Endothelial cell damage and thrombus formation after partial arterial constriction: relevance to the role of coronary artery spasm in the pathogenesis of myocardial infarction.

abstract：BACKGROUND:Consensus guidelines and hospital quality-of-care programs recommend that ST-elevation myocardial infarction patients achieve a door-to-balloon time of < or = 90 minutes. However, there are limited prospective data on specific measures to significantly reduce door-to-balloon time. METHODS AND RESULTS:We pro...

journal_title：Circulation

authors： Khot UN,Johnson ML,Ramsey C,Khot MB,Todd R,Shaikh SR,Berg WJ

更新日期：2007-07-03 00:00:00

abstract：BACKGROUND:Women receive less evidence-based medical care than men and have higher rates of death after acute myocardial infarction (AMI). It is unclear whether efforts undertaken to improve AMI care have mitigated these sex disparities in the current era. METHODS AND RESULTS:Using the Get With the Guidelines-Coronary...

journal_title：Circulation

authors： Jneid H,Fonarow GC,Cannon CP,Hernandez AF,Palacios IF,Maree AO,Wells Q,Bozkurt B,Labresh KA,Liang L,Hong Y,Newby LK,Fletcher G,Peterson E,Wexler L,Get With the Guidelines Steering Committee and Investigators.

更新日期：2008-12-16 00:00:00

abstract：BACKGROUND:Coronary blood flow occurs mainly during the diastolic phase of each cardiac cycle and is mainly dependent on diastolic driving pressure, especially in the left anterior descending coronary artery (LAD). We hypothesized that calculation of the ratio of the diastolic driving pressure of a stenotic LAD to its ...

journal_title：Circulation

authors： Abe M,Tomiyama H,Yoshida H,Doba N

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:Metformin is first-line therapy for type 2 diabetes mellitus, although its effects on the cardiovascular system are unproved. METHODS:In this post hoc analysis, patients in SAVOR-TIMI 53 (Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus) with baseline biomarker samples (n=12...

journal_title：Circulation

authors： Bergmark BA,Bhatt DL,McGuire DK,Cahn A,Mosenzon O,Steg PG,Im K,Kanevsky E,Gurmu Y,Raz I,Braunwald E,Scirica BM,SAVOR-TIMI 53 Steering Committee and Investigators.

更新日期：2019-09-17 00:00:00

abstract：BACKGROUND:Heart failure is a growing cause of morbidity and mortality worldwide. Transforming growth factor beta (TGF-β1) promotes cardiac fibrosis, but also activates counterregulatory pathways that serve to regulate TGF-β1 activity in heart failure. Bone morphogenetic protein 9 (BMP9) is a member of the TGFβ family ...

journal_title：Circulation

authors： Morine KJ,Qiao X,York S,Natov PS,Paruchuri V,Zhang Y,Aronovitz MJ,Karas RH,Kapur NK

更新日期：2018-07-31 00:00:00

abstract：BACKGROUND:Patients surviving ventricular fibrillation (VF) or sustained ventricular tachycardia (VT) are at a high risk of death due to a recurrence of arrhythmia. The implantable cardioverter defibrillator (ICD) terminates VT or VF, but it is not known whether this device prolongs life in these patients compared with...

journal_title：Circulation

authors： Connolly SJ,Gent M,Roberts RS,Dorian P,Roy D,Sheldon RS,Mitchell LB,Green MS,Klein GJ,O'Brien B

更新日期：2000-03-21 00:00:00

abstract：BACKGROUND:beta-Adrenergic receptor kinase 1 (beta ARK1) mediates beta-adrenergic receptor signaling via receptor phosphorylation, which results in functional uncoupling. The physiological importance of beta ARK1 on cardiac performance in the setting of ischemia and reperfusion injury, however, has not been clearly est...

journal_title：Circulation

authors： Chen EP,Bittner HB,Akhter SA,Koch WJ,Davis RD

更新日期：1998-11-10 00:00:00

abstract：:Quantitative detection of left ventricular segmental wall motion abnormalities by any modality depends on the reference system used because of the dynamic geometry of contraction and cardiac motion within the thorax. To assess the feasibility and accuracy of quantitative analysis of left ventricular wall motion by two...

journal_title：Circulation

authors： Schnittger I,Fitzgerald PJ,Gordon EP,Alderman EL,Popp RL

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:The mechanism through which ischemic preconditioning causes cardioprotection is unknown. The present study investigated the role of stunning in preconditioning. METHODS AND RESULTS:We studied three different protocols of preconditioning: two cycles of 2-minute ischemia separated by 5-minute reperfusion (2'P...

journal_title：Circulation

authors： Miura T,Goto M,Urabe K,Endoh A,Shimamoto K,Iimura O

更新日期：1991-12-01 00:00:00

abstract：:The release of the American Heart Association's 2030 Impact Goal and associated metrics for success underscores the importance of cardiovascular health and cardiovascular disease surveillance systems for the acquisition of information sufficient to support implementation and evaluation. The aim of this policy statemen...

journal_title：Circulation

authors： Roger VL,Sidney S,Fairchild AL,Howard VJ,Labarthe DR,Shay CM,Tiner AC,Whitsel LP,Rosamond WD,American Heart Association Advocacy Coordinating Committee.

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of midpregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later-life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in ...

journal_title：Circulation

authors： Benschop L,Schalekamp-Timmermans S,Broere-Brown ZA,Roeters van Lennep JE,Jaddoe VWV,Roos-Hesselink JW,Ikram MK,Steegers EAP,Roberts JM,Gandley RE

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Less invasive methods are replacing traditional invasive means of measuring coronary flow reserve (CFR). Transesophageal echocardiography (TEE) is becoming a useful tool for evaluation of coronary artery disease and has recently been used to measure CFR. This has always been done using dipyridamole, but aden...

journal_title：Circulation

authors： Redberg RF,Sobol Y,Chou TM,Malloy M,Kumar S,Botvinick E,Kane J

更新日期：1995-07-15 00:00:00

abstract：BACKGROUND:Radiofrequency ablation of type 1 atrial flutter (AF1) has recently evolved toward an anatomically guided procedure directed to isthmuses at the lower part of the right atrium (RA). However, different types of block at these isthmuses may be observed and potentially correlated with different late outcomes. I...

journal_title：Circulation

authors： Poty H,Saoudi N,Nair M,Anselme F,Letac B

更新日期：1996-12-15 00:00:00

abstract：BACKGROUND:Aortic valve-preserving procedures have resulted in excellent outcomes in selected patients, particularly those with normal aortic valve leaflets and dilated aortic roots. However, several congenital heart lesions are associated with abnormal aortic valve leaflets. The long-term results of aortic valve repai...

journal_title：Circulation

authors： Rao V,Van Arsdell GS,David TE,Azakie A,Williams WG

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:The timing of onset of angina before myocardial infarction in relation to outcome is unknown. METHODS AND RESULTS:We prospectively determined the importance of the time of onset of preinfarction angina in relation to 30-day outcomes in the TIMI-9B study from standardized forms. Of the 3002 patients entered ...

journal_title：Circulation

authors： Kloner RA,Shook T,Antman EM,Cannon CP,Przyklenk K,Yoo K,McCabe CH,Braunwald E

更新日期：1998-03-24 00:00:00

abstract：:Lidocaine is a commonly used antiarrhythmic drug that causes use-dependent blockade of sodium channels in vitro and reduces conduction velocity in vitro and in vivo. According to the modulated receptor hypothesis of antiarrhythmic drug action, lidocaine has a low affinity for rested sodium channels but a high affinity...

journal_title：Circulation

authors： Davis J,Matsubara T,Scheinman MM,Katzung B,Hondeghem LH

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Thioredoxin 2 (Trx2) is a key mitochondrial protein that regulates cellular redox and survival by suppressing mitochondrial reactive oxygen species generation and by inhibiting apoptosis stress kinase-1 (ASK1)-dependent apoptotic signaling. To date, the role of the mitochondrial Trx2 system in heart failure ...

journal_title：Circulation

authors： Huang Q,Zhou HJ,Zhang H,Huang Y,Hinojosa-Kirschenbaum F,Fan P,Yao L,Belardinelli L,Tellides G,Giordano FJ,Budas GR,Min W

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:Leptin has been implicated in cardiovascular disease. A diet rich in fish has been associated with decreased cardiac and vascular risk. METHODS AND RESULTS:We examined the relationship between diet and leptin in 2 related homogeneous African tribal populations of Tanzania. One tribe consumes freshwater fish...

journal_title：Circulation

authors： Winnicki M,Somers VK,Accurso V,Phillips BG,Puato M,Palatini P,Pauletto P

更新日期：2002-07-16 00:00:00

abstract：BACKGROUND:Diastolic dysfunction associated with high blood pressure (BP) leads to cardiac remodeling and fibrosis and progression to congestive heart failure. B-type natriuretic peptide (BNP) has BP-lowering, antifibrotic, and antihypertrophic properties, which makes BNP an attractive agent for attenuating the adverse...

journal_title：Circulation

authors： Cataliotti A,Tonne JM,Bellavia D,Martin FL,Oehler EA,Harders GE,Campbell JM,Peng KW,Russell SJ,Malatino LS,Burnett JC Jr,Ikeda Y

更新日期：2011-03-29 00:00:00

abstract：BACKGROUND:The late hemodynamic effects of preserving the papillary muscles during mitral valve replacement have not been evaluated. METHODS AND RESULTS:Sixteen patients who had chronic mitral regurgitation due to myxomatous degeneration were randomized to preservation (Pres group, n = 8) or no preservation (No Pres g...

journal_title：Circulation

authors： Komeda M,David TE,Rao V,Sun Z,Weisel RD,Burns RJ

更新日期：1994-11-01 00:00:00

abstract：:An experiment was designed to determine optimal methods of myocardial reperfusion after normothermic ischemic arrest in the in vivo pig heart. Four variables were studied: 1) ischemic arrest for 15 minutes repeated six times vs 30 minutes repeated three times: 2) coronary reperfusion between each arrest period lasting...

journal_title：Circulation

authors： Engelman RM,Levitsky S,Wyndham CR

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:The alpha(v)beta3 integrin plays a critical role in cell proliferation and migration. We hypothesized that vascular cell proliferation, a hallmark of injury-induced remodeling, can be tracked by targeting alpha(v)beta3 integrin expression in vivo. METHODS AND RESULTS:RP748, a novel 111In-labeled alpha(v)bet...

journal_title：Circulation

authors： Sadeghi MM,Krassilnikova S,Zhang J,Gharaei AA,Fassaei HR,Esmailzadeh L,Kooshkabadi A,Edwards S,Yalamanchili P,Harris TD,Sinusas AJ,Zaret BL,Bender JR

更新日期：2004-07-06 00:00:00

abstract：BACKGROUND:A mortality follow-up of 12,866 men was conducted 16 years after randomization to special intervention (SI) or usual care (UC) groups of the Multiple Risk Factor Intervention Trial to assess the long-term effect of cardiovascular risk factor intervention on coronary heart disease (CHD), cardiovascular death ...

journal_title：Circulation

authors：

更新日期：1996-09-01 00:00:00

abstract：:Purine compounds modulate sympathetic neurotransmission; this modulation decreases nervous discharge by stimulating presynaptic inhibitory adenosine receptors, an effect antagonized by theophylline, and causes vasoconstriction through the stimulation of postsynaptic ATP receptors. In humans we evaluated the effect of ...

journal_title：Circulation

authors： Taddei S,Pedrinelli R,Salvetti A

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Iron deficiency is common in patients with heart failure (HF) and is associated with reduced exercise capacity and poor outcomes. Whether correction of iron deficiency with (intravenous) ferric carboxymaltose (FCM) affects peak oxygen consumption [peak VO2], an objective measure of exercise intolerance in HF...

journal_title：Circulation

authors： van Veldhuisen DJ,Ponikowski P,van der Meer P,Metra M,Böhm M,Doletsky A,Voors AA,Macdougall IC,Anker SD,Roubert B,Zakin L,Cohen-Solal A,EFFECT-HF Investigators.

更新日期：2017-10-10 00:00:00

abstract：BACKGROUND:The uptake of oxidized low-density lipoprotein (OxLDL) by macrophage scavenger receptors is thought to be a key process in the formation of foam cells, the hallmark of early atherosclerotic lesions. CXCL16/scavenger receptor for phosphatidylserine and OxLDL is a multifunctional chemokine that exhibits scaven...

journal_title：Circulation

authors： Aslanian AM,Charo IF

更新日期：2006-08-08 00:00:00

abstract：BACKGROUND:In patients with symptoms of heart failure, elevations in B-type natriuretic peptide (BNP) accurately identify ventricular dysfunction. However, BNP levels are not specific for ventricular dysfunction in patients who do not have overt symptoms of heart failure, suggesting that other cardiac processes such as...

journal_title：Circulation

authors： Bibbins-Domingo K,Ansari M,Schiller NB,Massie B,Whooley MA

更新日期：2003-12-16 00:00:00

abstract：BACKGROUND:Increased plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been identified as predictors of cardiac dysfunction and prognosis in congestive heart failure and ischemic heart disease. In severe sepsis patients, however, no information is available yet about the prognos...

journal_title：Circulation

authors： Brueckmann M,Huhle G,Lang S,Haase KK,Bertsch T,Weiss C,Kaden JJ,Putensen C,Borggrefe M,Hoffmann U

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:Clinical detection of transplant rejection by repeated endomyocardial biopsy requires catheterization and entails risks. Recently developed molecular and cellular imaging techniques that visualize macrophage host responses could provide a noninvasive alternative. Yet, which macrophage functions may provide u...

journal_title：Circulation

authors： Christen T,Nahrendorf M,Wildgruber M,Swirski FK,Aikawa E,Waterman P,Shimizu K,Weissleder R,Libby P

更新日期：2009-04-14 00:00:00

abstract：:We used Doppler echocardiography to quantitate the changes in intracardiac blood flow velocities and right and left ventricular stroke volumes in 80 normal human fetuses from 19 to 40 weeks gestation. Blood flow velocity spectra across the aortic, pulmonary, tricuspid, and mitral valves were digitized to obtain peak v...

journal_title：Circulation

authors： Kenny JF,Plappert T,Doubilet P,Saltzman DH,Cartier M,Zollars L,Leatherman GF,St John Sutton MG

更新日期：1986-12-01 00:00:00