Research related to medical treatment of cardiovascular disease.

abstract：BACKGROUND:Previous studies in animal models of angioplasty have suggested a role in neointimal hyperplasia for endothelins (ETs), potent vasoconstricting peptides that also exert growth-promoting effects. The present studies were undertaken to test the hypothesis that endothelin receptor blockade can reduce neointimal...

journal_title：Circulation

authors： Huckle WR,Drag MD,Acker WR,Powers M,McFall RC,Holder DJ,Walsh TF,Schwartz RS,Greenlee WJ,Johnson RG Jr

更新日期：2001-04-10 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS, or NOS2) reduces the severity of accelerated graft arteriosclerosis (AGA) in transplanted organs, although the precise mechanism is unclear. METHODS AND RESULTS:We transplanted wild-type murine hearts into either wild-type or NOS2-null recipient mice; we then measured ...

journal_title：Circulation

authors： Qian Z,Gelzer-Bell R,Yang Sx SX,Cao W,Ohnishi T,Wasowska BA,Hruban RH,Rodriguez ER,Baldwin WM 3rd,Lowenstein CJ

更新日期：2001-11-06 00:00:00

abstract：:The evidence supporting the thesis that hypertension can be prevented by eliminating salt from the diet is based on four principal sources: (1) epidemiological studies in unacculturated peoples showing that the prevalence of hypertension is inversely correlated with the degree of salt intake; (2) hemodynamic studies s...

journal_title：Circulation

authors： Freis ED

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:New methods of R-R interval variability based on fractal scaling and nonlinear dynamics ("chaos theory") may give new insights into heart rate dynamics. The aims of this study were to (1) systematically characterize and quantify the effects of aging from early childhood to advanced age on 24-hour heart rate ...

journal_title：Circulation

authors： Pikkujämsä SM,Mäkikallio TH,Sourander LB,Räihä IJ,Puukka P,Skyttä J,Peng CK,Goldberger AL,Huikuri HV

更新日期：1999-07-27 00:00:00

abstract：BACKGROUND:The cross-talk between vascular endothelial growth factor (VEGF)-A, angiopoietin (Ang), and VE-cadherin coregulates endothelial cell (EC) survival. Cardiac expression of VEGF-A but not its receptor KDR is blunted in dilated cardiomyopathy (DCM). Whether VE-cadherin/Ang function is affected in DCM is unknown....

journal_title：Circulation

authors： Schäfer R,Abraham D,Paulus P,Blumer R,Grimm M,Wojta J,Aharinejad S

更新日期：2003-09-30 00:00:00

abstract：:The acute coronary hemodynamic and metabolic effects of intravenous dipyridamole were studied in 13 patients. Total left ventricular (LV), anterior (supplied by the left anterior descending coronary artery) and inferior (supplied by circumflex and right coronary arteries) regional flows and metabolic responses were as...

journal_title：Circulation

authors： Feldman RL,Nichols WW,Pepine CJ,Conti CR

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Microvascular dysfunction posttreatment of stroke with recombinant human tissue-type plasminogen activator (rht-PA) constrains the therapeutic window to 3 hours. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) promote vascular thrombolysis and reduce the inflammation response. We therefo...

journal_title：Circulation

authors： Zhang L,Zhang ZG,Ding GL,Jiang Q,Liu X,Meng H,Hozeska A,Zhang C,Li L,Morris D,Zhang RL,Lu M,Chopp M

更新日期：2005-11-29 00:00:00

abstract：BACKGROUND:Adenosine can initiate ischemic preconditioning, and mitochondrial ATP-sensitive potassium (K(ATP)) channels have emerged as the likely effectors. We sought to determine the mechanistic interactions between these 2 observations. METHODS AND RESULTS:The mitochondrial flavoprotein oxidation induced by diazoxi...

journal_title：Circulation

authors： Sato T,Sasaki N,O'Rourke B,Marbán E

更新日期：2000-08-15 00:00:00

abstract：:Although immediate and late changes in coronary stenoses after percutaneous transluminal coronary angioplasty (PTCA) have been reported, most investigators have employed qualitative or semiquantitative techniques to analyze the angiograms. Such data is not optimal because of considerable interobserver variability and ...

journal_title：Circulation

authors： Johnson MR,Brayden GP,Ericksen EE,Collins SM,Skorton DJ,Harrison DG,Marcus ML,White CW

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Prosthetic valve thrombosis during pregnancy is life-threatening for mother and fetus, and the treatment of this complication is unclear. Cardiac surgery in pregnancy is associated with very high maternal and fetal mortality and morbidity. Thrombolytic therapy has rarely been used in these patients. The aim ...

journal_title：Circulation

authors： Özkan M,Çakal B,Karakoyun S,Gürsoy OM,Çevik C,Kalçık M,Oğuz AE,Gündüz S,Astarcioglu MA,Aykan AÇ,Bayram Z,Biteker M,Kaynak E,Kahveci G,Duran NE,Yıldız M

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Coronary heart disease (CHD) is the leading cause of morbidity and mortality in persons with type 2 diabetes mellitus (T2DM). Electron-beam computed tomography (EBCT) detects coronary artery calcium (CAC), a marker of atherosclerotic plaque. Few studies have described EBCT-defined CHD among ethnic minorities...

journal_title：Circulation

authors： Araneta MR,Barrett-Connor E

更新日期：2004-11-02 00:00:00

abstract：BACKGROUND:Whether the benefit in quality of life (QOL) after percutaneous coronary intervention depends on the severity of the stenosis as determined by fractional flow reserve (FFR) remains unknown. This study sought to investigate the relationship between FFR values and improvement in QOL. METHODS:From the FAME 1 a...

journal_title：Circulation

authors： Nishi T,Piroth Z,De Bruyne B,Jagic N,Möbius-Winkler S,Kobayashi Y,Derimay F,Fournier S,Barbato E,Tonino P,Jüni P,Pijls NHJ,Fearon WF

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Adenosine has several potentially cardioprotective effects. We hypothesized that the effects of endogenous adenosine vary with degree of ischemia and that elevating endogenous levels is protective. METHODS AND RESULTS:Isolated blood-perfused piglet hearts underwent 120 minutes of low-flow ischemia (10% flow...

journal_title：Circulation

authors： Sommerschild HT,Grund F,Offstad J,Jynge P,Ilebekk A,Kirkebøen KA

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Precise knowledge of the expected "normal" lumen diameter at a given coronary anatomic location is a first step toward developing a quantitative estimate of coronary disease severity that could be more useful than the traditional "percent stenosis." METHODS AND RESULTS:Eighty-three arteriograms were careful...

journal_title：Circulation

authors： Dodge JT Jr,Brown BG,Bolson EL,Dodge HT

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Indications for surgical correction of aortic regurgitation have been established mostly in men and have not been validated in women. The outcome of this surgical correction in women is unknown. METHODS AND RESULTS:Baseline characteristics and postoperative outcomes were compared between 51 women and 198 me...

journal_title：Circulation

authors： Klodas E,Enriquez-Sarano M,Tajik AJ,Mullany CJ,Bailey KR,Seward JB

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:There is an inverse relationship between HDL cholesterol and coronary heart disease. Experimental studies have indicated that HDL cholesterol may exert an antiatherogenic effect by inducing regression of atherosclerotic plaques and by turning lipid-rich plaques into more fibrotic lesions. In this prospective...

journal_title：Circulation

authors： Johnsen SH,Mathiesen EB,Fosse E,Joakimsen O,Stensland-Bugge E,Njølstad I,Arnesen E

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:Previous electrophysiological studies in patients with typical atrial flutter suggested that the slow conduction zone might be located in the low right atrial isthmus, which is a path formed by orifice of inferior vena cava, eustachian valve/ridge, coronary sinus ostium, and tricuspid annulus. The conduction...

journal_title：Circulation

authors： Tai CT,Chen SA,Chiang CE,Lee SH,Ueng KC,Wen ZC,Huang JL,Chen YJ,Yu WC,Feng AN,Chiou CW,Chang MS

更新日期：1997-10-21 00:00:00

abstract：BACKGROUND:Present therapies for acute coronary syndromes aim toward limiting platelet-platelet adhesion and aggregation processes. However, platelet-leukocyte interactions may contribute importantly to disease progression in the arterial wall. Recent studies suggest that prevention of platelet-leukocyte binding via P-...

journal_title：Circulation

authors： Sarma J,Laan CA,Alam S,Jha A,Fox KA,Dransfield I

更新日期：2002-05-07 00:00:00

abstract：BACKGROUND:Repolarization dispersion (Rd) is frequently mentioned as a predictor of cardiac abnormalities. We present a new measure of Rd based on the root-mean-square (RMS) curve of an ECG lead set and compare its performance with that of the commonly used QT dispersion (QTd) measure with the use of recovery times mea...

journal_title：Circulation

authors： Fuller MS,Sándor G,Punske B,Taccardi B,MacLeod RS,Ershler PR,Green LS,Lux RL

更新日期：2000-08-08 00:00:00

abstract：:Nonoperative therapy includes conservative noninterventional modalities and the endovascular interventional modalities of percutaneous transluminal angioplasty and a variety of laser systems and atherectomy devices. The role and impact of all nonoperative treatments are considered in the perspectives of the natural hi...

journal_title：Circulation

authors： Veith FJ,Gupta SK,Wengerter KR,Rivers SP,Bakal CW

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Specific transcription factors (TFs) modulate cardiac gene expression in murine models of heart failure, but their relevance in human subjects remains untested. We developed and applied a computational approach called transcriptional genomics to test the hypothesis that a discrete set of cardiac TFs is assoc...

journal_title：Circulation

authors： Hannenhalli S,Putt ME,Gilmore JM,Wang J,Parmacek MS,Epstein JA,Morrisey EE,Margulies KB,Cappola TP

更新日期：2006-09-19 00:00:00

abstract：:To evaluate possible occult myocardial disease in 18 patients whose only major manifestation of heart disease was spontaneous ventricular tachycardia or fibrillation, right ventricular endomyocardial biopsies were performed. None of the patients had symptoms of ischemic or congestive heart disease, and at catheterizat...

journal_title：Circulation

authors： Strain JE,Grose RM,Factor SM,Fisher JD

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:This study was designed to investigate whether collagen type I degradation is altered in patients with essential hypertension and whether this alteration could be related to disturbances in the serum matrix metalloproteinase pathway of collagen degradation. A second aim of the study was to assess whether som...

journal_title：Circulation

authors： Laviades C,Varo N,Fernández J,Mayor G,Gil MJ,Monreal I,Díez J

更新日期：1998-08-11 00:00:00

abstract：:Coronary artery bypass grafts, angioplasty, and thrombolysis are beneficial procedures for patients with coronary artery disease. However, these procedures can fail by mechanisms related to interactions between platelets and the damaged arterial wall. An experimental model for studying some of the mechanisms of platel...

journal_title：Circulation

authors： Folts J

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Temporal trends regarding the epidemiology of atherosclerotic renovascular disease (ARVD) in dialysis populations are poorly defined. METHODS AND RESULTS:United States Renal Data System data were used to identify patients aged 67 years or older at dialysis inception between 1996 and 2001 (n=146,973). Medica...

journal_title：Circulation

authors： Guo H,Kalra PA,Gilbertson DT,Liu J,Chen SC,Collins AJ,Foley RN

更新日期：2007-01-02 00:00:00

abstract：BACKGROUND:In patients with symptoms of heart failure, elevations in B-type natriuretic peptide (BNP) accurately identify ventricular dysfunction. However, BNP levels are not specific for ventricular dysfunction in patients who do not have overt symptoms of heart failure, suggesting that other cardiac processes such as...

journal_title：Circulation

authors： Bibbins-Domingo K,Ansari M,Schiller NB,Massie B,Whooley MA

更新日期：2003-12-16 00:00:00

abstract：BACKGROUND:The effects of carteolol, a nonselective beta-adrenergic receptor blocker with intrinsic sympathomimetic activity, were compared with those of metoprolol in a murine model of viral myocarditis and dilated cardiomyopathy caused by encephalomyocarditis virus. METHODS AND RESULTS:In the acute experiment, BALB/...

journal_title：Circulation

authors： Tominaga M,Matsumori A,Okada I,Yamada T,Kawai C

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Cardiac allograft arteriosclerosis is a complex process of alloimmune response, chronic inflammation, and smooth muscle cell proliferation that includes cross talk between cytokines and growth factors. METHODS AND RESULTS:Our results in rat cardiac allografts established alloimmune response as an alternativ...

journal_title：Circulation

authors： Lemström KB,Krebs R,Nykänen AI,Tikkanen JM,Sihvola RK,Aaltola EM,Häyry PJ,Wood J,Alitalo K,Ylä-Herttuala S,Koskinen PK

更新日期：2002-05-28 00:00:00

abstract：BACKGROUND:The transient outward potassium current (I(to)) encoded by the Kv4 family of potassium channels is important in the repolarization of cardiac myocytes. KChIPs are a recently identified group of Ca2+-binding accessory subunits that modulate Kv4-encoded currents. KChIP2 is the only family member expressed in t...

journal_title：Circulation

authors： Deschênes I,DiSilvestre D,Juang GJ,Wu RC,An WF,Tomaselli GF

更新日期：2002-07-23 00:00:00

abstract：BACKGROUND:Inhibitors of adenosine membrane transport cause vasodilation and enhance the plasma adenosine concentration. However, it is unclear why the plasma adenosine concentration rises rather than falls when membrane transport is inhibited. We tested the hypothesis that the cytosolic adenosine concentration exceeds...

journal_title：Circulation

authors： Deussen A,Stappert M,Schäfer S,Kelm M

更新日期：1999-04-20 00:00:00