Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial.


BACKGROUND:Restenosis after percutaneous coronary intervention (PCI) is a major problem affecting 15% to 30% of patients after stent placement. No oral agent has shown a beneficial effect on restenosis or on associated major adverse cardiovascular events. In limited trials, the oral agent tranilast has been shown to decrease the frequency of angiographic restenosis after PCI. METHODS AND RESULTS:In this double-blind, randomized, placebo-controlled trial of tranilast (300 and 450 mg BID for 1 or 3 months), 11 484 patients were enrolled. Enrollment and drug were initiated within 4 hours after successful PCI of at least 1 vessel. The primary end point was the first occurrence of death, myocardial infarction, or ischemia-driven target vessel revascularization within 9 months and was 15.8% in the placebo group and 15.5% to 16.1% in the tranilast groups (P=0.77 to 0.81). Myocardial infarction was the only component of major adverse cardiovascular events to show some evidence of a reduction with tranilast (450 mg BID for 3 months): 1.1% versus 1.8% with placebo (P=0.061 for intent-to-treat population). The primary reason for not completing treatment was > or =1 hepatic laboratory test abnormality (11.4% versus 0.2% with placebo, P<0.01). In the angiographic substudy composed of 2018 patients, minimal lumen diameter (MLD) was measured by quantitative coronary angiography. At follow-up, MLD was 1.76+/-0.77 mm in the placebo group, which was not different from MLD in the tranilast groups (1.72 to 1.78+/-0.76 to 80 mm, P=0.49 to 0.89). In a subset of these patients (n=1107), intravascular ultrasound was performed at follow-up. Plaque volume was not different between the placebo and tranilast groups (39.3 versus 37.5 to 46.1 mm(3), respectively; P=0.16 to 0.72). CONCLUSIONS:Tranilast does not improve the quantitative measures of restenosis (angiographic and intravascular ultrasound) or its clinical sequelae.






Holmes DR Jr,Savage M,LaBlanche JM,Grip L,Serruys PW,Fitzgerald P,Fischman D,Goldberg S,Brinker JA,Zeiher AM,Shapiro LM,Willerson J,Davis BR,Ferguson JJ,Popma J,King SB 3rd,Lincoff AM,Tcheng JE,Chan R,Granett JR,P




Has Abstract


2002-09-03 00:00:00












  • Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1).

    abstract:BACKGROUND:Chemokines are important mediators of inflammatory cell recruitment that play a significant role in atherosclerosis. Fractalkine (CX3CL1) is an unusual membrane-bound chemokine that mediates chemotaxis through the CX3CR1 receptor. Recently, functional polymorphisms in the human CX3CR1 gene have been describe...


    pub_type: 杂志文章


    authors: Lucas AD,Bursill C,Guzik TJ,Sadowski J,Channon KM,Greaves DR

    更新日期:2003-11-18 00:00:00

  • PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine.

    abstract:BACKGROUND:Signaling through protein tyrosine kinases (PTKs) is a major contributor to the transmission of mitogenic stimuli to the interior of the cell and nucleus. The present study was designed to determine the effect of the tyrphostin AG1295, a selective blocker of PDGF-receptor PTK, on the growth of porcine and hu...


    pub_type: 杂志文章


    authors: Banai S,Wolf Y,Golomb G,Pearle A,Waltenberger J,Fishbein I,Schneider A,Gazit A,Perez L,Huber R,Lazarovichi G,Rabinovich L,Levitzki A,Gertz SD

    更新日期:1998-05-19 00:00:00

  • Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure.

    abstract:BACKGROUND:Adrenomedullin is a recently discovered endogenous peptide with hypotensive and natriuretic actions in normal animals. Circulating and ventricular adrenomedullin are elevated in congestive heart failure, suggesting a possible role in the pathophysiology of this disease. No studies have previously examined th...


    pub_type: 杂志文章


    authors: Rademaker MT,Charles CJ,Lewis LK,Yandle TG,Cooper GJ,Coy DH,Richards AM,Nicholls MG

    更新日期:1997-09-16 00:00:00

  • Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.

    abstract:BACKGROUND:We hypothesized that cytomegalovirus (CMV) may contribute to the vasculopathy observed in cardiac allograft recipients by impairing the endothelial nitric oxide synthase pathway. We focused on asymmetric dimethylarginine (ADMA, the endogenous inhibitor of nitric oxide synthase) as a potential mediator of the...


    pub_type: 杂志文章


    authors: Weis M,Kledal TN,Lin KY,Panchal SN,Gao SZ,Valantine HA,Mocarski ES,Cooke JP

    更新日期:2004-02-03 00:00:00

  • Concealed intraventricular conduction in the His bundle electrogram.

    abstract::Multiple areas of concealed intraventricular conduction are deduced on the basis of aftereffects observed in His bundle recordings. Electrocardiograms and His bundle recordings are presented from two patients with unstable bilateral bundle branch block, the instability of which depended on the interval at which ventri...


    pub_type: 杂志文章


    authors: Cohen HC,D'Cruz I,Pick A

    更新日期:1976-05-01 00:00:00

  • Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study.

    abstract:BACKGROUND:Low endothelial shear stress (ESS) promotes the development of atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution to inflamed high-risk plaques has not been studied. Our hypothesis was that the lowest values of ESS are responsible for the development of high-risk c...


    pub_type: 杂志文章


    authors: Chatzizisis YS,Jonas M,Coskun AU,Beigel R,Stone BV,Maynard C,Gerrity RG,Daley W,Rogers C,Edelman ER,Feldman CL,Stone PH

    更新日期:2008-02-26 00:00:00

  • Effects of stress and beta-blockade on platelet function.

    abstract::Platelet function can be assessed by various techniques in vitro or in vivo, but methodological problems in the field are considerable. By use of the conventional in vitro technique (Born aggregometry), it has been shown that sympathoadrenal activation in vivo (e.g., mental stress, epinephrine infusions, exercise, and...


    pub_type: 杂志文章,评审


    authors: Hjemdahl P,Larsson PT,Wallén NH

    更新日期:1991-12-01 00:00:00

  • The nitrovasodilators. New ideas about old drugs.

    abstract::The nitrovasodilators are a diverse group of pharmacological agents that produce vascular relaxation by releasing nitric oxide. The mechanisms by which these compounds release nitric oxide vary, depending on their chemical structure. Compounds with lower oxidation states of nitrogen such as nitroprusside, nitrosamines...


    pub_type: 杂志文章,评审


    authors: Harrison DG,Bates JN

    更新日期:1993-05-01 00:00:00

  • Does coronary artery bypass surgery restore normal maximal coronary flow reserve? The effect of diffuse atherosclerosis and focal obstructive lesions.

    abstract::Aortocoronary vein bypass surgery might not restore normal maximal coronary flow reserve to bypassed coronary vessels because residual diffuse coronary atherosclerosis might limit maximal hyperemia. To investigate the effect of diffuse atherosclerosis and a focal stenosis at the graft-coronary anastomosis, we measured...


    pub_type: 杂志文章


    authors: Wilson RF,White CW

    更新日期:1987-09-01 00:00:00

  • Role of thrombin compared with factor Xa in the procoagulant activity of whole blood clots.

    abstract:BACKGROUND:Thrombi are known to induce activation of the coagulation system, which may be a mechanism for progression of thrombosis and its recurrence after thrombolysis. This study was designed to characterize the relative role of thrombin and activated factor X (factor Xa) as mediators of procoagulant activity of who...


    pub_type: 杂志文章


    authors: Prager NA,Abendschein DR,McKenzie CR,Eisenberg PR

    更新日期:1995-08-15 00:00:00

  • Linear ablation of the isthmus between the inferior vena cava and tricuspid annulus for the treatment of atrial flutter. A study in the canine atrial flutter model.

    abstract:BACKGROUND:The isthmus between the inferior vena cava and the tricuspid annulus has been shown to be involved in the reentry circuit of common atrial flutter. The effects of radio-frequency catheter ablation of this isthmus were examined in the canine model of atrial flutter due to reentry around the tricuspid annulus....


    pub_type: 杂志文章


    authors: Tabuchi T,Okumura K,Matsunaga T,Tsunoda R,Jougasaki M,Yasue H

    更新日期:1995-09-01 00:00:00

  • Stabilization of atherosclerotic plaques by blockade of macrophage migration inhibitory factor after vascular injury in apolipoprotein E-deficient mice.

    abstract:BACKGROUND:Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its functional contribution to lesion development has not been evaluated. METHODS AND RESULTS:We studied the role of MIF on neointima lesion formation after ...


    pub_type: 杂志文章


    authors: Schober A,Bernhagen J,Thiele M,Zeiffer U,Knarren S,Roller M,Bucala R,Weber C

    更新日期:2004-01-27 00:00:00

  • Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats.

    abstract:BACKGROUND:Estrogen may increase the long-term survival of women who have suffered from a myocardial infarction (MI). We examined the acute and chronic influence of estrogen on MI in the rat left coronary artery ligation model. METHODS AND RESULTS:Female Sprague-Dawley rats (10 to 12 weeks, n=93), divided into 3 group...


    pub_type: 杂志文章


    authors: Smith PJ,Ornatsky O,Stewart DJ,Picard P,Dawood F,Wen WH,Liu PP,Webb DJ,Monge JC

    更新日期:2000-12-12 00:00:00

  • Elevated serum triglyceride levels and long-term mortality in patients with coronary heart disease: the Bezafibrate Infarction Prevention (BIP) Registry.

    abstract:BACKGROUND:The association between elevated blood triglyceride levels and subsequent mortality risk in patients with established coronary heart disease (CHD) has been investigated rarely. The aim of the present study was to investigate this association. METHODS AND RESULTS:We evaluated mortality over a mean follow-up ...


    pub_type: 杂志文章


    authors: Haim M,Benderly M,Brunner D,Behar S,Graff E,Reicher-Reiss H,Goldbourt U

    更新日期:1999-08-03 00:00:00

  • Smoking is associated with epicardial coronary endothelial dysfunction and elevated white blood cell count in patients with chest pain and early coronary artery disease.

    abstract:BACKGROUND:Smoking is a major risk factor for cardiovascular events. One of the potential mechanisms may be related to both coronary endothelial dysfunction and increased inflammatory response. The present study was designed to test the hypothesis that smoking is associated with epicardial coronary endothelial dysfunct...


    pub_type: 杂志文章


    authors: Lavi S,Prasad A,Yang EH,Mathew V,Simari RD,Rihal CS,Lerman LO,Lerman A

    更新日期:2007-05-22 00:00:00

  • Red wine inhibits monocyte chemotactic protein-1 expression and modestly reduces neointimal hyperplasia after balloon injury in cholesterol-Fed rabbits.

    abstract:BACKGROUND:Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte c...


    pub_type: 杂志文章


    authors: Feng AN,Chen YL,Chen YT,Ding YZ,Lin SJ

    更新日期:1999-11-30 00:00:00

  • Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction. GUSTO-I (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) Trial Investigators.

    abstract:BACKGROUND:Ventricular septal defect (VSD) complicating acute myocardial infarction has been studied primarily in small, prethrombolytic-era trials. Our goal was to determine clinical predictors and angiographic and clinical outcomes of this complication in the thrombolytic era. METHODS AND RESULTS:We compared enrollm...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Crenshaw BS,Granger CB,Birnbaum Y,Pieper KS,Morris DC,Kleiman NS,Vahanian A,Califf RM,Topol EJ

    更新日期:2000-01-04 00:00:00

  • Quantification of myocardial infarct size by thallium-201 single-photon emission computed tomography: experimental validation in the dog.

    abstract::To evaluate the potential advantages of thallium-201 (201T1) single-photon emission computerized tomography (SPECT) to assess myocardial infarct size in the experimental animal, six normal dogs and 14 dogs with 6 to 8 hr closed-chest coronary occlusion (eight left anterior descending and six left circumflex) were stud...


    pub_type: 杂志文章


    authors: Prigent F,Maddahi J,Garcia EV,Satoh Y,Van Train K,Berman DS

    更新日期:1986-10-01 00:00:00

  • Endocardial carbon-braid electrodes. A new concept for lower defibrillation thresholds.

    abstract:BACKGROUND:In the treatment of patients with life-threatening ventricular arrhythmia, transvenous implantable cardioverter/defibrillators provide significant advantages over devices requiring a thoracotomy. This study tested the hypothesis that a new carbon-fiber electrode, designed at the Technische Universität in Mun...


    pub_type: 杂志文章


    authors: Alt EU,Fotuhi PC,Callihan RL,Mestre E,Smith WM,Ideker RE

    更新日期:1995-09-15 00:00:00

  • Mechanism of atrial sounds in atrial fibrillation. Phonoechocardiographic correlation. Report of a case.

    abstract::Audible atrial sounds were noted in a patient with congestive cardiomyopathy and atrial fibrillation with slow ventricular rate. Oscillatory motion of similar periodicity as fibrillation waves in the ECG and the sounds in the phonocardiogram was demonstrated in aortic and left ventricular walls, mitral, tricuspid and ...


    pub_type: 杂志文章


    authors: Bamrah VS,Hughes CV,Tristani FE

    更新日期:1976-03-01 00:00:00

  • Incidence and prognosis of resistant hypertension in hypertensive patients.

    abstract:BACKGROUND:Despite a recent American Heart Association (AHA) consensus statement emphasizing the importance of resistant hypertension, the incidence and prognosis of this condition are largely unknown. METHODS AND RESULTS:This retrospective cohort study in 2 integrated health plans included patients with incident hype...


    pub_type: 杂志文章


    authors: Daugherty SL,Powers JD,Magid DJ,Tavel HM,Masoudi FA,Margolis KL,O'Connor PJ,Selby JV,Ho PM

    更新日期:2012-04-03 00:00:00

  • Quantitative determination of aortic regurgitant volumes in dogs by ultrafast computed tomography.

    abstract::Current imaging modalities can provide only a qualitative or semiquantitative measure of the severity of aortic regurgitation. Ultrafast computed tomography (CT) has the capability of rapid imaging (17 frames/sec) coupled with high spatial resolution (1.5 mm2). Eight millimeter thick images can be acquired to interrog...


    pub_type: 杂志文章


    authors: Reiter SJ,Rumberger JA,Stanford W,Marcus ML

    更新日期:1987-09-01 00:00:00

  • Sex-related differences in the normal cardiac response to upright exercise.

    abstract::In previous studies from this laboratory, we found that approximately 30% of women with chest pain and normal coronary arteries demonstrated either a decrease in or a failure to increase radionuclide ejection fraction during exercise. To examine the hypothesis that this apparent abnormality in left ventricular functio...


    pub_type: 杂志文章


    authors: Higginbotham MB,Morris KG,Coleman RE,Cobb FR

    更新日期:1984-09-01 00:00:00

  • Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE).

    abstract:BACKGROUND:Clinical trials have demonstrated that, compared with placebo, intensive statin therapy reduces ischemia in patients with acute coronary syndromes and in patients with stable coronary artery disease. However, no studies to date have assessed intensive versus moderate statin therapy in older patients with sta...


    pub_type: 杂志文章,随机对照试验


    authors: Deedwania P,Stone PH,Bairey Merz CN,Cosin-Aguilar J,Koylan N,Luo D,Ouyang P,Piotrowicz R,Schenck-Gustafsson K,Sellier P,Stein JH,Thompson PL,Tzivoni D

    更新日期:2007-02-13 00:00:00

  • Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice.

    abstract:BACKGROUND:Oxidative stress has been implicated in vascular injury and atherogenesis, and antioxidant treatment has shown favorable results in preclinical studies. Despite this, antioxidant therapy has failed to show benefit in clinical trials. Failure of antioxidants in clinical trials may be partly because such thera...


    pub_type: 杂志文章


    authors: Chyu KY,Babbidge SM,Zhao X,Dandillaya R,Rietveld AG,Yano J,Dimayuga P,Cercek B,Shah PK

    更新日期:2004-05-25 00:00:00

  • Effect of intense angiotensin II suppression on the diuretic response to furosemide during chronic ACE inhibition.

    abstract:BACKGROUND:Contrary to expectation, most studies have demonstrated that initiation of an angiotensin-converting enzyme (ACE) inhibitor in conventional doses in patients with heart failure reduces the diuretic efficacy of furosemide. Recently, it has been suggested that single low doses (1 mg) but not high doses (25 mg)...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Good JM,Brady AJ,Noormohamed FH,Oakley CM,Cleland JG

    更新日期:1994-07-01 00:00:00

  • Subcostal two-dimensional echocardiographic imaging of peripheral right coronary artery in Kawasaki disease.

    abstract::A new two-dimensional echocardiographic technique was developed to detect peripheral right coronary aneurysms in Kawasaki disease. Because the main stem of the right coronary artery runs along the tricuspid valve ring and the posterior interventricular groove, these regions were examined for coronary aneurysms using t...


    pub_type: 杂志文章


    authors: Yoshida H,Maeda T,Funabashi T,Nakaya S,Takabatake S,Taniguchi N

    更新日期:1982-05-01 00:00:00

  • Fifteen year survival study of patients with obstructive coronary artery disease.

    abstract::Survival rates were determined for a group of 598 patients in whom severe coronary disease was demonstrated by arteriography; initially they were treated medically and were followed-up for 15 years. Deaths due to noncoronary causes were uncommon (5% of total) in the first 5 year period but were frequent (36%) in the t...


    pub_type: 杂志文章


    authors: Proudfit WJ,Bruschke AV,MacMillan JP,Williams GW,Sones FM Jr

    更新日期:1983-11-01 00:00:00

  • Techniques for prevention of calcification of valvular bioprostheses.

    abstract::Calcification of valvular bioprostheses in children is a major problem that has stimulated extensive research in our laboratory. In previous reports, we have shown that the rate of calcification could be reduced by decreasing the phosphate content in the tissue or by blocking calcification binding sites with Mg++ and/...


    pub_type: 杂志文章


    authors: Carpentier A,Nashef A,Carpentier S,Ahmed A,Goussef N

    更新日期:1984-09-01 00:00:00

  • QT dispersion as an attribute of T-loop morphology.

    abstract:BACKGROUND:The suggestion that increased QT dispersion (QTD) is due to increased differences in local action potential durations within the myocardium is wanting. An alternative explanation was sought by relating QTD to vectorcardiographic T-loop morphology. METHODS AND RESULTS:The T loop is characterized by its ampli...


    pub_type: 杂志文章


    authors: Kors JA,van Herpen G,van Bemmel JH

    更新日期:1999-03-23 00:00:00