Rapid heart rate increase at onset of exercise predicts adverse cardiac events in patients with coronary artery disease.

abstract：BACKGROUND:Abnormalities of arterial pulse and limb growth after retrograde femoral arterial catheterization have been well documented. However, the magnitude of such complications after transfemoral artery balloon dilatation has not been thoroughly investigated. This study sought to evaluate the prevalence of these ab...

journal_title：Circulation

authors： Lee HY,Reddy SC,Rao PS

更新日期：1997-02-18 00:00:00

abstract：BACKGROUND:Female sex is an independent risk factor for torsade de pointes in long-QT syndrome. In women, QT interval and torsade de pointes risk fluctuate dynamically during the menstrual cycle and pregnancy. Accumulating clinical evidence suggests a role for progesterone; however, the effect of progesterone on cardia...

journal_title：Circulation

authors： Nakamura H,Kurokawa J,Bai CX,Asada K,Xu J,Oren RV,Zhu ZI,Clancy CE,Isobe M,Furukawa T

更新日期：2007-12-18 00:00:00

abstract：BACKGROUND:Myocardial salvage is most likely to occur when thrombolytic therapy is administered within 4 to 6 hours of the onset of symptoms of myocardial infarction. The impact of delays within this early time period on final myocardial infarct size are unknown. The purpose of this study was to quantitate the relation...

journal_title：Circulation

authors： Raitt MH,Maynard C,Wagner GS,Cerqueira MD,Selvester RH,Weaver WD

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) and diabetes are both associated with a high risk of ischemic events, but the role of intensive blood pressure control in PAD has not been established. METHODS AND RESULTS:The Appropriate Blood Pressure Control in Diabetes study followed 950 subjects with type 2 diabetes fo...

journal_title：Circulation

authors： Mehler PS,Coll JR,Estacio R,Esler A,Schrier RW,Hiatt WR

更新日期：2003-02-11 00:00:00

abstract：BACKGROUND:The contractile dysfunction observed in end-stage myocardial hypertrophy has at its base an abnormality in myocyte function. However, whether depressed contractile function is related to an alteration in contractile protein function is presently unknown. METHODS AND RESULTS:Contractile force, tension, and c...

journal_title：Circulation

authors： Fan D,Wannenburg T,de Tombe PP

更新日期：1997-05-06 00:00:00

abstract：BACKGROUND:We explored the feasibility of measuring regional tracer activity concentrations and flow defects in myocardium of rats with a high spatial resolution small-animal PET system (microPET). METHODS AND RESULTS:Myocardial images were obtained after intravenous (18)F-fluorodeoxyglucose (18FDG) in 11 normal rats ...

journal_title：Circulation

authors： Kudo T,Fukuchi K,Annala AJ,Chatziioannou AF,Allada V,Dahlbom M,Tai YC,Inubushi M,Huang SC,Cherry SR,Phelps ME,Schelbert HR

更新日期：2002-07-02 00:00:00

abstract：BACKGROUND:Few published data describe long-term survival of dialysis patients undergoing surgical versus percutaneous coronary revascularization in the era of drug-eluting stents (DES). METHODS AND RESULTS:Using United States Renal Data System data, we identified 23 033 dialysis patients who underwent coronary revasc...

journal_title：Circulation

authors： Shroff GR,Solid CA,Herzog CA

更新日期：2013-05-07 00:00:00

abstract：BACKGROUND:The role of angiotensin II (Ang II) type 2 (AT2) receptor in atherosclerosis was explored with the use of AT2 receptor/apolipoprotein E (ApoE)-double-knockout (AT2/ApoE-DKO) mice, with a focus on oxidative stress. METHODS AND RESULTS:After treatment with a high-cholesterol diet (1.25% cholesterol) for 10 we...

journal_title：Circulation

authors： Iwai M,Chen R,Li Z,Shiuchi T,Suzuki J,Ide A,Tsuda M,Okumura M,Min LJ,Mogi M,Horiuchi M

更新日期：2005-09-13 00:00:00

abstract：BACKGROUND:Patients with chronic granulomatous disease (CGD) experience immunodeficiency because of defects in the phagocyte NADPH oxidase and the concomitant reduction in reactive oxygen intermediates. This may result in a reduction in atherosclerotic injury. METHODS AND RESULTS:We prospectively assessed the prevalen...

journal_title：Circulation

authors： Sibley CT,Estwick T,Zavodni A,Huang CY,Kwan AC,Soule BP,Long Priel DA,Remaley AT,Rudman Spergel AK,Turkbey EB,Kuhns DB,Holland SM,Malech HL,Zarember KA,Bluemke DA,Gallin JI

更新日期：2014-12-02 00:00:00

abstract：BACKGROUND:The physiological assessment of angiographically intermediate-severity stenoses remains problematic. Functional measurements of poststenotic intracoronary Doppler coronary flow reserve can be performed in humans but have not been correlated with hyperemic myocardial perfusion imaging or angiographic data in ...

journal_title：Circulation

authors： Miller DD,Donohue TJ,Younis LT,Bach RG,Aguirre FV,Wittry MD,Goodgold HM,Chaitman BR,Kern MJ

更新日期：1994-05-01 00:00:00

abstract：:The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition of platelet aggregation wit...

journal_title：Circulation

authors： Quinn MJ,Fitzgerald DJ

更新日期：1999-10-12 00:00:00

abstract：BACKGROUND:Diabetes is an independent risk factor for the development of neointimal hyperplasia and subsequent vein graft failure after coronary or peripheral artery bypass grafting. We evaluate a new mouse model of surgical vein grafting to investigate the mechanisms of neointimal formation in the setting of type 2 di...

journal_title：Circulation

authors： Salzberg SP,Filsoufi F,Anyanwu A,von Harbou K,Karlof E,Carpentier A,Dansky HM,Adams DH

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Ventricular tachyarrhythmias are the major clinical manifestation of arrhythmogenic right ventricular disease. Although antiarrhythmic therapy has been widely advocated, there is only limited information available on the efficacy of antiarrhythmic drugs in these patients. METHODS AND RESULTS:The short- and ...

journal_title：Circulation

authors： Wichter T,Borggrefe M,Haverkamp W,Chen X,Breithardt G

更新日期：1992-07-01 00:00:00

abstract：:Cerebral and retinal ischemic events have been described in mitral valve prolapse. To determine whether platelets play a part in the pathogenesis of thromboembolism we studied 29 patients with mitral valve prolapse, including nine (group I) with thromboembolism (cerebral, retinal and deep venous), eight (group II) wit...

journal_title：Circulation

authors： Walsh PN,Kansu TA,Corbett JJ,Savion PJ,Goldburgh WP,Schatz NJ

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:Ventricular tachyarrhythmias present a unique set of stimuli to arterial and cardiopulmonary baroreceptors by increasing cardiac filling pressures and decreasing arterial pressure. The net effect on the control of sympathetic nerve activity (SNA) in humans is unknown. The purpose of this study was to determi...

journal_title：Circulation

authors： Smith ML,Joglar JA,Wasmund SL,Carlson MD,Welch PJ,Hamdan MH,Quan K,Page RL

更新日期：1999-08-10 00:00:00

abstract：:A new technology, leadless pacemaker therapy, was recently introduced clinically to address lead- and pocket-related complications in conventional transvenous pacemaker therapy. These leadless devices are self-contained right ventricular single-chamber pacemakers implanted by using a femoral percutaneous approach. In ...

journal_title：Circulation

authors： Tjong FV,Reddy VY

更新日期：2017-04-11 00:00:00

abstract：:This study was undertaken to provide a better anatomic description of the location and course of the left coronary artery within a commonly used ultrasonic tomographic plane. Twenty-three hearts were excised at autopsy and scanned in vitro. The locations of the left main (LMCA), left anterior descending (LAD), and lef...

journal_title：Circulation

authors： Rogers EW,Feigenbaum H,Weyman AE,Godley RW,Vakili ST

更新日期：1980-10-01 00:00:00

abstract：:A patient is described in whom a large congenital aneurysm or diverticulum of the right atrium caused repeated attacks of supraventricular arrhythmia and a strikingly reduced cardiac output. The aneurysm, which contained a large thrombus, was demonstrated by preoperative angiographic examinations. At the time of opera...

journal_title：Circulation

authors： Morrow AG,Behrendt DM

更新日期：1968-07-01 00:00:00

abstract：:The National Heart, Lung, and Blood Institute and Office of Rare Diseases at the National Institutes of Health organized a workshop (September 14 to 15, 2006, in Bethesda, Md) to advise on new research directions needed for improved identification and treatment of rare inherited arrhythmias. These included the followi...

journal_title：Circulation

authors： Lehnart SE,Ackerman MJ,Benson DW Jr,Brugada R,Clancy CE,Donahue JK,George AL Jr,Grant AO,Groft SC,January CT,Lathrop DA,Lederer WJ,Makielski JC,Mohler PJ,Moss A,Nerbonne JM,Olson TM,Przywara DA,Towbin JA,Wang LH,M

更新日期：2007-11-13 00:00:00

abstract：BACKGROUND:Worldwide, diabetes mellitus and heart failure represent frequent comorbidities with high socioeconomic impact and steadily growing incidence, calling for a better understanding of how diabetic metabolism promotes cardiac dysfunction. Paradoxically, some glucose-lowering drugs have been shown to worsen heart...

journal_title：Circulation

authors： Kronlage M,Dewenter M,Grosso J,Fleming T,Oehl U,Lehmann LH,Falcão-Pires I,Leite-Moreira AF,Volk N,Gröne HJ,Müller OJ,Sickmann A,Katus HA,Backs J

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Coronary flow reserve has been considered an important diagnostic index of the functional significance of coronary artery stenosis. With Doppler technique, it has been assessed as the ratio of hyperemic to basal coronary flow velocity (coronary flow velocity reserve [CFVR]) by invasive or semiinvasive method...

journal_title：Circulation

authors： Hozumi T,Yoshida K,Ogata Y,Akasaka T,Asami Y,Takagi T,Morioka S

更新日期：1998-04-28 00:00:00

abstract：BACKGROUND:Reperfusion of acutely infarcted myocardium may be beneficial in limiting infarct expansion and ventricular remodeling even if established after the time that salvage of ischemic myocardium is possible. METHODS AND RESULTS:To examine the permanency, time course, and mechanism of this effect of late reperfus...

journal_title：Circulation

authors： Boyle MP,Weisman HF

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Atherosclerosis is a multifactorial disorder involving inflammatory processes. These responses are associated with robust activation of signaling cascades by diverse cell surface receptors in a variety of cell types. The processes that are involved in atherosclerosis would likely require intact Ras pathways,...

journal_title：Circulation

authors： George J,Afek A,Keren P,Herz I,Goldberg I,Haklai R,Kloog Y,Keren G

更新日期：2002-05-21 00:00:00

abstract：BACKGROUND:Hemodialysis vascular access dysfunction is the single most important cause of morbidity in kidney hemodialysis patients. Failure of an arteriovenous polytetrafluoroethylene (PTFE) graft, the most common form of hemodialysis access, is primarily due to intimal hyperplasia and thrombosis at the venous anastom...

journal_title：Circulation

authors： Luo Z,Akita GY,Date T,Treleaven C,Vincent KA,Woodcock D,Cheng SH,Gregory RJ,Jiang C

更新日期：2005-04-05 00:00:00

abstract：BACKGROUND:Blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) has been used to measure T2* changes in skeletal muscle tissue of healthy volunteers. The BOLD effect is assumed to primarily reflect changes in blood oxygenation at the tissue level. We compared the calf muscle BOLD response of patien...

journal_title：Circulation

authors： Ledermann HP,Schulte AC,Heidecker HG,Aschwanden M,Jäger KA,Scheffler K,Steinbrich W,Bilecen D

更新日期：2006-06-27 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the major cause of death in older women. Information on the relation of menopause and hormone replacement therapy with carotid atherosclerosis is limited. METHODS AND RESULTS:We examined cross-sectionally the association of menopausal status, years since last menstruation, and horm...

journal_title：Circulation

authors： Nabulsi AA,Folsom AR,Szklo M,White A,Higgins M,Heiss G

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) is associated with significant morbidity and mortality and is an important marker of subclinical coronary heart disease. However, estimates of PAD prevalence in the general US population have varied widely. METHODS AND RESULTS:We analyzed data from 2174 participants aged 40...

journal_title：Circulation

authors： Selvin E,Erlinger TP

更新日期：2004-08-10 00:00:00

abstract：BACKGROUND:We investigated whether L-arginine induces regression of preexisting atheromatous lesions and reversal of endothelial dysfunction in hypercholesterolemic rabbits, whether similar effects can be obtained by cholesterol-lowering therapy with lovastatin, and which mechanism leads to these effects. METHODS AND ...

journal_title：Circulation

authors： Böger RH,Bode-Böger SM,Brandes RP,Phivthong-ngam L,Böhme M,Nafe R,Mügge A,Frölich JC

更新日期：1997-08-19 00:00:00

abstract：:Thirty patients with triple-vessel coronary artery disease proven by angiography, symptomatic angina and a positive ECG stress test were evaluated with thallium-201 (201TI) scintigraphy. Twenty patients also had aortocoronary saphenous vein bypass surgery; 15 of them had repeat noninvasive evaluation. Seventy percent ...

journal_title：Circulation

authors： Leppo J,Yipintsoi T,Blankstein R,Bontemps R,Freeman LM,Zohman L,Scheuer J

更新日期：1979-04-01 00:00:00

abstract：:Echocardiographic measurements of the left ventricle were used to define rates of circumferential fiber lengthening at the endocardium and midwall in 12 normal subjects and six patients with concentric left ventricular hypertrophy (wall thickness 11 to 16 mm). There was no difference in chamber size and systolic short...

journal_title：Circulation

authors： Shimizu G,Conrad CH,Gaasch WH

更新日期：1987-01-01 00:00:00