From stem cells to viable autologous semilunar heart valve.

abstract：BACKGROUND:Estradiol (E2) modulates the kinetics of circulating endothelial progenitor cells (EPCs) and favorably affects neovascularization after ischemic injury. However, the roles of estrogen receptors alpha (ER alpha) and beta (ER beta) in EPC biology are largely unknown. METHODS AND RESULTS:In response to E2, mig...

journal_title：Circulation

authors： Hamada H,Kim MK,Iwakura A,Ii M,Thorne T,Qin G,Asai J,Tsutsumi Y,Sekiguchi H,Silver M,Wecker A,Bord E,Zhu Y,Kishore R,Losordo DW

更新日期：2006-11-21 00:00:00

abstract：BACKGROUND:In the Myocardial Infarction, Triage, and Intervention (MITI) registry of acute myocardial infarction, 441 (12%) of 3750 patients had direct angioplasty as initial treatment. Approximately half (233) were performed in hospitals with no on-site surgery. METHODS AND RESULTS:Procedure success rates, use of eme...

journal_title：Circulation

authors： Weaver WD,Litwin PE,Martin JS

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Outcomes for organ transplantation are constantly improving because of advances in organ preservation, surgical techniques, immune clinical monitoring, and immunosuppressive treatment preventing acute transplant rejection. However, chronic rejection including transplant vasculopathy still limits long-term pa...

journal_title：Circulation

authors： Galvani S,Trayssac M,Augé N,Thiers JC,Calise D,Krell HW,Sallusto F,Kamar N,Rostaing L,Thomsen M,Nègre-Salvayre A,Salvayre R

更新日期：2011-12-13 00:00:00

abstract：:The left anterior descending coronary artery of four dogs and the right common carotid artery of 15 rabbits were subjected to 40-60% reduction in transluminal diameter for 1 hour by partial ligation with suture thread. Scanning electron microscopic examination of the luminal surface of these vessels revealed endotheli...

journal_title：Circulation

authors： Gertz SD,Uretsky G,Wajnberg RS,Navot N,Gotsman MS

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:Chronic heart failure is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). Since endothelial function is thought to play an important role in coordinating tissue perfusion and modulating arterial compliance, interventions to improve endothelial dy...

journal_title：Circulation

authors： Hornig B,Maier V,Drexler H

更新日期：1996-01-15 00:00:00

abstract：BACKGROUND:Recent advances in surgical techniques for the repair of left ventricular aneurysms (LVAs) include the use of an endoventricular patch to exclude the aneurysm cavity. This technique has replaced conventional linear plication of the aneurysm. The endoventricular patch technique remodels the left ventricular c...

journal_title：Circulation

authors： Grossi EA,Chinitz LA,Galloway AC,Delianides J,Schwartz DS,McLoughlin DE,Keller N,Kronzon I,Spencer FC,Colvin SB

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Angiogenesis is a critical feature of plaque development in atherosclerosis and might play a key role in both the initiation and later rupture of plaques that lead to myocardial infarction and stroke. The precursory molecular or cellular events that initiate plaque growth and that ultimately contribute to pl...

journal_title：Circulation

authors： Winter PM,Morawski AM,Caruthers SD,Fuhrhop RW,Zhang H,Williams TA,Allen JS,Lacy EK,Robertson JD,Lanza GM,Wickline SA

更新日期：2003-11-04 00:00:00

abstract：:To investigate the electrocardiographic and hemodynamic changes in isolated right ventricular infarction, 0.25 ml or 0.5 ml of metallic mercury was injected into the right coronary artery of 14 closed-chest dogs. At autopsy, at least 60% of the right ventricle was necrotic in every dog. Hemodynamic observations were m...

journal_title：Circulation

authors： Chou TC,Fowler NO,Gabel M,van der Bel-Kahn J,Feltner EJ

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:During rest and exercise, patients with heart failure hyperventilate; therefore, the diaphragm can be viewed as undergoing constant moderate-intensity exercise. Accordingly, we hypothesized that heart failure elicits adaptations in the diaphragm similar to those elicited by endurance exercise in the limb mus...

journal_title：Circulation

authors： Tikunov B,Levine S,Mancini D

更新日期：1997-02-18 00:00:00

abstract：BACKGROUND:Pulmonary veno-occlusive disease is caused by excessive cell proliferation and fibrosis, which obliterate the lumen of pulmonary venules, leading to pulmonary hypertension, right ventricular failure, and death. This condition has no effective treatment and a 5-year survival of <5%. Understanding the mechanis...

journal_title：Circulation

authors： Lathen C,Zhang Y,Chow J,Singh M,Lin G,Nigam V,Ashraf YA,Yuan JX,Robbins IM,Thistlethwaite PA

更新日期：2014-09-30 00:00:00

abstract：:Eleven consecutive patients with idiopathic dilated cardiomyopathy and spontaneous, sustained ventricular tachycardia (VT) of uniform morphology underwent programmed ventricular stimulation and serial antiarrhythmic drug testing. The mean ejection fraction was 30 +/- 6.4%. Sustained VT was induced by programmed electr...

journal_title：Circulation

authors： Poll DS,Marchlinski FE,Buxton AE,Doherty JU,Waxman HL,Josephson ME

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Patients with anorexia nervosa exhibit abnormal myocardial repolarization and are susceptible to sudden cardiac death. Exercise testing is useful in unmasking QT prolongation in disorders associated with abnormal repolarization. We characterized QT adaptation during exercise in anorexia. METHODS AND RESULTS...

journal_title：Circulation

authors： Padfield GJ,Escudero CA,DeSouza AM,Steinberg C,Gibbs K,Puyat JH,Lam PY,Sanatani S,Sherwin E,Potts JE,Sandor G,Krahn AD

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human cor...

journal_title：Circulation

authors： Wallner K,Li C,Shah PK,Fishbein MC,Forrester JS,Kaul S,Sharifi BG

更新日期：1999-03-16 00:00:00

abstract：BACKGROUND:More than 300 000 out-of-hospital cardiac arrests (OHCA) occur each year in the United States. The relationship between time of day and OHCA outcomes in the prehospital setting is unknown. Any such association may have important implications for emergency medical services resource allocation. METHODS AND RE...

journal_title：Circulation

authors： Wallace SK,Abella BS,Shofer FS,Leary M,Agarwal AK,Mechem CC,Gaieski DF,Becker LB,Neumar RW,Band RA

更新日期：2013-04-16 00:00:00

abstract：BACKGROUND:In this study we tested the hypothesis that atrial fibrillation (AF) causes electrophysiological changes of the atrial myocardium which might explain the progressive nature of the arrhythmia. METHODS AND RESULTS:Twelve goats were chronically instrumented with multiple electrodes sutured to the epicardium of...

journal_title：Circulation

authors： Wijffels MC,Kirchhof CJ,Dorland R,Allessie MA

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Epidemiological findings suggest an association between low-for-age birth weight and the risk to develop coronary heart diseases in adulthood. During pregnancy, an imbalance between fetal demands and supply may result in permanent alterations of neuroendocrine development in the fetus. We evaluated whether c...

journal_title：Circulation

authors： Ruijtenbeek K,le Noble FA,Janssen GM,Kessels CG,Fazzi GE,Blanco CE,De Mey JG

更新日期：2000-12-05 00:00:00

abstract：BACKGROUND:Surviving cells in the postinfarction border zone are subjected to intense fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been specifically implicated in cardiac regeneration. Here, we defined their unique transcriptional and regulatory properties, and comprehensively valid...

journal_title：Circulation

authors： van Duijvenboden K,de Bakker DEM,Man JCK,Janssen R,Günthel M,Hill MC,Hooijkaas IB,van der Made I,van der Kraak PH,Vink A,Creemers EE,Martin JF,Barnett P,Bakkers J,Christoffels VM

更新日期：2019-09-09 00:00:00

abstract：BACKGROUND:Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleuk...

journal_title：Circulation

authors： Liuzzo G,Buffon A,Biasucci LM,Gallimore JR,Caligiuri G,Vitelli A,Altamura S,Ciliberto G,Rebuzzi AG,Crea F,Pepys MB,Maseri A

更新日期：1998-12-01 00:00:00

abstract：:Although previous studies in both animals and humans have suggested that cardiac baroreceptors modulate reflex sympathetic vasoconstriction during exercise, more recent studies in conscious animals have not supported this view. To further test this concept in humans, we measured sympathetic nerve discharge with intran...

journal_title：Circulation

authors： Scherrer U,Vissing SF,Victor RG

更新日期：1988-07-01 00:00:00

abstract：:The dynamics between mitral anulus motion, and, thus, motion of the base of the heart, and filling of the left atrium and ventricle were studied by Doppler echocardiography in 12 normal subjects and 28 patients with dilated cardiomyopathy. The normal motion of the mitral anulus is associated with two phases of inflow ...

journal_title：Circulation

authors： Keren G,Sonnenblick EH,LeJemtel TH

更新日期：1988-09-01 00:00:00

abstract：:In 61 patients sinus node function was tested by programmed (sinoatrial conduction time, SACT) and overdrive atrial pacing (sinus node recovery time, SRT). In the control group (N = 20), mean sinus cycle length was 773 +/- 140.2 msec, mean absolute SRT 1044 +/- 215.8 msec [corrected SRT (CSRT) 270 +/- 112.5 msec; mean...

journal_title：Circulation

authors： Breithardt G,Seipel L,Loogen F

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:The incidence of pulmonary arterial hypertension secondary to the use of indirect serotinergic agonists such as aminorex and dexfenfluramine led to the "serotonin hypothesis" of pulmonary arterial hypertension; however, the role of serotonin in dexfenfluramine-induced pulmonary arterial hypertension remains ...

journal_title：Circulation

authors： Dempsie Y,Morecroft I,Welsh DJ,MacRitchie NA,Herold N,Loughlin L,Nilsen M,Peacock AJ,Harmar A,Bader M,MacLean MR

更新日期：2008-06-03 00:00:00

abstract：BACKGROUND:Increased activity of the sympathetic nervous system contributes significantly to the pathophysiology of heart failure. However, cardiac efferent sympathetic function has not been well characterized in this disorder. In this study, we evaluated cardiac sympathetic innervation using [123I]metaiodobenzylguanid...

journal_title：Circulation

authors： Simmons WW,Freeman MR,Grima EA,Hsia TW,Armstrong PW

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen-G (HLA-G) expression in heart transplant patients has been negatively associated with acute cellular rejection and cardiac allograft vasculopathy. We assessed HLA-G expression in vascular human endothelial and smooth muscle cell cultures to determine if future therapeutic agents can b...

journal_title：Circulation

authors： Sheshgiri R,Rao V,Tumiati LC,Xiao R,Prodger JL,Badiwala M,Librach C,Delgado DH

更新日期：2008-09-30 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia is an independent risk factor for coronary heart disease (CHD). Dietary supplementation with B vitamins lowers plasma homocysteine by up to 30%. However, little is known about the potential beneficial effects of homocysteine lowering on vascular function in patients with CHD. METHODS AN...

journal_title：Circulation

authors： Chambers JC,Ueland PM,Obeid OA,Wrigley J,Refsum H,Kooner JS

更新日期：2000-11-14 00:00:00

abstract：:We studied the effects of experimentally induced emotional stress (mental arithmetic) on different hemodynamic parameters, catecholamine levels, and serum and platelet function tests in 25 postinfarction patients and in 10 apparently healthy, age-matched control subjects. Mental stress (10 minutes) induced significant...

journal_title：Circulation

authors： Grignani G,Soffiantino F,Zucchella M,Pacchiarini L,Tacconi F,Bonomi E,Pastoris A,Sbaffi A,Fratino P,Tavazzi L

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Alteration of the circadian rhythm and increased vascular senescence are linked to cardiovascular disease. Per2, a circadian gene, is known to regulate endothelium-dependent vasomotion. However, the mechanism by which Per2 affects endothelial function is unknown. We hypothesize that endothelial dysfunction i...

journal_title：Circulation

authors： Wang CY,Wen MS,Wang HW,Hsieh IC,Li Y,Liu PY,Lin FC,Liao JK

更新日期：2008-11-18 00:00:00

abstract：BACKGROUND:Left ventricular (LV) reconstruction surgery leads to early improvement in LV function in ischemic cardiomyopathy (ICM) patients. This study was designed to evaluate the impact of mitral valve (MV) repair associated with LV reconstruction on LV function 1-year after surgery in ICM patients assessed by real-t...

journal_title：Circulation

authors： Qin JX,Shiota T,McCarthy PM,Asher CR,Hail M,Agler DA,Popović ZB,Greenberg NL,Smedira NG,Starling RC,Young JB,Thomas JD

更新日期：2003-09-09 00:00:00

abstract：:The acute hemodynamic effects of dobutamine and nitroprusside were compared in 19 patients with low output cardiac failure. At dosage levels yielding similar increases in cardiac index (12 patients), nitroprusside resulted in significantly lower arterial systolic and wedge pressures and did not increase heart rate sug...

journal_title：Circulation

authors： Berkowitz C,McKeever L,Croke RP,Jacobs WR,Loeb HS,Gunnar RM

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy patients exhibit myocardial energetic impairment, but a causative role for this energy deficiency in the pathophysiology of hypertrophic cardiomyopathy remains unproven. We hypothesized that the metabolic modulator perhexiline would ameliorate myocardial energy deficiency and ther...

journal_title：Circulation

authors： Abozguia K,Elliott P,McKenna W,Phan TT,Nallur-Shivu G,Ahmed I,Maher AR,Kaur K,Taylor J,Henning A,Ashrafian H,Watkins H,Frenneaux M

更新日期：2010-10-19 00:00:00