Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.

abstract：BACKGROUND:Matricellular proteins are extracellular matrix proteins that do not contribute directly to tissue integrity but are capable of modulating cell function. We hypothesized that the matricellular protein thrombospondin (TSP)-1, a potent inhibitor of angiogenesis and activator of transforming growth factor (TGF-...

journal_title：Circulation

authors： Frangogiannis NG,Ren G,Dewald O,Zymek P,Haudek S,Koerting A,Winkelmann K,Michael LH,Lawler J,Entman ML

更新日期：2005-06-07 00:00:00

abstract：BACKGROUND:Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. We aimed to...

journal_title：Circulation

authors： Tang X,Chen XF,Wang NY,Wang XM,Liang ST,Zheng W,Lu YB,Zhao X,Hao DL,Zhang ZQ,Zou MH,Liu DP,Chen HZ

更新日期：2017-11-21 00:00:00

abstract：BACKGROUND:Experimental models suggest that brain natriuretic peptide (BNP) can modify left ventricular diastolic performance. The aim of this study was to evaluate the effects of BNP on resting and exercise hemodynamics and neurohormones in patients with isolated diastolic heart failure. METHODS AND RESULTS:Six patie...

journal_title：Circulation

authors： Clarkson PB,Wheeldon NM,MacFadyen RJ,Pringle SD,MacDonald TM

更新日期：1996-06-01 00:00:00

abstract：:The nature, prevalence, functional significance, and indeed existence of myocardial disease in progressive systemic sclerosis (PSS) has been debated. In this study the clinical and pathological features of 52 autopsied patients were analyzed in an attempt to resolve these questions. A distinctive focal myocardial lesi...

journal_title：Circulation

authors： Bulkley BH,Ridolfi RL,Salyer WR,Hutchins GM

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:Preconditioning protects the myocardium from ischemia and may be a potent means of endogenous cardioprotection during cardioplegic arrest and rewarming. However, fundamental mechanisms that potentially contribute to the beneficial effects of preconditioning during cardioplegic arrest and rewarming remain unc...

journal_title：Circulation

authors： O SJ,Zellner JL,Cox MH,Hebbar L,Brothers TE,Mukherjee R,Tempel GE,Dorman BH,Crawford FA Jr,Spinale FG

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Transfer of the coronary arteries is a crucial step during the arterial switch operation (ASO) for transposition of the great arteries. This retrospective study aims to assess the incidence and risk factors of coronary events after ASO and sensitivity of noninvasive tests in the diagnosis of the coronary obs...

journal_title：Circulation

authors： Legendre A,Losay J,Touchot-Koné A,Serraf A,Belli E,Piot JD,Lambert V,Capderou A,Planche C

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence of significant orthostatic hypotension. A heart rate increase of >/=30 bpm is typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary...

journal_title：Circulation

authors： Jacob G,Shannon JR,Costa F,Furlan R,Biaggioni I,Mosqueda-Garcia R,Robertson RM,Robertson D

更新日期：1999-04-06 00:00:00

abstract：BACKGROUND:Initially based on histology, the diagnosis of renal artery fibromuscular dysplasia (FMD) is now based mostly on angiographic appearance because arterial tissue samples are rarely available. This retrospective cross-sectional study aimed to assess the clinical relevance of a binary angiographic classificatio...

journal_title：Circulation

authors： Savard S,Steichen O,Azarine A,Azizi M,Jeunemaitre X,Plouin PF

更新日期：2012-12-18 00:00:00

abstract：BACKGROUND:It is uncertain whether Helicobacter pylori is associated with ischemic syndromes and whether this association is mediated by the induction of atherosclerosis. In this study, we tested the hypothesis that atherosclerotic stroke shows a selective association with virulent H pylori strains. METHODS AND RESULT...

journal_title：Circulation

authors： Pietroiusti A,Diomedi M,Silvestrini M,Cupini LM,Luzzi I,Gomez-Miguel MJ,Bergamaschi A,Magrini A,Carrabs T,Vellini M,Galante A

更新日期：2002-07-30 00:00:00

abstract：BACKGROUND:We investigated whether L-arginine induces regression of preexisting atheromatous lesions and reversal of endothelial dysfunction in hypercholesterolemic rabbits, whether similar effects can be obtained by cholesterol-lowering therapy with lovastatin, and which mechanism leads to these effects. METHODS AND ...

journal_title：Circulation

authors： Böger RH,Bode-Böger SM,Brandes RP,Phivthong-ngam L,Böhme M,Nafe R,Mügge A,Frölich JC

更新日期：1997-08-19 00:00:00

abstract：:We assessed the effects of ethanol and autonomic blockade on left ventricular function in nine normal subjects, age 20--35 years, using M-mode echocardiography and systolic time intervals. On day 1, measurements were made of heart rate, mean velocity of circumferential fiber shortening, and left ventricular pre-ejecti...

journal_title：Circulation

authors： Child JS,Kovick RB,Levisman JA,Pearce ML

更新日期：1979-01-01 00:00:00

abstract：:Patency of the femoral artery of infants and children who previously had percutaneous arterial catheterization at a weight of less than 25 kg was studied angiographically. During the study period, 118 patients had repeat arterial catheterization. 48 from the opposite leg. Femoral artery occlusion was found in four pat...

journal_title：Circulation

authors： Hurwitz RA,Franken EA Jr,Girod DA,Smith JA,Smith WL

更新日期：1977-07-01 00:00:00

abstract：:A family is reported in which two siblings had congenital complete heart block with resultant congestive heart failure, the father and paternal grandfather show adult-onset conduction defects, and the mother has systemic lupus erythematosis. The interaction of heredity and environment is discussed in this context. A r...

journal_title：Circulation

authors： Winkler RB,Nora AH,Nora JJ

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:The mechanisms of thrombosis on plaque erosion are poorly understood. We examined the potential role of endothelial apoptosis in endothelial erosion and vessel thrombosis. METHODS AND RESULTS:Segments of New Zealand White rabbit femoral arteries were temporarily isolated in vivo. One artery was incubated wi...

journal_title：Circulation

authors： Durand E,Scoazec A,Lafont A,Boddaert J,Al Hajzen A,Addad F,Mirshahi M,Desnos M,Tedgui A,Mallat Z

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications. METHODS AND RESULTS:To test the hypothesis that optical molecular imaging with the use of an activatable near-infrared fluorescence (NIRF) p...

journal_title：Circulation

authors： Deguchi JO,Aikawa M,Tung CH,Aikawa E,Kim DE,Ntziachristos V,Weissleder R,Libby P

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:The use of cells derived from human induced pluripotent stem cells as cellular therapy for myocardial injury has yet to be examined in a large-animal model. METHODS AND RESULTS:Immunosuppressed Yorkshire pigs were assigned to 1 of 3 groups: A myocardial infarction group (MI group; distal left anterior desce...

journal_title：Circulation

authors： Xiong Q,Ye L,Zhang P,Lepley M,Tian J,Li J,Zhang L,Swingen C,Vaughan JT,Kaufman DS,Zhang J

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:The mechanisms responsible for tumor necrosis factor (TNF)-induced LV structural remodeling in the adult heart are not known. METHODS AND RESULTS:We generated a line of transgenic mice (MHCsTNF) with cardiac restricted overexpression of TNF that develop progressive LV dilation/remodeling from 4 to 12 weeks ...

journal_title：Circulation

authors： Sivasubramanian N,Coker ML,Kurrelmeyer KM,MacLellan WR,DeMayo FJ,Spinale FG,Mann DL

更新日期：2001-08-14 00:00:00

abstract：BACKGROUND:Ventricular septal defect (VSD) complicating acute myocardial infarction has been studied primarily in small, prethrombolytic-era trials. Our goal was to determine clinical predictors and angiographic and clinical outcomes of this complication in the thrombolytic era. METHODS AND RESULTS:We compared enrollm...

journal_title：Circulation

authors： Crenshaw BS,Granger CB,Birnbaum Y,Pieper KS,Morris DC,Kleiman NS,Vahanian A,Califf RM,Topol EJ

更新日期：2000-01-04 00:00:00

abstract：:Catheter ablation has gained a prominent role in the management of atrial fibrillation (AF), with recent data providing positive evidence on hard outcomes, including hospitalization and mortality. Ablation, however, exposes the patient to a rather unique situation, combining risks for both major bleeding and thromboem...

journal_title：Circulation

authors： Martin AC,Godier A,Narayanan K,Smadja DM,Marijon E

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:We previously demonstrated that reduced vagal activity and/or increased sympathetic activity identify post-myocardial infarction patients at high risk for cardiac mortality. Simple and inexpensive autonomic markers are necessary to perform autonomic screening in large populations. We tested our hypothesis th...

journal_title：Circulation

authors： Falcone C,Buzzi MP,Klersy C,Schwartz PJ

更新日期：2005-09-27 00:00:00

abstract：:Cross-sectional echocardiographic studies of the aortic arch and proximal descending aorta were performed in 18 patients with coarctation of the aorta and 20 normal subjects. In normals the aortic arch and proximal descending aorta appeared as an arcuate, echo-free structure curving across the plane of the scan. There...

journal_title：Circulation

authors： Weyman AE,Caldwell RL,Hurwitz RA,Girod DA,Dillon JC,Feigenbaum H,Green D

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND:This study was performed to determine whether chronic cocaine abuse is associated with left ventricular hypertrophy in humans. METHODS AND RESULTS:A consecutive series of 40 chronic cocaine abusers 23-44 years old who were enrolled in an inpatient drug rehabilitation program were considered for the study. S...

journal_title：Circulation

authors： Brickner ME,Willard JE,Eichhorn EJ,Black J,Grayburn PA

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:HMG CoA reductase inhibitors (or statins), a new class of lipid-lowering compounds, have raised expectations for more widespread use than that of the older lipid-lowering drugs. Not only are they more effective in lowering LDL cholesterol, but they are better tolerated as well. No data exist concerning the e...

journal_title：Circulation

authors： Furberg CD,Adams HP Jr,Applegate WB,Byington RP,Espeland MA,Hartwell T,Hunninghake DB,Lefkowitz DS,Probstfield J,Riley WA

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Macrophages in human atherosclerotic plaques produce a family of matrix metalloproteinases (MMPs), which may influence vascular remodeling and plaque disruption. Because oxidized LDL (ox-LDL) is implicated in many proatherogenic events, we hypothesized that ox-LDL would regulate expression of MMP-9 and tissu...

journal_title：Circulation

authors： Xu XP,Meisel SR,Ong JM,Kaul S,Cercek B,Rajavashisth TB,Sharifi B,Shah PK

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on risk for cardiovascular diseases, thus informing the potential utility of pharmacological stimulation of...

journal_title：Circulation

authors： Emdin CA,Khera AV,Klarin D,Natarajan P,Zekavat SM,Nomura A,Haas M,Aragam K,Ardissino D,Wilson JG,Schunkert H,McPherson R,Watkins H,Elosua R,Bown MJ,Samani NJ,Baber U,Erdmann J,Gormley P,Palotie A,Stitziel NO,Gup

更新日期：2018-01-16 00:00:00

abstract：:An increasing number of premature ventricular stimuli are being used during programmed stimulation of the heart in the investigation of patients with documented or suspected ventricular arrhythmias. To analyze the significance of the different types of ventricular arrhythmias that are initiated, we evaluated in a pros...

journal_title：Circulation

authors： Brugada P,Green M,Abdollah H,Wellens HJ

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Coronary artery disease is the major cause of late cardiac allograft failure. However, few data exist regarding the natural history of changes in intimal and external elastic membrane (EEM) areas after heart transplantation. METHODS AND RESULTS:In 38 transplant recipients, serial intravascular ultrasound ex...

journal_title：Circulation

authors： Tsutsui H,Ziada KM,Schoenhagen P,Iyisoy A,Magyar WA,Crowe TD,Klingensmith JD,Vince DG,Rincon G,Hobbs RE,Yamagishi M,Nissen SE,Tuzcu EM

更新日期：2001-08-07 00:00:00

abstract：BACKGROUND:Cerebral protection during surgery for acute aortic dissection type A relies on hypothermic circulatory arrest, either alone or in conjunction with cerebral perfusion. METHODS AND RESULTS:The perioperative and intraoperative conditions of 1558 patients submitted from 44 cardiac surgery centers in German-spe...

journal_title：Circulation

authors： Krüger T,Weigang E,Hoffmann I,Blettner M,Aebert H,GERAADA Investigators.

更新日期：2011-07-26 00:00:00

abstract：:To evaluate possible occult myocardial disease in 18 patients whose only major manifestation of heart disease was spontaneous ventricular tachycardia or fibrillation, right ventricular endomyocardial biopsies were performed. None of the patients had symptoms of ischemic or congestive heart disease, and at catheterizat...

journal_title：Circulation

authors： Strain JE,Grose RM,Factor SM,Fisher JD

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:Imaging of the flow convergence region (FCR) proximal to a regurgitant orifice has been shown to provide a method for quantifying the regurgitant flow rate. According to the continuity principle, the FCR is constituted by concentric hemispheric isovelocity surfaces centered at the orifice. The flow rate is c...

journal_title：Circulation

authors： Bargiggia GS,Tronconi L,Sahn DJ,Recusani F,Raisaro A,De Servi S,Valdes-Cruz LM,Montemartini C

更新日期：1991-10-01 00:00:00