Abstract:
BACKGROUND:The contractile dysfunction observed in end-stage myocardial hypertrophy has at its base an abnormality in myocyte function. However, whether depressed contractile function is related to an alteration in contractile protein function is presently unknown. METHODS AND RESULTS:Contractile force, tension, and calcium responsiveness were measured in single-skinned myocytes isolated from rats with right ventricular hypertrophy (RVH) and control rats. RVH was induced by pulmonary artery constriction for 36 weeks and was associated with significant myocyte hypertrophy. Myocytes were attached to micropipettes that extended from a force transducer and motor. Isometric force was measured over a wide range of calcium concentrations at two sarcomere lengths (SLs). Maximal force was increased in the RVH group: 1.20 +/- 0.10 versus 1.62 +/- 0.13 mg at SL = 2.0 microns and 1.33 +/- 0.10 versus 1.84 +/- 0.15 mg at SL = 2.3 microns (P < .05). Maximal tension, however, was reduced in the RVH group: 24.3 +/- 1.91 versus 37.5 +/- 2.92 mN/mm2 at SL = 2.0 microns and 27.4 +/- 1.78 versus 41.8 +/- 3.19 mN/mm2 at SL = 2.3 microns (P < .01). The concentration of calcium ions required for half-maximal activation was increased in the RVH group: 2.64 +/- 0.13 versus 3.47 +/- 0.22 mumol/L at SL = 2.0 microns and 2.23 +/- 0.15 versus 2.86 +/- 0.18 mumol/L at SL = 2.3 microns (P < .01). The slope of the force-calcium relationship (Hill coefficient) was decreased in the RVH group at SL = 2.0 microns (4.3 +/- 0.4 versus 3.1 +/- 0.2, P = .04) but not at SL = 2.3 microns (3.8 +/- 0.2 versus 3.6 +/- 0.2, P = NS). CONCLUSIONS:These results suggest that the depressed cardiac function of end-stage myocardial hypertrophy may be due, in part, to altered contractile protein function.
journal_name
Circulationjournal_title
Circulationauthors
Fan D,Wannenburg T,de Tombe PPdoi
10.1161/01.cir.95.9.2312subject
Has Abstractpub_date
1997-05-06 00:00:00pages
2312-7issue
9eissn
0009-7322issn
1524-4539journal_volume
95pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::Myocardial lactate production indicates anaerobic metabolism resulting from hypoxia or anoxia. Clinically, myocardial lactate extraction of less than 10% has also been used as an indicator of ischemia. Sixteen healthy young male volunteers underwent coronary sinus and aterial catheterization. A coronary sinus pacing c...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.61.2.256
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:Anthracyclines are the most effective drugs available in the treatment of neoplastic diseases; however, they have profound consequences on the structure and function of the heart, which over time cause a cardiomyopathy that leads to congestive heart failure. METHODS AND RESULTS:Administration of doxorubicin...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.895771
更新日期:2010-01-19 00:00:00
abstract:BACKGROUND:Indications for surgical correction of aortic regurgitation have been established mostly in men and have not been validated in women. The outcome of this surgical correction in women is unknown. METHODS AND RESULTS:Baseline characteristics and postoperative outcomes were compared between 51 women and 198 me...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.10.2472
更新日期:1996-11-15 00:00:00
abstract::From November 1981 to November 1982, intra-aortic balloon pumping (IABP) was used after surgery in eight patients who were from 6 weeks to 6 years old and who weighed from 4.2 to 16.2 kg. In seven patients, specially constructed intra-aortic balloons with 2.5 and 5.0 ml volumes mounted on No. 5F catheters were used. I...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.68.5.1095
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs) are key mechanisms of pulmonary arterial hypertension (PAH). Despite the multiple combination therapy, a considerable number of patients develop severe pulmonary hypertension (PH) because of the lack of diagnost...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.117.033113
更新日期:2018-08-07 00:00:00
abstract:BACKGROUND:Patients with atrial fibrillation (AF) often take multiple medications. METHODS AND RESULTS:We examined characteristics and compared adjusted outcomes between rivaroxaban and warfarin according to number of concomitant baseline medications and the presence of combined cytochrome P450 3A4 and P-glycoprotein ...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.115.018544
更新日期:2016-01-26 00:00:00
abstract:BACKGROUND:Microvascular dysfunction in hypertrophic cardiomyopathy (HCM) may create an ischemic substrate conducive to sudden death, but it remains unknown whether the extent of hypertrophy is associated with proportionally poorer perfusion reserve. Comparisons between magnitude of hypertrophy, impairment of perfusion...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.657023
更新日期:2007-05-08 00:00:00
abstract:BACKGROUND:Nitric oxide (NO) modulates autonomic effects on myocardial contractility and sinus and atrioventricular nodal function of the heart. Whether NO influences autonomic actions on ventricular electrophysiological properties and arrhythmogenesis is not known. METHODS AND RESULTS:Four groups consisting of 43 aut...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.11.4044
更新日期:1997-12-02 00:00:00
abstract:BACKGROUND:The Department of Veterans Affairs Randomized On/Off Bypass (ROOBY) trial compared clinical and angiographic outcomes in off-pump versus on-pump coronary artery bypass graft (CABG) surgery to ascertain the relative efficacy of the 2 techniques. METHODS AND RESULTS:From February 2002 to May 2007, the ROOBY t...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.111.069260
更新日期:2012-06-12 00:00:00
abstract::This study analyzes the response to overdrive suppression of junctional pacemakers (JP) and correlates it with symptoms in 21 patients. Junctional rhythm (JR) was seen in 5 patients with intact A-V conduction, and in 16 with complete heart block, the JPs were located proximal to or within the His bundle (BH). Junction...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.57.5.880
更新日期:1978-05-01 00:00:00
abstract::Acute aortic regurgitation was created experimentally in 21 mongrel dogs to examine the relationship of the regurgitant jet to observed echocardiographic findings. The direction of the regurgitant jet was studied by echo contrast injections in the aortic root. Diastolic fluttering of the anterior mitral leaflet (AML) ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.67.4.860
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND:Proto-oncogenes have been implicated in the pathogenesis of gene-mediated myocardial remodeling. In the human heart, however, it has not been clarified whether these proto-oncogenes are related to contractile impairment and structural alteration of the myocardium. The present study is designed to investigate...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1997-11-04 00:00:00
abstract::The reduced responsiveness of the renin-angiotensin system to hemodynamic changes in patients with congestive heart failure (CHF) could be due to a defect of the juxtaglomerular apparatus. To test this hypothesis, the responses to viprostol, an analog of prostaglandin E2 (PGE2) that is known to stimulate both the macu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.74.6.1203
更新日期:1986-12-01 00:00:00
abstract::Statistical multivariate and conventional deterministic methods of computerized interpretation of the electrocardiogram (ECG) were compared in the analysis of 1711 pediatric orthogonal ECGs validated by nonelectrocardiographic criteria on the basis of clinical and anatomic diagnoses. Among 642 children catheterized fo...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.70.2.255
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Administration of angiogenic factors stimulates neovascularization in ischemic tissues. However, there is no evidence that angiogenesis can be induced in normoperfused skeletal muscles. We tested the hypothesis that adenovirus-mediated intramuscular (IM) gene transfer of the 121-amino-acid form of vascular e...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.5.565
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:In animal models of cardiac arrest, the benefit afforded by hypothermia is closely linked to the rapidity of the decrease in body temperature after resuscitation. Because total liquid ventilation (TLV) with temperature-controlled perfluorocarbons induces a very rapid and generalized cooling, we aimed to dete...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.111.039388
更新日期:2011-08-23 00:00:00
abstract:BACKGROUND:Disturbed fibrinolytic function may influence the progression of coronary atherosclerosis and contribute to thrombotic cardiovascular (CV) events. METHODS AND RESULTS:In the Angina Prognosis Study in Stockholm (APSIS), patients with stable angina pectoris were studied prospectively during double-blind treat...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.95.10.2380
更新日期:1997-05-20 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the prevalence of skeletal muscle atrophy and its relation to exercise intolerance and abnormal muscle metabolism in patients with heart failure (HF). METHODS AND RESULTS:Peak VO2, percent ideal body weight (% IBW), 24-hour urine creatinine (Cr), and anthropometr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.4.1364
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Although molecular biological studies suggest a pathogenic link between enterovirus infection and dilated cardiomyopathy (DCM), the frequency of detection of enteroviral RNA is not consistently high in myocardial tissue from patients with DCM. A recent study has suggested that hepatitis C virus (HCV) may als...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.1.22
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:The accumulation of macrophage-derived foam cells in atherosclerotic lesions correlates with increased local release of matrix-degrading metalloproteinases (MMPs) and a thin fibrous cap. The activity of these enzymes is controlled by specific tissue inhibitors of metalloproteinases (TIMPs). METHODS AND RESU...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.3.420
更新日期:1999-01-26 00:00:00
abstract:BACKGROUND:Blood clotting activation is an important component of the inflammatory response; the outbursts of unstable angina are usually associated with increased thrombin formation and coronary mural thrombosis. METHODS AND RESULTS:To investigate 1) whether monocyte activation is responsible for the enhanced thrombi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.3.790
更新日期:1992-09-01 00:00:00
abstract::Considerable variability was observed among recruitment sources and centers in the proportion of first protocol visits proceeding to entry. Some of the reasons for these differences are explored. Several characteristics of the participants were also analyzed to determine whether significant variability existed among r...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1982-12-01 00:00:00
abstract::To determine the effect of calcium-channel blockers on beta-adrenergic receptors, we studied the interactions of verapamil, diltiazem, and nifedipine with both human lymphocyte beta 2-adrenergic receptors and rat myocardial beta 1-adrenergic receptors by means of radioligand binding assays. We also determined the func...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.72.3.547
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Patients with low-flow, low-gradient aortic stenosis have a poor prognosis with conservative therapy but a high operative mortality if treated surgically. Recently, we proposed a new index of aortic stenosis severity derived from dobutamine stress echocardiography, the projected aortic valve area at a normal...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.107.757427
更新日期:2008-09-30 00:00:00
abstract:BACKGROUND:Right ventricular (RV) function is the major determinant for both functional capacity and survival in patients with pulmonary arterial hypertension (PAH). Despite the recognized clinical importance of preserving RV function, the subcellular mechanisms that govern the transition from a compensated to a decomp...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.120.047626
更新日期:2020-10-13 00:00:00
abstract:BACKGROUND:This study was designed to evaluate the effect of arglabin on the NLRP3 inflammasome inhibition and atherosclerotic lesion in ApoE2Ki mice fed a high-fat Western-type diet. METHODS AND RESULTS:Arglabin was purified, and its chemical identity was confirmed by mass spectrometry. It inhibited, in a concentrati...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.013730
更新日期:2015-03-24 00:00:00
abstract::Neuroendocrine activation is known to occur in patients with congestive heart failure, but there is uncertainty as to whether this occurs before or after the presence of overt symptoms. In the Studies of Left Ventricular Dysfunction (SOLVD), a multicenter study of patients with ejection fractions of 35% or less, we co...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.cir.82.5.1724
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Central aortic pressures and waveform convey important information about cardiovascular status, but direct measurements are invasive. Peripheral pressures can be measured noninvasively, and although they often differ substantially from central pressures, they may be mathematically transformed to approximate ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.7.1827
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to describe the long-term event-free survival patterns of patients with significant coronary artery disease treated medically versus patterns of those treated surgically and to evaluate the factors associated with improved event-free survival. METHODS AND RESULTS:We studied the...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in pa...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.92.9.2579
更新日期:1995-11-01 00:00:00