Oxygenation in patients with a functionally univentricular circulation and complete mixing of blood: are saturation and flow interchangeable?

abstract：BACKGROUND:Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. METHODS AND RESULTS:To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic cir...

journal_title：Circulation

authors： Nemmar A,Hoet PH,Vanquickenborne B,Dinsdale D,Thomeer M,Hoylaerts MF,Vanbilloen H,Mortelmans L,Nemery B

更新日期：2002-01-29 00:00:00

abstract：BACKGROUND:Indications for surgical correction of aortic regurgitation have been established mostly in men and have not been validated in women. The outcome of this surgical correction in women is unknown. METHODS AND RESULTS:Baseline characteristics and postoperative outcomes were compared between 51 women and 198 me...

journal_title：Circulation

authors： Klodas E,Enriquez-Sarano M,Tajik AJ,Mullany CJ,Bailey KR,Seward JB

更新日期：1996-11-15 00:00:00

abstract：:Recent reports of selected observational studies and a meta-analysis have stirred controversy and have become the impetus for calls to abandon recommendations for reduced sodium intake by the US general population. A detailed review of these studies documents substantial methodological concerns that limit the usefulne...

journal_title：Circulation

authors： Whelton PK,Appel LJ,Sacco RL,Anderson CA,Antman EM,Campbell N,Dunbar SB,Frohlich ED,Hall JE,Jessup M,Labarthe DR,MacGregor GA,Sacks FM,Stamler J,Vafiadis DK,Van Horn LV

更新日期：2012-12-11 00:00:00

abstract：BACKGROUND:Coronary flow reserve (CFR), an integrated measure of focal, diffuse, and small-vessel coronary artery disease (CAD), identifies patients at risk for cardiac death. We sought to determine the association between CFR, angiographic CAD, and cardiovascular outcomes. METHODS AND RESULTS:Consecutive patients (n=...

journal_title：Circulation

authors： Taqueti VR,Hachamovitch R,Murthy VL,Naya M,Foster CR,Hainer J,Dorbala S,Blankstein R,Di Carli MF

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:The mechanisms by which replacement hormones may reduce the risk of coronary heart disease are not fully understood. Of specific interest is a potential effect of replacement hormones on plasma fibrinolytic activity, a putative determinant of thrombotic events. METHODS AND RESULTS:We investigated the relati...

journal_title：Circulation

authors： Shahar E,Folsom AR,Salomaa VV,Stinson VL,McGovern PG,Shimakawa T,Chambless LE,Wu KK

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Observational studies have identified an association between body mass index (BMI) and incident atrial fibrillation (AF). Inferring causality from observational studies, however, is subject to residual confounding, reverse causation, and bias. The primary objective of this study was to evaluate the causal as...

journal_title：Circulation

authors： Chatterjee NA,Giulianini F,Geelhoed B,Lunetta KL,Misialek JR,Niemeijer MN,Rienstra M,Rose LM,Smith AV,Arking DE,Ellinor PT,Heeringa J,Lin H,Lubitz SA,Soliman EZ,Verweij N,Alonso A,Benjamin EJ,Gudnason V,Stricker BHC

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice that overexpress HSP72 demonstrate improved functional recovery and decreased inf...

journal_title：Circulation

authors： Hutter JJ,Mestril R,Tam EK,Sievers RE,Dillmann WH,Wolfe CL

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:The relationship between autonomic activation and the mechanisms of paroxysmal atrial fibrillation remains unclear. METHODS AND RESULTS:We implanted a pacemaker and a radio transmitter in 7 dogs (group 1). After baseline recording, we paced the left atrium at 20 Hz for 1 week and then monitored left stellat...

journal_title：Circulation

authors： Tan AY,Zhou S,Ogawa M,Song J,Chu M,Li H,Fishbein MC,Lin SF,Chen LS,Chen PS

更新日期：2008-08-26 00:00:00

abstract：BACKGROUND:Despite successful restoration of epicardial vessel patency with primary percutaneous coronary intervention, coronary microvascular injury occurs in a large proportion of patients with ST-segment-elevation myocardial infarction, adversely affecting clinical and functional outcome. Ticagrelor has been reporte...

journal_title：Circulation

authors： van Leeuwen MAH,van der Hoeven NW,Janssens GN,Everaars H,Nap A,Lemkes JS,de Waard GA,van de Ven PM,van Rossum AC,Ten Cate TJF,Piek JJ,von Birgelen C,Escaned J,Valgimigli M,Diletti R,Riksen NP,van Mieghem NM,Nijveldt R,

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Epinephrine has been the mainstay for cardiac resuscitation for more than 30 years. Its vasopressor effect by which it increases coronary perfusion pressure is likely to favor initial resuscitation. Its beta-adrenergic action, however, may have detrimental effects on postresuscitation myocardial function whe...

journal_title：Circulation

authors： Tang W,Weil MH,Sun S,Noc M,Yang L,Gazmuri RJ

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:Drug-eluting stents have shown promising antirestenotic effects in clinical trials. Non-stent-based local delivery of antiproliferative drugs may offer additional flexibility and also reach vessel areas beyond the immediate stent coverage. The aim of the present study was to evaluate a novel method of local ...

journal_title：Circulation

authors： Scheller B,Speck U,Abramjuk C,Bernhardt U,Böhm M,Nickenig G

更新日期：2004-08-17 00:00:00

abstract：BACKGROUND:Isomerism is associated with a complex spectrum of anomalies. There is paucity of data on prenatally detected cases. METHODS AND RESULTS:Between January 1990 and February 2004, 83 of 166 cases (50%) had a prenatal diagnosis of left isomerism (LAI; 52 of 97) or right isomerism (RAI; 31 of 69) at our institut...

journal_title：Circulation

authors： Lim JS,McCrindle BW,Smallhorn JF,Golding F,Caldarone CA,Taketazu M,Jaeggi ET

更新日期：2005-10-18 00:00:00

abstract：BACKGROUND:Cardiac hypertrophy is a common response to circulatory or neurohumoral stressors as a mechanism to augment contractility. When the heart is under sustained stress, the hypertrophic response can evolve into decompensated heart failure, although the mechanism(s) underlying this transition remain largely unkno...

journal_title：Circulation

authors： Warren SA,Briggs LE,Zeng H,Chuang J,Chang EI,Terada R,Li M,Swanson MS,Lecker SH,Willis MS,Spinale FG,Maupin-Furlowe J,McMullen JR,Moss RL,Kasahara H

更新日期：2012-11-27 00:00:00

abstract：:Twenty adult patients with predominant mitral valve disease and variable degrees of tricuspid incompetence (TI) were reinvestigated 6-28 months after mitral valve operation. Postoperatively, 10 of the 20 patients were in sinus rhythm, compared with four of 20 preoperatively. Right ventricula peak systolic pressure dec...

journal_title：Circulation

authors： Simon R,Oelert H,Borst HG,Lichtlen PR

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:Although hepatocyte growth factor (HGF), a novel angiogenic growth factor, plays an important role in angiogenesis, regulation of local HGF production under hypoxia has not yet been clarified in vascular smooth muscle cells (VSMC) and endothelial cells (EC). Thus, we have studied the role of HGF in hypoxia-i...

journal_title：Circulation

authors： Hayashi S,Morishita R,Nakamura S,Yamamoto K,Moriguchi A,Nagano T,Taiji M,Noguchi H,Matsumoto K,Nakamura T,Higaki J,Ogihara T

更新日期：1999-11-09 00:00:00

abstract：BACKGROUND:The ability of echocardiographic dyssynchrony to predict response to cardiac resynchronization therapy (CRT) has been unclear. METHODS AND RESULTS:A prospective, longitudinal study was designed with predefined dyssynchrony indexes and outcome variables to test the hypothesis that baseline dyssynchrony is as...

journal_title：Circulation

authors： Gorcsan J 3rd,Oyenuga O,Habib PJ,Tanaka H,Adelstein EC,Hara H,McNamara DM,Saba S

更新日期：2010-11-09 00:00:00

abstract：BACKGROUND:The goal of this study was to assess the clinical value of stress myocardial perfusion scintigraphy (MPS) in elderly patients (> or =75 years of age). METHODS AND RESULTS:We followed up 5200 elderly patients (41% exercise) after dual-isotope MPS over 2.8+/-1.7 years (362 cardiac deaths [CDs], 7.0%, 2.6%/y) ...

journal_title：Circulation

authors： Hachamovitch R,Kang X,Amanullah AM,Abidov A,Hayes SW,Friedman JD,Cohen I,Thomson LE,Germano G,Berman DS

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The absence of functional dystrophin in Duchenne muscular dystrophy (DMD) patients and in mdx mice results in progressive muscle degeneration associated with necrosis, fibrosis, and inflammation. Because vascular supply plays a key role in tissue repair, we examined whether new blood vessel development was a...

journal_title：Circulation

authors： Straino S,Germani A,Di Carlo A,Porcelli D,De Mori R,Mangoni A,Napolitano M,Martelli F,Biglioli P,Capogrossi MC

更新日期：2004-11-23 00:00:00

abstract：BACKGROUND:The mechanisms of thrombosis on plaque erosion are poorly understood. We examined the potential role of endothelial apoptosis in endothelial erosion and vessel thrombosis. METHODS AND RESULTS:Segments of New Zealand White rabbit femoral arteries were temporarily isolated in vivo. One artery was incubated wi...

journal_title：Circulation

authors： Durand E,Scoazec A,Lafont A,Boddaert J,Al Hajzen A,Addad F,Mirshahi M,Desnos M,Tedgui A,Mallat Z

更新日期：2004-06-01 00:00:00

abstract：:Ventilation with positive end-expiratory pressure (PEEP) is associated with reduced cardiac output, but the mechanisms involved are controversial. Possible explanations include increased intrathoracic pressure, reflex changes in myocardial inotropism, pulmonary vascular obstruction and abnormal ventricular interaction...

journal_title：Circulation

authors： Rankin JS,Olsen CO,Arentzen CE,Tyson GS,Maier G,Smith PK,Hammon JW Jr,Davis JW,McHale PA,Anderson RW,Sabiston DC Jr

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Chronic inhibition of endothelial nitric oxide (NO) synthesis by the administration of N:(omega)-nitro-L-arginine methyl ester (L-NAME) to rats induces early vascular inflammatory changes (monocyte infiltration into coronary vessels and monocyte chemoattractant protein-1 [MCP-1] expression) as well as subseq...

journal_title：Circulation

authors： Koyanagi M,Egashira K,Kitamoto S,Ni W,Shimokawa H,Takeya M,Yoshimura T,Takeshita A

更新日期：2000-10-31 00:00:00

abstract：BACKGROUND:The accumulation of macrophage-derived foam cells in atherosclerotic lesions correlates with increased local release of matrix-degrading metalloproteinases (MMPs) and a thin fibrous cap. The activity of these enzymes is controlled by specific tissue inhibitors of metalloproteinases (TIMPs). METHODS AND RESU...

journal_title：Circulation

authors： Moreau M,Brocheriou I,Petit L,Ninio E,Chapman MJ,Rouis M

更新日期：1999-01-26 00:00:00

abstract：BACKGROUND:The present article aims to provide accurate estimates of the prevalence, awareness, treatment, and control of hypertension in adults in China. METHODS AND RESULTS:Data were obtained from sphygmomanometer measurements and an administered questionnaire from 141 892 Chinese adults >/=18 years of age who parti...

journal_title：Circulation

authors： Wu Y,Huxley R,Li L,Anna V,Xie G,Yao C,Woodward M,Li X,Chalmers J,Gao R,Kong L,Yang X,China NNHS Steering Committee.,China NNHS Working Group.

更新日期：2008-12-16 00:00:00

abstract：:The two new 99m (99mTc) labeled myocardial perfusion agents, 99mTc-Sestamibi and 99mTc-Teboroxime, are now available for routine clinical application. Both agents allow assessment of ejection fraction by the first-pass technique at rest or during exercise, thus providing additional information not available with thall...

journal_title：Circulation

authors： Berman DS,Kiat H,Maddahi J

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:A decreased cardiac compliance is a major feature of the cardiomyopathy of diabetes mellitus. Either an increase in the resistance afterload to the LV or an increase in collagen cross-linking induced by the formation of advanced glycosylation end products (AGEs) of collagen may be responsible for the stiff m...

journal_title：Circulation

authors： Norton GR,Candy G,Woodiwiss AJ

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:The diagnosis of infective endocarditis (IE) in prosthetic valves and intracardiac devices is challenging because both the modified Duke criteria (DC) and echocardiography have limitations in this population. The added value of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed ...

journal_title：Circulation

authors： Pizzi MN,Roque A,Fernández-Hidalgo N,Cuéllar-Calabria H,Ferreira-González I,Gonzàlez-Alujas MT,Oristrell G,Gracia-Sánchez L,González JJ,Rodríguez-Palomares J,Galiñanes M,Maisterra-Santos O,Garcia-Dorado D,Castell-Conesa J,Alm

更新日期：2015-09-22 00:00:00

abstract：:The dynamics between mitral anulus motion, and, thus, motion of the base of the heart, and filling of the left atrium and ventricle were studied by Doppler echocardiography in 12 normal subjects and 28 patients with dilated cardiomyopathy. The normal motion of the mitral anulus is associated with two phases of inflow ...

journal_title：Circulation

authors： Keren G,Sonnenblick EH,LeJemtel TH

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Heart rate (HR) variability is a marker of tonic cardiac autonomic activity and contributes in assessing risk for sudden death after myocardial infarction. Recent clinical observations have indicated that attenuation of HR variability, which occurs after myocardial infarction, may be transient. This study ad...

journal_title：Circulation

authors： Adamson PB,Huang MH,Vanoli E,Foreman RD,Schwartz PJ,Hull SS Jr

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Elevated lipoprotein (Lp) (a) concentrations are associated with coronary artery disease and myocardial infarction. Lp(a) is structurally related to proteins involved in lipid transport, fibrinolysis, coagulation, and cellular mitogenesis and is known to have important physiological interactions with the coa...

journal_title：Circulation

authors： Desmarais RL,Sarembock IJ,Ayers CR,Vernon SM,Powers ER,Gimple LW

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:The aims of the present study were to define the prevalence of untreated atrial fibrillation (AF) in a systematic screening program using intermittent ECG recordings among 75- to 76-year-old individuals and to study the feasibility of initiating protective oral anticoagulant (OAC) treatment. METHODS AND RES...

journal_title：Circulation

authors： Svennberg E,Engdahl J,Al-Khalili F,Friberg L,Frykman V,Rosenqvist M

更新日期：2015-06-23 00:00:00