Differential response to right and left ansae subclaviae stimulation of early afterdepolarizations and ventricular tachycardia induced by cesium in dogs.

Abstract:

:Early afterdepolarizations (EADs) are depolarizing potentials that occur before complete repolarization. They may be important in the acquired and possibly the idiopathic long QT syndrome and associated ventricular tachycardia (VT). The purpose of these experiments was to study in 20 open-chest dogs the effects of sympathetic stimulation on EADs and VT produced with cesium chloride (84 mg/kg i.v.) alone or combined with left (LAS), right (RAS), or bilateral (BAS) ansae subclaviae stimulation (2 Hz, 4 msec, 2 mA). We compared the EAD amplitude and area as a percentage of monophasic action potential amplitude and area, respectively, recorded simultaneously with contact electrodes from right (RV) and left ventricular (LV) endocardium and recorded the prevalence of VT induction during each intervention. Both LAS and BAS produced left ventricular EADs with larger amplitudes and areas than did RAS or cesium alone. BAS and LAS produced larger EADs recorded from the LV than from the RV. Cesium produced VT in six of 20 dogs, RAS in three of 20, BAS in 12 of 20, and LAS in 16 of 20. Norepinephrine (0.1-1.5 micrograms/kg/min) caused VT in all dogs by producing a dose-related increase in EAD amplitude that was similar in RV and LV, suggesting that the response of RV and LV EADs to catecholamine stimulation was not intrinsically different. During stimulation of left ansae subclaviae at increasing frequencies (1, 2, 4, and 6 Hz), EADs were significantly larger in LV than in RV at all stimulus frequencies, and the amplitude of EADs in both ventricles increased with increasing stimulus frequencies. Based on the increased LV amplitude and area of cesium chloride-induced EADs during LAS and BAS, with EAD amplitude dependent on the frequency of LAS but with an equal RV and LV EAD amplitude during norepinephrine infusion, it is possible that more norepinephrine released into the LV during LAS and BAS compared with RAS causes larger amplitude LV EADs that reach threshold to cause VT more often. Thus, quantitative differences between the effects of left and right stellate ganglia stimulation rather than qualitative differences or imbalance may account for the arrhythmogenic potential of the left stellate ganglion.

journal_name

Circulation

journal_title

Circulation

authors

Ben-David J,Zipes DP

doi

10.1161/01.cir.78.5.1241

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

1241-50

issue

5 Pt 1

eissn

0009-7322

issn

1524-4539

journal_volume

78

pub_type

杂志文章
  • In vivo cell seeding with anti-CD34 antibodies successfully accelerates endothelialization but stimulates intimal hyperplasia in porcine arteriovenous expanded polytetrafluoroethylene grafts.

    abstract:BACKGROUND:The patency of AV expanded polytetrafluoroethylene (ePTFE) grafts for hemodialysis is impaired by intimal hyperplasia (IH) at the venous outflow tract. The absence of a functional endothelial monolayer on the prosthetic grafts is an important stimulus for IH. In the present study, we evaluated the feasibilit...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.104.504407

    authors: Rotmans JI,Heyligers JM,Verhagen HJ,Velema E,Nagtegaal MM,de Kleijn DP,de Groot FG,Stroes ES,Pasterkamp G

    更新日期:2005-07-05 00:00:00

  • Prevention and treatment of coronary heart disease: who benefits?

    abstract::Coronary heart disease (CHD) remains a leading cause of morbidity and mortality in the United States, despite our better understanding of the pathobiology of atherosclerosis, our knowledge of risk factors, the widespread availability of inexpensive cholesterol screening, and the availability of effective and well-tole...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc3901.096665

    authors: LaRosa JC

    更新日期:2001-10-02 00:00:00

  • QT interval is linked to 2 long-QT syndrome loci in normal subjects.

    abstract:BACKGROUND:The rate-corrected QT interval (QTc) is heritable, and the discovery of quantitative trait loci that influence the QTc would be an important step in identifying the genes responsible for life-threatening arrhythmias in the general population. We studied 66 pairs of unselected normal dizygotic (DZ) twin subje...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.99.24.3161

    authors: Busjahn A,Knoblauch H,Faulhaber HD,Boeckel T,Rosenthal M,Uhlmann R,Hoehe M,Schuster H,Luft FC

    更新日期:1999-06-22 00:00:00

  • The relationship of cardiac output and arterial pressure control.

    abstract::Many basic concepts of cardiac output and arterial pressure control have changed considerably in the past few years. In general, each tissue controls its own local resistance and blood flow regardless of the level of arterial pressure; the sum of the local flows then determines the venous return and cardiac output. Ho...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/01.cir.64.6.1079

    authors: Guyton AC

    更新日期:1981-12-01 00:00:00

  • Noninvasive measurement of myocardial activity concentrations and perfusion defect sizes in rats with a new small-animal positron emission tomograph.

    abstract:BACKGROUND:We explored the feasibility of measuring regional tracer activity concentrations and flow defects in myocardium of rats with a high spatial resolution small-animal PET system (microPET). METHODS AND RESULTS:Myocardial images were obtained after intravenous (18)F-fluorodeoxyglucose (18FDG) in 11 normal rats ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000020221.28996.78

    authors: Kudo T,Fukuchi K,Annala AJ,Chatziioannou AF,Allada V,Dahlbom M,Tai YC,Inubushi M,Huang SC,Cherry SR,Phelps ME,Schelbert HR

    更新日期:2002-07-02 00:00:00

  • Aneurysm of the membraous septum in ventricular septal defect.

    abstract::An aneurysm of the membranous septum was found frequently in patients with ventricular septal defect; although appearance at catheterization during infancy was not common, aneurysms were detected in about half of the patients older than 2 years of age. A significant decrease in the left-to-right shunt occurred with th...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Nugent EW,Freedom RM,Rowe RD,Wagner HR,Rees JK

    更新日期:1977-08-01 00:00:00

  • P waves during ectopic atrial rhythms in man: a study utilizing atrial pacing with fixed electrodes.

    abstract::Threshold bipolar pacing was performed from one of 12 selected atrial sites with temporary implanted electrodes in 69 patients following open-heart surgery in order to study P wave polarity and morphology and the P-R interval during paced ectopic atrial rhythms. A negative P wave was recorded in lead I only with paci...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.52.3.426

    authors: MacLean WA,Karp RB,Kouchoukos NT,James TN,Waldo AL

    更新日期:1975-09-01 00:00:00

  • Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.

    abstract::The relationship between the degree of obesity and the incidence of cardiovascular disease (CVD) was reexamined in the 5209 men and women of the original Framingham cohort. Recent observations of disease occurrence over 26 years indicate that obesity, measured by Metropolitan Relative Weight, was a significant indepen...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.67.5.968

    authors: Hubert HB,Feinleib M,McNamara PM,Castelli WP

    更新日期:1983-05-01 00:00:00

  • Defining the transmurality of a chronic myocardial infarction by ultrasonic strain-rate imaging: implications for identifying intramural viability: an experimental study.

    abstract:BACKGROUND:In a correlative functional/histopathologic study, we investigated the regional deformation characteristics of both chronic nontransmural and transmural infarctions before and after a dobutamine challenge. METHODS AND RESULTS:After stenosing copper-coated stent implantation to produce circumflex artery endo...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000050146.66577.4b

    authors: Weidemann F,Dommke C,Bijnens B,Claus P,D'hooge J,Mertens P,Verbeken E,Maes A,Van de Werf F,De Scheerder I,Sutherland GR

    更新日期:2003-02-18 00:00:00

  • Impairment of collateral formation in lipoprotein(a) transgenic mice: therapeutic angiogenesis induced by human hepatocyte growth factor gene.

    abstract:BACKGROUND:Although lipoprotein(a) (Lp[a]) is a risk factor for atherosclerosis, no study has documented the effects of Lp(a) on angiogenesis. In this study, we examined collateral formation in peripheral arterial disease (PAD) model in Lp(a) transgenic mice. In addition, we examined the feasibility of gene therapy by ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000012146.07240.fd

    authors: Morishita R,Sakaki M,Yamamoto K,Iguchi S,Aoki M,Yamasaki K,Matsumoto K,Nakamura T,Lawn R,Ogihara T,Kaneda Y

    更新日期:2002-03-26 00:00:00

  • Chest compression rates during cardiopulmonary resuscitation are suboptimal: a prospective study during in-hospital cardiac arrest.

    abstract:BACKGROUND:Recent data highlight a vital link between well-performed cardiopulmonary resuscitation (CPR) and survival after cardiac arrest; however, the quality of CPR as actually performed by trained healthcare providers is largely unknown. We sought to measure in-hospital chest compression rates and to determine comp...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.CIR.0000153811.84257.59

    authors: Abella BS,Sandbo N,Vassilatos P,Alvarado JP,O'Hearn N,Wigder HN,Hoffman P,Tynus K,Vanden Hoek TL,Becker LB

    更新日期:2005-02-01 00:00:00

  • Environmental tobacco smoke and coronary heart disease in the American Cancer Society CPS-II cohort.

    abstract:BACKGROUND:Thirteen of 14 epidemiological studies have shown an increased risk of approximately 20% for coronary heart disease (CHD) for never-smokers exposed to environmental tobacco smoke (ETS), but this association remains controversial. If true, ETS might account for an estimated 35,000 to 40,000 heart disease deat...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.4.622

    authors: Steenland K,Thun M,Lally C,Heath C Jr

    更新日期:1996-08-15 00:00:00

  • Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.

    abstract:BACKGROUND:Poststroke angiogenesis contributes to long-term recovery after stroke. Signal transducer and activator of transcription-3 (Stat3) is a key regulator for various inflammatory signals and angiogenesis. It was the aim of this study to determine its function in poststroke outcome. METHODS AND RESULTS:We genera...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.114.013003

    authors: Hoffmann CJ,Harms U,Rex A,Szulzewsky F,Wolf SA,Grittner U,Lättig-Tünnemann G,Sendtner M,Kettenmann H,Dirnagl U,Endres M,Harms C

    更新日期:2015-05-19 00:00:00

  • Persistence of functional atrioventricular accessory pathways in postseptated embryonic avian hearts: implications for morphogenesis and functional maturation of the cardiac conduction system.

    abstract:BACKGROUND:During heart development, the ventricular activation sequence changes from a base-to-apex to an apex-to-base pattern. We investigated the possibility of impulse propagation through remnants of atrioventricular (AV) connections in quail hearts. METHODS AND RESULTS:In 86 hearts (group A, HH30-34, n=15; group ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.658807

    authors: Kolditz DP,Wijffels MC,Blom NA,van der Laarse A,Markwald RR,Schalij MJ,Gittenberger-de Groot AC

    更新日期:2007-01-02 00:00:00

  • Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice.

    abstract:BACKGROUND:Fat inflammation may play an important role in comorbidities associated with obesity such as atherosclerosis. METHODS AND RESULTS:To first establish feasibility of fat transplantation, epididymal fat pads were harvested from wild-type C57BL/6J mice and transplanted into leptin-deficient (Lep(ob/ob)) mice. F...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.717595

    authors: Ohman MK,Shen Y,Obimba CI,Wright AP,Warnock M,Lawrence DA,Eitzman DT

    更新日期:2008-02-12 00:00:00

  • Cardiovascular and Ventilatory Consequences of Laparoscopic Surgery.

    abstract::Although laparoscopic surgery accounts for >2 million surgical procedures every year, the current preoperative risk scores and guidelines do not adequately assess the risks of laparoscopy. In general, laparoscopic procedures have a lower risk of morbidity and mortality compared with operations requiring a midline lapa...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.116.023262

    authors: Atkinson TM,Giraud GD,Togioka BM,Jones DB,Cigarroa JE

    更新日期:2017-02-14 00:00:00

  • Postoperative investigation of left ventricular aneurysm resection.

    abstract::We reviewed 35 patients undergoing resection of a chronic postinfarction left ventricular aneurysm. There was 5.7% operative mortality. Of the long-term survivors, 80% are functional class I or II. Ten patients had postoperative left ventriculograms studied by means of a computerized analysis of endocardial motion usi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Shaw RC,Connors JP,Hieb BR,Ludbrook PA,Krone R,Kleiger RE,Ferguson TB,Weldon CS

    更新日期:1977-09-01 00:00:00

  • Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis.

    abstract:BACKGROUND:Matrix metalloproteinase-9 could exhibit an important role in the destabilization of atherosclerotic carotid plaques. We hypothesized that in patients with carotid stenosis, elevated levels of plasma matrix metalloproteinase-9 are associated with ipsilateral stroke or cardiovascular death. METHODS AND RESUL...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.593483

    authors: Eldrup N,Grønholdt ML,Sillesen H,Nordestgaard BG

    更新日期:2006-10-24 00:00:00

  • Report of the Inter-Society Commission for Heart Disease Resources. Optimal resource guidelines for radioactive tracer studies of the heart and circulation.

    abstract::The status of radioactive tracer studies in cardiovascular diagnosis is summarized. Planning guidelines are suggested for a hospital nuclear medical service including a central nuclear medical facility and satellite units, and resource criteria are given for professional personnel including training and duties, equipm...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Adelstein SJ,Jansen C,Wagner HN Jr

    更新日期:1975-07-01 00:00:00

  • B-type natriuretic peptide and ischemia in patients with stable coronary disease: data from the Heart and Soul study.

    abstract:BACKGROUND:In patients with symptoms of heart failure, elevations in B-type natriuretic peptide (BNP) accurately identify ventricular dysfunction. However, BNP levels are not specific for ventricular dysfunction in patients who do not have overt symptoms of heart failure, suggesting that other cardiac processes such as...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000103681.04726.9C

    authors: Bibbins-Domingo K,Ansari M,Schiller NB,Massie B,Whooley MA

    更新日期:2003-12-16 00:00:00

  • Magnetic resonance imaging assessment of the severity of mitral regurgitation. Comparison with invasive techniques.

    abstract:BACKGROUND:In the patient with mitral regurgitation who is being considered for valvular surgery, cardiac catheterization is usually performed to quantify the severity of regurgitation and to determine its influence on left ventricular volumes and systolic function. Magnetic resonance imaging (MRI) potentially provides...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.5.1151

    authors: Hundley WG,Li HF,Willard JE,Landau C,Lange RA,Meshack BM,Hillis LD,Peshock RM

    更新日期:1995-09-01 00:00:00

  • Does retrograde warm blood cardioplegia provide equal protection to both ventricles? A magnetic resonance spectroscopy study in pigs.

    abstract:BACKGROUND:The degree of protection provided to the right ventricle during retrograde continuous normothermic blood cardioplegia (RCNBC) remains controversial. The purpose of this study was to determine whether RCNBC is able to provide "adequate" nutritive flow to both ventricles to prevent ischemic metabolism in norma...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Ye J,Sun J,Shen J,Gregorash L,Summers R,Salerno TA,Deslauriers R

    更新日期:1997-11-04 00:00:00

  • Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.

    abstract:BACKGROUND:Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease. The pathways that govern titin-dependent cardiac growth and contribute to disease are diverse and difficult to dissect. METHOD...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.118.037588

    authors: Radke MH,Polack C,Methawasin M,Fink C,Granzier HL,Gotthardt M

    更新日期:2019-04-09 00:00:00

  • Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2.

    abstract:BACKGROUND:Pulmonary hypertension induced by chronic hypoxia is characterized by thickening of pulmonary artery walls, elevated pulmonary vascular resistance, and right-heart failure. Prostacyclin analogues reduce pulmonary pressures in this condition; raising the possibility that cycloxygenase-2 (COX-2) modulates the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000145613.01188.0B

    authors: Pidgeon GP,Tamosiuniene R,Chen G,Leonard I,Belton O,Bradford A,Fitzgerald DJ

    更新日期:2004-10-26 00:00:00

  • Heterogeneous atrial denervation creates substrate for sustained atrial fibrillation.

    abstract:BACKGROUND:Heterogeneous electrophysiological properties, which may be due in part to autonomic innervation, are important in the maintenance of atrial fibrillation (AF). We hypothesized that heterogeneous sympathetic denervation with phenol would create a milieu for sustained AF. METHODS AND RESULTS:After the determi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.98.23.2608

    authors: Olgin JE,Sih HJ,Hanish S,Jayachandran JV,Wu J,Zheng QH,Winkle W,Mulholland GK,Zipes DP,Hutchins G

    更新日期:1998-12-08 00:00:00

  • Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction.

    abstract:BACKGROUND:Accumulating evidence suggests that the ubiquitous anion nitrite (NO2-) is a physiological signaling molecule, with roles in intravascular endocrine nitric oxide transport, hypoxic vasodilation, signaling, and cytoprotection. Thus, nitrite could enhance the efficacy of reperfusion therapy for acute myocardia...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.748814

    authors: Gonzalez FM,Shiva S,Vincent PS,Ringwood LA,Hsu LY,Hon YY,Aletras AH,Cannon RO 3rd,Gladwin MT,Arai AE

    更新日期:2008-06-10 00:00:00

  • A Tale of Two Patients: Patient-Centered Approaches to Adherence as a Gateway to Reducing Disparities.

    abstract::The disparate effects of social determinants of health on cardiovascular health status and health care have been extensively documented by epidemiology. Yet, very little attention has been paid to how understanding and addressing social determinants of health might improve the quality of clinical interactions, especia...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.116.015361

    authors: Kressin NR,Chapman SE,Magnani JW

    更新日期:2016-06-14 00:00:00

  • Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein.

    abstract:BACKGROUND:The estrogen receptor-alpha (ER-alpha) IVS1-401 polymorphism identifies a group of women (approximately 20%) who have augmented effects of hormone replacement therapy (HRT) on levels of HDL cholesterol. This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.0000016173.98826.88

    authors: Herrington DM,Howard TD,Brosnihan KB,McDonnell DP,Li X,Hawkins GA,Reboussin DM,Xu J,Zheng SL,Meyers DA,Bleecker ER

    更新日期:2002-04-23 00:00:00

  • Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization.

    abstract:BACKGROUND:Bronchopulmonary dysplasia (BPD) and pulmonary emphysema, both significant global health problems, are characterized by a loss of alveoli. Vascular endothelial growth factor (VEGF) is a trophic factor required for endothelial cell survival and is abundantly expressed in the lung. METHODS AND RESULTS:We repo...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.541524

    authors: Thébaud B,Ladha F,Michelakis ED,Sawicka M,Thurston G,Eaton F,Hashimoto K,Harry G,Haromy A,Korbutt G,Archer SL

    更新日期:2005-10-18 00:00:00

  • Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences.

    abstract:BACKGROUND:In various heart disease paradigms, atria show stronger fibrotic responses than ventricles. The possibility that atrial and ventricular fibroblasts respond differentially to pathological stimuli has not been examined. METHODS AND RESULTS:We compared various morphological, secretory, and proliferative respon...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.748053

    authors: Burstein B,Libby E,Calderone A,Nattel S

    更新日期:2008-04-01 00:00:00