Serum antibodies against Chlamydia pneumoniae outer membrane protein cross-react with the heavy chain of immunoglobulin in the wall of abdominal aortic aneurysms.

Abstract:

BACKGROUND:Chlamydia pneumoniae (Cp) has been demonstrated in arteries and abdominal aortic aneurysms (AAAs). However, the validity of the methods used is questioned, and antibiotic treatment trials have thus far shown disappointing results. Nevertheless, antibodies against the Cp outer membrane proteins (OMPs) have been associated with progression of atherosclerosis and AAAs. The aim of this study was to detect Cp OMPs in the wall of AAA patients by use of purified serum antibodies directed against Cp OMP and to assess potential cross-reacting proteins in AAA walls. METHODS AND RESULTS:Seventeen patients undergoing infrarenal AAA repair were studied. Full AAA thickness tissue was collected from the anterior wall of the aneurysm. Anti-OMP was extracted from seropositive AAA patients by use of an ELISA kit (Labsystems). Analysis was performed by use of 2D polyacrylamide gel electrophoresis, immunoblotting, and mass spectrometric protein identification. OMP antigens were not detected in 16 of 17 AAA walls. However, 3 major AAA proteins cross-reacted with anti-OMP. The proteins were all identified as heavy chains of human immunoglobulin. CONCLUSIONS:We could not find evidence of Cp OMP in 16 of 17 AAA walls, but instead, all samples showed a strong cross-reaction between Cp OMP antibodies and human immunoglobulin. This might indicate that AAA is an autoimmune disease, perhaps triggered by an initial Cp infection.

journal_name

Circulation

journal_title

Circulation

authors

Lindholt JS,Støvring J,Østergaard L,Urbonavicius S,Henneberg EW,Honoré B,Vorum H

doi

10.1161/01.CIR.0000127772.58427.7E

subject

Has Abstract

pub_date

2004-05-04 00:00:00

pages

2097-102

issue

17

eissn

0009-7322

issn

1524-4539

pii

01.CIR.0000127772.58427.7E

journal_volume

109

pub_type

杂志文章
  • Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program.

    abstract:BACKGROUND:Surviving cells in the postinfarction border zone are subjected to intense fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been specifically implicated in cardiac regeneration. Here, we defined their unique transcriptional and regulatory properties, and comprehensively valid...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.118.038944

    authors: van Duijvenboden K,de Bakker DEM,Man JCK,Janssen R,Günthel M,Hill MC,Hooijkaas IB,van der Made I,van der Kraak PH,Vink A,Creemers EE,Martin JF,Barnett P,Bakkers J,Christoffels VM

    更新日期:2019-09-09 00:00:00

  • Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K ant

    abstract:BACKGROUND:We sought to define the factors associated with the occurrence of stroke and systemic embolism in a large, international atrial fibrillation (AF) trial. METHODS AND RESULTS:In ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.112.107128

    authors: Piccini JP,Stevens SR,Chang Y,Singer DE,Lokhnygina Y,Go AS,Patel MR,Mahaffey KW,Halperin JL,Breithardt G,Hankey GJ,Hacke W,Becker RC,Nessel CC,Fox KA,Califf RM,ROCKET AF Steering Committee and Investigators.

    更新日期:2013-01-15 00:00:00

  • Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein E-/- mice and rabbits fed a high-fat and -cholesterol diet.

    abstract:BACKGROUND:Glycosphingolipids, integral components of the cell membrane, have been shown to serve as messengers, transducing growth factor-initiated phenotypes. Here, we have examined whether inhibition of glycosphingolipid synthesis could ameliorate atherosclerosis and arterial stiffness in transgenic mice and rabbits...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.113.007559

    authors: Chatterjee S,Bedja D,Mishra S,Amuzie C,Avolio A,Kass DA,Berkowitz D,Renehan M

    更新日期:2014-06-10 00:00:00

  • Cardiac autonomic patterns preceding occasional vasovagal reactions in healthy humans.

    abstract:BACKGROUND:The wide range of clinical presentation of orthostatic vasovagal syncope suggests different underlying changes in the cardiac autonomic modulation. METHODS AND RESULTS:To evaluate the beat-by-beat modifications in the neural control of heart period preceding a syncopal event, we studied RR interval variabil...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.98.17.1756

    authors: Furlan R,Piazza S,Dell'Orto S,Barbic F,Bianchi A,Mainardi L,Cerutti S,Pagani M,Malliani A

    更新日期:1998-10-27 00:00:00

  • Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction.

    abstract:BACKGROUND:Myocardial infarction (MI) is an ischemic wound that recruits millions of leukocytes. MI-associated blood leukocytosis correlates inversely with patient survival, yet the signals driving heightened leukocyte production after MI remain incompletely understood. METHODS AND RESULTS:With the use of parabiosis s...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.115.016160

    authors: Sager HB,Heidt T,Hulsmans M,Dutta P,Courties G,Sebas M,Wojtkiewicz GR,Tricot B,Iwamoto Y,Sun Y,Weissleder R,Libby P,Swirski FK,Nahrendorf M

    更新日期:2015-11-17 00:00:00

  • C-reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis.

    abstract:BACKGROUND:LDL and C-reactive protein (CRP) are important cardiovascular risk factors. Both LDL and CRP deposit in the arterial wall during atherogenesis. Stranded LDL is taken up by macrophages, causing foam cell formation. Because native LDL does not induce foam cell formation, we hypothesized that CRP may opsonize n...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.103.9.1194

    authors: Zwaka TP,Hombach V,Torzewski J

    更新日期:2001-03-06 00:00:00

  • Distinct downregulation of C-type natriuretic peptide system in human aortic valve stenosis.

    abstract:BACKGROUND:Aortic valve calcification is an actively regulated process that displays hallmarks of atherosclerosis. Natriuretic peptides (A-, B-, and C-type natriuretic peptides [ANP, BNP, and CNP]) have been reported to have a role in the pathogenesis of vascular atherosclerosis, but their expression in aortic valves i...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.685743

    authors: Peltonen TO,Taskinen P,Soini Y,Rysä J,Ronkainen J,Ohtonen P,Satta J,Juvonen T,Ruskoaho H,Leskinen H

    更新日期:2007-09-11 00:00:00

  • Coronary stenting with a new, radiopaque, balloon-expandable endoprosthesis in pigs.

    abstract:BACKGROUND:Intracoronary stents may be effective when used as "bail-out" devices for acute complications after percutaneous transluminal coronary angioplasty. Furthermore, preliminary reports have demonstrated some promising results with stents with regard to the reduction of restenosis. Several stent devices are avail...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.83.5.1788

    authors: van der Giessen WJ,Serruys PW,van Beusekom HM,van Woerkens LJ,van Loon H,Soei LK,Strauss BH,Beatt KJ,Verdouw PD

    更新日期:1991-05-01 00:00:00

  • Cardiac manifestations of malignant hyperthermia susceptibility.

    abstract::Malignant hyperthermia is a disease resulting from defective cellular membranes, usually presenting as drug-induced pyrexic crises. We describe four patients with life threatening ventricular arrhythmias or chest pain in the absence of pyrexic crises. Three presented with life threatening arrhythmias and the fourth wi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.58.5.916

    authors: Huckell VF,Staniloff HM,Britt BA,Waxman MB,Morch JE

    更新日期:1978-11-01 00:00:00

  • Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

    abstract::Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiova...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.119.040551

    authors: Tian R,Colucci WS,Arany Z,Bachschmid MM,Ballinger SW,Boudina S,Bruce JE,Busija DW,Dikalov S,Dorn GW II,Galis ZS,Gottlieb RA,Kelly DP,Kitsis RN,Kohr MJ,Levy D,Lewandowski ED,McClung JM,Mochly-Rosen D,O'Brien KD,O'R

    更新日期:2019-10-01 00:00:00

  • Prevalence and prognostic significance of wall-motion abnormalities in adults without clinically recognized cardiovascular disease: the Strong Heart Study.

    abstract:BACKGROUND:Left ventricular wall motion (WM) abnormalities have recognized prognostic significance in patients with coronary or other heart diseases; however, whether abnormal WM predicts adverse events in adults without overt cardiovascular disease has not been assessed. Our objective was to determine whether echocard...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.652149

    authors: Cicala S,de Simone G,Roman MJ,Best LG,Lee ET,Wang W,Welty TK,Galloway JM,Howard BV,Devereux RB

    更新日期:2007-07-10 00:00:00

  • Reappraisal of Reported Genes for Sudden Arrhythmic Death: Evidence-Based Evaluation of Gene Validity for Brugada Syndrome.

    abstract:BACKGROUND:Implicit in the genetic evaluation of patients with suspected genetic diseases is the assumption that the genes evaluated are causative for the disease based on robust scientific and statistical evidence. However, in the past 20 years, considerable variability has existed in the study design and quality of e...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.118.035070

    authors: Hosseini SM,Kim R,Udupa S,Costain G,Jobling R,Liston E,Jamal SM,Szybowska M,Morel CF,Bowdin S,Garcia J,Care M,Sturm AC,Novelli V,Ackerman MJ,Ware JS,Hershberger RE,Wilde AAM,Gollob MH,National Institutes of Health C

    更新日期:2018-09-18 00:00:00

  • Genetic components of the circadian clock regulate thrombogenesis in vivo.

    abstract:BACKGROUND:Myocardial infarction, stroke, and sudden death undergo diurnal variation. Although genes relevant to hemostasis and vascular integrity undergo circadian oscillation, the role of the molecular clock in thrombotic events remains to be established. METHODS AND RESULTS:A diurnal variation in the time to thromb...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.739227

    authors: Westgate EJ,Cheng Y,Reilly DF,Price TS,Walisser JA,Bradfield CA,FitzGerald GA

    更新日期:2008-04-22 00:00:00

  • Arterial oxygenation and arterial oxygen transport in chronic myocardial failure at rest, during exercise and after hydralazine treatment.

    abstract::Arterial oxygen transport (cardiac output x arterial oxygen content) may be decreased in heart failure. We studied the determinants of arterial oxygen transport in 15 patients with chronic, severe myocardial failure at rest and during cycle ergometry. During control therapy at rest, arterial oxygen tension was normal ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.66.1.143

    authors: Rubin SA,Brown HV,Swan HJ

    更新日期:1982-07-01 00:00:00

  • Waiting list mortality among children listed for heart transplantation in the United States.

    abstract:BACKGROUND:Children listed for heart transplantation face the highest waiting list mortality in solid-organ transplantation medicine. We examined waiting list mortality since the pediatric heart allocation system was revised in 1999 to determine whether the revised allocation system is prioritizing patients optimally a...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.108.815712

    authors: Almond CSD,Thiagarajan RR,Piercey GE,Gauvreau K,Blume ED,Bastardi HJ,Fynn-Thompson F,Singh TP

    更新日期:2009-02-10 00:00:00

  • A new method for quantitation of mitral regurgitation based on color flow Doppler imaging of flow convergence proximal to regurgitant orifice.

    abstract:BACKGROUND:Imaging of the flow convergence region (FCR) proximal to a regurgitant orifice has been shown to provide a method for quantifying the regurgitant flow rate. According to the continuity principle, the FCR is constituted by concentric hemispheric isovelocity surfaces centered at the orifice. The flow rate is c...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.84.4.1481

    authors: Bargiggia GS,Tronconi L,Sahn DJ,Recusani F,Raisaro A,De Servi S,Valdes-Cruz LM,Montemartini C

    更新日期:1991-10-01 00:00:00

  • Dronedarone.

    abstract::Amiodarone is the most effective antiarrhythmic drug for maintaining sinus rhythm for patients with atrial fibrillation. Extra-cardiac side effects have been a limiting factor, especially during chronic use, and may offset its benefits. Dronedarone is a noniodinated benzofuran derivative of amiodarone that has been de...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.109.858027

    authors: Patel C,Yan GX,Kowey PR

    更新日期:2009-08-18 00:00:00

  • Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.

    abstract:BACKGROUND:Atherosclerosis is an inflammatory disease in which interferon (IFN)-gamma, the signature cytokine of Th1 cells, plays a central role. We investigated whether interleukin (IL)-17, the signature cytokine of Th17 cells, is also associated with human coronary atherosclerosis. METHODS AND RESULTS:Circulating IL...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.108.827618

    authors: Eid RE,Rao DA,Zhou J,Lo SF,Ranjbaran H,Gallo A,Sokol SI,Pfau S,Pober JS,Tellides G

    更新日期:2009-03-17 00:00:00

  • Feasibility, safety, and therapeutic efficacy of human induced pluripotent stem cell-derived cardiomyocyte sheets in a porcine ischemic cardiomyopathy model.

    abstract:BACKGROUND:Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are a promising source of cells for regenerating myocardium. However, several issues, especially the large-scale preparation of hiPS-CMs and elimination of undifferentiated iPS cells, must be resolved before hiPS cells can be used clinical...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.111.084343

    authors: Kawamura M,Miyagawa S,Miki K,Saito A,Fukushima S,Higuchi T,Kawamura T,Kuratani T,Daimon T,Shimizu T,Okano T,Sawa Y

    更新日期:2012-09-11 00:00:00

  • Hypertension, white matter hyperintensities, and concurrent impairments in mobility, cognition, and mood: the Cardiovascular Health Study.

    abstract:BACKGROUND:Our objective was to investigate the association between hypertension and concurrent impairments in mobility, cognition, and mood; the role of brain white matter hyperintensities in mediating this association; and the impact of these impairments on disability and mortality in elderly hypertensive individuals...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.110.978114

    authors: Hajjar I,Quach L,Yang F,Chaves PH,Newman AB,Mukamal K,Longstreth W Jr,Inzitari M,Lipsitz LA

    更新日期:2011-03-01 00:00:00

  • Mitral leaflet remodeling in dilated cardiomyopathy.

    abstract:BACKGROUND:Normal mammalian mitral leaflets have regional heterogeneity of biochemical composition, collagen fiber orientation, and geometric deformation. How leaflet shape and regional geometry are affected in dilated cardiomyopathy is unknown. METHODS AND RESULTS:Nine sheep had 8 radio-opaque markers affixed to the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.000554

    authors: Timek TA,Lai DT,Dagum P,Liang D,Daughters GT,Ingels NB Jr,Miller DC

    更新日期:2006-07-04 00:00:00

  • Ninety-minute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I.

    abstract:BACKGROUND:Diagnostic strategies with ECG and serum cardiac markers have been used to rule out acute myocardial infarction in 6 to 12 hours. The present study evaluated whether a multimarker strategy that used point-of-care measurement of myoglobin, creatine kinase (CK)-MB, and troponin I could exclude acute myocardial...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc3801.096336

    authors: McCord J,Nowak RM,McCullough PA,Foreback C,Borzak S,Tokarski G,Tomlanovich MC,Jacobsen G,Weaver WD

    更新日期:2001-09-25 00:00:00

  • Adverse intrauterine conditions diminish the fetal defense against acute hypoxia by increasing nitric oxide activity.

    abstract:BACKGROUND:The incidence of perinatal morbidity arising from birth hypoxia or asphyxia has not changed significantly in recent years despite marked improvements in labor management. Perinatal mortality in these circumstances may therefore reflect antenatal compromise and subsequent alteration of the fetal capacity to r...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000033827.48974.c8

    authors: Gardner DS,Fowden AL,Giussani DA

    更新日期:2002-10-22 00:00:00

  • Double-blind placebo-controlled trial of digoxin in symptomatic paroxysmal atrial fibrillation.

    abstract:BACKGROUND:Digoxin is commonly prescribed in symptomatic paroxysmal atrial fibrillation (AF) but has never been evaluated in this condition. METHODS AND RESULTS:From a multicenter registry, 43 representative patients with frequent symptomatic AF episodes were recruited into a randomized, double-blind crossover compari...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.cir.99.21.2765

    authors: Murgatroyd FD,Gibson SM,Baiyan X,O'Nunain S,Poloniecki JD,Ward DE,Malik M,Camm AJ

    更新日期:1999-06-01 00:00:00

  • Brief antecedent ischemia enhances recombinant tissue plasminogen activator-induced coronary thrombolysis by adenosine-mediated mechanism.

    abstract:BACKGROUND:Clinical studies have implicated preinfarct angina (brief antecedent ischemia/reperfusion [I/R]) as a predictor of more rapid thrombolysis and lower rates of reocclusion. However, the effects of antecedent ischemia on the efficacy of thrombolysis have not been rigorously assessed. Using a canine model of cor...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.1.88

    authors: Przyklenk K,Whittaker P

    更新日期:2000-07-04 00:00:00

  • Measles virus nucleoprotein induces a regulatory immune response and reduces atherosclerosis in mice.

    abstract:BACKGROUND:Recent studies clearly suggest that regulatory T cells play a critical role in the control of the immunoinflammatory response in atherosclerosis and substantially limit lesion development. Measles virus infection or vaccination is associated with immune depression, in part through the induction of an antiinf...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.699470

    authors: Ait-Oufella H,Horvat B,Kerdiles Y,Herbin O,Gourdy P,Khallou-Laschet J,Merval R,Esposito B,Tedgui A,Mallat Z

    更新日期:2007-10-09 00:00:00

  • Depression, heart rate variability, and acute myocardial infarction.

    abstract:BACKGROUND:Clinical depression is associated with an increased risk for mortality in patients with a recent myocardial infarction (MI). Reduced heart rate variability (HRV) has been suggested as a possible explanation for this association. The purpose of this study was to determine if depression is associated with redu...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/hc4201.097834

    authors: Carney RM,Blumenthal JA,Stein PK,Watkins L,Catellier D,Berkman LF,Czajkowski SM,O'Connor C,Stone PH,Freedland KE

    更新日期:2001-10-23 00:00:00

  • Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.

    abstract:BACKGROUND:Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly understood. METHODS AND RESULTS:We used a forward genetic screen in zebrafish to identify novel genes required for myocardial fu...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.689984

    authors: Knöll R,Postel R,Wang J,Krätzner R,Hennecke G,Vacaru AM,Vakeel P,Schubert C,Murthy K,Rana BK,Kube D,Knöll G,Schäfer K,Hayashi T,Holm T,Kimura A,Schork N,Toliat MR,Nürnberg P,Schultheiss HP,Schaper W,Schaper J,

    更新日期:2007-07-31 00:00:00

  • Recent progress in understanding apolipoprotein B.

    abstract::For the past 5 years, investigators from many different laboratories have contributed to a greatly increased understanding of two very important lipid-carrying proteins in plasma--apo B-100 and apo B-48. Apo B-100, an extremely large protein composed of 4,536 amino acids, is synthesized by the liver and is crucial for...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/01.cir.82.5.1574

    authors: Young SG

    更新日期:1990-11-01 00:00:00

  • Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo.

    abstract:BACKGROUND:Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications. METHODS AND RESULTS:To test the hypothesis that optical molecular imaging with the use of an activatable near-infrared fluorescence (NIRF) p...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.619056

    authors: Deguchi JO,Aikawa M,Tung CH,Aikawa E,Kim DE,Ntziachristos V,Weissleder R,Libby P

    更新日期:2006-07-04 00:00:00