Abstract:
:The effect of timolol vs placebo on the frequency of anginal episodes, nitroglycerin consumption and exercise performance was investigated in a double-blind, randomized, crossover study in 23 patients with angina pectoris. The optimal dose of timolol (10-30 mg twice daily) for each patient was titrated by exercise studies. Compared with placebo, timolol decreased the weekly number of anginal attacks and the weekly number of nitroglycerin tablets consumed, reduced the resting heart rate, systolic and diastolic blood pressure, and product of systolic blood pressure times heart rate, decreased the heart rate, systolic and diastolic blood pressure, and product of systolic blood pressure times heart rate at the onset of angina pectoris or marked fatigue, prolonged exercise duration, and diminished electrocardiographic evidence of myocardial ischemia. Timolol is an excellent antianginal agent when prescribed twice daily, with the optimal dose titrated by exercise studies.
journal_name
Circulationjournal_title
Circulationauthors
Aronow WS,Turbow M,Van Camp S,Lurie M,Whittaker Kdoi
10.1161/01.cir.61.1.66subject
Has Abstractpub_date
1980-01-01 00:00:00pages
66-9issue
1eissn
0009-7322issn
1524-4539journal_volume
61pub_type
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