Abstract:
:Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occurred within 1 hour of onset of symptoms, 34% within 24 hours, and 25% in greater than 24 hours. Patients prone to sudden death were characterized as having severe multiple-vessel disease in combination with left ventricular dysfunction and disturbances in intraventricular conduction and rhythm. The best five-variable model to predict sudden death in these patients included the following variables: number of vessels greater than or equal to 70% obstructed (P less than .001); therapeutic requirement of inotropic (P less than .003) and diuretic (P less than .006) drugs; premature beats (P less than .006); and ventricular conduction defects (P less than .008). Additional variables were related significantly to the duration of the terminal episode. These data are preliminary, but indicate the possibility of identifying patients prone to sudden death.
journal_name
Circulationjournal_title
Circulationauthors
Oberman A,Ray M,Turner ME,Barnes G,Grooms Csubject
Has Abstractpub_date
1975-12-01 00:00:00pages
III170-5issue
6 Suppleissn
0009-7322issn
1524-4539journal_volume
52pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:There has been increasing interest in the development of agents that utilize endogenous adenosine to exert their actions. We tested the hypothesis that substances that either potentiate the activity (allosteric enhancers) or increase the interstitial concentration (inhibitors of metabolism) of endogenous ade...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.10.2551
更新日期:1996-11-15 00:00:00
abstract:BACKGROUND:Adhesion of monocytes to the endothelium is an initial step in the early stages of atherosclerosis and inflammation. Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates a range of functional activities of monocytes, including regulation of monocyte adhesion and induction of cytokine producti...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.93.6.1185
更新日期:1996-03-15 00:00:00
abstract::Mitral valve closure during cardiopulmonary resuscitation may result from direct cardiac compression. An alternative hypothesis is that with a rise in intrathoracic pressure, mitral valve closure can occur but may be influenced by whether the lungs are inflated or deflated. To test this hypothesis, we placed a large-b...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.78.3.754
更新日期:1988-09-01 00:00:00
abstract::On May 20, 1984, the Surgeon General challenged the health community to work toward attainment of a smoke-free society by the year 2000. The leadership of the nation's three major voluntary organizations joined numerous associations of health professionals in accepting the challenge. The Subcommittee on Smoking of the...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Adenosine is believed to be cardioprotective; however, it has not been elucidated whether the plasma adenosine level is increased in chronic heart failure. METHODS AND RESULTS:Seventy-one patients attending a specialized heart failure clinic during a 6-month period were grouped according to the cause of chr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.6.1363
更新日期:1997-03-18 00:00:00
abstract:BACKGROUND:The heart can synthesize epinephrine. Homogenates of rat heart, which contain the enzymes phenylethanolamine N-methyltransferase (PNMT) and nonspecific N-methyltransferase (NMT), methylate norepinephrine to form epinephrine. The cardiac atrium contains primarily PNMT and the cardiac ventricle contains both P...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.2.891
更新日期:1991-08-01 00:00:00
abstract::It is generally agreed that the conditions leading to myocardial ischemia occur when the oxygen demands of the myocardium exceed the oxygen supply. The major limitations of oxygen supply to the myocardium are atherogenic disease and vasospasm of the coronary arteries. The major hemodynamic determinants of myocardial o...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:An estimated 275,000 patients undergo heart valve replacement each year. However, existing solutions for valve replacement are complicated by the morbidity associated with lifelong anticoagulation of mechanical valves and the limited durability of bioprostheses. Recent advances in tissue engineering and our ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.498378
更新日期:2005-05-31 00:00:00
abstract:BACKGROUND:AL amyloidosis with heart failure is associated with decreased longitudinal myocardial contraction measured by pulsed tissue Doppler imaging. We sought to clarify whether new modalities of myocardial strain Doppler (change in length per unit length) or strain rate (the temporal derivative of strain) were mor...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.CIR.0000068313.67758.4F
更新日期:2003-05-20 00:00:00
abstract:BACKGROUND:Hypertrophic cardiomyopathy (HCM) is characterized by myocardial hypertrophy of unknown etiology. Missense mutations of the cardiac beta-myosin-heavy-chain (beta-MHC) gene that may be responsible for cardiac hypertrophy have been detected in patients with HCM. On the other hand, gross structural abnormalitie...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.12.2911
更新日期:1995-06-15 00:00:00
abstract:BACKGROUND:This study reports on the trends in the volume and outcomes of coronary revascularization procedures performed on Medicare beneficiaries between 2008 and 2012. METHODS AND RESULTS:This retrospective study identifies all Medicare beneficiaries undergoing a coronary revascularization procedure: coronary arter...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.012485
更新日期:2015-01-27 00:00:00
abstract::Although exercise ECG testing has been shown to have important prognostic value after acute myocardial infarction, exercise 201Tl scintigraphy offers several potential advantages, including: 1) increased sensitivity for detecting residual myocardial ischemia; 2) the ability to localize ischemia to a specific area or a...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::The cellular electrophysiologic effects of myocardial ablation performed in vitro with argon laser energy were compared with those of high-energy electrical shocks. A border zone of injured but nonnecrotic tissue surrounding the site of energy delivery was present after tissue ablation by both energy modalities. A dec...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.76.1.217
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Paraplegia remains a devastating complication of thoracic aortic surgery. The mechanism of the antecedent spinal cord ischemia and reperfusion injury (IR) remains poorly described. IR involves 2 injuries, an initial ischemic insult and subsequent inflammatory amplification of the injury. This mechanism is co...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.111.080275
更新日期:2012-09-11 00:00:00
abstract:BACKGROUND:Very early (day 4) hospital discharge has recently been proposed for selected patients with acute myocardial infarction (MI). The purpose of this study was to determine the most useful factors for identifying acute MI patients treated with aggressive interventional therapy who could be safely discharged on d...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.83.4.1186
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Few data are available on the prevalence of hypertension in Mexico. METHODS AND RESULTS:We compared the prevalence of mild hypertension (systolic blood pressure > or = 140 mm Hg and/or diastolic blood pressure > or = 90 mm Hg and/or use of antihypertensive medications) in 1500 low-income Mexican Americans w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.3.1542
更新日期:1994-09-01 00:00:00
abstract::To determine how survival and clinical status were related to left ventricular (LV) size and systolic function after mitral valve replacement, 104 patients (48 mitral regurgitation [MR], 33 mitral stenosis [MS], and 23 MS/MR) with isolated mitral valve replacement were evaluated before and after surgery. Preoperative ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.81.4.1173
更新日期:1990-04-01 00:00:00
abstract::To assess the impact of operative reduction of left ventricular outflow obstruction in hypertrophic cardiomyopathy, measurements of great cardiac vein flow, oxygen and lactate content, left ventricular pressures, and cardiac index were measured at rest and during pacing stress in 20 consecutive patients (13, myotomy-m...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.79.4.766
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence of significant orthostatic hypotension. A heart rate increase of >/=30 bpm is typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.99.13.1706
更新日期:1999-04-06 00:00:00
abstract:BACKGROUND:The heart contains a variety of morphologically distinct nerve terminals known to influence cardiac function. Little is known about the distribution, morphology, and neurochemistry of these terminals in the human heart. METHODS AND RESULTS:We examined the entire endocardial and epicardial surfaces of infant...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.8.2343
更新日期:1995-10-15 00:00:00
abstract:BACKGROUND:Vascular inflammation and subsequent matrix degradation play an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipose-specific plasma protein, accumulated to the injured artery and attenuated vascular inflammatory response. Clinically, high plasma adiponect...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000127953.98131.ED
更新日期:2004-05-04 00:00:00
abstract:BACKGROUND:A decreased cardiac compliance is a major feature of the cardiomyopathy of diabetes mellitus. Either an increase in the resistance afterload to the LV or an increase in collagen cross-linking induced by the formation of advanced glycosylation end products (AGEs) of collagen may be responsible for the stiff m...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.93.10.1905
更新日期:1996-05-15 00:00:00
abstract:BACKGROUND:Right ventricular (RV) dilatation that occurs as a consequence of RV infarction is thought to produce hemodynamic instability by reducing left ventricular (LV) preload and compliance. We hypothesized that these geometric changes may also adversely affect LV systolic performance. METHODS AND RESULTS:Twelve 4...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.7.761
更新日期:1999-08-17 00:00:00
abstract::Although a family history of ischemic heart disease is a well-accepted risk factor for cardiovascular disease, only three prospective studies--all in men--have examined the predictive strength of a positive family history after adjusting for other heart disease risk factors. The present analysis is based on a 9 year f...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.69.6.1065
更新日期:1984-06-01 00:00:00
abstract:BACKGROUND:Up to 30% of patients with end-stage heart failure experience biventricular failure that requires biventricular mechanical support. For these patients, only bulky extracorporeal or implantable displacement pumps or the total artificial heart have been available to date, which enables only limited quality of ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.011502
更新日期:2011-09-13 00:00:00
abstract:BACKGROUND:We have demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone predominantly synthesized in and secreted from the ventricle. We have also reported that, compared with atrial natriuretic peptide (ANP), the plasma concentration of BNP is increased to a greater degree in patients with congestive...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.6.1558
更新日期:1995-09-15 00:00:00
abstract:BACKGROUND:Patients with heart failure and systolic dysfunction may develop disordered breathing during sleep. Repeated episodes of apnea and hypopnea may result in desaturation and arousals, which could adversely affect left ventricular function. The purpose of this study was to determine the short-term effects of con...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.4.392
更新日期:2000-02-01 00:00:00
abstract::As part of two Department of Veterans Affairs Cooperative Trials, we obtained angiographic patency data for internal mammary artery (IMA) and saphenous vein grafts to the left anterior descending (LAD) coronary artery at 1 year after coronary artery bypass surgery. Patients received either aspirin 325 mg q.d., aspirin...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-11-01 00:00:00
abstract::Thirteen male patients with NYHA class IV congestive heart failure refractory to conventional therapy were treated with oral fenoximone, a new imidazole compound with inotropic and vasodilator effects, for a mean duration of 11 weeks (range 2 to 34). On initial hemodynamic evaluation, the effects of oral fenoximone we...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.71.2.326
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Chronic heart failure (CHF) is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). There is evidence for increased radical formation in CHF, raising the possibility that nitric oxide is inactivated by radicals, thereby impairing endothelial function...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.97.4.363
更新日期:1998-02-03 00:00:00