Coagulant activities of platelets in coronary artery disease.

abstract：BACKGROUND:Platelet aggregation plays a critical role in myocardial infarction and stroke; however, the role of platelet secretion in atherosclerotic vascular disease is poorly understood. Therefore, we examined the hypothesis that platelet dense-granule secretion modulates thrombosis, inflammation, and atherosclerotic...

journal_title：Circulation

authors： King SM,McNamee RA,Houng AK,Patel R,Brands M,Reed GL

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Macrophages contribute to the progression and acute complications of atherosclerosis. Macrophage imaging may serve as a biomarker to identify subclinical inflamed lesions, to predict future risk, and to aid in the assessment of novel therapies. METHODS AND RESULTS:To test the hypothesis that nanoparticle-en...

journal_title：Circulation

authors： Morishige K,Kacher DF,Libby P,Josephson L,Ganz P,Weissleder R,Aikawa M

更新日期：2010-10-26 00:00:00

abstract：BACKGROUND:Chronic heart failure is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). Since endothelial function is thought to play an important role in coordinating tissue perfusion and modulating arterial compliance, interventions to improve endothelial dy...

journal_title：Circulation

authors： Hornig B,Maier V,Drexler H

更新日期：1996-01-15 00:00:00

abstract：BACKGROUND:Progression of heart failure after initial myocardial injury is mediated in part by various redundant inflammatory mediators, including the widely expressed cyclooxygenase-2 (COX-2). Because COX-2 inhibitors are useful in treating many inflammation-mediated diseases, we asked whether COX-2 inhibition can att...

journal_title：Circulation

authors： Delgado RM 3rd,Nawar MA,Zewail AM,Kar B,Vaughn WK,Wu KK,Aleksic N,Sivasubramanian N,McKay K,Mann DL,Willerson JT

更新日期：2004-03-23 00:00:00

abstract：BACKGROUND:There is increasing evidence of a link between conduit vessel stiffness and cardiovascular events, although the association has never been tested in a large post-myocardial infarction patient population. METHODS AND RESULTS:We evaluated the relationship between baseline pulse pressure, measured by sphygmoma...

journal_title：Circulation

authors： Mitchell GF,Moyé LA,Braunwald E,Rouleau JL,Bernstein V,Geltman EM,Flaker GC,Pfeffer MA

更新日期：1997-12-16 00:00:00

abstract：BACKGROUND:Depletion of L-arginine (L-arg), the substrate for nitric oxide (NO) synthesis, could be one of the mechanisms responsible for the reduced production of NO and decreased coronary flow (CF) during reperfusion. This, in turn, may adversely affect mechanical function. We aimed to study the benefits of exogenous...

journal_title：Circulation

authors： Amrani M,Gray CC,Smolenski RT,Goodwin AT,London A,Yacoub MH

更新日期：1997-11-04 00:00:00

abstract：:While the steady-state effects of positive pleural pressure on the circulation have been extensively studied, less is known about the immediate effects of positive intrathoracic pressure on cardiac dynamics. Therefore, we performed electrocardiographically gated radionuclide ventriculography with a respiratory gating ...

journal_title：Circulation

authors： Natarajan TK,Wise RA,Karam M,Permutt S,Wagner HN Jr

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The purpose of the present study was to investigate plasma lipid-independent mechanisms for the sex difference in the development of atherosclerosis. METHODS AND RESULTS:In the first experiment, 20 male and 20 female rabbits were balloon-injured in the middle thoracic aorta and maintained at the same plasma...

journal_title：Circulation

authors： Holm P,Andersen HL,Arrøe G,Stender S

更新日期：1998-12-15 00:00:00

abstract：:The nature, prevalence, functional significance, and indeed existence of myocardial disease in progressive systemic sclerosis (PSS) has been debated. In this study the clinical and pathological features of 52 autopsied patients were analyzed in an attempt to resolve these questions. A distinctive focal myocardial lesi...

journal_title：Circulation

authors： Bulkley BH,Ridolfi RL,Salyer WR,Hutchins GM

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:Chronic Chlamydia pneumoniae and Helicobacter pylori infections could be a risk factor for ischemic heart disease (IHD), possibly by increasing fibrinogen levels. The aim of our study was to evaluate changes in fibrinogen level in patients with IHD and H pylori and/or C pneumoniae positivity randomly assigne...

journal_title：Circulation

authors： Torgano G,Cosentini R,Mandelli C,Perondi R,Blasi F,Bertinieri G,Tien TV,Ceriani G,Tarsia P,Arosio C,Ranzi ML

更新日期：1999-03-30 00:00:00

abstract：BACKGROUND:Alterations in the balance of matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload-induced LV hypertrophy, howev...

journal_title：Circulation

authors： Heymans S,Schroen B,Vermeersch P,Milting H,Gao F,Kassner A,Gillijns H,Herijgers P,Flameng W,Carmeliet P,Van de Werf F,Pinto YM,Janssens S

更新日期：2005-08-23 00:00:00

abstract：:The present study was performed to determine whether positron emission tomography (PET) performed after i.v. 11C-palmitate permits detection and characterization of nontransmural myocardial infarction. PET was performed after the i.v. injection of 11C-palmitate in 10 normal subjects, 24 patients with initial nontransm...

journal_title：Circulation

authors： Geltman EM,Biello D,Welch MJ,Ter-Pogossian MM,Roberts R,Sobel BE

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:People who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that often follows it that leads to higher blood pressure. METHODS AND RESULTS:We studied blood pressure in 346 British men and ...

journal_title：Circulation

authors： Law CM,Shiell AW,Newsome CA,Syddall HE,Shinebourne EA,Fayers PM,Martyn CN,de Swiet M

更新日期：2002-03-05 00:00:00

abstract：BACKGROUND:Although patients with heart failure express elevated circulating levels of tumor necrosis factor-alpha (TNF-alpha) in their peripheral circulation, the structural and functional effects of circulating levels of pathophysiologically relevant concentrations of TNF-alpha on the heart are not known. METHODS AN...

journal_title：Circulation

authors： Bozkurt B,Kribbs SB,Clubb FJ Jr,Michael LH,Didenko VV,Hornsby PJ,Seta Y,Oral H,Spinale FG,Mann DL

更新日期：1998-04-14 00:00:00

abstract：BACKGROUND:Aldosterone and angiotensin (Ang) II both may cause organ damage. Circulating aldosterone is produced in the adrenals; however, local cardiac synthesis has been reported. Aldosterone concentrations depend on the activity of aldosterone synthase (CYP11B2). We tested the hypothesis that reducing aldosterone by...

journal_title：Circulation

authors： Fiebeler A,Nussberger J,Shagdarsuren E,Rong S,Hilfenhaus G,Al-Saadi N,Dechend R,Wellner M,Meiners S,Maser-Gluth C,Jeng AY,Webb RL,Luft FC,Muller DN

更新日期：2005-06-14 00:00:00

abstract：:This two-part article provides an overview of the global burden of atherothrombotic cardiovascular disease. Part I initially discusses the epidemiologic transition which has resulted in a decrease in deaths in childhood due to infections, with a concomitant increase in cardiovascular and other chronic diseases; and th...

journal_title：Circulation

authors： Yusuf S,Reddy S,Ounpuu S,Anand S

更新日期：2001-11-27 00:00:00

abstract：BACKGROUND:Peak early-diastolic mitral annulus velocity (e') by tissue Doppler imaging has been introduced as a clinical marker of diastolic function. This study investigates whether lengthening load (early-diastolic load) and restoring forces are determinants of e' in addition to rate of left ventricular (LV) relaxati...

journal_title：Circulation

authors： Opdahl A,Remme EW,Helle-Valle T,Lyseggen E,Vartdal T,Pettersen E,Edvardsen T,Smiseth OA

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:In diabetic patients in the Evaluation of Platelet IIb/IIIa Inhibitor for Stenting (EPISTENT) trial, abciximab reduced target vessel revascularization by approximately 50% compared with placebo. Whether this is a result of a lower restenosis rate caused by inhibition of intimal hyperplasia remains to be defi...

journal_title：Circulation

authors： Chaves AJ,Sousa AG,Mattos LA,Abizaid A,Staico R,Feres F,Centemero M,Tanajura LF,Abizaid A,Pinto I,Maldonado G,Seixas A,Costa MA,Paes A,Mintz GS,Sousa JE

更新日期：2004-02-24 00:00:00

abstract：BACKGROUND:Several noninvasive methods are available to investigate the severity of extracoronary atherosclerotic disease. No population-based study has yet examined whether differences exist between these measures with regard to their predictive value for myocardial infarction (MI) or whether a given measure of athero...

journal_title：Circulation

authors： van der Meer IM,Bots ML,Hofman A,del Sol AI,van der Kuip DA,Witteman JC

更新日期：2004-03-09 00:00:00

abstract：BACKGROUND:NO has been advocated as an adjunct to cardioplegia solutions. However, NO undergoes a rapid biradical reaction with superoxide anions to produce peroxynitrite (ONOO(-)). ONOO(-) in crystalloid cardioplegia solution induces injury to coronary endothelium and to systolic function after cardioplegia and reperf...

journal_title：Circulation

authors： Nakamura M,Thourani VH,Ronson RS,Velez DA,Ma XL,Katzmark S,Robinson J,Schmarkey LS,Zhao ZQ,Wang NP,Guyton RA,Vinten-Johansen J

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:Ten percent to 20% of potential cardiac donors with brain injury and no previous cardiac history have myocardial dysfunction. We assessed components of the beta-receptor-G-protein-adenylyl cyclase complex as well as the contractile response in 10 explanted acutely failing human hearts (donor heart dysfunctio...

journal_title：Circulation

authors： White M,Wiechmann RJ,Roden RL,Hagan MB,Wollmering MM,Port JD,Hammond E,Abraham WT,Wolfel EE,Lindenfeld J

更新日期：1995-10-15 00:00:00

abstract：:The dynamics of acute mitral regurgitation were studied in six open-chest dogs in whom a portion of the anterior leaflet was excised. Phasic mitral and aortic flows were measured electromagnetically and left ventricular filling volume, regurgitant volume (RV) and forward stroke volume (SV) were calculated. The systoli...

journal_title：Circulation

authors： Yoran C,Yellin EL,Becker RM,Gabbay S,Frater RW,Sonnenblick EH

更新日期：1979-07-01 00:00:00

abstract：:Coronary arteriography was performed before and after the intracoronary injection of nitroglycerin to determine the presence or absence of spasm in patients within the first 12 hours of acute myocardial infarction. Coronary arterial spasm was demonstrated in six of fifteen (40%) acute myocardial infarctions associated...

journal_title：Circulation

authors： Oliva PB,Breckinridge JC

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:Biventricular direct cardiac compression (DCC) can potentially support the failing heart without the complications associated with a blood/device interface. The effect of uniform DCC on left and right ventricular performance was evaluated in 7 isolated canine heart preparations. METHODS AND RESULTS:A comput...

journal_title：Circulation

authors： Artrip JH,Wang J,Leventhal AR,Tsitlik JE,Levin HR,Burkhoff D

更新日期：1999-04-27 00:00:00

abstract：BACKGROUND:Isoprostanes (iPs) are free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Several iPs exert biological effects in vitro and may contribute to the functional consequences of oxidant stress. For example, iPF(2alpha)-III (8-iso PGF(2alpha)) and iPE(2)-III modulate plate...

journal_title：Circulation

authors： Audoly LP,Rocca B,Fabre JE,Koller BH,Thomas D,Loeb AL,Coffman TM,FitzGerald GA

更新日期：2000-06-20 00:00:00

abstract：BACKGROUND:We tested prospectively the hypothesis that stroke development can be predicted by echolucency of carotid atherosclerotic plaques in previously symptomatic and asymptomatic patients. METHODS AND RESULTS:We followed incidence of ipsilateral ischemic strokes for 4.4 years in 111 asymptomatic and 135 symptomat...

journal_title：Circulation

authors： Grønholdt ML,Nordestgaard BG,Schroeder TV,Vorstrup S,Sillesen H

更新日期：2001-07-03 00:00:00

abstract：BACKGROUND:Mutations in the gene G4.5 result in a wide spectrum of severe infantile cardiomyopathic phenotypes, including isolated left ventricular noncompaction (LVNC), as well as Barth syndrome (BTHS) with dilated cardiomyopathy (DCM). The purpose of this study was to investigate patients with LVNC or BTHS for mutati...

journal_title：Circulation

authors： Ichida F,Tsubata S,Bowles KR,Haneda N,Uese K,Miyawaki T,Dreyer WJ,Messina J,Li H,Bowles NE,Towbin JA

更新日期：2001-03-06 00:00:00

abstract：BACKGROUND:Intravascular ultrasound imaging was performed in 27 patients after coronary balloon angioplasty to quantify the lumen and atheroma cross-sectional areas. METHODS AND RESULTS:A 20-MHz ultrasound catheter was inserted through a 1.6-mm plastic introducer sheath across the dilated area to obtain real-time imag...

journal_title：Circulation

authors： Tobis JM,Mallery J,Mahon D,Lehmann K,Zalesky P,Griffith J,Gessert J,Moriuchi M,McRae M,Dwyer ML

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Previous studies suggest that management of ambulatory hemodynamics may improve outcomes in chronic heart failure. We conducted a prospective, observational, first-in-human study of a physician-directed patient self-management system targeting left atrial pressure. METHODS AND RESULTS:Forty patients with re...

journal_title：Circulation

authors： Ritzema J,Troughton R,Melton I,Crozier I,Doughty R,Krum H,Walton A,Adamson P,Kar S,Shah PK,Richards M,Eigler NL,Whiting JS,Haas GJ,Heywood JT,Frampton CM,Abraham WT,Hemodynamically Guided Home Self-Therapy in Severe Hea

更新日期：2010-03-09 00:00:00

abstract：BACKGROUND:Nontranscriptional signaling through estrogen receptors (ERs) is important in the cardiovascular system. In particular, estrogen stimulates endothelial NO synthase (eNOS) via the phosphatidylinositol 3-kinase (PI3K) pathway. The selective estrogen receptor modulator (SERM) raloxifene is effective for the tre...

journal_title：Circulation

authors： Simoncini T,Genazzani AR,Liao JK

更新日期：2002-03-19 00:00:00