Increased diastolic chamber stiffness during demand ischemia: response to quick length change differentiates rigor-activated from calcium-activated tension.

abstract：:The prognostic value of abnormalities on the electrocardiogram (ECG) present 1 year after initial myocardial infarction (MI) is examined in relation to reinfarction and coronary death throughout 32 years (mean, 10.1 years) of follow-up in the Framingham Heart Study. Resting 12-lead ECGs were available in 251 survivors...

journal_title：Circulation

authors： Wong ND,Levy D,Kannel WB

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into biliverdin, iron, and carbon monoxide (CO). Although HO-1 is induced in vascular smooth muscle cells (SMCs), the biological role of HO-1 in these cells has not been completely characterized. METHODS AND RESULTS:In the present study, we overexpre...

journal_title：Circulation

authors： Liu XM,Chapman GB,Wang H,Durante W

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Vascular injury and atherothrombosis involve vessel infiltration by inflammatory leukocytes, migration of medial vascular smooth muscle cells to the intimal layer, and ultimately acute thrombosis. A strategy to simultaneously target these pathological processes has yet to be identified. The secreted protein,...

journal_title：Circulation

authors： Patel S,Huang YW,Reheman A,Pluthero FG,Chaturvedi S,Mukovozov IM,Tole S,Liu GY,Li L,Durocher Y,Ni H,Kahr WH,Robinson LA

更新日期：2012-09-11 00:00:00

abstract：:Although immediate and late changes in coronary stenoses after percutaneous transluminal coronary angioplasty (PTCA) have been reported, most investigators have employed qualitative or semiquantitative techniques to analyze the angiograms. Such data is not optimal because of considerable interobserver variability and ...

journal_title：Circulation

authors： Johnson MR,Brayden GP,Ericksen EE,Collins SM,Skorton DJ,Harrison DG,Marcus ML,White CW

更新日期：1986-03-01 00:00:00

abstract：:In response to the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, the Chinese Society of Cardiology (CSC) issued this consensus statement after consulting with 125 medical experts in the fields of cardiovascular disease and infectious disease. The over-arching principles laid out here are the followi...

journal_title：Circulation

authors： Han Y,Zeng H,Jiang H,Yang Y,Yuan Z,Cheng X,Jing Z,Liu B,Chen J,Nie S,Zhu J,Li F,Ma C

更新日期：2020-05-19 00:00:00

abstract：:Heart potentials were recorded from the entire chest surface in 42 patients suffering from Wolff-Parkinson-White syndrome. We were able to identify six types of surface maps, according to the location of the potential maximum and minimum during the delta wave. For each of these types we suggested the most likely locat...

journal_title：Circulation

authors： De Ambroggi L,Taccardi B,Macchi E

更新日期：1976-08-01 00:00:00

abstract：:The purpose of the present study was to evaluate potential diurnal changes in resting coronary blood flow under conditions of comparable myocardial oxygen requirements. We studied 21 conscious, resting dogs instrumented for the measurement of coronary flow, left ventricular pressure, and regional myocardial segment le...

journal_title：Circulation

authors： Fujita M,Franklin D

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Continuous-flow rotary pumps with axial design are increasingly used for left ventricular assist support. The efficacy of this design compared with pulsatile, volume displacement pumps, with respect to characteristics of left ventricular unloading, and exercise performance remains largely unstudied. METHODS...

journal_title：Circulation

authors： Haft J,Armstrong W,Dyke DB,Aaronson KD,Koelling TM,Farrar DJ,Pagani FD

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:The possible contribution of endothelin-1, a potent endothelium-derived vasoconstrictor peptide, to neurohumoral compensation for hemodynamic stress was examined in nine normal volunteers and six patients with severe congestive heart failure. METHODS AND RESULTS:Plasma levels of endothelin-1 were measured w...

journal_title：Circulation

authors： Stewart DJ,Cernacek P,Costello KB,Rouleau JL

更新日期：1992-02-01 00:00:00

abstract：:Adults are living longer, and cardiovascular disease is endemic in the growing population of older adults who are surviving into old age. Functional capacity is a key metric in this population, both for the perspective it provides on aggregate health and as a vital goal of care. Whereas cardiorespiratory function has ...

journal_title：Circulation

authors： Forman DE,Arena R,Boxer R,Dolansky MA,Eng JJ,Fleg JL,Haykowsky M,Jahangir A,Kaminsky LA,Kitzman DW,Lewis EF,Myers J,Reeves GR,Shen WK,American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and St

更新日期：2017-04-18 00:00:00

abstract：BACKGROUND:The purpose of this study was to define the degree of intrinsic tone in conductance and resistance vessels, to define the calcium dependency of intrinsic tone in these vascular preparations, and to investigate the efficacy of vasodilatory agents on the level of intrinsic tone in these vascular preparations. ...

journal_title：Circulation

authors： Jain M,Dai HB,Carrozza JP,Sellke FW,Morgan KG

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:A variety of transcatheter atrial septal defect (ASD) occluders are currently in use around the world. Although for the most part effective, all of these devices lack features that would be desirable in a "perfect" device. The Helex septal occluder is a new type of device designed to improve the results of t...

journal_title：Circulation

authors： Zahn EM,Wilson N,Cutright W,Latson LA

更新日期：2001-08-07 00:00:00

abstract：BACKGROUND:The diagnosis of infective endocarditis (IE) in prosthetic valves and intracardiac devices is challenging because both the modified Duke criteria (DC) and echocardiography have limitations in this population. The added value of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed ...

journal_title：Circulation

authors： Pizzi MN,Roque A,Fernández-Hidalgo N,Cuéllar-Calabria H,Ferreira-González I,Gonzàlez-Alujas MT,Oristrell G,Gracia-Sánchez L,González JJ,Rodríguez-Palomares J,Galiñanes M,Maisterra-Santos O,Garcia-Dorado D,Castell-Conesa J,Alm

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:The CAPRICORN trial has shown that carvedilol improved outcome in patients with left ventricular dysfunction after acute myocardial infarction treated with ACE inhibitors. The aim of this substudy was to determine the effects of carvedilol on left ventricular remodeling in this patient group. METHODS AND RE...

journal_title：Circulation

authors： Doughty RN,Whalley GA,Walsh HA,Gamble GD,López-Sendón J,Sharpe N,CAPRICORN Echo Substudy Investigators.

更新日期：2004-01-20 00:00:00

abstract：BACKGROUND:Microvascular dysfunction in hypertrophic cardiomyopathy (HCM) may create an ischemic substrate conducive to sudden death, but it remains unknown whether the extent of hypertrophy is associated with proportionally poorer perfusion reserve. Comparisons between magnitude of hypertrophy, impairment of perfusion...

journal_title：Circulation

authors： Petersen SE,Jerosch-Herold M,Hudsmith LE,Robson MD,Francis JM,Doll HA,Selvanayagam JB,Neubauer S,Watkins H

更新日期：2007-05-08 00:00:00

abstract：BACKGROUND:Prosthetic valve thrombosis during pregnancy is life-threatening for mother and fetus, and the treatment of this complication is unclear. Cardiac surgery in pregnancy is associated with very high maternal and fetal mortality and morbidity. Thrombolytic therapy has rarely been used in these patients. The aim ...

journal_title：Circulation

authors： Özkan M,Çakal B,Karakoyun S,Gürsoy OM,Çevik C,Kalçık M,Oğuz AE,Gündüz S,Astarcioglu MA,Aykan AÇ,Bayram Z,Biteker M,Kaynak E,Kahveci G,Duran NE,Yıldız M

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Chronic inhibition of endothelial nitric oxide (NO) synthesis by the administration of N:(omega)-nitro-L-arginine methyl ester (L-NAME) to rats induces early vascular inflammatory changes (monocyte infiltration into coronary vessels and monocyte chemoattractant protein-1 [MCP-1] expression) as well as subseq...

journal_title：Circulation

authors： Koyanagi M,Egashira K,Kitamoto S,Ni W,Shimokawa H,Takeya M,Yoshimura T,Takeshita A

更新日期：2000-10-31 00:00:00

abstract：:R-wave synchronous equilbrium radionuclide angiography (RNA) is a noninvasive method that provides time-activity curve count information proportional to ventricular volumes and is used for relative volume comparisons within the left or right ventricle to derive the ejection fraction. Comparison of the ventricular coun...

journal_title：Circulation

authors： Sorensen SG,O'Rourke RA,Chaudhuri TK

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:Iron overload has an increasing worldwide prevalence and is associated with significant cardiovascular morbidity and mortality. Elevated iron levels in the myocardium lead to impaired systolic and diastolic function and elevated oxidative stress. Taurine accounts for 25% to 50% of the amino acid pool in myoc...

journal_title：Circulation

authors： Oudit GY,Trivieri MG,Khaper N,Husain T,Wilson GJ,Liu P,Sole MJ,Backx PH

更新日期：2004-04-20 00:00:00

abstract：:Disorders associated with the overproduction or delayed clearance of beta-very low density lipoprotein and low density lipoprotein (LDL) are strikingly related to premature coronary artery disease. There are five recognized classes of LDL-lowering drugs, each acting through different basic mechanisms. The increased pr...

journal_title：Circulation

authors： Levy RI,Troendle AJ,Fattu JM

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:The extent and mechanism of the antithrombotic properties of fibrin-selective and non-fibrin-selective thrombolytic agents have not yet been established. METHODS AND RESULTS:The antithrombotic, thrombolytic, fibrinogenolytic, and pharmacokinetic properties of the following substances were determined in hams...

journal_title：Circulation

authors： Stassen JM,Nyström A,Hoylaerts M,Collen D

更新日期：1995-03-01 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic has affected health and economy worldwide on an unprecedented scale. Patients have diverse clinical outcomes, but those with preexisting cardiovascular disease, hypertension, and related conditions incur disproportionately worse outcome. The high infectivity of severe a...

journal_title：Circulation

authors： Liu PP,Blet A,Smyth D,Li H

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:The relationship between autonomic activation and the mechanisms of paroxysmal atrial fibrillation remains unclear. METHODS AND RESULTS:We implanted a pacemaker and a radio transmitter in 7 dogs (group 1). After baseline recording, we paced the left atrium at 20 Hz for 1 week and then monitored left stellat...

journal_title：Circulation

authors： Tan AY,Zhou S,Ogawa M,Song J,Chu M,Li H,Fishbein MC,Lin SF,Chen LS,Chen PS

更新日期：2008-08-26 00:00:00

abstract：BACKGROUND:We recently reported that arterial superoxide (O2-) is augmented by increased endothelin-1 (ET-1) in deoxycorticosterone acetate (DOCA)-salt hypertension, a model of low renin hypertension. Tetrahydrobiopterin (BH4), a potent reducing molecule with antioxidant properties and an essential cofactor for endothe...

journal_title：Circulation

authors： Zheng JS,Yang XQ,Lookingland KJ,Fink GD,Hesslinger C,Kapatos G,Kovesdi I,Chen AF

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Hypercholesterolemia causes an upregulation of vascular angiotensin II type 1 (AT1) receptor expression in cell culture and animal models. The presented studies were undertaken to examine AT1 receptor overexpression in hypercholesterolemic men and therapeutic interventions thereof by HMG CoA reductase inhibi...

journal_title：Circulation

authors： Nickenig G,Bäumer AT,Temur Y,Kebben D,Jockenhövel F,Böhm M

更新日期：1999-11-23 00:00:00

abstract：BACKGROUND:Graft survival after skeletal myoblast transplantation is affected by various pathological processes caused by environmental stress. Heat shock is known to afford protection of several aspects of cell metabolism and function. We hypothesized that prior heat shock treatment of graft cells would improve their ...

journal_title：Circulation

authors： Suzuki K,Smolenski RT,Jayakumar J,Murtuza B,Brand NJ,Yacoub MH

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:Recognition of the complex pathophysiology of heart failure and its high mortality has emphasized the need for prognostic markers that can be used in clinical assessment as well as in the design of mortality trials. Data from the Department of Veterans Affairs Cooperative Vasodilator-Heart Failure Trials (V-...

journal_title：Circulation

authors： Cohn JN,Johnson GR,Shabetai R,Loeb H,Tristani F,Rector T,Smith R,Fletcher R

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:The Na+-H+ exchanger figures prominently in cardiac ischemia-reperfusion injury. Several experimental and clinical studies have demonstrated a cardioprotective effect of Na+-H+ exchanger inhibition; however, the precise mechanisms have not been established. METHODS AND RESULTS:We examined the effects of car...

journal_title：Circulation

authors： Teshima Y,Akao M,Jones SP,Marbán E

更新日期：2003-11-04 00:00:00

abstract：:Despite a 2% to 3% prevalence of echocardiographically defined mitral valve prolapse (MVP) in the general population, the actual burden, risk stratification, and treatment of the so-called arrhythmic MVP are unknown. The clinical profile is characterized by a patient, usually female, with mostly bileaflet myxomatous d...

journal_title：Circulation

authors： Basso C,Iliceto S,Thiene G,Perazzolo Marra M

更新日期：2019-09-10 00:00:00

abstract：BACKGROUND:Early stages of coronary atherosclerosis are characterized by a mainly functional impairment of coronary vasodilator capacity under the impact of such risk factors as hypercholesterolemia. The goal of this study was to determine whether 6-month cholesterol-lowering therapy improves coronary flow reserve in p...

journal_title：Circulation

authors： Baller D,Notohamiprodjo G,Gleichmann U,Holzinger J,Weise R,Lehmann J

更新日期：1999-06-08 00:00:00