Augmentation of left ventricular contractility by cardiac sympathetic neural stimulation.

abstract：BACKGROUND:The pathobiological basis of ischemic heart disease and thus the manifestations and response to therapy can differ between women and men. In prior studies, sex-based treatment differences have been observed with the antiischemic ranolazine, with a possibly diminished effect in women. METHODS AND RESULTS:We ...

journal_title：Circulation

authors： Mega JL,Hochman JS,Scirica BM,Murphy SA,Sloan S,McCabe CH,Merlini P,Morrow DA

更新日期：2010-04-27 00:00:00

abstract：:The formula for survival in resuscitation describes educational efficiency and local implementation as key determinants in survival after cardiac arrest. Current educational offerings in the form of standardized online and face-to-face courses are falling short, with providers demonstrating a decay of skills over time...

journal_title：Circulation

authors： Cheng A,Nadkarni VM,Mancini MB,Hunt EA,Sinz EH,Merchant RM,Donoghue A,Duff JP,Eppich W,Auerbach M,Bigham BL,Blewer AL,Chan PS,Bhanji F,American Heart Association Education Science Investigators; and on behalf of the American

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:There is no published randomized study comparing amiodarone therapy and radiofrequency catheter ablation (RFA) after only 1 episode of symptomatic atrial flutter (AFL). The aim of the Loire-Ardèche-Drôme-Isère-Puy-de-Dôme (LADIP) Trial of Atrial Flutter was 2-fold: (1) to prospectively compare first-line RFA...

journal_title：Circulation

authors： Da Costa A,Thévenin J,Roche F,Romeyer-Bouchard C,Abdellaoui L,Messier M,Denis L,Faure E,Gonthier R,Kruszynski G,Pages JM,Bonijoly S,Lamaison D,Defaye P,Barthélemy JC,Gouttard T,Isaaz K,Loire-Ardèche-Drôme-Isère-Puy-de-D

更新日期：2006-10-17 00:00:00

abstract：BACKGROUND:Autoantibodies against the beta 1-adrenoceptor have been detected in the sera of patients with idiopathic dilated cardiomyopathy (DCM). The mechanisms by which these autoantibodies can alter normal receptor function are investigated, and the results are interpreted in the light of the beneficial effects of b...

journal_title：Circulation

authors： Magnusson Y,Wallukat G,Waagstein F,Hjalmarson A,Hoebeke J

更新日期：1994-06-01 00:00:00

abstract：:The radial artery (RA) is a commonly used conduit for coronary artery bypass grafting, and recent studies have demonstrated that it provides superior long-term patency rates to the saphenous vein in most situations. In addition, the RA is also being used with increasing frequency as the access point for coronary angio...

journal_title：Circulation

authors： Mounsey CA,Mawhinney JA,Werner RS,Taggart DP

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Airborne particulate matter has been linked to excess morbidity and mortality. Recent attention has focused on the effects of particulate exposure on cardiac autonomic control. Inhaled particulates may affect the autonomic nervous system either directly, by eliciting a sympathetic stress response, or indirec...

journal_title：Circulation

authors： Magari SR,Hauser R,Schwartz J,Williams PL,Smith TJ,Christiani DC

更新日期：2001-08-28 00:00:00

abstract：BACKGROUND:We sought to separately examine the effects of either weight loss or diets varying in protein content and glycemic index without further changes in body weight on cardiovascular risk factors within the Diet, Obesity, and Genes study (DiOGenes). METHODS AND RESULTS:DiOGenes is a pan-European controlled dieta...

journal_title：Circulation

authors： Gögebakan O,Kohl A,Osterhoff MA,van Baak MA,Jebb SA,Papadaki A,Martinez JA,Handjieva-Darlenska T,Hlavaty P,Weickert MO,Holst C,Saris WH,Astrup A,Pfeiffer AF,DiOGenes.

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice that overexpress HSP72 demonstrate improved functional recovery and decreased inf...

journal_title：Circulation

authors： Hutter JJ,Mestril R,Tam EK,Sievers RE,Dillmann WH,Wolfe CL

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients. METHODS AND RESULTS:We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoprotein...

journal_title：Circulation

authors： Deguchi H,Pecheniuk NM,Elias DJ,Averell PM,Griffin JH

更新日期：2005-08-09 00:00:00

abstract：BACKGROUND:Apoptotic microparticles are responsible for almost all tissue factor activity of the plaque lipid core. We hypothesized that elevated levels of procoagulant microparticles could also circulate in the peripheral blood of patients with recent clinical signs of plaque disruption and thrombosis. METHODS AND RE...

journal_title：Circulation

authors： Mallat Z,Benamer H,Hugel B,Benessiano J,Steg PG,Freyssinet JM,Tedgui A

更新日期：2000-02-29 00:00:00

abstract：BACKGROUND:Perioperative management of patients with complete mixing of pulmonary and systemic blood centers on approximately equating pulmonary (Qp) and systemic (Qs) blood flow (Qp/Qs approximately 1). This empirically derived target is opposed by theoretical studies advocating a target Qp/Qs well below 1. We studied...

journal_title：Circulation

authors： Francis DP,Willson K,Thorne SA,Davies LC,Coats AJ

更新日期：1999-11-23 00:00:00

abstract：BACKGROUND:Although the dominant product of vascular Cyclooxygenase-2 (COX-2), prostacyclin (PGI(2)), restrains atherogenesis, inhibition and deletion of COX-2 have yielded conflicting results in mouse models of atherosclerosis. Floxed mice were used to parse distinct cellular contributions of COX-2 in macrophages and ...

journal_title：Circulation

authors： Hui Y,Ricciotti E,Crichton I,Yu Z,Wang D,Stubbe J,Wang M,Puré E,FitzGerald GA

更新日期：2010-06-22 00:00:00

abstract：:A lack in prostacyclin (PGI2) production due to atherosclerosis may play a role in the pathophysiology of some of the clinical manifestations of ischemic heart disease and in particular, of coronary vasospasm. We therefore evaluated the effects of i.v. PGI2 in nine patients with variant angina and six normal volunteer...

journal_title：Circulation

authors： Chierchia S,Patrono C,Crea F,Ciabattoni G,De Caterina R,Cinotti GA,Distante A,Maseri A

更新日期：1982-03-01 00:00:00

abstract：:The electrophysiologic mechanisms for the initiation and termination of re-entrant ventricular arrhythmias (RVA) were critically analyzed in dogs 3-7 days following ligation of the anterior descending coronary artery, utilizing direct recordings of the re-entrant pathway (RP) from the epicardial surface of the infarct...

journal_title：Circulation

authors： El-Sherif N,Hope RR,Scherlag BJ,Lazzara R

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:The age association of cardiovascular disease may be in part because its metabolic risk factors tend to rise with age. Few studies have analyzed age associations of multiple metabolic risks in the same population, especially in nationally representative samples. We examined worldwide variations in the age as...

journal_title：Circulation

authors： Singh GM,Danaei G,Pelizzari PM,Lin JK,Cowan MJ,Stevens GA,Farzadfar F,Khang YH,Lu Y,Riley LM,Lim SS,Ezzati M

更新日期：2012-05-08 00:00:00

abstract：BACKGROUND:We have developed a new measure of myocardial viability, the water-perfusable tissue index (PTI), which is calculated from transmission, C15O, and H2(15)O positron emission tomography (PET) data sets. It is defined as the proportion of the total anatomical tissue within a given region of interest (ROI) that ...

journal_title：Circulation

authors： Yamamoto Y,de Silva R,Rhodes CG,Araujo LI,Iida H,Rechavia E,Nihoyannopoulos P,Hackett D,Galassi AR,Taylor CJ

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Beta-blockers improve clinical outcome when administered early after acute myocardial infarction. However, whether beta-blockers actually reduce the myocardial infarction size is still in dispute. Cardiac magnetic resonance imaging can accurately depict the left ventricular (LV) ischemic myocardium at risk (...

journal_title：Circulation

authors： Ibanez B,Prat-González S,Speidl WS,Vilahur G,Pinero A,Cimmino G,García MJ,Fuster V,Sanz J,Badimon JJ

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:Drug-induced QT interval prolongation, a risk factor for life-threatening ventricular arrhythmias, is a potential side effect of many marketed and withdrawn medications. The contribution of common genetic variants previously associated with baseline QT interval to drug-induced QT prolongation and arrhythmias...

journal_title：Circulation

authors： Strauss DG,Vicente J,Johannesen L,Blinova K,Mason JW,Weeke P,Behr ER,Roden DM,Woosley R,Kosova G,Rosenberg MA,Newton-Cheh C

更新日期：2017-04-04 00:00:00

abstract：BACKGROUND:To date, the uptake of drugs into the human heart by transport proteins is poorly understood. A candidate protein is the organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent transport protein for carnitine. We investigated expression and localization of OCTN...

journal_title：Circulation

authors： Grube M,Meyer zu Schwabedissen HE,Präger D,Haney J,Möritz KU,Meissner K,Rosskopf D,Eckel L,Böhm M,Jedlitschky G,Kroemer HK

更新日期：2006-02-28 00:00:00

abstract：:Three patients developed late pulmonary vein obstruction (PVO) following Mustard's operation for transposition of the great arteries. In all three the absence of PVO had been documented by an earlier postoperative cardiac catheterization. At reoperation shrinkage and kinking of the dacron baffle was evident. After Mus...

journal_title：Circulation

authors： Driscoll DJ,Nihill MR,Vargo TA,Mullins CE,McNamara DG

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:To assess the extent and nature of the dysfunction surrounding aneurysms of the left ventricle (LV), we examined the parameters of local and global three-dimensional shape, size, and function of LVs of eight patients with histologically confirmed anterior fibrous aneurysms. METHODS AND RESULTS:Three-dimensi...

journal_title：Circulation

authors： Lessick J,Sideman S,Azhari H,Marcus M,Grenadier E,Beyar R

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:In patients with severe congestive heart failure (CHF), short-term administration of dobutamine exerts sustained clinical benefits that are partially mediated by a training-like effect on skeletal muscle. Recently, physical training has been shown to enhance endothelial function in the skeletal muscle vascul...

journal_title：Circulation

authors： Patel MB,Kaplan IV,Patni RN,Levy D,Strom JA,Shirani J,LeJemtel TH

更新日期：1999-01-05 00:00:00

abstract：BACKGROUND:The clinical significance of the interaction between clopidogrel and proton pump inhibitors (PPIs) remains unclear. METHODS AND RESULTS:We examined the relationship between PPI use and 1-year cardiovascular events (cardiovascular death, myocardial infarction, or stroke) in patients with acute coronary syndr...

journal_title：Circulation

authors： Goodman SG,Clare R,Pieper KS,Nicolau JC,Storey RF,Cantor WJ,Mahaffey KW,Angiolillo DJ,Husted S,Cannon CP,James SK,Kilhamn J,Steg PG,Harrington RA,Wallentin L,Platelet Inhibition and Patient Outcomes Trial Investigators.

更新日期：2012-02-28 00:00:00

abstract：BACKGROUND:The excess risk of atherosclerosis among patients with non-insulin dependent diabetes mellitus (NIDDM) is well documented. However, the presence of conventional risk factors cannot fully account for this excess risk, and the underlying mechanism remains to be elucidated. The present study prospectively evalu...

journal_title：Circulation

authors： Austin MA,Mykkänen L,Kuusisto J,Edwards KL,Nelson C,Haffner SM,Pyörälä K,Laakso M

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Functional mitral regurgitation (MR) is common in patients with heart failure and left ventricular (LV) dysfunction, and its severity may vary over time, depending primarily on the loading conditions. Because dynamic changes in the severity of functional MR may affect forward stroke volume, we hypothesized t...

journal_title：Circulation

authors： Lapu-Bula R,Robert A,Van Craeynest D,D'Hondt AM,Gerber BL,Pasquet A,Melin JA,De Kock M,Vanoverschelde JL

更新日期：2002-09-10 00:00:00

abstract：:Nineteen patients with chronic low output cardiac failure were studied before, during and after infusion of phentolamine in doses of 10, 20, 30 and 40 microgram/kg/min. Significant reduction of left- and right-sided pressures and increases in cardiac index and heart rate (HR) were present within 15 minutes of starting...

journal_title：Circulation

authors： Stern MA,Gohlke HK,Loeb HS,Croke RP,Gunnar RM

更新日期：1978-07-01 00:00:00

abstract：:Of 1,801 patients in the 1985-1986 Percutaneous Transluminal Coronary Angioplasty (PTCA) Registry, 122 (6.8%) had periprocedural occlusion (4.9% in the catheterization laboratory, 1.9% outside the laboratory). Baseline patient factors independently associated with increased occlusion rates included triple-vessel disea...

journal_title：Circulation

authors： Detre KM,Holmes DR Jr,Holubkov R,Cowley MJ,Bourassa MG,Faxon DP,Dorros GR,Bentivoglio LG,Kent KM,Myler RK

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:During ischemia, the intracellular calcium and inorganic phosphate (P(i)) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial r...

journal_title：Circulation

authors： van Der Velden J,Klein LJ,Zaremba R,Boontje NM,Huybregts MA,Stooker W,Eijsman L,de Jong JW,Visser CA,Visser FC,Stienen GJ

更新日期：2001-09-04 00:00:00

abstract：PURPOSE:The Kantrowitz CardioVAD (KCV) is an electrically powered, pneumatically driven circulatory assist device which provides diastolic augmentation and systolic unloading to the failing heart. It consists of a 60cc-pumping chamber, a percutaneous access device (PAD), and an external controller. The pumping chamber,...

journal_title：Circulation

authors： Jeevanandam V,Jayakar D,Anderson AS,Martin S,Piccione W Jr,Heroux AL,Wynne J,Stephenson LW,Hsu J,Freed PS,Kantrowitz A

更新日期：2002-09-24 00:00:00

abstract：BACKGROUND:The characteristics of transmembrane potential (TMP) at the core of functional reentry in the atrium are not well understood. METHODS AND RESULTS:In protocol 1 (11 dogs), isolated perfused canine right atria were mapped from the endocardial surface while simultaneous TMPs were recorded from the epicardial s...

journal_title：Circulation

authors： Athill CA,Ikeda T,Kim YH,Wu TJ,Fishbein MC,Karagueuzian HS,Chen PS

更新日期：1998-10-13 00:00:00