A new strategy for the assessment of viable myocardium and regional myocardial blood flow using 15O-water and dynamic positron emission tomography.

abstract：BACKGROUND:Although a major role of coronary thrombosis in the pathogenesis of unstable angina has been demonstrated, the results of a series of studies have suggested that activation of the hemostatic system may not be confined to ischemic episodes. The purpose of this study was to investigate the temporal relation be...

journal_title：Circulation

authors： Biasucci LM,Liuzzo G,Caligiuri G,Quaranta G,Andreotti F,Sperti G,van de Greef W,Rebuzzi AG,Kluft C,Maseri A

更新日期：1996-06-15 00:00:00

abstract：BACKGROUND:We postulated that the variability of the phase shift between blood pressure and heart rate fluctuation near the frequency of 0.10 Hz might be useful in assessing autonomic circulatory control. METHODS AND RESULTS:We tested this hypothesis in 4 groups of subjects: 28 young, healthy individuals; 13 elderly h...

journal_title：Circulation

authors： Halámek J,Kára T,Jurák P,Soucek M,Francis DP,Davies LC,Shen WK,Coats AJ,Novák M,Nováková Z,Panovský R,Toman J,Sumbera J,Somers VK

更新日期：2003-07-22 00:00:00

abstract：BACKGROUND:The rate of coronary heart disease (CHD) mortality in eastern Finland has been the highest in the world. The official mortality statistics suggest, however, that is has declined by 60% during the past 20 years. The aim of the present study was to examine the contributions of incidence, recurrence, and case f...

journal_title：Circulation

authors： Salomaa V,Miettinen H,Kuulasmaa K,Niemelä M,Ketonen M,Vuorenmaa T,Lehto S,Palomäki P,Mähönen M,Immonen-Räihä P,Arstila M,Kaarsalo E,Mustaniemi H,Torppa J,Tuomilehto J,Puska P,Pyörälä K

更新日期：1996-12-15 00:00:00

abstract：BACKGROUND:The first compounds considered for stent-based delivery, such as heparin, were chosen on the basis of promising tissue culture and animal experiments, and yet they have failed to stop restenosis clinically. More recent compounds, such as paclitaxel, are of a different sort, being hydrophobic in nature, and t...

journal_title：Circulation

authors： Hwang CW,Wu D,Edelman ER

更新日期：2001-07-31 00:00:00

abstract：BACKGROUND:Clinical studies have implicated preinfarct angina (brief antecedent ischemia/reperfusion [I/R]) as a predictor of more rapid thrombolysis and lower rates of reocclusion. However, the effects of antecedent ischemia on the efficacy of thrombolysis have not been rigorously assessed. Using a canine model of cor...

journal_title：Circulation

authors： Przyklenk K,Whittaker P

更新日期：2000-07-04 00:00:00

abstract：BACKGROUND:Epidemiological studies have identified clinical and echocardiographic factors associated with increased stroke risk in atrial fibrillation (AF), but mechanisms linking these factors to stroke in AF are incompletely understood. We hypothesized that stroke risk factors may be associated with increased endothe...

journal_title：Circulation

authors： Conway DS,Pearce LA,Chin BS,Hart RG,Lip GY

更新日期：2002-10-08 00:00:00

abstract：BACKGROUND:Conventional x-ray angiography frequently underestimates the true burden of atherosclerosis. Although intravascular ultrasound allows for imaging of coronary plaque, this invasive technique is inappropriate for screening or serial examinations. We therefore sought to develop a noninvasive free-breathing MR t...

journal_title：Circulation

authors： Botnar RM,Stuber M,Kissinger KV,Kim WY,Spuentrup E,Manning WJ

更新日期：2000-11-21 00:00:00

abstract：:Between July 1980 and November 1982, there were 935 coronary angioplasties attempted at Emory University Hospital. Of these patients, 20 developed acute occlusion. Of these 20, 19 presented within 3 hr of surgery or within 3 hr after stopping a continuous heparin infusion. Five patients required emergency surgery, but...

journal_title：Circulation

authors： Hollman J,Gruentzig AR,Douglas JS Jr,King SB 3rd,Ischinger T,Meier B

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Ambulatory outpatients (n = 150) with a history of paroxysmal supraventricular arrhythmia were studied to establish the characteristics of the first recurrence of symptomatic tachycardia (time to first recurrence, heart rate during tachycardia, and observed rhythm that was regular versus irregular) when no a...

journal_title：Circulation

authors： Clair WK,Wilkinson WE,McCarthy EA,Page RL,Pritchett EL

更新日期：1993-04-01 00:00:00

abstract：:Since the discovery that neuregulin-1 (NRG-1)/ErbB signaling is indispensable in cardiac development, evidence has shown that this system also plays a crucial role in the adult heart. In patients, an inhibitory ErbB2 antibody, trastuzumab, used in the treatment of mammary carcinomas, increases the risk for the develop...

journal_title：Circulation

authors： Lemmens K,Doggen K,De Keulenaer GW

更新日期：2007-08-21 00:00:00

abstract：BACKGROUND:Previous experimental studies have shown that the effect of serotonin on a coronary stenosis depends on whether that stenosis is compliant or fixed. However, the relation between coronary stenosis morphology and the response to serotonin in patients with angina is not known. METHODS AND RESULTS:Using comput...

journal_title：Circulation

authors： Tousoulis D,Davies G,McFadden E,Clarke J,Kaski JC,Maseri A

更新日期：1993-10-01 00:00:00

abstract：:Variations in the frequency of ventricular premature depolarizations (VPDs) were evaluated with three consecutive 24-hour long-term electrocardiography monitor recordings from 15 clinically stable patients with various cardiac disorders. Mean hourly VPD frequencies ranged from 37--1,801 per hour. Data were subjected t...

journal_title：Circulation

authors： Morganroth J,Michelson EL,Horowitz LN,Josephson ME,Pearlman AS,Dunkman WB

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:The overall performance of available mechanical intravascular ultrasound catheters for fetal transesophageal echocardiography during fetoscopic fetal cardiac interventions in sheep has been limited by radioelectronic interference, low system frame rates, and low acoustic outputs. Therefore, a more reliable d...

journal_title：Circulation

authors： Kohl T,Westphal M,Strümper D,Achenbach S,Halimeh S,Petry P,Aryee S,Buller T,Aleksiene R,Asfour B,Witteler R,Vogt J,Van Aken H,Scheld HH

更新日期：2001-10-09 00:00:00

abstract：BACKGROUND:Previous studies have shown that hypertrophy of surviving myocytes after myocardial infarction (MI) is limited. Progressive ventricular dilatation after MI may occur when compensatory hypertrophy cannot restore left ventricular (LV) wall stress to normal. METHODS AND RESULTS:To test whether induction of add...

journal_title：Circulation

authors： Litwin SE,Raya TE,Anderson PG,Litwin CM,Bressler R,Goldman S

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Although LDL cholesterol (LDL-C) is generally accepted to be a major risk factor for progression of atherosclerosis, the traditional measurement of LDL-C includes measurement of IDL. Little is known about the relationship between IDL and progression of atherosclerosis. Therefore, we investigated the associat...

journal_title：Circulation

authors： Hodis HN,Mack WJ,Dunn M,Liu C,Liu C,Selzer RH,Krauss RM

更新日期：1997-04-15 00:00:00

abstract：BACKGROUND:Cigarette smoking has been recognized as an important risk factor for cardiovascular disease in men and women. Whether the increased risk results from an atherogenic effect of smoking is still debated. We examined the relation between cigarette smoking and atherosclerotic changes in the abdominal aorta. MET...

journal_title：Circulation

authors： Witteman JC,Grobbee DE,Valkenburg HA,van Hemert AM,Stijnen T,Hofman A

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:To further evaluate the mechanism of beta-blocker-induced benefits in heart failure, the relationships between bisoprolol-induced hemodynamic effects and survival were studied during the Cardiac Insufficiency BIsoprolol Study (CIBIS). METHODS AND RESULTS:In 557 patients studied, bisoprolol significantly red...

journal_title：Circulation

authors： Lechat P,Escolano S,Golmard JL,Lardoux H,Witchitz S,Henneman JA,Maisch B,Hetzel M,Jaillon P,Boissel JP,Mallet A

更新日期：1997-10-07 00:00:00

abstract：BACKGROUND:The aims of this study were to identify hibernating myocardium (hypocontractile, hypoperfused viable myocardium that regains contractility after revascularization) in the clinical setting and to predict functional outcome in patients with coronary artery disease after coronary revascularization. METHODS AND...

journal_title：Circulation

authors： Shivalkar B,Maes A,Borgers M,Ausma J,Scheys I,Nuyts J,Mortelmans L,Flameng W

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Unlike skeletal myocytes, mammalian adult cardiomyocytes cannot regenerate after injury. A possible strategy to increase viability and augment ventricular function after myocardial injury is fetal myocardial tissue transplantation. The engrafted fetal cells are a potential source of growth factors and can be...

journal_title：Circulation

authors： Leor J,Patterson M,Quinones MJ,Kedes LH,Kloner RA

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:This experiment sought to determine the effects of fish oil on superoxide anion production in the myocardium and coronary arteries of atherosclerotic monkeys. Recent evidence indicates that dietary supplementation with fish oil preserves normal vasomotion of atherosclerotic coronary arteries and reduces dama...

journal_title：Circulation

authors： Supari F,Ungerer T,Harrison DG,Williams JK

更新日期：1995-02-15 00:00:00

abstract：:Cardiac positron emission tomography (PET) has evolved rapidly from a relatively esoteric research tool into clinical applications providing unique, quantitative information on myocardial perfusion, metabolism, and cell membrane function and having a potentially significant impact on cardiovascular medicine. Although ...

journal_title：Circulation

authors： Gould KL

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Chronic inhibition of endothelial nitric oxide (NO) synthesis by the administration of N:(omega)-nitro-L-arginine methyl ester (L-NAME) to rats induces early vascular inflammatory changes (monocyte infiltration into coronary vessels and monocyte chemoattractant protein-1 [MCP-1] expression) as well as subseq...

journal_title：Circulation

authors： Koyanagi M,Egashira K,Kitamoto S,Ni W,Shimokawa H,Takeya M,Yoshimura T,Takeshita A

更新日期：2000-10-31 00:00:00

abstract：:In a placebo-controlled, randomized, cross-over, double-blind study of 12 patients with stable exertional angina, we measured at rest and during bicycle exercise the effects of 20 mg of nifedipine administered sublingually on hemodynamics and systemic and regional oxygen extraction and metabolism. Nifedipine decreased...

journal_title：Circulation

authors： Choong CY,Roubin GS,Shen WF,Harris PJ,Kelly DT

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Controversy exists as to whether low-osmolality radiographic contrast agents, which have less detrimental pharmacological effects but are considerably more expensive than high-osmolality agents, should be used universally or only for selected high-risk patients. METHODS AND RESULTS:A randomized, double-blin...

journal_title：Circulation

authors： Matthai WH Jr,Kussmaul WG 3rd,Krol J,Goin JE,Schwartz JS,Hirshfeld JW Jr

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Recent in vitro studies have shown that disturbed flow and oxidative conditions induce the expression of bone morphogenic proteins (BMPs 2 and 4) in cultured endothelial cells. BMPs can stimulate superoxide production and inflammatory responses in endothelial cells, raising the possibility that BMPs may play...

journal_title：Circulation

authors： Miriyala S,Gongora Nieto MC,Mingone C,Smith D,Dikalov S,Harrison DG,Jo H

更新日期：2006-06-20 00:00:00

abstract：BACKGROUND:Previous reports have suggested that an attenuated exercise heart rate response may be associated with coronary heart disease risk and with mortality. These observations may parallel the association between reduced heart rate variability during normal activities and adverse outcome. This investigation was de...

journal_title：Circulation

authors： Lauer MS,Okin PM,Larson MG,Evans JC,Levy D

更新日期：1996-04-15 00:00:00

abstract：BACKGROUND:Physical activity is associated with lower risk of cardiovascular disease, but the mechanisms are uncertain. Hemostatic and inflammatory markers have been linked with risk of cardiovascular disease. We therefore examined the relationship between physical activity and hemostatic and inflammatory variables. M...

journal_title：Circulation

authors： Wannamethee SG,Lowe GD,Whincup PH,Rumley A,Walker M,Lennon L

更新日期：2002-04-16 00:00:00

abstract：BACKGROUND:Long-term implantable left ventricular assist devices (LVADs) are increasingly used as a bridge to cardiac transplantation and may be used as long-term therapy for end-stage heart failure. After insertion of an LVAD, patients frequently become ambulatory. Sensors contained within these devices can measure th...

journal_title：Circulation

authors： Foray A,Williams D,Reemtsma K,Oz M,Mancini D

更新日期：1996-11-01 00:00:00

abstract：:The ability to quantify the quality of cardiovascular care critically depends on the translation of recommendations for high-quality care into the measurement of that care. As payers and regulatory agencies increasingly seek to quantify healthcare quality, the implications of the measurement process on practicing phys...

journal_title：Circulation

authors： Spertus JA,Eagle KA,Krumholz HM,Mitchell KR,Normand SL,American College of Cardiology.,American Heart Association Task Force on Performance Measures.

更新日期：2005-04-05 00:00:00

abstract：BACKGROUND:Uncertainty exists regarding the frequency of early occlusion when the left internal mammary artery (LIMA) is anastomosed to the left anterior descending artery (LAD) through a sternotomy with conventional coronary artery bypass grafting (CABG). The issue has gained importance for comparison with less invasi...

journal_title：Circulation

authors： Berger PB,Alderman EL,Nadel A,Schaff HV

更新日期：1999-12-07 00:00:00