Abstract:
BACKGROUND:Uncoupling protein 2 (UCP2) regulates the production of reactive oxygen species in macrophages. However, its role in atherosclerosis is unknown. METHODS AND RESULTS:Irradiated low-density lipoprotein receptor deficient mice (LDLR-/-) were transplanted with bone marrow from either UCP2 deficient mice (Ucp2-/-) or wild type mice (Ucp2+/+). Mice were fed an atherogenic diet for 7 weeks. Engraftment of bone marrow cells was confirmed by the presence of UCP2 protein expression in spleen cell mitochondria of Ucp2+/+ transplanted mice and its absence in Ucp2-/- transplanted mice. Leukocyte counts and plasma cholesterol levels were comparable in both groups. We found a marked increase in atherosclerotic lesion size in the thoracic aorta of Ucp2-/- transplanted mice compared with control Ucp2+/+ transplanted mice (8.3+/-0.9% versus 4.3+/-0.4%, respectively; P<0.005), as well as in the aortic sinus (150 066+/-12 388 microm2 versus 105 689+/-9 727 microm2, respectively; P<0.05). This was associated with increased nitrotyrosine staining, which suggests enhanced oxidative stress. Analysis of plaque composition revealed a significant increase in macrophage accumulation (P<0.05) and apoptosis (P<0.05), along with a decrease in collagen content (P<0.05), suggesting a potentially more vulnerable phenotype. CONCLUSION:These results suggest a protective role for UCP2 against atherosclerosis.
journal_name
Circulationjournal_title
Circulationauthors
Blanc J,Alves-Guerra MC,Esposito B,Rousset S,Gourdy P,Ricquier D,Tedgui A,Miroux B,Mallat Zdoi
10.1161/01.cir.0000051722.66074.60subject
Has Abstractpub_date
2003-01-28 00:00:00pages
388-90issue
3eissn
0009-7322issn
1524-4539journal_volume
107pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:Associations of obesity with incidence of heart failure have been observed, but the causality is uncertain. We hypothesized that gastric bypass surgery leads to a lower incidence of heart failure compared with intensive lifestyle modification in obese people. METHODS:We included obese people without previou...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.116.025629
更新日期:2017-04-25 00:00:00
abstract:BACKGROUND:Clinical cardiac volumetric measurement techniques are essential for assessing cardiac performance but produce significant inaccuracies in extrapolation of the volume of a three-dimensional (3D) object from two-dimensional images and lack the ability to associate cardiac electrical and mechanical activities....
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.10.3672
更新日期:1997-11-18 00:00:00
abstract:BACKGROUND:The cytoskeleton plays an important role in maintaining cell structure and integrity. Defects in cytoskeletal proteins can cripple cell strength and may cause cardiomyopathy. We analyzed heart tissues from subjects with dilated cardiomyopathy for abnormalities in the cardiac cytoskeleton. Metavinculin, a car...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.1.17
更新日期:1997-01-07 00:00:00
abstract:BACKGROUND:Our purpose was to use multislice MRI for detection of reversible myocardial ischemia and assessment of the effect of revascularization on tissue perfusion in patients with coronary artery disease. METHODS AND RESULTS:Eleven patients with single-vessel proximal left anterior descending coronary artery disea...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.9.2859
更新日期:1997-11-04 00:00:00
abstract:BACKGROUND:Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the present study, we evaluated the direct effects of resistin, a novel adipocyte-derived hormone, on endothelial activation. METHODS AND RESULTS:Endothelial cells (ECs) were incubated with human re...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000084503.91330.49
更新日期:2003-08-12 00:00:00
abstract::Early afterdepolarizations (EADs) are depolarizing potentials that occur before complete repolarization. They may be important in the acquired and possibly the idiopathic long QT syndrome and associated ventricular tachycardia (VT). The purpose of these experiments was to study in 20 open-chest dogs the effects of sym...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.78.5.1241
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:To simplify extensive primary repair of the thoracic aorta in acute type A aortic dissection, we developed the open triple-branched stent graft placement technique. The early results of this new technique are reported. METHODS AND RESULTS:Between June 2008 and November 2009, 30 patients with acute Stanford ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.946012
更新日期:2010-10-05 00:00:00
abstract::Although past reports have identified a variety of prognostic factors in patients with severe chronic heart failure, previous studies have not evaluated the interaction of prognostic variables and drug treatment. We analyzed the association of 30 clinical, hemodynamic, and biochemical variables with survival in 203 co...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.73.2.257
更新日期:1986-02-01 00:00:00
abstract::Platelets have been implicated in the pathogenesis of coronary artery disease, and a number of studies have examined platelet function and coagulation parameters in such patients. We have examined platelet coagulant activities, volumes, and aggregate ratios in 23 patients with chest pain, seven of whom had normal coro...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.69.1.15
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Epidemiological findings suggest an association between low-for-age birth weight and the risk to develop coronary heart diseases in adulthood. During pregnancy, an imbalance between fetal demands and supply may result in permanent alterations of neuroendocrine development in the fetus. We evaluated whether c...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.23.2892
更新日期:2000-12-05 00:00:00
abstract:BACKGROUND:Conventional transmitral Doppler indices are unreliable in assessing clinical status in patients with hypertrophic cardiomyopathy (HCM) because they are affected by loading conditions. This study sought to determine whether tissue Doppler velocities are predictive of adverse clinical outcomes including death...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000124723.16433.31
更新日期:2004-04-13 00:00:00
abstract:BACKGROUND:Application of pyruvate was shown to improve contractile function in isolated animal myocardium and hemodynamics in patients with congestive heart failure. We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-st...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc0202.102238
更新日期:2002-01-15 00:00:00
abstract::We have monitored ambulant intra-arterial blood pressure with the Oxford system in six subjects with autonomic failure who exhibited postural hypotension. Plotting pooled hourly mean values we have demonstrated a consistent circadian trend in blood pressure that was the inverse of the normal pattern, with the highest ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.68.3.477
更新日期:1983-09-01 00:00:00
abstract::Platelets labeled with indium-111 have been used successfully as a marker of active thrombosis in man. To establish the diagnostic accuracy of platelet scintigraphy in comparison to contrast venography in the diagnosis of acute lower limb venous thrombosis, we evaluated 103 consecutive patients divided into two groups...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.73.4.668
更新日期:1986-04-01 00:00:00
abstract::Statins (HMG-CoA reductase inhibitors) are used widely for the treatment of hypercholesterolemia. They inhibit HMG-CoA reductase competitively, reduce LDL levels more than other cholesterol-lowering drugs, and lower triglyceride levels in hypertriglyceridemic patients. Statins are well tolerated and have an excellent ...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.cir.101.2.207
更新日期:2000-01-18 00:00:00
abstract:BACKGROUND:Increased expression of osteopontin (OPN), fibroblast growth factors (FGFs), and their type-1 receptor (FGFR-1) is associated with neointima formation and atherosclerosis. This study tested the hypothesis that ligand activation of FGFR-1 stimulates OPN expression in rat aortic smooth muscle cells (RASMCs), e...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000024113.26985.cc
更新日期:2002-08-13 00:00:00
abstract::Many vasodilators have been tried as antianginal agents, but the reflex increase in sympathetic tone produced by these drugs necessitate their use with caution in patients with angina. In the first part of this study, captopril was given to 14 patients with angina and systolic arterial pressures of greater than 120 mm...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.71.2.317
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Second trimester routine ultrasound evaluation of the fetal heart by means of the four-chamber view has been proposed for prenatal detection of cardiac anomalies. The aim of this study was to evaluate the efficacy of this procedure. METHODS AND RESULTS:A prospective follow-up study on 6922 scanned fetuses w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.1.67
更新日期:1996-07-01 00:00:00
abstract::To compare angiographically-determined coronary artery disease in diabetic patients with controls, 1,653 patients coming to cardiac catheterization were reviewed retrospectively to find 37 diabetic and 79 control patients matched for sex, age (+/- 3 years), and risk factors (hypertension, hyperlipidemia, and smoking)....
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.57.1.133
更新日期:1978-01-01 00:00:00
abstract::Conventional wall motion analysis of contrast ventriculograms assesses only that part of the wall that is tangential to the x-ray beam. To assess regional left ventricular function in three dimensions, a new computerized method based on densitometric analysis of digital subtraction left ventriculograms was developed a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.77.2.457
更新日期:1988-02-01 00:00:00
abstract::R-wave synchronous equilbrium radionuclide angiography (RNA) is a noninvasive method that provides time-activity curve count information proportional to ventricular volumes and is used for relative volume comparisons within the left or right ventricle to derive the ejection fraction. Comparison of the ventricular coun...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.62.5.1089
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes is associated with accelerated atherosclerosis. Because cell-derived microparticles support coagulation and inflammation, they may be involved in atherogenesis. We characterized circulating microparticles both in patients with uncomplicated, well-regulated type 2 diabetes and in healthy subje...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.0000036596.59665.c6
更新日期:2002-11-05 00:00:00
abstract::Digoxin, in a common clinical dose and at a low serum level, brought out severe manifestations of sinus node dysfunction in a patient who had previously undergone successful mitral valve replacement. This report presents the results of extensive clinical and electrophysiologic studies of this patient before and after ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.52.1.162
更新日期:1975-07-01 00:00:00
abstract:BACKGROUND:Inflammation and matrix degradation may play a pathogenic role in chronic heart failure (CHF), and therefore, we examined whether thalidomide, a drug with potential immunomodulating and matrix-stabilizing properties, could improve left ventricular (LV) function in patients with CHF secondary to idiopathic di...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.105.564971
更新日期:2005-11-29 00:00:00
abstract:BACKGROUND:Early detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development. We have retrospectively applied large-scale proteomics to blood samples from ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.117.028213
更新日期:2018-03-06 00:00:00
abstract:BACKGROUND:C-kit is a receptor tyrosine kinase family member expressed in hematopoietic stem cells. C-kit is also transiently expressed in cardiomyocyte precursors during development and in a rare cell population in the normal adult heart. In the present study, the cardiomyogenic potential of c-kit(+) cells isolated fr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.909093
更新日期:2010-05-11 00:00:00
abstract::The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition of platelet aggregation wit...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.cir.100.15.1667
更新日期:1999-10-12 00:00:00
abstract:BACKGROUND:Accumulating evidence suggests that several subsets of regulatory T cells that actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally administered anti-CD3 monoclonal antibody has been shown as an inducer of novel regulatory T cells expressing latency-associated peptide ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.863431
更新日期:2009-11-17 00:00:00
abstract::The purpose of this study was to assess the sensitivity and specificity of two-dimensional echocardiography in detecting ischemia-induced transient myocardial dyskinesis. We prepared an open-chest dog model of severe coronary stenosis (90% reduction of circumflex coronary artery diameter) and induced ischemia by acute...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.66.3.597
更新日期:1982-09-01 00:00:00
abstract:BACKGROUND:The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.008750
更新日期:2015-03-17 00:00:00