Abstract:
:A family is reported in which two siblings had congenital complete heart block with resultant congestive heart failure, the father and paternal grandfather show adult-onset conduction defects, and the mother has systemic lupus erythematosis. The interaction of heredity and environment is discussed in this context. A review of the literature on familial complete heart block suggests that so-called pure congenital-onset familial heart block, originally felt to be genetic, may in fact have an important enivronmental component, specifically related to ongoing maternal factors such as systemic lupus erythematosis.
journal_name
Circulationjournal_title
Circulationauthors
Winkler RB,Nora AH,Nora JJdoi
10.1161/01.cir.56.6.1103subject
Has Abstractpub_date
1977-12-01 00:00:00pages
1103-7issue
6eissn
0009-7322issn
1524-4539journal_volume
56pub_type
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