Weight Loss and Heart Failure: A Nationwide Study of Gastric Bypass Surgery Versus Intensive Lifestyle Treatment.

abstract：BACKGROUND:Although long-term lipid-lowering therapy improves endothelium-dependent vasodilatation in humans, it remains unknown whether the short-term removal of LDL per se ameliorates endothelial dysfunction. METHODS AND RESULTS:To examine the effects of a single session of LDL apheresis on endothelial function in p...

journal_title：Circulation

authors： Tamai O,Matsuoka H,Itabe H,Wada Y,Kohno K,Imaizumi T

更新日期：1997-01-07 00:00:00

abstract：:The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein B-containing lipoproteins. Local biological responses to these retained lipoproteins, including a chronic and maladaptive macrophage- and T-cell-dominated inflammatory response, promote subsequent lesion development. The most...

journal_title：Circulation

authors： Tabas I,Williams KJ,Borén J

更新日期：2007-10-16 00:00:00

abstract：:Calcium metabolism may play an important role in the pathogenesis of myocardial ischemic injury. The effect of the sarcolemmal calcium flux inhibitor, verapamil, on myocardial necrosis was studied in dogs subjected to temporary coronary artery occlusion. One group of dogs was untreated. A second group was given 0.8 mg...

journal_title：Circulation

authors： Reimer KA,Lowe JE,Jennings RB

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Dickkopf-related protein 3 (DKK3) is a secreted protein that is involved in the regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is known about its role in atherosclerosis. METHODS:We tested the hypothesis that DKK3 is atheroprotective using both epidemiological a...

journal_title：Circulation

authors： Yu B,Kiechl S,Qi D,Wang X,Song Y,Weger S,Mayr A,Le Bras A,Karamariti E,Zhang Z,Barco Barrantes ID,Niehrs C,Schett G,Hu Y,Wang W,Willeit J,Qu A,Xu Q

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:We evaluated the prognosis of deferred and revascularized coronary stenoses after fractional flow reserve (FFR) measurement to assess its revascularization threshold in clinical practice. METHODS:The IRIS-FFR registry (Interventional Cardiology Research In-cooperation Society Fractional Flow Reserve) prospe...

journal_title：Circulation

authors： Ahn JM,Park DW,Shin ES,Koo BK,Nam CW,Doh JH,Kim JH,Chae IH,Yoon JH,Her SH,Seung KB,Chung WY,Yoo SY,Lee JB,Choi SW,Park K,Hong TJ,Lee SY,Han M,Lee PH,Kang SJ,Lee SW,Kim YH,Lee CW,Park SW,Park SJ,IRIS-FF

更新日期：2017-06-06 00:00:00

abstract：:Medical treatment of heart disease has improved significantly in the past 30 years. The spectacular change in the natural history of rheumatic heart disease is apparent from a 1948 article that reported that 42% of children with rheumatic heart disease died of rheumatic infection or bacterial endocarditis. Antibiotics...

journal_title：Circulation

authors： Ross RS

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Recently, it has been shown that stem/progenitor cells may repair damaged/lost endothelial cells in vein grafts and wire-injured arteries. In the present study, we investigated endothelial cell turnover and regeneration in apolipoprotein E (apoE)(-/-)/transgenic mice carrying LacZ genes driven by an endothel...

journal_title：Circulation

authors： Foteinos G,Hu Y,Xiao Q,Metzler B,Xu Q

更新日期：2008-04-08 00:00:00

abstract：BACKGROUND:Transluminal stent-graft placement (TSGP) for aortic dissection is a relatively new procedure. We performed TSGPs to seal the primary entry site to treat and prevent complications of aortic dissection. The early to mid-term outcomes were analyzed. METHODS AND RESULTS:Thirty-seven patients with a primary int...

journal_title：Circulation

authors： Shimono T,Kato N,Yasuda F,Suzuki T,Yuasa U,Onoda K,Hirano T,Takeda K,Yada I

更新日期：2002-09-24 00:00:00

abstract：BACKGROUND:Electric stimulation of mediastinal sympathetic cardiac nerves increases cardiac contractility but is not selective for the left ventricle because it elicits sinus tachycardia and enhanced atrioventricular conduction. The aim of this study was to identify sympathetic neural structures inside the heart that s...

journal_title：Circulation

authors： Meyer C,Rana OR,Saygili E,Gemein C,Becker M,Nolte KW,Weis J,Schimpf T,Knackstedt C,Mischke K,Hoffmann R,Kelm M,Pauza D,Schauerte P

更新日期：2010-03-23 00:00:00

abstract：:In experimental animals, the calcium channel-blocking agents lessen the arrhythmogenic, ionic, metabolic, and electrical changes that occur during acute myocardial ischemia. To date, these effects have been studied separately, and the effects of these agents on local activation have not been correlated with ionic or m...

journal_title：Circulation

authors： Fleet WF,Johnson TA,Graebner CA,Engle CL,Gettes LS

更新日期：1986-04-01 00:00:00

abstract：:Twenty-three children with valvar or discrete subvalvar aortic stenosis underwent a controlled, progressive bicycle exercise test within 6 months before and 3-30 months after surgery for left ventricular outflow tract obstruction. The patients were divided into three groups according to the preoperative resting gradie...

journal_title：Circulation

authors： Whitmer JT,James FW,Kaplan S,Schwartz DC,Knight MJ

更新日期：1981-02-01 00:00:00

abstract：:The concept of plaque stabilization was developed to explain how lipid lowering could decrease adverse coronary events without a substantial reduction in the regression of atherosclerosis. Plaques were stabilized by reducing serum cholesterol leading to several favorable pathobiological changes in the vessel wall of l...

journal_title：Circulation

authors： Ambrose JA,Martinez EE

更新日期：2002-04-23 00:00:00

abstract：BACKGROUND:Mutations in the gene G4.5 result in a wide spectrum of severe infantile cardiomyopathic phenotypes, including isolated left ventricular noncompaction (LVNC), as well as Barth syndrome (BTHS) with dilated cardiomyopathy (DCM). The purpose of this study was to investigate patients with LVNC or BTHS for mutati...

journal_title：Circulation

authors： Ichida F,Tsubata S,Bowles KR,Haneda N,Uese K,Miyawaki T,Dreyer WJ,Messina J,Li H,Bowles NE,Towbin JA

更新日期：2001-03-06 00:00:00

abstract：BACKGROUND:The impact of mitral regurgitation (MR) on elderly patients (> or = 70 years) undergoing isolated aortic valve replacement (AVR) is not clearly defined. This study investigates the long-term effects of preoperative, moderate MR on survival and functional outcome in elderly AVR patients. METHODS AND RESULTS:...

journal_title：Circulation

authors： Barreiro CJ,Patel ND,Fitton TP,Williams JA,Bonde PN,Chan V,Alejo DE,Gott VL,Baumgartner WA

更新日期：2005-08-30 00:00:00

abstract：:To determine whether a ventricular (LV) end-systolic dimension (ESD) greater than or equal to 55 mm and LV left fractional shortening less than 25% are risk factors for aortic valve replacement (AVR) in patients with aortic insufficiency, we analyzed the clinical course and M-mode echocardiograms in 47 consecutive pat...

journal_title：Circulation

authors： Fioretti P,Roelandt J,Bos RJ,Meltzer RS,van Hoogenhuijze D,Serruys PW,Nauta J,Hugenholtz PG

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Cardiac allograft vascular disease is characterized by accelerated and diffuse intimal proliferation involving both the microvasculature and epicardial vessels. Because in vivo documentation of this complication is now possible with intracoronary ultrasound imaging, we can examine the relationship of intimal...

journal_title：Circulation

authors： Deng MC,Bell S,Huie P,Pinto F,Hunt SA,Stinson EB,Sibley R,Hall BM,Valantine HA

更新日期：1995-03-15 00:00:00

abstract：:The cellular electrophysiologic effects of myocardial ablation performed in vitro with argon laser energy were compared with those of high-energy electrical shocks. A border zone of injured but nonnecrotic tissue surrounding the site of energy delivery was present after tissue ablation by both energy modalities. A dec...

journal_title：Circulation

authors： Levine JH,Merillat JC,Stern M,Weisman HF,Kadish AH,Moore EN,Spear JF,Fonger J,Guarnieri T

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:The degree of protection provided to the right ventricle during retrograde continuous normothermic blood cardioplegia (RCNBC) remains controversial. The purpose of this study was to determine whether RCNBC is able to provide "adequate" nutritive flow to both ventricles to prevent ischemic metabolism in norma...

journal_title：Circulation

authors： Ye J,Sun J,Shen J,Gregorash L,Summers R,Salerno TA,Deslauriers R

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Coronary irradiation is a new concept to reduce restenosis. We evaluated the feasibility and safety of intracoronary irradiation with a balloon catheter filled with (188)Re, a liquid, high-energy beta-emitter. METHODS AND RESULTS:Irradiation with 15 Gy at 0.5-mm tissue depth was performed in 28 lesions afte...

journal_title：Circulation

authors： Höher M,Wöhrle J,Wohlfrom M,Hanke H,Voisard R,Osterhues HH,Kochs M,Reske SN,Hombach V,Kotzerke J

更新日期：2000-05-23 00:00:00

abstract：BACKGROUND:Hypercholesterolemic mice lacking factors required for activation of CD4+ T cells are characterized by reduced development of atherosclerosis. Consequently, it has been assumed that atherosclerosis involves loss of tolerance against modified self-antigens generated in response to hypercholesterolemia and tha...

journal_title：Circulation

authors： Wigren M,Rattik S,Yao Mattisson I,Tomas L,Grönberg C,Söderberg I,Alm R,Sundius L,Ljungcrantz I,Björkbacka H,Fredrikson GN,Nilsson J

更新日期：2019-05-28 00:00:00

abstract：BACKGROUND:Pulmonary vein (PV) -encircling radiofrequency ablation frequently is effective in vagal atrial fibrillation (AF), and there is evidence that PVs may be particularly prone to cholinergically induced arrhythmia mechanisms. However, PV ablation procedures also can affect intracardiac autonomic ganglia. The pre...

journal_title：Circulation

authors： Lemola K,Chartier D,Yeh YH,Dubuc M,Cartier R,Armour A,Ting M,Sakabe M,Shiroshita-Takeshita A,Comtois P,Nattel S

更新日期：2008-01-29 00:00:00

abstract：:We evaluated the accuracy of the recently reported technique of estimating intraventricular volume by measurement of intracavitary electrical conductance in six isolated, ejecting, canine left ventricles. Left ventricular volumes were measured directly by a previously validated servosystem that employed an electrocond...

journal_title：Circulation

authors： Burkhoff D,van der Velde E,Kass D,Baan J,Maughan WL,Sagawa K

更新日期：1985-08-01 00:00:00

abstract：:Previous studies in patients with sustained ventricular tachycardia (VT) have demonstrated the efficacy of surgical and catheter-mediated ablative procedures based on activation mapping during VT. Since extensive preoperative or intraoperative mapping may be impractical due to time constraints or patient intolerance, ...

journal_title：Circulation

authors： Miller JM,Marchlinski FE,Buxton AE,Josephson ME

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Although it has been suggested that elevation of CK-MB after percutaneous coronary intervention is associated with adverse clinical outcomes, limited data are available in the setting of coronary bypass grafting. The aim of the present study was to determine the incidence, predictors, and prognostic signific...

journal_title：Circulation

authors： Costa MA,Carere RG,Lichtenstein SV,Foley DP,de Valk V,Lindenboom W,Roose PC,van Geldorp TR,Macaya C,Castanon JL,Fernandez-Avilèz F,Gonzáles JH,Heyer G,Unger F,Serruys PW

更新日期：2001-11-27 00:00:00

abstract：:The amplitude and distribution of epicardial ST-segment elevation (ST) were examined for an 8-hour period after coronary occlusion in eight baboons and five pigs. ST was determined from unipolar epicardial electrograms obtained from a high-resolution matrix of fixed electrodes overlying a transmural region of ischemia...

journal_title：Circulation

authors： Smith GT,Geary G,Ruf W,Roelofs TH,McNamara JJ

更新日期：1979-10-01 00:00:00

abstract：:Over a 3 year period we evaluated 23 patients (16 men, seven women) with apical hypertrophic cardiomyopathy by noninvasive and invasive methods. Sixteen patients had chest pain. In 17, results of cardiovascular examination were normal. The electrocardiogram showed precordial inverted T waves in all patients and these ...

journal_title：Circulation

authors： Keren G,Belhassen B,Sherez J,Miller HI,Megidish R,Berenfeld D,Laniado S

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Smoking cessation is a key component of secondary cardiovascular disease prevention. Varenicline, a partial alpha4beta2 nicotinic acetylcholine receptor agonist, is effective for smoking cessation in healthy smokers, but its efficacy and safety in smokers with cardiovascular disease are unknown. METHODS AND...

journal_title：Circulation

authors： Rigotti NA,Pipe AL,Benowitz NL,Arteaga C,Garza D,Tonstad S

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:Although aspirin is an effective, inexpensive, and safe treatment of acute myocardial infarction, the frequency of use of aspirin in actual medical practice is not known. Elderly patients, a group with low rates of utilization of effective therapies such as thrombolytic therapy, also may be at risk of not re...

journal_title：Circulation

authors： Krumholz HM,Radford MJ,Ellerbeck EF,Hennen J,Meehan TP,Petrillo M,Wang Y,Kresowik TF,Jencks SF

更新日期：1995-11-15 00:00:00

abstract：:Frank lead vectorcardiograms (VCG) from four carefully selected patient subgroups (226 patients) were analyzed to develop optimal criteria for the diagnosis of anterior myocardial infarction. Specificity was evaluated using 100 healthy volunteers under age 30 and 80 patients with normal left ventriculogram and normal ...

journal_title：Circulation

authors： Starr JW,Wagner GS,Draffin RM,Reed JB,Walston A 2nd,Behar VS

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:Recent studies have identified critical roles for microRNAs (miRNAs) in a variety of cellular processes, including regulation of cardiomyocyte death. However, the signature of miRNA expression and possible roles of miRNA in the ischemic heart have been less well studied. METHODS AND RESULTS:We performed miR...

journal_title：Circulation

authors： Ren XP,Wu J,Wang X,Sartor MA,Jones K,Qian J,Nicolaou P,Pritchard TJ,Fan GC

更新日期：2009-05-05 00:00:00