertain. We evaluated this association among 22,071 male physicians, a population homogeneous for high educational attainme...

journal_title：Circulation

authors： Hebert PR,Rich-Edwards JW,Manson JE,Ridker PM,Cook NR,O'Connor GT,Buring JE,Hennekens CH

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:The relationships between childhood lifestyle risk factors and adulthood pulse wave velocity (PWV) have not been reported. We studied whether childhood and adulthood lifestyle risk factors are associated with PWV assessed in adulthood. METHODS AND RESULTS:The study cohort comprised 1622 subjects of the Card...

journal_title：Circulation

authors： Aatola H,Koivistoinen T,Hutri-Kähönen N,Juonala M,Mikkilä V,Lehtimäki T,Viikari JS,Raitakari OT,Kähönen M

更新日期：2010-12-14 00:00:00

abstract：BACKGROUND:Analyses from randomized controlled trials suggest that bleeding in patients with acute myocardial infarction is associated with poor outcomes. Because these data are not generalizable to all patients with acute myocardial infarction, we sought to better understand the scope of this problem in a "real-world"...

journal_title：Circulation

authors： Spencer FA,Moscucci M,Granger CB,Gore JM,Goldberg RJ,Steg PG,Goodman SG,Budaj A,FitzGerald G,Fox KA,GRACE Investigators.

更新日期：2007-12-11 00:00:00

abstract：BACKGROUND:Percutaneous transluminal coronary angioplasty (PTCA) is a widely used and important method of reperfusing coronary arteries. However, it is also associated with serious complications such as acute reocclusion and accelerated restenosis. The factors as well as the mechanisms involved in PTCA-associated compl...

journal_title：Circulation

authors： Brezinski DA,Nesto RW,Serhan CN

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:In patients with asymptomatic valvular aortic stenosis, exercise testing may help to stratify the clinical risk. However, data are limited, and the role of quantitative exercise Doppler echocardiography has never been investigated. METHODS AND RESULTS:Sixty-nine consecutive patients with severe asymptomatic...

journal_title：Circulation

authors： Lancellotti P,Lebois F,Simon M,Tombeux C,Chauvel C,Pierard LA

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:The pulmonary circulation is an important site for the production and clearance of endothelin (ET)-1, a potent vasoactive and mitogenic peptide. Increased plasma ET-1 levels are observed in pulmonary arterial hypertension (PHT) and may contribute to the regulation of pulmonary vascular resistance, as well as...

journal_title：Circulation

authors： Bauer M,Wilkens H,Langer F,Schneider SO,Lausberg H,Schäfers HJ

更新日期：2002-03-05 00:00:00

abstract：:In rats, atrial natriuretic factor (ANF) reduces sympathetic nerve activity (SNA) reflexively by sensitizing cardiac mechanoreceptors with inhibitory vagal afferents. We performed three series of experiments in 26 normal young men to document whether ANF inhibits SNA in humans and if so, to determine potential mechani...

journal_title：Circulation

authors： Floras JS

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:The positions, sizes, and shapes of ventricular septal defects (VSDs) can be difficult to assess by 2-dimensional echocardiography (2DE). Volume-rendered 3-dimensional echocardiography (3DE) can provide unique views of VSDs from the left ventricular (LV) side, allowing complete assessment of their circumfere...

journal_title：Circulation

authors： Kardon RE,Cao QL,Masani N,Sugeng L,Supran S,Warner KG,Pandian NG,Marx GR

更新日期：1998-09-29 00:00:00

abstract：BACKGROUND:The purpose of this study was to define the degree of intrinsic tone in conductance and resistance vessels, to define the calcium dependency of intrinsic tone in these vascular preparations, and to investigate the efficacy of vasodilatory agents on the level of intrinsic tone in these vascular preparations. ...

journal_title：Circulation

authors： Jain M,Dai HB,Carrozza JP,Sellke FW,Morgan KG

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Women receive less evidence-based medical care than men and have higher rates of death after acute myocardial infarction (AMI). It is unclear whether efforts undertaken to improve AMI care have mitigated these sex disparities in the current era. METHODS AND RESULTS:Using the Get With the Guidelines-Coronary...

journal_title：Circulation

authors： Jneid H,Fonarow GC,Cannon CP,Hernandez AF,Palacios IF,Maree AO,Wells Q,Bozkurt B,Labresh KA,Liang L,Hong Y,Newby LK,Fletcher G,Peterson E,Wexler L,Get With the Guidelines Steering Committee and Investigators.

更新日期：2008-12-16 00:00:00

abstract：BACKGROUND:The role of valve surgery in left-sided infective endocarditis has not been evaluated in randomized controlled trials. We examined the association between valve surgery and all-cause 6-month mortality among patients with left-sided infective endocarditis. METHODS AND RESULTS:A total of 546 consecutive patie...

journal_title：Circulation

authors： Tleyjeh IM,Ghomrawi HM,Steckelberg JM,Hoskin TL,Mirzoyev Z,Anavekar NS,Enders F,Moustafa S,Mookadam F,Huskins WC,Wilson WR,Baddour LM

更新日期：2007-04-03 00:00:00

abstract：:Depression of myocardial conduction velocity can be an important mechanism of action of antiarrhythmic drugs but it can also facilitate arrhythmogenesis. We used lidocaine in an anesthetized canine preparation to address the hypothesis that drug-induced rate-dependent conduction velocity depression causes ventricular ...

journal_title：Circulation

authors： Anderson KP,Walker R,Lux RL,Ershler PR,Menlove R,Williams MR,Krall R,Moddrelle D

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:It is not known whether progression of aortic arch (AA) atheroma is associated with vascular events in patients with stroke or transient ischemic attack (TIA). METHODS AND RESULTS:AA atheroma was detected on baseline transesophageal echocardiogram in 167 consecutive patients who had prevalent stroke or TIA....

journal_title：Circulation

authors： Sen S,Hinderliter A,Sen PK,Simmons J,Beck J,Offenbacher S,Ohman EM,Oppenheimer SM

更新日期：2007-08-21 00:00:00

abstract：BACKGROUND:Hemodialysis vascular access dysfunction is the single most important cause of morbidity in kidney hemodialysis patients. Failure of an arteriovenous polytetrafluoroethylene (PTFE) graft, the most common form of hemodialysis access, is primarily due to intimal hyperplasia and thrombosis at the venous anastom...

journal_title：Circulation

authors： Luo Z,Akita GY,Date T,Treleaven C,Vincent KA,Woodcock D,Cheng SH,Gregory RJ,Jiang C

更新日期：2005-04-05 00:00:00

abstract：BACKGROUND:Mildly oxidized LDL (moxLDL) is thought to play a role in atherogenesis. MoxLDL induces derivatization of cell proteins and triggers a variety of intracellular signaling. We aimed to investigate whether moxLDL-induced protein derivatization may influence the activity of platelet-derived growth factor recepto...

journal_title：Circulation

authors： Escargueil-Blanc I,Salvayre R,Vacaresse N,Jürgens G,Darblade B,Arnal JF,Parthasarathy S,Nègre-Salvayre A

更新日期：2001-10-09 00:00:00