Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure.

abstract：BACKGROUND:We tested the hypothesis that long-term administration of the specific angiotensin II subtype 1 (AT1)-receptor blocker BMS-186295 will regress hypertrophy and modify left ventricular angiotensin converting enzyme (ACE) expression in rats with ascending aortic stenosis. METHODS AND RESULTS:Six weeks after su...

journal_title：Circulation

authors： Weinberg EO,Lee MA,Weigner M,Lindpaintner K,Bishop SP,Benedict CR,Ho KK,Douglas PS,Chafizadeh E,Lorell BH

更新日期：1997-03-18 00:00:00

abstract：:To determine whether calcium channel blockers influence the progression of coronary atherosclerosis, 383 patients age 65 years or less with 5-75% stenoses in at least four coronary artery segments were selected at random within 1 month of coronary arteriography to participate in double-blind therapy with a placebo or ...

journal_title：Circulation

authors： Waters D,Lespérance J,Francetich M,Causey D,Théroux P,Chiang YK,Hudon G,Lemarbre L,Reitman M,Joyal M

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Two sequential biphasic shocks delivered over separate lead configurations markedly improve defibrillation efficacy compared with a single shock alone. We investigated the effect of varying the intershock interval between sequential biphasic shocks on defibrillation. METHODS AND RESULTS:Defibrillation thres...

journal_title：Circulation

authors： Johnson EE,Alferness CA,Wolf PD,Smith WM,Ideker RE

更新日期：1992-06-01 00:00:00

abstract：:Prospective data was recorded on 217 percutaneous transluminal angioplasty (PTA) procedures performed in the superficial femoral and popliteal arteries over an 8-year period. After the initial procedure, patients were followed with serial noninvasive studies and, in 71 patients, repeat angiography. The mean follow-up ...

journal_title：Circulation

authors： Capek P,McLean GK,Berkowitz HD

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Cardiac troponin I (cTnI), a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes. Small studies report that cTnI is elevated in severe heart failure (HF) and may predict adverse outcomes. METHODS AND RESULTS:The present study e...

journal_title：Circulation

authors： Horwich TB,Patel J,MacLellan WR,Fonarow GC

更新日期：2003-08-19 00:00:00

abstract：BACKGROUND:People who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that often follows it that leads to higher blood pressure. METHODS AND RESULTS:We studied blood pressure in 346 British men and ...

journal_title：Circulation

authors： Law CM,Shiell AW,Newsome CA,Syddall HE,Shinebourne EA,Fayers PM,Martyn CN,de Swiet M

更新日期：2002-03-05 00:00:00

abstract：BACKGROUND:The role of angiotensin as a vasoconstrictor is well established. Lately, several other actions of this hormone on vascular smooth muscle (VSM) cells have been recognized including the induction of hypertrophy and/or DNA synthesis. Platelet-derived growth factor (PDGF), a mitogen recently shown to increase p...

journal_title：Circulation

authors： van Leeuwen RT,Kol A,Andreotti F,Kluft C,Maseri A,Sperti G

更新日期：1994-07-01 00:00:00

abstract：:The loss of coronary vasodilator reserve after ischemia-reperfusion may be due to endothelial injury, and this vascular dysfunction may contribute to functional alterations observed after ischemia. To determine whether endothelial dysfunction occurs after relatively brief periods of moderate low-flow ischemia in vivo,...

journal_title：Circulation

authors： Headrick JP,Angello DA,Berne RM

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) may have proatherogenic but also vasoprotective properties. We tested the hypothesis that the configuration of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) determines these different characteristics in an in vivo model. METHODS AND RESULTS:We investigated...

journal_title：Circulation

authors： Schwedler SB,Amann K,Wernicke K,Krebs A,Nauck M,Wanner C,Potempa LA,Galle J

更新日期：2005-08-16 00:00:00

abstract：BACKGROUND:Defining the arrhythmogenic substrate is essential for successful ablation of scar-related ventricular tachycardia. The visual characteristics of endocardial ischemic scar have not been described in vivo. The goal of this study was (1) to quantify the visual characteristics of normal tissue, scar border zone...

journal_title：Circulation

authors： Betensky BP,Jauregui M,Campos B,Michele J,Marchlinski FE,Oley L,Wylie B,Robinson D,Gerstenfeld EP

更新日期：2012-10-23 00:00:00

abstract：BACKGROUND:Despite recommendations in the guidelines and consensus documents, there has been no randomized controlled trial evaluating oral anticoagulation (OAC) alone without antiplatelet therapy (APT) in patients with atrial fibrillation and stable coronary artery disease beyond 1 year after coronary stenting. METHO...

journal_title：Circulation

authors： Matsumura-Nakano Y,Shizuta S,Komasa A,Morimoto T,Masuda H,Shiomi H,Goto K,Nakai K,Ogawa H,Kobori A,Kono Y,Kaitani K,Suwa S,Aoyama T,Takahashi M,Sasaki Y,Onishi Y,Mano T,Matsuda M,Motooka M,Tomita H,Inoko M,Wak

更新日期：2019-01-29 00:00:00

abstract：BACKGROUND:Epidemiological studies have identified clinical and echocardiographic factors associated with increased stroke risk in atrial fibrillation (AF), but mechanisms linking these factors to stroke in AF are incompletely understood. We hypothesized that stroke risk factors may be associated with increased endothe...

journal_title：Circulation

authors： Conway DS,Pearce LA,Chin BS,Hart RG,Lip GY

更新日期：2002-10-08 00:00:00

abstract：BACKGROUND:The formation of prostacyclin (PGI(2)), thromboxane (TX) A(2), and isoprostanes is markedly enhanced in atherosclerosis. We examined the relative contribution of cyclooxygenase (COX)-1 and -2 to the generation of these eicosanoids in patients with atherosclerosis. METHODS AND RESULTS:The study population co...

journal_title：Circulation

authors： Belton O,Byrne D,Kearney D,Leahy A,Fitzgerald DJ

更新日期：2000-08-22 00:00:00

abstract：BACKGROUND:Although prospective studies, systematic reviews, and meta-analyses have documented an association between depression and increased morbidity and mortality in a variety of cardiac populations, depression has not yet achieved formal recognition as a risk factor for poor prognosis in patients with acute corona...

journal_title：Circulation

authors： Lichtman JH,Froelicher ES,Blumenthal JA,Carney RM,Doering LV,Frasure-Smith N,Freedland KE,Jaffe AS,Leifheit-Limson EC,Sheps DS,Vaccarino V,Wulsin L,American Heart Association Statistics Committee of the Council on Epidemiology an

更新日期：2014-03-25 00:00:00

abstract：BACKGROUND:The potential biological significance of hydrogen sulfide (H(2)S) has attracted growing interest in recent years. The aim of this study was to characterize a novel, water-soluble, slow-releasing H(2)S compound [morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137)] and evaluate its use as ...

journal_title：Circulation

authors： Li L,Whiteman M,Guan YY,Neo KL,Cheng Y,Lee SW,Zhao Y,Baskar R,Tan CH,Moore PK

更新日期：2008-05-06 00:00:00

abstract：BACKGROUND:Abnormal vascular reactivity represents a fundamental disturbance in vascular biology with the development of atherosclerosis. Because endothelial vasodilator function plays a pivotal role in controlling vasomotor tone, we hypothesized that atherosclerotic wall thickening might directly interfere with defici...

journal_title：Circulation

authors： Zeiher AM,Schächlinger V,Hohnloser SH,Saurbier B,Just H

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Obstruction to left ventricular outflow can be seen after surgical repair of congenital heart disease in which a ventricular septal defect (VSD) is closed by means of a baffle to the systemic great artery arising from the right ventricle (Rastelli operation, intraventricular repair, for conotruncal anomaly)....

journal_title：Circulation

authors： Rychik J,Jacobs ML,Norwood WI

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Assessment of systemic right ventricular (RV) function is a key point in the follow-up of patients with transposition of the great arteries (TGA). Current echocardiographic assessment of RV function is at best an estimate, and cardiac magnetic resonance (CMR) is considered the gold standard. However, this te...

journal_title：Circulation

authors： Salehian O,Schwerzmann M,Merchant N,Webb GD,Siu SC,Therrien J

更新日期：2004-11-16 00:00:00

abstract：:Total body surface maps from 15 subjects with left bundle branch block and normal axis (LBBB-NA) and 10 subjects with left bundle branch block and left axis (LBBB-LA) were analyzed and compared with maps from normal subjects. In 19 of the 25 subjects with LBBB, the timing of early upper sternal positivity was similar ...

journal_title：Circulation

authors： Sohi GS,Flowers NC,Horan LG,Sridharan MR,Johnson JC

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:The goal of this study was to examine a possible association between systemic microinflammation, as reflected by C-reactive protein (CRP) serum levels, and coronary vasomotion in patients with coronary risk factors but with angiographically normal coronary arteries. METHODS AND RESULTS:Coronary vasomotor fu...

journal_title：Circulation

authors： Schindler TH,Nitzsche EU,Olschewski M,Magosaki N,Mix M,Prior JO,Facta AD,Solzbach U,Just H,Schelbert HR

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is an important active protein for the induction of angiogenesis and improvement in cardiac function after myocardial ischemia; however, the lack of a delivery system targeted to the injured myocardium reduces the local therapeutic efficacy of VEGF and increases its ...

journal_title：Circulation

authors： Zhang J,Ding L,Zhao Y,Sun W,Chen B,Lin H,Wang X,Zhang L,Xu B,Dai J

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:Present therapies for acute coronary syndromes aim toward limiting platelet-platelet adhesion and aggregation processes. However, platelet-leukocyte interactions may contribute importantly to disease progression in the arterial wall. Recent studies suggest that prevention of platelet-leukocyte binding via P-...

journal_title：Circulation

authors： Sarma J,Laan CA,Alam S,Jha A,Fox KA,Dransfield I

更新日期：2002-05-07 00:00:00

abstract：BACKGROUND:Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. METHODS:We applied a liquid chromatography-tandem mass spectrometry metabolomics platfor...

journal_title：Circulation

authors： Paynter NP,Balasubramanian R,Giulianini F,Wang DD,Tinker LF,Gopal S,Deik AA,Bullock K,Pierce KA,Scott J,Martínez-González MA,Estruch R,Manson JE,Cook NR,Albert CM,Clish CB,Rexrode KM

更新日期：2018-02-20 00:00:00

abstract：:Catheter ablation has gained a prominent role in the management of atrial fibrillation (AF), with recent data providing positive evidence on hard outcomes, including hospitalization and mortality. Ablation, however, exposes the patient to a rather unique situation, combining risks for both major bleeding and thromboem...

journal_title：Circulation

authors： Martin AC,Godier A,Narayanan K,Smadja DM,Marijon E

更新日期：2018-08-07 00:00:00

abstract：:Between 1976 and 1982, 413 consecutive patients underwent valvular replacement with a bioprosthesis. Aortic valve replacement was performed in 240 patients, mitral valve replacement in 132, and multiple-valve replacement in 41. Four prostheses were employed: Carpentier-Edwards porcine (n = 336), Angel-Shiley porcine (...

journal_title：Circulation

authors： Teoh KH,Ivanov J,Weisel RD,Darcel IC,Rakowski H

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:The efficacy of bypass surgery in patients with ischemic cardiomyopathy is not easily predictable; preoperative clinical conditions may be similar, but the outcome may differ significantly. We hypothesized that the growth reserve of cardiac stem cells (CSCs) and circulating cytokines promoting CSC activation...

journal_title：Circulation

authors： D'Amario D,Leone AM,Iaconelli A,Luciani N,Gaudino M,Kannappan R,Manchi M,Severino A,Shin SH,Graziani F,Biasillo G,Macchione A,Smaldone C,De Maria GL,Cellini C,Siracusano A,Ottaviani L,Massetti M,Goichberg P,Leri A,

更新日期：2014-01-14 00:00:00

abstract：:The antiarrhythmic efficacy and safety of oral flecainide acetate and quinidine sulfate were compared in a double-blind, 16-center parallel trial involving 280 patients with chronic premature ventricular complexes (PVCs). Eighty-five percent of the flecainide patients had at least 80% suppression of PVCs, vs 57% of th...

journal_title：Circulation

authors：

更新日期：1983-05-01 00:00:00

abstract：:Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occu...

journal_title：Circulation

authors： Oberman A,Ray M,Turner ME,Barnes G,Grooms C

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:The mechanism and treatment of diastolic heart failure are poorly understood. We compared the effects of an ACE inhibitor, an angiotensin receptor blocker (ARB), and their combination on diastolic heart failure in Dahl salt-sensitive (DS) rats. METHODS AND RESULTS:DS rats fed an 8% NaCl diet from 7 weeks of...

journal_title：Circulation

authors： Kim S,Yoshiyama M,Izumi Y,Kawano H,Kimoto M,Zhan Y,Iwao H

更新日期：2001-01-02 00:00:00

abstract：:Eighty-seven patients who had out-of-hospital cardiac arrests received defibrillating shocks delivered by minimally trained first responders before the arrival of paramedics in a city with short emergency response times. Their outcomes were compared with those of 370 other victims who received only basic life support ...

journal_title：Circulation

authors： Weaver WD,Copass MK,Bufi D,Ray R,Hallstrom AP,Cobb LA

更新日期：1984-05-01 00:00:00