Diffuse coronary artery disease in diabetic patients: fact or fiction?

abstract：BACKGROUND:In patients with symptoms of heart failure, elevations in B-type natriuretic peptide (BNP) accurately identify ventricular dysfunction. However, BNP levels are not specific for ventricular dysfunction in patients who do not have overt symptoms of heart failure, suggesting that other cardiac processes such as...

journal_title：Circulation

authors： Bibbins-Domingo K,Ansari M,Schiller NB,Massie B,Whooley MA

更新日期：2003-12-16 00:00:00

abstract：BACKGROUND:We investigated the feasibility of bioluminescence imaging (BLI) for the in vivo assessment of cardiac allograft viability and visualization of passenger leukocytes during the course of acute rejection. METHODS AND RESULTS:Hearts of FVB (H-2q) luciferase-green fluorescent protein transgenic mice (beta-actin...

journal_title：Circulation

authors： Tanaka M,Swijnenburg RJ,Gunawan F,Cao YA,Yang Y,Caffarelli AD,de Bruin JL,Contag CH,Robbins RC

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:Stress cardiomyopathy (SCM) is a peculiar form of reversible left ventricular dysfunction seen predominantly in women and occurs in response to emotional or physical stress. Because dysfunction in SCM is reversible and that of acute myocardial infarction (MI) is not, we hypothesized that these fundamental me...

journal_title：Circulation

authors： Medeiros K,O'Connor MJ,Baicu CF,Fitzgibbons TP,Shaw P,Tighe DA,Zile MR,Aurigemma GP

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:There is no consensus on how, when, or at what intensity exercise should be performed after heart transplantation (HTx). We have recently shown that high-intensity interval training (HIT) is safe, well tolerated, and efficacious in the maintenance state after HTx, but studies have not investigated HIT effect...

journal_title：Circulation

authors： Nytrøen K,Rolid K,Andreassen AK,Yardley M,Gude E,Dahle DO,Bjørkelund E,Relbo Authen A,Grov I,Philip Wigh J,Have Dall C,Gustafsson F,Karason K,Gullestad L

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Smooth muscle cell (SMC) migration and proliferation critically influence the clinical course of vascular disease. We tested the effect of the novel small leucine-rich repeat protein podocan on SMC migration and proliferation using a podocan-deficient mouse in combination with a model of arterial injury and ...

journal_title：Circulation

authors： Hutter R,Huang L,Speidl WS,Giannarelli C,Trubin P,Bauriedel G,Klotman ME,Fuster V,Badimon JJ,Klotman PE

更新日期：2013-11-26 00:00:00

abstract：:In patients with atrioventricular (A-V) nodal re-entrant paroxysmal supraventricular tachycardia (PSVT), atrial extrastimulus technique frequently reveals discontinuous A1-A2, H1-H2 curves suggestive of dual A-V nodal pathways. To further test the hypothesis that these curves in fact reflect dual A-V nodal pathways, a...

journal_title：Circulation

authors： Wu D,Denes P,Wyndham C,Amat-y-Leon F,Dhingra RC,Rosen KM

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND:In PTCA patients with multivessel coronary artery disease, incomplete revascularization (IR) is the result of both pre-PTCA strategy and initial lesion outcome. The unique contribution of these components on long-term patient outcome is uncertain. METHODS AND RESULTS:From the Bypass Angioplasty Revasculariz...

journal_title：Circulation

authors： Kip KE,Bourassa MG,Jacobs AK,Schwartz L,Feit F,Alderman EL,Weiner BH,Weiss MB,Kellett MA Jr,Sharaf BL,Dimas AP,Jones RH,Sopko G,Detre KM

更新日期：1999-08-31 00:00:00

abstract：BACKGROUND:Bone marrow-derived cells have been shown to contribute to endothelial replacement after vascular injury. In vitro culture of peripheral blood mononuclear cells produces cells with phenotypic characteristics of endothelium. To test the hypothesis that delivery of autologous culture-modified mononuclear cells...

journal_title：Circulation

authors： Gulati R,Jevremovic D,Peterson TE,Witt TA,Kleppe LS,Mueske CS,Lerman A,Vile RG,Simari RD

更新日期：2003-09-23 00:00:00

abstract：:Myocardial fiber disarray is a distinctive histopathologic finding seen in asymmetric hypertrophic cardiomyopathy. We studied 14 hearts with aortic atresia and intact interventricular septum, six hearts with pulmonic atresia and intact interventricular septum, eight normal infant hearts matched for age of the study he...

journal_title：Circulation

authors： Bulkley BH,D'Amico B,Taylor AL

更新日期：1983-01-01 00:00:00

abstract：:Although for most children the process of atherosclerosis is subclinical, dramatically accelerated atherosclerosis occurs in some pediatric disease states, with clinical coronary events occurring in childhood and very early adult life. As with most scientific statements about children and the future risk for cardiovas...

journal_title：Circulation

authors： Kavey RE,Allada V,Daniels SR,Hayman LL,McCrindle BW,Newburger JW,Parekh RS,Steinberger J,American Heart Association Expert Panel on Population and Prevention Science.,American Heart Association Council on Cardiovascular Disease in the

更新日期：2006-12-12 00:00:00

abstract：BACKGROUND:Dickkopf-related protein 3 (DKK3) is a secreted protein that is involved in the regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is known about its role in atherosclerosis. METHODS:We tested the hypothesis that DKK3 is atheroprotective using both epidemiological a...

journal_title：Circulation

authors： Yu B,Kiechl S,Qi D,Wang X,Song Y,Weger S,Mayr A,Le Bras A,Karamariti E,Zhang Z,Barco Barrantes ID,Niehrs C,Schett G,Hu Y,Wang W,Willeit J,Qu A,Xu Q

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:Chronic Chlamydia pneumoniae and Helicobacter pylori infections could be a risk factor for ischemic heart disease (IHD), possibly by increasing fibrinogen levels. The aim of our study was to evaluate changes in fibrinogen level in patients with IHD and H pylori and/or C pneumoniae positivity randomly assigne...

journal_title：Circulation

authors： Torgano G,Cosentini R,Mandelli C,Perondi R,Blasi F,Bertinieri G,Tien TV,Ceriani G,Tarsia P,Arosio C,Ranzi ML

更新日期：1999-03-30 00:00:00

abstract：BACKGROUND:Reperfusion injury is insufficiently addressed in current clinical management of acute limb ischemia. Controlled reperfusion carries an enormous clinical potential and was tested in a new reality-driven rodent model. METHODS AND RESULTS:Acute hind-limb ischemia was induced in Wistar rats and maintained for ...

journal_title：Circulation

authors： Dick F,Li J,Giraud MN,Kalka C,Schmidli J,Tevaearai H

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF), the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), is capable of producing symptoms that impact quality of life and is associated with risk for embolic stroke. However, the influence of AF on clinical course and outcome in HCM remains incompletely resolved. ...

journal_title：Circulation

authors： Rowin EJ,Hausvater A,Link MS,Abt P,Gionfriddo W,Wang W,Rastegar H,Estes NAM,Maron MS,Maron BJ

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:Ten percent to 20% of potential cardiac donors with brain injury and no previous cardiac history have myocardial dysfunction. We assessed components of the beta-receptor-G-protein-adenylyl cyclase complex as well as the contractile response in 10 explanted acutely failing human hearts (donor heart dysfunctio...

journal_title：Circulation

authors： White M,Wiechmann RJ,Roden RL,Hagan MB,Wollmering MM,Port JD,Hammond E,Abraham WT,Wolfel EE,Lindenfeld J

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:Most myocardial infarctions are caused by the rupture of small rather than large plaques in the arteries of the heart that are beyond the detection limit of current technologies. METHODS AND RESULTS:Recently, optical coherence tomography (OCT) has demonstrated considerable potential as a method for high-res...

journal_title：Circulation

authors： Brezinski M,Saunders K,Jesser C,Li X,Fujimoto J

更新日期：2001-04-17 00:00:00

abstract：BACKGROUND:Cigarette smoking has been recognized as an important risk factor for cardiovascular disease in men and women. Whether the increased risk results from an atherogenic effect of smoking is still debated. We examined the relation between cigarette smoking and atherosclerotic changes in the abdominal aorta. MET...

journal_title：Circulation

authors： Witteman JC,Grobbee DE,Valkenburg HA,van Hemert AM,Stijnen T,Hofman A

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:ATP-sensitive K+ channels are activated when the myocardium becomes ischemic. However, the role of the ATP-sensitive K+ current in the emergence of ECG ST changes during ischemia remained unclarified. METHODS AND RESULTS:The left anterior descending coronary artery (LAD) was cannulated and perfused with art...

journal_title：Circulation

authors： Kubota I,Yamaki M,Shibata T,Ikeno E,Hosoya Y,Tomoike H

更新日期：1993-10-01 00:00:00

abstract：:Twenty-six major cardiovascular centers participated in a cooperative study of all cases of infective endocarditis occurring during a single calendar year to obtain an overview of infective endocarditis. The study was designed to learn which patients appear to be at highest risk to develop this infection after palliat...

journal_title：Circulation

authors： Kaplan EL,Rich H,Gersony W,Manning J

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:Three distinct cardiac arrhythmia disorders, the long-QT syndrome, Brugada syndrome, and conduction system disease, have been associated with heterozygous mutations in the cardiac voltage-gated sodium channel alpha-subunit gene (SCN5A). We present clinical, genetic, and biophysical features of 2 new SCN5A mu...

journal_title：Circulation

authors： Wang DW,Viswanathan PC,Balser JR,George AL Jr,Benson DW

更新日期：2002-01-22 00:00:00

abstract：:To determine whether multiple lead precordial electrocardiographic recordings offer an improved index for noninvasive estimation of left ventricular hemodynamic function and segmental dyssynergy, precordial mapping was performed in patients with anterior myocardial infarction, and the number of pathologic Q waves (gre...

journal_title：Circulation

authors： Awan NA,Miller RR,Vera Z,Janzen DA,Amsterdam EA,Mason DT

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND:There are few data regarding medium-term outcome of coronary artery bypass grafting (CABG) in patients with severe left ventricular (LV) systolic dysfunction, particularly in the modern era, and even less assessing preoperative factors that might identify patients at highest risk. METHODS AND RESULTS:Three ...

journal_title：Circulation

authors： Hillis GS,Zehr KJ,Williams AW,Schaff HV,Orzulak TA,Daly RC,Mullany CJ,Rodeheffer RJ,Oh JK

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Spectral analysis of heart rate (HR) variability (HRV) requires, as a rule, some level of stationarity and, as a result, is inadequate to quantify biological transients. A time-/frequency-domain method (TF) was developed to obtain an instant spectral power (SP) of HRV during tilt. METHODS AND RESULTS:HR was...

journal_title：Circulation

authors： Jasson S,Médigue C,Maison-Blanche P,Montano N,Meyer L,Vermeiren C,Mansier P,Coumel P,Malliani A,Swynghedauw B

更新日期：1997-11-18 00:00:00

abstract：:Aortic root motion was studied in 24 normal volunteers at rest and during the Valsalva maneuver, isometric exercise, and amyl nitrite inhalation. In addition root motion was correlated with the stroke volumes determined at cardiac catheterization in 24 patients. The root has distinct systolic movement, the amplitude a...

journal_title：Circulation

authors： Pratt RC,Parisi AF,Harrington JJ,Sasahara AA

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Automatic implantable cardioverter-defibrillator therapy is considered the only effective treatment for high-risk patients with Brugada syndrome. Quinidine depresses I(to) current, which may play an important role in the arrhythmogenesis of this disease. METHODS AND RESULTS:The effects of quinidine bisulfat...

journal_title：Circulation

authors： Belhassen B,Glick A,Viskin S

更新日期：2004-09-28 00:00:00

abstract：BACKGROUND:The aim of this study was to compare the risk conferred by white-coat versus sustained mild hypertension for the development of cardiovascular disease. METHODS AND RESULTS:Patients (n=479) who underwent 24-hour intra-arterial ambulatory blood pressure monitoring on the basis of a persistently elevated clini...

journal_title：Circulation

authors： Khattar RS,Senior R,Lahiri A

更新日期：1998-11-03 00:00:00

abstract：:In experimental animals, the calcium channel-blocking agents lessen the arrhythmogenic, ionic, metabolic, and electrical changes that occur during acute myocardial ischemia. To date, these effects have been studied separately, and the effects of these agents on local activation have not been correlated with ionic or m...

journal_title：Circulation

authors： Fleet WF,Johnson TA,Graebner CA,Engle CL,Gettes LS

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Few published data describe long-term survival of dialysis patients undergoing surgical versus percutaneous coronary revascularization in the era of drug-eluting stents (DES). METHODS AND RESULTS:Using United States Renal Data System data, we identified 23 033 dialysis patients who underwent coronary revasc...

journal_title：Circulation

authors： Shroff GR,Solid CA,Herzog CA

更新日期：2013-05-07 00:00:00

abstract：BACKGROUND:Theoretically, the efficacy of continuous warm blood cardioplegia may be improved when administered retrogradely (RCWBC) rather than antegradely (ACWBC) in the setting of acute regional ischemia because of enhanced oxygen and substrate delivery to myocardial tissue distal to an acute coronary artery occlusio...

journal_title：Circulation

authors： Misare BD,Krukenkamp IB,Lazer ZP,Levitsky S

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Heart failure treatment depends partly on the underlying cause of the disease. We evaluated cardiovascular magnetic resonance (CMR) for the problem of differentiating dilated cardiomyopathy (DCM) from left ventricular (LV) dysfunction caused by coronary artery disease (CAD). METHODS AND RESULTS:Late gadolin...

journal_title：Circulation

authors： McCrohon JA,Moon JC,Prasad SK,McKenna WJ,Lorenz CH,Coats AJ,Pennell DJ

更新日期：2003-07-08 00:00:00