The early posthospital phase of myocardial infarction. Prognostic stratification.

abstract：BACKGROUND:Recent studies suggest that mutations in cardiac mitochondrial DNA (mtDNA) may contribute to the development of dilated cardiomyopathy. The mechanisms that regulate those mutations, however, remain undefined. Thus, we studied cardiac mtDNA repair mechanisms, mtDNA damage, and mitochondrial structure and func...

journal_title：Circulation

authors： Li YY,Chen D,Watkins SC,Feldman AM

更新日期：2001-11-13 00:00:00

abstract：:Because acute segmental wall motion abnormalities (SWMAs) of the left ventricle are highly sensitive and specific indicators of myocardial ischemia, this study compared the incidence and significance of ischemia, as detected by two-dimensional transesophageal echocardiography and surface electrocardiography, during an...

journal_title：Circulation

authors： Smith JS,Cahalan MK,Benefiel DJ,Byrd BF,Lurz FW,Shapiro WA,Roizen MF,Bouchard A,Schiller NB

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:The late hemodynamic effects of preserving the papillary muscles during mitral valve replacement have not been evaluated. METHODS AND RESULTS:Sixteen patients who had chronic mitral regurgitation due to myxomatous degeneration were randomized to preservation (Pres group, n = 8) or no preservation (No Pres g...

journal_title：Circulation

authors： Komeda M,David TE,Rao V,Sun Z,Weisel RD,Burns RJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Cardiac Na/K-ATPase (NKA) regulates intracellular Na ([Na](i)), which in turn affects intracellular Ca and thus contractility via Na/Ca exchange. Recent evidence shows that phosphorylation of the NKA-associated small transmembrane protein phospholemman (PLM) mediates beta-adrenergic-induced NKA stimulation. ...

journal_title：Circulation

authors： Despa S,Tucker AL,Bers DM

更新日期：2008-04-08 00:00:00

abstract：BACKGROUND:Electrophysiological mechanisms by which adenosine may activate cardiac afferent neurons are unknown. Slow afterhyperpolarizations (AHPs) follow action potentials in a subset of vagal C afferents, rendering them inexcitable. The purpose of this study was to test the hypothesis that adenosine increases vagal ...

journal_title：Circulation

authors： Middlekauff HR,Doering A,Weiss JN

更新日期：2001-03-06 00:00:00

abstract：BACKGROUND:It is still unclear what role the sinus node may play in the genesis or perpetuation of atrial fibrillation. Therefore, we studied the electrical activity in different regions of the sinus node during atrial fibrillation. METHODS AND RESULTS:In Langendorff-perfused rabbit hearts, paroxysms of atrial fibrill...

journal_title：Circulation

authors： Kirchhof CJ,Allessie MA

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:An objective of the United States' Healthy People 2010 Initiative is to eliminate disparities based on socioeconomic status. We assessed the effect of difficulty affording health care on the health status (symptoms, function, and quality of life) of patients treated with percutaneous coronary intervention or...

journal_title：Circulation

authors： Spertus J,Decker C,Woodman C,House J,Jones P,O'Keefe J,Borkon AM

更新日期：2005-05-24 00:00:00

abstract：:Between 1970 and 1987, 112 patients were diagnosed as having thromboangiitis obliterans (TAO). The age was 42 +/- 11 years (mean +/- SD; range, 20-75 years); 23% were women, and 7% were more than 60 years old when they were first diagnosed. Ischemic ulcerations were present in 85 (76%) patients: 24 (28%) patients with...

journal_title：Circulation

authors： Olin JW,Young JR,Graor RA,Ruschhaupt WF,Bartholomew JR

更新日期：1990-11-01 00:00:00

abstract：:In previous studies from this laboratory, we found that approximately 30% of women with chest pain and normal coronary arteries demonstrated either a decrease in or a failure to increase radionuclide ejection fraction during exercise. To examine the hypothesis that this apparent abnormality in left ventricular functio...

journal_title：Circulation

authors： Higginbotham MB,Morris KG,Coleman RE,Cobb FR

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:It has been suggested that intracellular Ca2+ overload in cardiac myocytes leads to the development of diabetic cardiomyopathy. Troglitazone, an insulin-sensitizing agent, is a promising therapeutic agent for diabetes and has been shown to prevent diabetes-induced myocardial changes. To elucidate the underly...

journal_title：Circulation

authors： Nakajima T,Iwasawa K,Oonuma H,Imuta H,Hazama H,Asano M,Morita T,Nakamura F,Suzuki J,Suzuki S,Kawakami Y,Omata M,Okuda Y

更新日期：1999-06-08 00:00:00

abstract：BACKGROUND:Previous electrophysiological studies in patients with typical atrial flutter suggested that the slow conduction zone might be located in the low right atrial isthmus, which is a path formed by orifice of inferior vena cava, eustachian valve/ridge, coronary sinus ostium, and tricuspid annulus. The conduction...

journal_title：Circulation

authors： Tai CT,Chen SA,Chiang CE,Lee SH,Ueng KC,Wen ZC,Huang JL,Chen YJ,Yu WC,Feng AN,Chiou CW,Chang MS

更新日期：1997-10-21 00:00:00

abstract：BACKGROUND:The cross-talk between vascular endothelial growth factor (VEGF)-A, angiopoietin (Ang), and VE-cadherin coregulates endothelial cell (EC) survival. Cardiac expression of VEGF-A but not its receptor KDR is blunted in dilated cardiomyopathy (DCM). Whether VE-cadherin/Ang function is affected in DCM is unknown....

journal_title：Circulation

authors： Schäfer R,Abraham D,Paulus P,Blumer R,Grimm M,Wojta J,Aharinejad S

更新日期：2003-09-30 00:00:00

abstract：BACKGROUND:An effect of diet in determining blood pressure is suggested by epidemiological studies, but the role of specific nutrients is still unsettled. METHODS AND RESULTS:The relation of various nutritional factors with hypertension was examined prospectively among 30,681 predominantly white US male health profess...

journal_title：Circulation

authors： Ascherio A,Rimm EB,Giovannucci EL,Colditz GA,Rosner B,Willett WC,Sacks F,Stampfer MJ

更新日期：1992-11-01 00:00:00

abstract：:The antiarrhythmic efficacy and safety of oral flecainide acetate and quinidine sulfate were compared in a double-blind, 16-center parallel trial involving 280 patients with chronic premature ventricular complexes (PVCs). Eighty-five percent of the flecainide patients had at least 80% suppression of PVCs, vs 57% of th...

journal_title：Circulation

authors：

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Reports on outcome after the Ross procedure are limited by small study size and show variable durability results. A systematic review of evidence on outcome after the Ross procedure may improve insight into outcome and potential determinants. METHODS AND RESULTS:A systematic review of reports published from...

journal_title：Circulation

authors： Takkenberg JJ,Klieverik LM,Schoof PH,van Suylen RJ,van Herwerden LA,Zondervan PE,Roos-Hesselink JW,Eijkemans MJ,Yacoub MH,Bogers AJ

更新日期：2009-01-20 00:00:00

abstract：BACKGROUND:Paroxysmal atrial fibrillation (PAF) can be eliminated with continuous circular lesions (CCLs) around the pulmonary veins (PVs), but it is unclear whether all PVs are completely isolated. METHODS AND RESULTS:Forty-one patients with symptomatic PAF underwent 3D mapping, and all PV ostia were marked on the 3D...

journal_title：Circulation

authors： Ouyang F,Bänsch D,Ernst S,Schaumann A,Hachiya H,Chen M,Chun J,Falk P,Khanedani A,Antz M,Kuck KH

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:We tested prospectively the hypothesis that stroke development can be predicted by echolucency of carotid atherosclerotic plaques in previously symptomatic and asymptomatic patients. METHODS AND RESULTS:We followed incidence of ipsilateral ischemic strokes for 4.4 years in 111 asymptomatic and 135 symptomat...

journal_title：Circulation

authors： Grønholdt ML,Nordestgaard BG,Schroeder TV,Vorstrup S,Sillesen H

更新日期：2001-07-03 00:00:00

abstract：:Preliminary clinical and laboratory observations suggest that nifedipine might prevent progression of threatened myocardial infarction by reversing coronary spasm or might limit necrosis during the course of acute myocardial infarction. We screened 3143 patients with ischemic pain of greater than 45 min duration and r...

journal_title：Circulation

authors： Muller JE,Morrison J,Stone PH,Rude RE,Rosner B,Roberts R,Pearle DL,Turi ZG,Schneider JF,Serfas DH

更新日期：1984-04-01 00:00:00

abstract：:This is the first scientific statement from the American Heart Association on maternal resuscitation. This document will provide readers with up-to-date and comprehensive information, guidelines, and recommendations for all aspects of maternal resuscitation. Maternal resuscitation is an acute event that involves many ...

journal_title：Circulation

authors： Jeejeebhoy FM,Zelop CM,Lipman S,Carvalho B,Joglar J,Mhyre JM,Katz VL,Lapinsky SE,Einav S,Warnes CA,Page RL,Griffin RE,Jain A,Dainty KN,Arafeh J,Windrim R,Koren G,Callaway CW,American Heart Association Emergency Cardio

更新日期：2015-11-03 00:00:00

abstract：:The echocardiograms of 46 patients with aortic insufficiency which manifested typical high frequency vibrations of the anterior mitral valve leaflet were reviewed. All patients had overt clinical evidence of aortic insufficiency which was confirmed by angiography in 17 cases. In 17 cases (eight of whom underwent cat...

journal_title：Circulation

authors： Cope GD,Kisslo JA,Johnson ML,Myers S

更新日期：1975-04-01 00:00:00

abstract：BACKGROUND:New methods of R-R interval variability based on fractal scaling and nonlinear dynamics ("chaos theory") may give new insights into heart rate dynamics. The aims of this study were to (1) systematically characterize and quantify the effects of aging from early childhood to advanced age on 24-hour heart rate ...

journal_title：Circulation

authors： Pikkujämsä SM,Mäkikallio TH,Sourander LB,Räihä IJ,Puukka P,Skyttä J,Peng CK,Goldberger AL,Huikuri HV

更新日期：1999-07-27 00:00:00

abstract：BACKGROUND:We explored whether chronic hyperglycemia is associated with defects in endothelium-dependent vasodilatation in vivo and whether defects in the hemodynamic effects of insulin explain insulin resistance. METHODS AND RESULTS:Vasodilator responses to brachial artery infusions of acetylcholine, sodium nitroprus...

journal_title：Circulation

authors： Mäkimattila S,Virkamäki A,Groop PH,Cockcroft J,Utriainen T,Fagerudd J,Yki-Järvinen H

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:In patients with asymptomatic valvular aortic stenosis, exercise testing may help to stratify the clinical risk. However, data are limited, and the role of quantitative exercise Doppler echocardiography has never been investigated. METHODS AND RESULTS:Sixty-nine consecutive patients with severe asymptomatic...

journal_title：Circulation

authors： Lancellotti P,Lebois F,Simon M,Tombeux C,Chauvel C,Pierard LA

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte c...

journal_title：Circulation

authors： Feng AN,Chen YL,Chen YT,Ding YZ,Lin SJ

更新日期：1999-11-30 00:00:00

abstract：:Statins (HMG-CoA reductase inhibitors) are used widely for the treatment of hypercholesterolemia. They inhibit HMG-CoA reductase competitively, reduce LDL levels more than other cholesterol-lowering drugs, and lower triglyceride levels in hypertriglyceridemic patients. Statins are well tolerated and have an excellent ...

journal_title：Circulation

authors： Maron DJ,Fazio S,Linton MF

更新日期：2000-01-18 00:00:00

abstract：:The long-term results of 414 patients who underwent repair of tetralogy of Fallot between 1967 and 1977 were studied and correlated with the results of others. There were nine late deaths (8-year actuarial survival 95.8%). Six of the deaths wee directly related to the malformation or its treatment. Eight patients (2.4...

journal_title：Circulation

authors： Katz NM,Blackstone EH,Kirklin JW,Pacifico AD,Bargeron LM Jr

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND:The production of left ventricular (LV) restoring forces generated during contraction, which are responsible for diastolic suction, is dependent on end-systolic volume (ESV) and systolic transmural and 3D deformation. We tested the hypothesis that acute coronary occlusion would result in loss of forces that ...

journal_title：Circulation

authors： Bell SP,Fabian J,Watkins MW,LeWinter MM

更新日期：1997-10-07 00:00:00

abstract：BACKGROUND:Arterial hypertension is a prime cause of morbidity and mortality in the general population. Pharmacological treatment has limitations resulting from drug side effects, costs, and patient compliance. Thus, we investigated whether traditional Chinese medicine acupuncture is able to lower blood pressure. METH...

journal_title：Circulation

authors： Flachskampf FA,Gallasch J,Gefeller O,Gan J,Mao J,Pfahlberg AB,Wortmann A,Klinghammer L,Pflederer W,Daniel WG

更新日期：2007-06-19 00:00:00

abstract：BACKGROUND:Obesity is a risk factor for impaired cardiac performance, particularly in women. Animal studies suggest that alterations in myocardial fatty acid metabolism and efficiency in obesity can cause decreased cardiac performance. In the present study, we tested the hypothesis that myocardial fatty acid metabolism...

journal_title：Circulation

authors： Peterson LR,Herrero P,Schechtman KB,Racette SB,Waggoner AD,Kisrieva-Ware Z,Dence C,Klein S,Marsala J,Meyer T,Gropler RJ

更新日期：2004-05-11 00:00:00

abstract：BACKGROUND:Membrane contact sites are fundamental for transmission and translation of signals in multicellular organisms. The junctional membrane complexes in the cardiac dyads, where transverse (T) tubules are juxtaposed to the sarcoplasmic reticulum, are a prime example. T-tubule uncoupling and remodeling are well-kn...

journal_title：Circulation

authors： Liu C,Spinozzi S,Chen JY,Fang X,Feng W,Perkins G,Cattaneo P,Guimarães-Camboa N,Dalton ND,Peterson KL,Wu T,Ouyang K,Fu XD,Evans SM,Chen J

更新日期：2019-07-02 00:00:00