Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications.

abstract：BACKGROUND:Little information is available regarding the occurrence of perioperative and late cardiac events in women with vascular disease. The current study was performed to examine whether sex-specific differences exist in these outcomes in a large population of vascular surgery patients and to determine the value o...

journal_title：Circulation

authors： Hendel RC,Chen MH,L'Italien GJ,Newell JB,Paul SD,Eagle KA,Leppo JA

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:Mitral regurgitation (MR) generally accompanies inferobasal myocardial infarction (MI), with leaflet tethering by displaced papillary muscles. Mitral regurgitation is also reported with anteroapical MI without global dilatation or inferior wall motion abnormalities. We hypothesized that anteroapical MI exten...

journal_title：Circulation

authors： Yosefy C,Beeri R,Guerrero JL,Vaturi M,Scherrer-Crosbie M,Handschumacher MD,Levine RA

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:During ischemia, the intracellular calcium and inorganic phosphate (P(i)) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial r...

journal_title：Circulation

authors： van Der Velden J,Klein LJ,Zaremba R,Boontje NM,Huybregts MA,Stooker W,Eijsman L,de Jong JW,Visser CA,Visser FC,Stienen GJ

更新日期：2001-09-04 00:00:00

abstract：:Adults are living longer, and cardiovascular disease is endemic in the growing population of older adults who are surviving into old age. Functional capacity is a key metric in this population, both for the perspective it provides on aggregate health and as a vital goal of care. Whereas cardiorespiratory function has ...

journal_title：Circulation

authors： Forman DE,Arena R,Boxer R,Dolansky MA,Eng JJ,Fleg JL,Haykowsky M,Jahangir A,Kaminsky LA,Kitzman DW,Lewis EF,Myers J,Reeves GR,Shen WK,American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and St

更新日期：2017-04-18 00:00:00

abstract：BACKGROUND:Cellular transplantation is emerging as a promising strategy for the treatment of postinfarction ventricular dysfunction. Whether its beneficial effects can be extended to other cardiomyopathies remains an unexplored question. We evaluated the histological and functional effects of simultaneous autologous tr...

journal_title：Circulation

authors： Guarita-Souza LC,Carvalho KA,Woitowicz V,Rebelatto C,Senegaglia A,Hansen P,Miyague N,Francisco JC,Olandoski M,Faria-Neto JR,Brofman P

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Patients with bicuspid aortic valve (AV) stenosis were excluded from the pivotal evaluations of transcatheter AV replacement (TAVR) devices. We sought to evaluate the outcomes of TAVR in patients with bicuspid AV stenosis in comparison with those with tricuspid AV stenosis. METHODS:We used data from the Soc...

journal_title：Circulation

authors： Halim SA,Edwards FH,Dai D,Li Z,Mack MJ,Holmes DR,Tuzcu EM,Thourani VH,Harrison JK,Brennan JM

更新日期：2020-03-31 00:00:00

abstract：BACKGROUND:Right ventricular free wall (RVFW) ischemia impairs global RV performance and may result in acute hemodynamic compromise. However, RV function and hemodynamic performance typically improve spontaneously over time. This study was designed to determine whether reperfusion facilitates recovery of function in th...

journal_title：Circulation

authors： Laster SB,Ohnishi Y,Saffitz JE,Goldstein JA

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic responses. Here, we investigated the role of Sirt7 in cardiovascular tissue repair process. METHODS AND RESULTS:In wild-type mice, Sirt7 expression increa...

journal_title：Circulation

authors： Araki S,Izumiya Y,Rokutanda T,Ianni A,Hanatani S,Kimura Y,Onoue Y,Senokuchi T,Yoshizawa T,Yasuda O,Koitabashi N,Kurabayashi M,Braun T,Bober E,Yamagata K,Ogawa H

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly understood. METHODS AND RESULTS:We used a forward genetic screen in zebrafish to identify novel genes required for myocardial fu...

journal_title：Circulation

authors： Knöll R,Postel R,Wang J,Krätzner R,Hennecke G,Vacaru AM,Vakeel P,Schubert C,Murthy K,Rana BK,Kube D,Knöll G,Schäfer K,Hayashi T,Holm T,Kimura A,Schork N,Toliat MR,Nürnberg P,Schultheiss HP,Schaper W,Schaper J,

更新日期：2007-07-31 00:00:00

abstract：:We studied 14 patients to determine whether sustained-release diltiazem is a satisfactory long-term substitute for the combination of propranolol plus hydrochlorothiazide (HCTZ), control phase, in the treatment of systemic hypertension with coexisting chronic stable angina pectoris. All patients had either one- or two...

journal_title：Circulation

authors： Kawanishi DT,Reid CL,Gonzales A,O'Rourke RA,Rahimtoola SH

更新日期：1989-12-01 00:00:00

abstract：:Acute occlusion of the circumflex branch of the left coronary artery was produced in chronically instrumented conscious dogs. Tracer microspheres were used to measure during an established time period, the distribution of collateral flow within the infarcting myocardium. For up to 2 hours after coronary occlusion the ...

journal_title：Circulation

authors： Schaper W,Pasyk S

更新日期：1976-03-01 00:00:00

abstract：:Mitral valve closure during cardiopulmonary resuscitation may result from direct cardiac compression. An alternative hypothesis is that with a rise in intrathoracic pressure, mitral valve closure can occur but may be influenced by whether the lungs are inflated or deflated. To test this hypothesis, we placed a large-b...

journal_title：Circulation

authors： Halperin HR,Weiss JL,Guerci AD,Chandra N,Tsitlik JE,Brower R,Beattie C,Wurmb E,Cadden J,Weisfeldt ML

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation in the diseased heart. However, the roles...

journal_title：Circulation

authors： Chen S,Zhang Y,Lighthouse JK,Mickelsen DM,Wu J,Yao P,Small EM,Yan C

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:The associations between pregnancy hypertensive disorders and common cardiovascular disorders have not been investigated at scale in a contemporaneous population. We aimed to investigate the association between preeclampsia, hypertensive disorders of pregnancy, and subsequent diagnosis of 12 different cardio...

journal_title：Circulation

authors： Leon LJ,McCarthy FP,Direk K,Gonzalez-Izquierdo A,Prieto-Merino D,Casas JP,Chappell L

更新日期：2019-09-24 00:00:00

abstract：BACKGROUND:Radiofrequency ablation of the atrioventricular node and permanent pacing are used for symptomatic relief in patients with medically refractory atrial fibrillation. In this study, meta-analysis was used to clarify clinical outcomes and survival after ablation and pacing therapy using data from the published ...

journal_title：Circulation

authors： Wood MA,Brown-Mahoney C,Kay GN,Ellenbogen KA

更新日期：2000-03-14 00:00:00

abstract：BACKGROUND:The pulmonary circulation is an important site for the production and clearance of endothelin (ET)-1, a potent vasoactive and mitogenic peptide. Increased plasma ET-1 levels are observed in pulmonary arterial hypertension (PHT) and may contribute to the regulation of pulmonary vascular resistance, as well as...

journal_title：Circulation

authors： Bauer M,Wilkens H,Langer F,Schneider SO,Lausberg H,Schäfers HJ

更新日期：2002-03-05 00:00:00

abstract：:To elucidate the mechanism of regional hemostasis in the left ventricular (LV) cavity during myocardial infarction, the blood pathway in LV cavity was examined with contrast echocardiography injected from the left atrium before and after coronary ligation in nine canines. Before coronary ligation, contrast echoes spre...

journal_title：Circulation

authors： Beppu S,Izumi S,Miyatake K,Nagata S,Park YD,Sakakibara H,Nimura Y

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:The heart can synthesize epinephrine. Homogenates of rat heart, which contain the enzymes phenylethanolamine N-methyltransferase (PNMT) and nonspecific N-methyltransferase (NMT), methylate norepinephrine to form epinephrine. The cardiac atrium contains primarily PNMT and the cardiac ventricle contains both P...

journal_title：Circulation

authors： Kennedy B,Ziegler MG

更新日期：1991-08-01 00:00:00

abstract：:In patients treated with sulfinpyrazone, an apparent reduction in the incidence of sudden death and presumed ventricular fibrillation has been reported. Using an intact animal model without microcirculatory thrombosis, we studied the effects of sulfinpyrazone on ischemic myocardium in 58 anesthetized dogs divided into...

journal_title：Circulation

authors： Moschos CB,Escobinas AJ,Jorgensen OB Jr,Regan TJ

更新日期：1981-07-01 00:00:00

abstract：:The status of radioactive tracer studies in cardiovascular diagnosis is summarized. Planning guidelines are suggested for a hospital nuclear medical service including a central nuclear medical facility and satellite units, and resource criteria are given for professional personnel including training and duties, equipm...

journal_title：Circulation

authors： Adelstein SJ,Jansen C,Wagner HN Jr

更新日期：1975-07-01 00:00:00

abstract：:To define the role of portable two-dimensional echocardiography (2-D echo) in the immediate diagnosis of acute chest pain syndrome, 80 consecutive patients were studied. Adequate 2-D echo studies were obtained in 65 (81%). Thirty-three patients had clinical evidence of transmural or nontransmural acute myocardial infa...

journal_title：Circulation

authors： Horowitz RS,Morganroth J,Parrotto C,Chen CC,Soffer J,Pauletto FJ

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND:Among patients with documented stable coronary artery disease and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and fractional flow reserve (FFR) in predicting natural history. METHODS:The present analysis included the 607 patients from ...

journal_title：Circulation

authors： Ciccarelli G,Barbato E,Toth GG,Gahl B,Xaplanteris P,Fournier S,Milkas A,Bartunek J,Vanderheyden M,Pijls N,Tonino P,Fearon WF,Jüni P,De Bruyne B

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. METHODS:We applied a liquid chromatography-tandem mass spectrometry metabolomics platfor...

journal_title：Circulation

authors： Paynter NP,Balasubramanian R,Giulianini F,Wang DD,Tinker LF,Gopal S,Deik AA,Bullock K,Pierce KA,Scott J,Martínez-González MA,Estruch R,Manson JE,Cook NR,Albert CM,Clish CB,Rexrode KM

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:We hypothesized that a simple, unmeasured posterior annuloplasty technique (two thirds of a 27-mm Duran ring) offered advantages of standardization and ease of insertion. METHODS AND RESULTS:A consecutive series of all patients (n = 418; median age, 67 years) having mitral valve repair performed by two surg...

journal_title：Circulation

authors： Odell JA,Schaff HV,Orszulak TA

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection. METHODS AND RESULTS:In one series, 129/SvJ-derived mouse ESCs (ES-D3 line) were transplanted by direct myocardial injection (1 x 10(6) c...

journal_title：Circulation

authors： Swijnenburg RJ,Tanaka M,Vogel H,Baker J,Kofidis T,Gunawan F,Lebl DR,Caffarelli AD,de Bruin JL,Fedoseyeva EV,Robbins RC

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:Sudden Unexplained Death Syndrome (SUDS) is the leading cause of death in young, healthy, Southeast Asian men. The role of an implantable cardioverter defibrillator (ICD) for mortality reduction in these patients remains unclear. METHODS AND RESULTS:The Defibrillator Versus beta-Blockers for Unexplained Dea...

journal_title：Circulation

authors： Nademanee K,Veerakul G,Mower M,Likittanasombat K,Krittayapong R,Bhuripanyo K,Sitthisook S,Chaothawee L,Lai MY,Azen SP

更新日期：2003-05-06 00:00:00

abstract：BACKGROUND:There are few data regarding medium-term outcome of coronary artery bypass grafting (CABG) in patients with severe left ventricular (LV) systolic dysfunction, particularly in the modern era, and even less assessing preoperative factors that might identify patients at highest risk. METHODS AND RESULTS:Three ...

journal_title：Circulation

authors： Hillis GS,Zehr KJ,Williams AW,Schaff HV,Orzulak TA,Daly RC,Mullany CJ,Rodeheffer RJ,Oh JK

更新日期：2006-07-04 00:00:00

abstract：:These types of studies lay the foundation for understanding the human apolipoproteins at the genetic level. In addition, through a few specific examples, we have already shown evidence at the DNA level that lesions in apolipoprotein genes can play a role in human atherosclerosis. This work is in its infancy, but we ho...

journal_title：Circulation

authors： Breslow JL

更新日期：1984-06-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the hallmark of HFpEF and appears to be caused by both cardiac and peripheral abnormalities in the arterial tree and skeletal muscle. Mitochondrial abno...

journal_title：Circulation

authors： Kumar AA,Kelly DP,Chirinos JA

更新日期：2019-03-12 00:00:00

abstract：BACKGROUND:AL amyloidosis with heart failure is associated with decreased longitudinal myocardial contraction measured by pulsed tissue Doppler imaging. We sought to clarify whether new modalities of myocardial strain Doppler (change in length per unit length) or strain rate (the temporal derivative of strain) were mor...

journal_title：Circulation

authors： Koyama J,Ray-Sequin PA,Falk RH

更新日期：2003-05-20 00:00:00