ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno-occlusive disease.

abstract：BACKGROUND:The safety and effectiveness of the MitraClip device (Abbott Vascular, Menlo Park, CA) is being evaluated in the Endovascular Valve Edge-to-Edge Repair Study (EVEREST) clinical studies. The healing response after device implantation has not previously been characterized in humans. METHODS AND RESULTS:A tota...

journal_title：Circulation

authors： Ladich E,Michaels MB,Jones RM,McDermott E,Coleman L,Komtebedde J,Glower D,Argenziano M,Feldman T,Nakano M,Virmani R,Endovascular Valve Edge-to-Edge Repair Study (EVEREST) Investigators.

更新日期：2011-04-05 00:00:00

abstract：:Dispatcher-delivered telephone instruction in cardiopulmonary resuscitation (CPR) has been proposed to increase rates of bystander CPR in cases of out-of-hospital cardiac arrest. We tested the efficacy of a previously developed CPR message using a recording mannikin in a high stress, simulated cardiac arrest scenario....

journal_title：Circulation

authors： Kellermann AL,Hackman BB,Somes G

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Low-density lipoprotein (LDL) impairs endothelial cell function by uncoupling endothelial nitric oxide synthase (eNOS) activity, which allows superoxide anion (O2*-)) to be generated rather than nitric oxide (*NO). Recent reports indicate that apolipoprotein (apo) A-1 mimetics inhibit the development of athe...

journal_title：Circulation

authors： Ou Z,Ou J,Ackerman AW,Oldham KT,Pritchard KA Jr

更新日期：2003-03-25 00:00:00

abstract：:Background- Cardiovagal baroreflex sensitivity (BRS) declines with age but is favorably modulated by habitual aerobic exercise. We tested the hypothesis that compliance (transducing capacity) of an elastic artery in which baroreceptors are located is associated with these age-exercise interactions. Methods and Results...

journal_title：Circulation

authors： Monahan KD,Tanaka H,Dinenno FA,Seals DR

更新日期：2001-10-02 00:00:00

abstract：BACKGROUND:Many patients with implanted cardioverter defibrillators (ICDs) receive adjunctive antiarrhythmic drug therapy, most commonly amiodarone or sotalol. The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial. METHODS AND RESULTS:The Op...

journal_title：Circulation

authors： Hohnloser SH,Dorian P,Roberts R,Gent M,Israel CW,Fain E,Champagne J,Connolly SJ

更新日期：2006-07-11 00:00:00

abstract：BACKGROUND:Computed tomography (CT) allows estimation of coronary artery calcium (CAC) progression. We evaluated several progression algorithms in our unselected, population-based cohort for risk prediction of coronary and cardiovascular events. METHODS:In 3281 participants (45-74 years of age), free from cardiovascul...

journal_title：Circulation

authors： Lehmann N,Erbel R,Mahabadi AA,Rauwolf M,Möhlenkamp S,Moebus S,Kälsch H,Budde T,Schmermund A,Stang A,Führer-Sakel D,Weimar C,Roggenbuck U,Dragano N,Jöckel KH,Heinz Nixdorf Recall Study Investigators.

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Natural history of aortic dissection (AD) with intimal tear in the descending or abdominal aorta and retrograde extension into the ascending aorta (retrograde AD) remains unknown. The purpose of this study was to elucidate medium-term prognosis of patients with retrograde AD. METHODS AND RESULTS:Study popul...

journal_title：Circulation

authors： Kaji S,Akasaka T,Katayama M,Yamamuro A,Yamabe K,Tamita K,Akiyama M,Watanabe N,Tanemoto K,Morioka S,Yoshida K

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Treatment with an antibody that binds beta3 integrins (abciximab; c7E3 Fab) at the time of coronary angioplasty decreases the need for repeat revascularization. Two potential mechanisms have been proposed to explain this effect: (1) inhibition of platelet aggregation or (2) interruption of ligand binding to ...

journal_title：Circulation

authors： Stouffer GA,Hu Z,Sajid M,Li H,Jin G,Nakada MT,Hanson SR,Runge MS

更新日期：1998-03-10 00:00:00

abstract：BACKGROUND:Although several prospective cohort studies have found an inverse association between fish consumption and risk of coronary heart disease (CHD) or sudden cardiac death in the general population, limited data are available among diabetic patients. METHODS AND RESULTS:We examined prospectively the association...

journal_title：Circulation

authors： Hu FB,Cho E,Rexrode KM,Albert CM,Manson JE

更新日期：2003-04-15 00:00:00

abstract：:We studied regional myocardial perfusion by scintigraphic computer-assisted analysis of initial distribution, washout rates, and residual activity of 133Xe injected into the left coronary artery of four patients with normal arteriograms and 14 patients with coronary stenosis. At rest, residual activity in poststenotic...

journal_title：Circulation

authors： Maseri A,L'Abbate A,Pesola A,Michelassi C,Marzilli M,De Nes M

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:Although molecular biological studies suggest a pathogenic link between enterovirus infection and dilated cardiomyopathy (DCM), the frequency of detection of enteroviral RNA is not consistently high in myocardial tissue from patients with DCM. A recent study has suggested that hepatitis C virus (HCV) may als...

journal_title：Circulation

authors： Okabe M,Fukuda K,Arakawa K,Kikuchi M

更新日期：1997-07-01 00:00:00

abstract：:The loss of coronary vasodilator reserve after ischemia-reperfusion may be due to endothelial injury, and this vascular dysfunction may contribute to functional alterations observed after ischemia. To determine whether endothelial dysfunction occurs after relatively brief periods of moderate low-flow ischemia in vivo,...

journal_title：Circulation

authors： Headrick JP,Angello DA,Berne RM

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:An effect of diet in determining blood pressure is suggested by epidemiological studies, but the role of specific nutrients is still unsettled. METHODS AND RESULTS:The relation of various nutritional factors with hypertension was examined prospectively among 30,681 predominantly white US male health profess...

journal_title：Circulation

authors： Ascherio A,Rimm EB,Giovannucci EL,Colditz GA,Rosner B,Willett WC,Sacks F,Stampfer MJ

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Although patients with heart failure express elevated circulating levels of tumor necrosis factor-alpha (TNF-alpha) in their peripheral circulation, the structural and functional effects of circulating levels of pathophysiologically relevant concentrations of TNF-alpha on the heart are not known. METHODS AN...

journal_title：Circulation

authors： Bozkurt B,Kribbs SB,Clubb FJ Jr,Michael LH,Didenko VV,Hornsby PJ,Seta Y,Oral H,Spinale FG,Mann DL

更新日期：1998-04-14 00:00:00

abstract：BACKGROUND:Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleuk...

journal_title：Circulation

authors： Liuzzo G,Buffon A,Biasucci LM,Gallimore JR,Caligiuri G,Vitelli A,Altamura S,Ciliberto G,Rebuzzi AG,Crea F,Pepys MB,Maseri A

更新日期：1998-12-01 00:00:00

abstract：:The two-dimensional echocardiographic features of three patients with congenital aneurysms of the left atrium are described. The aneurysm arose from the left atrial appendage in two patients and from the posterior left atrial wall in one. The aneurysms were characterized by their origin from an otherwise normal left a...

journal_title：Circulation

authors： Foale RA,Gibson TC,Guyer DE,Gillam L,King ME,Weyman AE

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:The uptake of oxidized low-density lipoprotein (OxLDL) by macrophage scavenger receptors is thought to be a key process in the formation of foam cells, the hallmark of early atherosclerotic lesions. CXCL16/scavenger receptor for phosphatidylserine and OxLDL is a multifunctional chemokine that exhibits scaven...

journal_title：Circulation

authors： Aslanian AM,Charo IF

更新日期：2006-08-08 00:00:00

abstract：BACKGROUND:Drug-eluting stents have shown promising antirestenotic effects in clinical trials. Non-stent-based local delivery of antiproliferative drugs may offer additional flexibility and also reach vessel areas beyond the immediate stent coverage. The aim of the present study was to evaluate a novel method of local ...

journal_title：Circulation

authors： Scheller B,Speck U,Abramjuk C,Bernhardt U,Böhm M,Nickenig G

更新日期：2004-08-17 00:00:00

abstract：BACKGROUND:Age-adjusted stroke incidence has decreased over the past 50 years, likely as a result of changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the FHS (Framingham Heart Study) and other cohor...

journal_title：Circulation

authors： Dufouil C,Beiser A,McLure LA,Wolf PA,Tzourio C,Howard VJ,Westwood AJ,Himali JJ,Sullivan L,Aparicio HJ,Kelly-Hayes M,Ritchie K,Kase CS,Pikula A,Romero JR,D'Agostino RB,Samieri C,Vasan RS,Chêne G,Howard G,Seshadri S

更新日期：2017-03-21 00:00:00

abstract：:Three patients with total anomalous pulmonary venous drainage (TAPVD) into the innominate vein were studied by using M-mode and pulsed Doppler echocardiography. An abnormal continuous flow towards the transducer in a suprasternal notch position detected by pulsed Doppler echocardiography in the left hemithorax leftwar...

journal_title：Circulation

authors： Skovránek J,Tůma S,Urbancová D,Samánek M

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly understood. METHODS AND RESULTS:We used a forward genetic screen in zebrafish to identify novel genes required for myocardial fu...

journal_title：Circulation

authors： Knöll R,Postel R,Wang J,Krätzner R,Hennecke G,Vacaru AM,Vakeel P,Schubert C,Murthy K,Rana BK,Kube D,Knöll G,Schäfer K,Hayashi T,Holm T,Kimura A,Schork N,Toliat MR,Nürnberg P,Schultheiss HP,Schaper W,Schaper J,

更新日期：2007-07-31 00:00:00

abstract：:Correlates of high-density lipoprotein (HDL) cholesterol levels were studied in 4756 white males and females ages 20-59 years examined during a population survey conducted by 10 North American Lipid Research Clinics. Multivariable analysis was used to assess the relation of social, demographic, physical and behavioral...

journal_title：Circulation

authors： Heiss G,Johnson NJ,Reiland S,Davis CE,Tyroler HA

更新日期：1980-11-01 00:00:00

abstract：:All of the electrophysiological mechanisms of arrhythmias are sensitive to the influences of the autonomic nervous system, particularly to its adrenergic limb. Arrhythmogenic areas may also be dependent on the inhomogeneity of these influences because of their pathophysiological structure and/or the neurogenic or humo...

journal_title：Circulation

authors： Coumel P,Leenhardt A

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Aging is associated with an increased risk of women dying from coronary heart disease as well as from all causes combined. Alterations in the major biological risk factors for early coronary heart disease and all-cause mortality are frequently seen in aging. METHODS AND RESULTS:The present investigation tes...

journal_title：Circulation

authors： Owens JF,Matthews KA,Wing RR,Kuller LH

更新日期：1992-04-01 00:00:00

abstract：:We have shown previously that the physical properties of myocardium in dogs can be characterized with quantitative ultrasonic integrated backscatter and that interrogation of the tissue with ultrasound can delineate cardiac cycle-dependent changes in ultrasonic backscatter in normal tissue that disappear with ischemia...

journal_title：Circulation

authors： Vered Z,Barzilai B,Mohr GA,Thomas LJ 3rd,Genton R,Sobel BE,Shoup TA,Melton HE,Miller JG,Pérez JE

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Reports on outcome after the Ross procedure are limited by small study size and show variable durability results. A systematic review of evidence on outcome after the Ross procedure may improve insight into outcome and potential determinants. METHODS AND RESULTS:A systematic review of reports published from...

journal_title：Circulation

authors： Takkenberg JJ,Klieverik LM,Schoof PH,van Suylen RJ,van Herwerden LA,Zondervan PE,Roos-Hesselink JW,Eijkemans MJ,Yacoub MH,Bogers AJ

更新日期：2009-01-20 00:00:00

abstract：BACKGROUND:This study aimed to assess if clampless off-pump coronary artery bypass grafting (CABG) decreases risk-adjusted mortality, stroke rate, and morbidity in unselected patients in comparison to conventional CABG. METHODS AND RESULTS:Between July 2009 and November 2010, data of 1282 consecutive patients undergoi...

journal_title：Circulation

authors： Börgermann J,Hakim K,Renner A,Parsa A,Aboud A,Becker T,Masshoff M,Zittermann A,Gummert JF,Kuss O

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:Several recent studies attempted to classify plaques as those prone to cause clinical manifestations (vulnerable, atheromatous plaques) or those less frequently associated with acute thrombotic complication (stable, fibrous plaques). Defining the cellular and molecular mechanisms that underlie these morpholo...

journal_title：Circulation

authors： Sukhova GK,Schönbeck U,Rabkin E,Schoen FJ,Poole AR,Billinghurst RC,Libby P

更新日期：1999-05-18 00:00:00

abstract：BACKGROUND:While previous clinical studies have shown a possible beneficial effect of the reperfusion performed at a relatively late phase of acute myocardial infarction ("late reperfusion") in preventing left ventricular enlargement, the mechanism has not been clarified. METHODS AND RESULTS:Of 89 patients with an ini...

journal_title：Circulation

authors： Hirayama A,Adachi T,Asada S,Mishima M,Nanto S,Kusuoka H,Yamamoto K,Matsumura Y,Hori M,Inoue M

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Trends in cardiovascular mortality across Europe demonstrate significant geographical variation, and an understanding of these trends has a central role in global public health. METHODS AND RESULTS:Ischemic heart disease and cerebrovascular disease age-standardized death rates (as per International Classifi...

journal_title：Circulation

authors： Hartley A,Marshall DC,Salciccioli JD,Sikkel MB,Maruthappu M,Shalhoub J

更新日期：2016-05-17 00:00:00