Possible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation.

abstract：:Finn Waagstein was born in Copenhagen in 1938. He graduated from Aarhus University Medical School in 1964. He received his cardiology training in the Sahlgrenska University Hospital at the University of Gothenburg, Sweden. He was appointed Associate Professor in 1980, and he assisted in establishing and directing the ...

journal_title：Circulation

authors： Waagstein F,Rutherford JD

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Although surgery is indicated in patients with mitral regurgitation (MR) when left ventricular (LV) end-systolic (LVES) dimension is >40 mm, LV ejection fraction may decrease after mitral valve surgery. We hypothesize that significant LV remodeling before surgery is not reflected by standard echocardiographi...

journal_title：Circulation

authors： Schiros CG,Dell'Italia LJ,Gladden JD,Clark D 3rd,Aban I,Gupta H,Lloyd SG,McGiffin DC,Perry G,Denney TS Jr,Ahmed MI

更新日期：2012-05-15 00:00:00

abstract：:Cerebral neurons can tolerate at least 20 min of normothermic ischemic anoxia. Cerebral recovery from more than 5 min of cardiac arrest is hampered by complex secondary derangements of multiple organ systems after reperfusion. There is increasing support of our hypothesis that this "postresuscitation syndrome" include...

journal_title：Circulation

authors： Safar P

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Recurrent cerebrovascular events constitute an estimated 200,000 of the 700,000 strokes reported annually in the United States, which makes secondary stroke prevention an important goal in the management of disease among patients who have experienced stroke or transient ischemic attack. METHODS AND RESULTS:...

journal_title：Circulation

authors： Liao JK

更新日期：2007-03-27 00:00:00

abstract：BACKGROUND:Heterogeneous electrophysiological properties, which may be due in part to autonomic innervation, are important in the maintenance of atrial fibrillation (AF). We hypothesized that heterogeneous sympathetic denervation with phenol would create a milieu for sustained AF. METHODS AND RESULTS:After the determi...

journal_title：Circulation

authors： Olgin JE,Sih HJ,Hanish S,Jayachandran JV,Wu J,Zheng QH,Winkle W,Mulholland GK,Zipes DP,Hutchins G

更新日期：1998-12-08 00:00:00

abstract：BACKGROUND:Cardiac dyssynchrony in the failing heart worsens global function and efficiency and generates regional loading disparities that may exacerbate stress-response molecular signaling and worsen cell survival. We hypothesized that cardiac resynchronization (CRT) from biventricular stimulation reverses such molec...

journal_title：Circulation

authors： Chakir K,Daya SK,Tunin RS,Helm RH,Byrne MJ,Dimaano VL,Lardo AC,Abraham TP,Tomaselli GF,Kass DA

更新日期：2008-03-18 00:00:00

abstract：BACKGROUND:Endocardial mapping using standard electrode catheters is often technically limited in ventricular tachycardia and constitutes a major obstacle to successful ablation. We wished to examine the utility of a basket-shaped multielectrode mapping catheter (MMC) in the mapping and ablation of ventricular tachycar...

journal_title：Circulation

authors： Eldar M,Ohad DG,Goldberger JJ,Rotstein Z,Hsu S,Swanson DK,Greenspon AJ

更新日期：1997-10-07 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS, or NOS2) reduces the severity of accelerated graft arteriosclerosis (AGA) in transplanted organs, although the precise mechanism is unclear. METHODS AND RESULTS:We transplanted wild-type murine hearts into either wild-type or NOS2-null recipient mice; we then measured ...

journal_title：Circulation

authors： Qian Z,Gelzer-Bell R,Yang Sx SX,Cao W,Ohnishi T,Wasowska BA,Hruban RH,Rodriguez ER,Baldwin WM 3rd,Lowenstein CJ

更新日期：2001-11-06 00:00:00

abstract：:Few data are available regarding the effects of exercise training upon cardiac structure and performance in man. We evaluated the echograms of 24 normals before (PRE) and after (POST) 11 weeks of endurance exercise training. Conditioning consisted of a walk-jog-run protocol at 70% maximal heart rate for one hour four ...

journal_title：Circulation

authors： DeMaria AN,Neumann A,Lee G,Fowler W,Mason DT

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:The left ventricular (LV) dilatation of isolated mitral regurgitation (MR) is associated with an increase in chymase and a decrease in interstitial collagen and extracellular matrix. In addition to profibrotic effects, chymase has significant antifibrotic actions because it activates matrix metalloproteinase...

journal_title：Circulation

authors： Pat B,Chen Y,Killingsworth C,Gladden JD,Shi K,Zheng J,Powell PC,Walcott G,Ahmed MI,Gupta H,Desai R,Wei CC,Hase N,Kobayashi T,Sabri A,Granzier H,Denney T,Tillson M,Dillon AR,Husain A,Dell'italia LJ

更新日期：2010-10-12 00:00:00

abstract：BACKGROUND:Recent studies suggest that bone morphogenetic protein-2 (BMP-2), a transforming growth factor-beta superfamily member cytokine, plays an important role both in vascular development and pathophysiological processes, including endothelial activation that is likely to contribute to the development of coronary ...

journal_title：Circulation

authors： Csiszar A,Smith KE,Koller A,Kaley G,Edwards JG,Ungvari Z

更新日期：2005-05-10 00:00:00

abstract：:The two-dimensional echocardiographic features of three patients with congenital aneurysms of the left atrium are described. The aneurysm arose from the left atrial appendage in two patients and from the posterior left atrial wall in one. The aneurysms were characterized by their origin from an otherwise normal left a...

journal_title：Circulation

authors： Foale RA,Gibson TC,Guyer DE,Gillam L,King ME,Weyman AE

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:An association of chronic Chlamydia pneumoniae infection to coronary heart disease has been suggested recently. In a recent study, we demonstrated circulating immune complexes containing chlamydial genus-specific lipopolysaccharide in patients with coronary heart disease. The objective of the present study w...

journal_title：Circulation

authors： Linnanmäki E,Leinonen M,Mattila K,Nieminen MS,Valtonen V,Saikku P

更新日期：1993-04-01 00:00:00

abstract：:Patients with idiopathic hypertrophic subaortic stenosis (IHSS) have supernormal left ventricular systolic function at rest. Septal myotomy/myectomy reduces outflow obstruction and symptoms. However, it has been proposed that operation causes myocardial damage, with consequent reduction in left ventricular function an...

journal_title：Circulation

authors： Borer JS,Bacharach SL,Green MV,Kent KM,Rosing DR,Seides SF,Morrow AG,Epstein SE

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALD...

journal_title：Circulation

authors： Mizuno Y,Harada E,Morita S,Kinoshita K,Hayashida M,Shono M,Morikawa Y,Murohara T,Nakayama M,Yoshimura M,Yasue H

更新日期：2015-05-12 00:00:00

abstract：BACKGROUND:Dual antiplatelet therapy in older versus younger patients with acute coronary syndromes is understudied. Low-dose prasugrel (5 mg/d) is recommended for younger, lower-body-weight patients and elderly patients with acute coronary syndromes to mitigate the bleeding risk of standard-dose prasugrel (10 mg/d). ...

journal_title：Circulation

authors： Roe MT,Goodman SG,Ohman EM,Stevens SR,Hochman JS,Gottlieb S,Martinez F,Dalby AJ,Boden WE,White HD,Prabhakaran D,Winters KJ,Aylward PE,Bassand JP,McGuire DK,Ardissino D,Fox KA,Armstrong PW

更新日期：2013-08-20 00:00:00

abstract：:A Y-shaped lesion in the right atrium allows induction of atrial flutter in dogs. We recorded the activation sequence during this tachycardia from 96 endocardial bipolar electrodes using intracavitary electrode arrays during 12 separate episodes in three isolated perfused hearts. In each case a reentrant impulse circu...

journal_title：Circulation

authors： Frame LH,Page RL,Boyden PA,Fenoglio JJ Jr,Hoffman BF

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes is associated with accelerated atherosclerosis. Because cell-derived microparticles support coagulation and inflammation, they may be involved in atherogenesis. We characterized circulating microparticles both in patients with uncomplicated, well-regulated type 2 diabetes and in healthy subje...

journal_title：Circulation

authors： Diamant M,Nieuwland R,Pablo RF,Sturk A,Smit JW,Radder JK

更新日期：2002-11-05 00:00:00

abstract：:High-density lipoprotein (HDL) cholesterol distributions were compared among 191 black and 1341 white males and 233 black and 1088 white females, ages 5-44 years, examined in five of the Lipid Research Clinic (LRC) population-based surveys. Mean HDL cholesterol was higher in blacks than whites in each 5-year age group...

journal_title：Circulation

authors： Tyroler HA,Glueck CJ,Christensen B,Kwiterovich PO Jr

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that pericytes can differentiate into osteoblasts and form bone. This study investigated whether pericytes can also differentiate into chondrocytes and adipocytes. METHODS AND RESULTS:Reverse transcription-polymerase chain reaction demonstrated that pericytes express mRNA for the...

journal_title：Circulation

authors： Farrington-Rock C,Crofts NJ,Doherty MJ,Ashton BA,Griffin-Jones C,Canfield AE

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:Hypothermic hyperkalemic cardioplegia results in significant myocyte swelling and impaired contractility. These detrimental effects may be eliminated by the addition of an adenosine triphosphate-sensitive potassium (KATP) channel opener. This study evaluated the hypothesis that a KATP channel opener (diazoxi...

journal_title：Circulation

authors： Mizutani S,Prasad SM,Sellitto AD,Schuessler RB,Damiano RJ Jr,Lawton JS

更新日期：2005-08-30 00:00:00

abstract：:Body surface isochrone mapping was performed in 36 normal subjects and in 85 patients with previous myocardial infarction. Eighty-seven unipolar electrocardiograms distributed over the anterior chest and the back were recorded simultaneously. For each lead, activation time was measured as the time from the onset of QR...

journal_title：Circulation

authors： Ikeda K,Kubota I,Igarashi A,Yamaki M,Tsuiki K,Yasui S

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Development and validation of novel imaging modalities to assess the composition of human atherosclerotic plaques will improve the understanding of atheroma evolution and could facilitate evaluation of therapeutic strategies for plaque modification. Surface MRI can characterize tissue content of carotid but ...

journal_title：Circulation

authors： Larose E,Yeghiazarians Y,Libby P,Yucel EK,Aikawa M,Kacher DF,Aikawa E,Kinlay S,Schoen FJ,Selwyn AP,Ganz P

更新日期：2005-10-11 00:00:00

abstract：BACKGROUND:Cardiac-targeted expression of truncated K(v)4.2 subunit (K(v)4.2N) reduces transient outward current (I(to)) density, prolongs action potentials (APs), and enhances contractility in 3- to 4-week-old transgenic mice. By 13 to 15 weeks of age, these mice develop severely impaired cardiac function and signs of...

journal_title：Circulation

authors： Sah R,Oudit GY,Nguyen TT,Lim HW,Wickenden AD,Wilson GJ,Molkentin JD,Backx PH

更新日期：2002-04-16 00:00:00

abstract：BACKGROUND:Lipoprotein(a) [Lp(a)] may play a causal role in atherosclerosis. PCSK9 (proprotein convertase subtilisin/kexin 9) inhibitors have been shown to significantly reduce plasma Lp(a) concentration. However, the relationship between Lp(a) levels, PCSK9 inhibition, and cardiovascular risk reduction remains undefin...

journal_title：Circulation

authors： O'Donoghue ML,Fazio S,Giugliano RP,Stroes ESG,Kanevsky E,Gouni-Berthold I,Im K,Lira Pineda A,Wasserman SM,Češka R,Ezhov MV,Jukema JW,Jensen HK,Tokgözoğlu SL,Mach F,Huber K,Sever PS,Keech AC,Pedersen TR,Sabatine MS

更新日期：2019-03-19 00:00:00

abstract：BACKGROUND:To identify patients at risk for postoperative myocardial injury and death, measuring cardiac troponin routinely after noncardiac surgery has been suggested. Such monitoring was implemented in our hospital. The aim of this study was to determine the predictive value of postoperative myocardial injury, as mea...

journal_title：Circulation

authors： van Waes JA,Nathoe HM,de Graaff JC,Kemperman H,de Borst GJ,Peelen LM,van Klei WA,Cardiac Health After Surgery (CHASE) Investigators.

更新日期：2013-06-11 00:00:00

abstract：:Between 1964 and 1971, 49 patients were discharged from hospital following atrial baffle repair for transposition of the great arteries. Electrocardiograms of 47 of these patients were available for review seven months to eight and a half years (average 31 months) after operation. Of the 46 patients in sinus rhythm pr...

journal_title：Circulation

authors： Clarkson PM,Barratt-Boyles BG,Neutze JM

更新日期：1976-03-01 00:00:00

abstract：:Echocardiographic and cardiac catheterization findings were compared in 61 patients with mitral stenosis without other significant lesions in an attempt to determine the clinical usefulness of echocardiography in the assessment of such patients. There was a poor correlation between the E-F slope on the echocardiogram ...

journal_title：Circulation

authors： Cope GD,Kisslo JA,Johnson ML,Behar VS

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:Abnormalities of arterial pulse and limb growth after retrograde femoral arterial catheterization have been well documented. However, the magnitude of such complications after transfemoral artery balloon dilatation has not been thoroughly investigated. This study sought to evaluate the prevalence of these ab...

journal_title：Circulation

authors： Lee HY,Reddy SC,Rao PS

更新日期：1997-02-18 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the long-term value of dobutamine-atropine stress echocardiography (DSE) for prediction of late cardiac events in patients with proven or suspected coronary artery disease. METHODS AND RESULTS:Clinical data and DSE results were analyzed in 1734 consecutive patients un...

journal_title：Circulation

authors： Poldermans D,Fioretti PM,Boersma E,Bax JJ,Thomson IR,Roelandt JR,Simoons ML

更新日期：1999-02-16 00:00:00