Myocardial recovery after ischemia and reperfusion injury is significantly impaired in hearts with transgenic overexpression of beta-adrenergic receptor kinase.

abstract：BACKGROUND:Sudden cardiac death (SCD) is a major cause of mortality in adults with congenital heart disease (CHD). The aim of this study was to determine the adult CHD population at risk of SCD and the clinical parameters associated with SCD. METHODS AND RESULTS:We performed a multicenter case-control study. Patients ...

journal_title：Circulation

authors： Koyak Z,Harris L,de Groot JR,Silversides CK,Oechslin EN,Bouma BJ,Budts W,Zwinderman AH,Van Gelder IC,Mulder BJ

更新日期：2012-10-16 00:00:00

abstract：BACKGROUND:AL amyloidosis with heart failure is associated with decreased longitudinal myocardial contraction measured by pulsed tissue Doppler imaging. We sought to clarify whether new modalities of myocardial strain Doppler (change in length per unit length) or strain rate (the temporal derivative of strain) were mor...

journal_title：Circulation

authors： Koyama J,Ray-Sequin PA,Falk RH

更新日期：2003-05-20 00:00:00

abstract：BACKGROUND:The ability of apolipoprotein (apo)A-I to induce regression of preexisting atherosclerotic lesions has not been determined, and a mouse model of atherosclerosis regression has not yet been reported. METHODS AND RESULTS:LDL receptor-deficient mice were fed a western-type diet for 5 weeks to induce atheroscle...

journal_title：Circulation

authors： Tangirala RK,Tsukamoto K,Chun SH,Usher D,Puré E,Rader DJ

更新日期：1999-10-26 00:00:00

abstract：:Since platelet accumulation may be an important determinant of restenosis after angioplasty, the time course of 51Cr-labeled platelet accumulation after experimental angioplasty was evaluated in a deendothelialized, hypercholesterolemic rabbit preparation of atherosclerosis. Marked platelet accumulation (39.5 +/- 8.7 ...

journal_title：Circulation

authors： Wilentz JR,Sanborn TA,Haudenschild CC,Valeri CR,Ryan TJ,Faxon DP

更新日期：1987-03-01 00:00:00

abstract：:Platelets play an important role in the formation of a coronary thrombus and reocclusion after thrombolysis. Therefore, we examined the thrombolytic potential of concomitant intravenous administration of potent platelet inhibitor iloprost, a prostacyclin analogue, with tissue-type plasminogen activator (t-PA; n = 8) a...

journal_title：Circulation

authors： Nicolini FA,Mehta JL,Nichols WW,Saldeen TG,Grant M

更新日期：1990-03-01 00:00:00

abstract：:The effect of timolol vs placebo on the frequency of anginal episodes, nitroglycerin consumption and exercise performance was investigated in a double-blind, randomized, crossover study in 23 patients with angina pectoris. The optimal dose of timolol (10-30 mg twice daily) for each patient was titrated by exercise stu...

journal_title：Circulation

authors： Aronow WS,Turbow M,Van Camp S,Lurie M,Whittaker K

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:In contrast to systolic function, which is relatively well preserved with advancing age, diastolic function declines steadily after age 30. Our goal was to determine whether changes in diastolic function that occur with aging could be reversed with exercise training. Methods and Results-- Adult (6-month-old)...

journal_title：Circulation

authors： Brenner DA,Apstein CS,Saupe KW

更新日期：2001-07-10 00:00:00

abstract：BACKGROUND:In patients with symptoms of heart failure, elevations in B-type natriuretic peptide (BNP) accurately identify ventricular dysfunction. However, BNP levels are not specific for ventricular dysfunction in patients who do not have overt symptoms of heart failure, suggesting that other cardiac processes such as...

journal_title：Circulation

authors： Bibbins-Domingo K,Ansari M,Schiller NB,Massie B,Whooley MA

更新日期：2003-12-16 00:00:00

abstract：BACKGROUND:High-speed rotational atherectomy uses a diamond-coated, elliptical burr to abrade occlusive atherosclerosis, especially noncompliant calcified plaque. METHODS AND RESULTS:Intravascular ultrasound (IVUS) was used to analyze 28 patients after atherectomy. Arteries treated and imaged were left main (three), l...

journal_title：Circulation

authors： Mintz GS,Potkin BN,Keren G,Satler LF,Pichard AD,Kent KM,Popma JJ,Leon MB

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:The relation between left ventricular (LV) oxygen consumption (MVO2) and pressure-volume area (PVA) developed in isolated hearts provides a powerful method to understand cardiac energetics. We investigated application of this relation to the intact circulation, determining its response to steady-state and tr...

journal_title：Circulation

authors： Nozawa T,Cheng CP,Noda T,Little WC

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Present therapies for acute coronary syndromes aim toward limiting platelet-platelet adhesion and aggregation processes. However, platelet-leukocyte interactions may contribute importantly to disease progression in the arterial wall. Recent studies suggest that prevention of platelet-leukocyte binding via P-...

journal_title：Circulation

authors： Sarma J,Laan CA,Alam S,Jha A,Fox KA,Dransfield I

更新日期：2002-05-07 00:00:00

abstract：BACKGROUND:The morphological hallmark of tetralogy of Fallot is controversial, with much disagreement as to whether the subpulmonary infundibulum in this lesion is hypoplastic. In addition, few quantitative data are available regarding the morphometry of the subpulmonary infundibulum, what anatomic characteristics are ...

journal_title：Circulation

authors： Geva T,Ayres NA,Pac FA,Pignatelli R

更新日期：1995-08-15 00:00:00

abstract：:The dominance of the coronary arterial system was determined angiographically in 75 adult patients with isolated aortic stenosis with or without insufficiency, 25 adult patients with pure aortic insufficiency, 51 adult patients with combined aortic stenosis and mitral valve disease, and 44 children with bicuspid aorti...

journal_title：Circulation

authors： Higgins CB,Wexler L

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Lipoprotein oxidation plays an important part in atherogenesis. Autoantibodies to oxidation-specific epitopes of LDL occur in plasma and atherosclerotic lesions of humans and animals. The potential role of these autoantibodies in atherogenesis still remains unsolved. We studied the relationship between diffe...

journal_title：Circulation

authors： Karvonen J,Päivänsalo M,Kesäniemi YA,Hörkkö S

更新日期：2003-10-28 00:00:00

abstract：:Eighty-six of 452 patients (19%) with chronic bifascicular block were found to have no clinically apparent associated organic heart disease (OHD) and were defined as having primary conduction disease (PCD). Comparison of patients with PCD and OHD revealed a significantly lower incidence of the following clinical varia...

journal_title：Circulation

authors： Dhingra RC,Wyndham C,Bauernfeind R,Denes P,Wu D,Swiryn S,Rosen KM

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:Increased carotid intimal-medial thickness (IMT) and coronary artery calcification (CAC) are used as 2 markers of early atherosclerosis. Our objectives were to assess whether increased IMT and CAC are related and to determine the relationship between cardiovascular risk factors and carotid IMT in young adult...

journal_title：Circulation

authors： Davis PH,Dawson JD,Mahoney LT,Lauer RM

更新日期：1999-08-24 00:00:00

abstract：:The loss of coronary vasodilator reserve after ischemia-reperfusion may be due to endothelial injury, and this vascular dysfunction may contribute to functional alterations observed after ischemia. To determine whether endothelial dysfunction occurs after relatively brief periods of moderate low-flow ischemia in vivo,...

journal_title：Circulation

authors： Headrick JP,Angello DA,Berne RM

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Previous experimental studies have shown that the effect of serotonin on a coronary stenosis depends on whether that stenosis is compliant or fixed. However, the relation between coronary stenosis morphology and the response to serotonin in patients with angina is not known. METHODS AND RESULTS:Using comput...

journal_title：Circulation

authors： Tousoulis D,Davies G,McFadden E,Clarke J,Kaski JC,Maseri A

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Lead V(1) directly faces the right ventricle and may exhibit ST elevation during an acute inferior myocardial infarction when the right ventricle is also involved. Leads V(1) and V(3) indirectly face the posterolateral left ventricle, and ST depression ("mirror-image" ST elevation) in V(1) through V(3) may r...

journal_title：Circulation

authors： Wong CK,Gao W,Stewart RA,French JK,Aylward PE,Benatar J,White HD,Hirulog and Early Reperfusion or Occlusion-2 Investigators.

更新日期：2010-08-03 00:00:00

abstract：BACKGROUND:Radiofrequency ablation of the atrioventricular node and permanent pacing are used for symptomatic relief in patients with medically refractory atrial fibrillation. In this study, meta-analysis was used to clarify clinical outcomes and survival after ablation and pacing therapy using data from the published ...

journal_title：Circulation

authors： Wood MA,Brown-Mahoney C,Kay GN,Ellenbogen KA

更新日期：2000-03-14 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy for heart failure with left bundle branch block reduces left ventricular (LV) conduction delay, contraction asynchrony, and LV end-systolic volume ("reverse remodeling"). Up to one third of patients do not improve, and the electric requirements for reverse remodeling are unc...

journal_title：Circulation

authors： Sweeney MO,van Bommel RJ,Schalij MJ,Borleffs CJ,Hellkamp AS,Bax JJ

更新日期：2010-02-09 00:00:00

abstract：BACKGROUND:The role of angiotensin II (Ang II) type 2 (AT2) receptor in atherosclerosis was explored with the use of AT2 receptor/apolipoprotein E (ApoE)-double-knockout (AT2/ApoE-DKO) mice, with a focus on oxidative stress. METHODS AND RESULTS:After treatment with a high-cholesterol diet (1.25% cholesterol) for 10 we...

journal_title：Circulation

authors： Iwai M,Chen R,Li Z,Shiuchi T,Suzuki J,Ide A,Tsuda M,Okumura M,Min LJ,Mogi M,Horiuchi M

更新日期：2005-09-13 00:00:00

abstract：BACKGROUND:The synthetic catecholamine dobutamine increases stroke volume in normal subjects and in patients with congestive heart failure. In addition to its direct influence on myocardial contractility, dobutamine may significantly modulate vascular tone because of its alpha- and beta-adrenergic agonist activity. ME...

journal_title：Circulation

authors： Binkley PF,Murray KD,Watson KM,Myerowitz PD,Leier CV

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:The ability of echocardiographic dyssynchrony to predict response to cardiac resynchronization therapy (CRT) has been unclear. METHODS AND RESULTS:A prospective, longitudinal study was designed with predefined dyssynchrony indexes and outcome variables to test the hypothesis that baseline dyssynchrony is as...

journal_title：Circulation

authors： Gorcsan J 3rd,Oyenuga O,Habib PJ,Tanaka H,Adelstein EC,Hara H,McNamara DM,Saba S

更新日期：2010-11-09 00:00:00

abstract：:Six instances of sudden death were recorded by Holter monitoring, which showed ventricular fibrillation in five and a bradyarrhythmia in one. Complex ventricular ectopic activity preceded cardiac arrest in five patients, including the one with the bradyarrhythmic arrest. Two patients with chronic bifascicular block ar...

journal_title：Circulation

authors： Nikolic G,Bishop RL,Singh JB

更新日期：1982-07-01 00:00:00

abstract：:Patients with lower-extremity peripheral artery disease (PAD) have greater functional impairment, faster functional decline, increased rates of mobility loss, and poorer quality of life than people without PAD. Supervised exercise therapy (SET) improves walking ability, overall functional status, and health-related qu...

journal_title：Circulation

authors： Treat-Jacobson D,McDermott MM,Beckman JA,Burt MA,Creager MA,Ehrman JK,Gardner AW,Mays RJ,Regensteiner JG,Salisbury DL,Schorr EN,Walsh ME,American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular

更新日期：2019-09-24 00:00:00

abstract：:Coronary artery bypass surgery with or without aneurysmectomy has been used to treat patients with angiographically defined left ventricular aneurysm. To evaluate whether surgery benefits such patients, we analyzed the data from 1131 patients who were enrolled in the registry of the Coronary Artery Surgery Study. Four...

journal_title：Circulation

authors： Faxon DP,Myers WO,McCabe CH,Davis KB,Schaff HV,Wilson JW,Ryan TJ

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Previous studies found that percutaneous coronary intervention (PCI) does not improve outcome compared with medical therapy (MT) in patients with stable coronary artery disease, but PCI was guided by angiography alone. FAME 2 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) compa...

journal_title：Circulation

authors： Fearon WF,Nishi T,De Bruyne B,Boothroyd DB,Barbato E,Tonino P,Jüni P,Pijls NHJ,Hlatky MA,FAME 2 Trial Investigators.

更新日期：2018-01-30 00:00:00

abstract：BACKGROUND:It is recommended that comatose survivors of out-of-hospital cardiac arrest should be cooled to 32° to 34°C for 12 to 24 hours. However, the optimal level of cooling is unknown. The aim of this pilot study was to obtain initial data on the effect of different levels of hypothermia. We hypothesized that deepe...

journal_title：Circulation

authors： Lopez-de-Sa E,Rey JR,Armada E,Salinas P,Viana-Tejedor A,Espinosa-Garcia S,Martinez-Moreno M,Corral E,Lopez-Sendon J

更新日期：2012-12-11 00:00:00

abstract：BACKGROUND:Population screening for abdominal aortic aneurysm (AAA) has commenced in several countries, and has been shown to reduce AAA-related mortality by up to 50%. Most men who screen positive have an AAA <5.5 cm in diameter, the referral threshold for treatment, and are entered into an ultrasound surveillance pro...

journal_title：Circulation

authors： Oliver-Williams C,Sweeting MJ,Jacomelli J,Summers L,Stevenson A,Lees T,Earnshaw JJ

更新日期：2019-03-12 00:00:00