Flecainide versus quinidine for treatment of chronic ventricular arrhythmias. A multicenter clinical trial.

abstract：BACKGROUND:Previous studies found that percutaneous coronary intervention (PCI) does not improve outcome compared with medical therapy (MT) in patients with stable coronary artery disease, but PCI was guided by angiography alone. FAME 2 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) compa...

journal_title：Circulation

authors： Fearon WF,Nishi T,De Bruyne B,Boothroyd DB,Barbato E,Tonino P,Jüni P,Pijls NHJ,Hlatky MA,FAME 2 Trial Investigators.

更新日期：2018-01-30 00:00:00

abstract：BACKGROUND:The regional wall motion impairment and predisposition to arrhythmias in human ventricular hibernation may plausibly result from abnormal intercellular propagation of the depolarizing wave front. This study investigated the hypothesis that altered patterns of expression of connexin43, the principal gap junct...

journal_title：Circulation

authors： Kaprielian RR,Gunning M,Dupont E,Sheppard MN,Rothery SM,Underwood R,Pennell DJ,Fox K,Pepper J,Poole-Wilson PA,Severs NJ

更新日期：1998-02-24 00:00:00

abstract：BACKGROUND:Two phase III trials of enoxaparin for unstable angina/non-Q-wave myocardial infarction have shown it to be superior to unfractionated heparin for preventing a composite of death and cardiac ischemic events. A prospectively planned meta-analysis was performed to provide a more precise estimate of the effects...

journal_title：Circulation

authors： Antman EM,Cohen M,Radley D,McCabe C,Rush J,Premmereur J,Braunwald E

更新日期：1999-10-12 00:00:00

abstract：BACKGROUND:Cardiac tissue engineering offers the prospect of a novel treatment for acquired or congenital heart defects. We have created vascularized pieces of beating cardiac muscle in the rat that are as thick as the adult rat right ventricle wall. METHOD AND RESULTS:Neonatal rat cardiomyocytes in Matrigel were impl...

journal_title：Circulation

authors： Morritt AN,Bortolotto SK,Dilley RJ,Han X,Kompa AR,McCombe D,Wright CE,Itescu S,Angus JA,Morrison WA

更新日期：2007-01-23 00:00:00

abstract：BACKGROUND:Visceral adiposity is generally considered to play a key role in the metabolic syndrome, including hypertension. The purpose of this study was to evaluate cross-sectionally whether visceral adiposity is associated with prevalence of hypertension independent of other adipose depots and fasting plasma insulin....

journal_title：Circulation

authors： Hayashi T,Boyko EJ,Leonetti DL,McNeely MJ,Newell-Morris L,Kahn SE,Fujimoto WY

更新日期：2003-10-07 00:00:00

abstract：BACKGROUND:There is increasing evidence of a link between conduit vessel stiffness and cardiovascular events, although the association has never been tested in a large post-myocardial infarction patient population. METHODS AND RESULTS:We evaluated the relationship between baseline pulse pressure, measured by sphygmoma...

journal_title：Circulation

authors： Mitchell GF,Moyé LA,Braunwald E,Rouleau JL,Bernstein V,Geltman EM,Flaker GC,Pfeffer MA

更新日期：1997-12-16 00:00:00

abstract：BACKGROUND:Cystic medial degeneration (CMD) is a histological abnormality that is common in the aortic diseases associated with Marfan's syndrome (MFS). Although little known about the mechanism underlying CMD, several recent reports have demonstrated that vascular smooth muscle cell (VSMC) apoptosis could play a subst...

journal_title：Circulation

authors： Nagashima H,Sakomura Y,Aoka Y,Uto K,Kameyama Ki,Ogawa M,Aomi S,Koyanagi H,Ishizuka N,Naruse M,Kawana M,Kasanuki H

更新日期：2001-09-18 00:00:00

abstract：:We compared the effects of a cardioselective beta-adrenergic blocking drug, metoprolol, with a nonselective beta-adrenergic blocker, propranolol, on the response of 10 normal men to dynamic treadmill exercise. The volunteers underwent a standard graded exercise test to exhaustion while receiving placebo; propranolol, ...

journal_title：Circulation

authors： Sklar J,Johnston GD,Overlie P,Gerber JG,Brammell HL,Gal J,Nies AS

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND:Abnormalities of arterial pulse and limb growth after retrograde femoral arterial catheterization have been well documented. However, the magnitude of such complications after transfemoral artery balloon dilatation has not been thoroughly investigated. This study sought to evaluate the prevalence of these ab...

journal_title：Circulation

authors： Lee HY,Reddy SC,Rao PS

更新日期：1997-02-18 00:00:00

abstract：:One hundred eighteen consecutive patients undergoing valve replacement for aortic stenosis were analyzed to determine the incidence of and predisposing factors to postoperative atrial tachyarrhythmias. Univariate and multivariate analyses were performed on 70 clinical, hemodynamic, radiographic, electrocardiographic, ...

journal_title：Circulation

authors： Douglas PS,Hirshfeld JW Jr,Edmunds LH Jr

更新日期：1985-09-01 00:00:00

abstract：:In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with a first evolving myocardial infarction and with onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion of 100 mg recombinant tissue-type pla...

journal_title：Circulation

authors： O'Rourke M,Baron D,Keogh A,Kelly R,Nelson G,Barnes C,Raftos J,Graham K,Hillman K,Newman H

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:The first compounds considered for stent-based delivery, such as heparin, were chosen on the basis of promising tissue culture and animal experiments, and yet they have failed to stop restenosis clinically. More recent compounds, such as paclitaxel, are of a different sort, being hydrophobic in nature, and t...

journal_title：Circulation

authors： Hwang CW,Wu D,Edelman ER

更新日期：2001-07-31 00:00:00

abstract：BACKGROUND:Blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) has been used to measure T2* changes in skeletal muscle tissue of healthy volunteers. The BOLD effect is assumed to primarily reflect changes in blood oxygenation at the tissue level. We compared the calf muscle BOLD response of patien...

journal_title：Circulation

authors： Ledermann HP,Schulte AC,Heidecker HG,Aschwanden M,Jäger KA,Scheffler K,Steinbrich W,Bilecen D

更新日期：2006-06-27 00:00:00

abstract：BACKGROUND:Patients surviving ventricular fibrillation (VF) or sustained ventricular tachycardia (VT) are at a high risk of death due to a recurrence of arrhythmia. The implantable cardioverter defibrillator (ICD) terminates VT or VF, but it is not known whether this device prolongs life in these patients compared with...

journal_title：Circulation

authors： Connolly SJ,Gent M,Roberts RS,Dorian P,Roy D,Sheldon RS,Mitchell LB,Green MS,Klein GJ,O'Brien B

更新日期：2000-03-21 00:00:00

abstract：BACKGROUND:Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its functional contribution to lesion development has not been evaluated. METHODS AND RESULTS:We studied the role of MIF on neointima lesion formation after ...

journal_title：Circulation

authors： Schober A,Bernhagen J,Thiele M,Zeiffer U,Knarren S,Roller M,Bucala R,Weber C

更新日期：2004-01-27 00:00:00

abstract：BACKGROUND:Concern that trans-fatty acids formed in the partial hydrogenation of vegetable oils may increase the risk of coronary disease has existed for several decades, but direct evidence on this relation in humans is limited. METHODS AND RESULTS:With a case-control design, we studied the association between intake...

journal_title：Circulation

authors： Ascherio A,Hennekens CH,Buring JE,Master C,Stampfer MJ,Willett WC

更新日期：1994-01-01 00:00:00

abstract：:Cardiac arrest systems of care are successfully coordinating community, emergency medical services, and hospital efforts to improve the process of care for patients who have had a cardiac arrest. As a result, the number of people surviving sudden cardiac arrest is increasing. However, physical, cognitive, and emotiona...

journal_title：Circulation

authors： Sawyer KN,Camp-Rogers TR,Kotini-Shah P,Del Rios M,Gossip MR,Moitra VK,Haywood KL,Dougherty CM,Lubitz SA,Rabinstein AA,Rittenberger JC,Callaway CW,Abella BS,Geocadin RG,Kurz MC,American Heart Association Emergency Cardiovasc

更新日期：2020-03-24 00:00:00

abstract：BACKGROUND:Fixed-dose unmonitored treatment with dabigatran etexilate is effective and has a favorable safety profile in the prevention of stroke in atrial fibrillation patients compared with warfarin. We hypothesized that genetic variants could contribute to interindividual variability in blood concentrations of the a...

journal_title：Circulation

authors： Paré G,Eriksson N,Lehr T,Connolly S,Eikelboom J,Ezekowitz MD,Axelsson T,Haertter S,Oldgren J,Reilly P,Siegbahn A,Syvanen AC,Wadelius C,Wadelius M,Zimdahl-Gelling H,Yusuf S,Wallentin L

更新日期：2013-04-02 00:00:00

abstract：BACKGROUND:Race and sex disparities in in-hospital treatment and outcomes of patients with acute myocardial infarction (MI) have been described, but little is known about race and sex differences in post-MI angina and long-term risk of unplanned rehospitalization. We examined race and sex differences in post-MI angina ...

journal_title：Circulation

authors： Hess CN,Kaltenbach LA,Doll JA,Cohen DJ,Peterson ED,Wang TY

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:Classically, intrinsic coagulation proteins are thought to have a minor role in hemostasis. Recently, these proteins, especially FXII, were implicated as possible key players in the pathogenesis of arterial thrombosis. This study aims to determine the risks of arterial thrombosis conferred by increased activ...

journal_title：Circulation

authors： Siegerink B,Govers-Riemslag JW,Rosendaal FR,Ten Cate H,Algra A

更新日期：2010-11-02 00:00:00

abstract：BACKGROUND:Left ventricular (LV) mechanical dyssynchrony (LVMD) has emerged as a therapeutic target using cardiac resynchronization therapy (CRT) in selected patients with chronic heart failure. Current methods used to evaluate LVMD are technically difficult and do not assess LVMD of the whole LV simultaneously. We dev...

journal_title：Circulation

authors： Kapetanakis S,Kearney MT,Siva A,Gall N,Cooklin M,Monaghan MJ

更新日期：2005-08-16 00:00:00

abstract：BACKGROUND:Rel/NF-kappaB, an oxidative stress-responsive transcription factor, participates transiently in the control of gene expression. The cellular mechanisms that mediate NF-kappaB activation during ischemia (and during reperfusion in the course of treating ischemia) are not known. METHODS AND RESULTS:To investig...

journal_title：Circulation

authors： Canty TG Jr,Boyle EM Jr,Farr A,Morgan EN,Verrier ED,Pohlman TH

更新日期：1999-11-09 00:00:00

abstract：:A longitudinal study was made of 62 patients with dextro-transposition of the great arteries. The patients were managed with balloon atrial septostomy (BAS), palliative surgery if any operation was needed in the first year of life, and Mustard intra-atrial baffle repair after one year of age. Of the 47 patients with i...

journal_title：Circulation

authors： Gutgesell HP,McNamara DG

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:The morphological hallmark of tetralogy of Fallot is controversial, with much disagreement as to whether the subpulmonary infundibulum in this lesion is hypoplastic. In addition, few quantitative data are available regarding the morphometry of the subpulmonary infundibulum, what anatomic characteristics are ...

journal_title：Circulation

authors： Geva T,Ayres NA,Pac FA,Pignatelli R

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:To date, the uptake of drugs into the human heart by transport proteins is poorly understood. A candidate protein is the organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent transport protein for carnitine. We investigated expression and localization of OCTN...

journal_title：Circulation

authors： Grube M,Meyer zu Schwabedissen HE,Präger D,Haney J,Möritz KU,Meissner K,Rosskopf D,Eckel L,Böhm M,Jedlitschky G,Kroemer HK

更新日期：2006-02-28 00:00:00

abstract：:Since platelet accumulation may be an important determinant of restenosis after angioplasty, the time course of 51Cr-labeled platelet accumulation after experimental angioplasty was evaluated in a deendothelialized, hypercholesterolemic rabbit preparation of atherosclerosis. Marked platelet accumulation (39.5 +/- 8.7 ...

journal_title：Circulation

authors： Wilentz JR,Sanborn TA,Haudenschild CC,Valeri CR,Ryan TJ,Faxon DP

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:The study was designed to verify the concept of plaques "at risk" and whether inflammation could play a role in plaque rupture and thrombosis. METHODS AND RESULTS:In 20 patients who had died of acute myocardial infarction, the thrombosed coronary artery was identified and the site of plaque rupture was trac...

journal_title：Circulation

authors： van der Wal AC,Becker AE,van der Loos CM,Das PK

更新日期：1994-01-01 00:00:00

abstract：:We studied the effects of experimentally induced emotional stress (mental arithmetic) on different hemodynamic parameters, catecholamine levels, and serum and platelet function tests in 25 postinfarction patients and in 10 apparently healthy, age-matched control subjects. Mental stress (10 minutes) induced significant...

journal_title：Circulation

authors： Grignani G,Soffiantino F,Zucchella M,Pacchiarini L,Tacconi F,Bonomi E,Pastoris A,Sbaffi A,Fratino P,Tavazzi L

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and bacterial pathogenetic mechanisms underlying the induction of BA are largely unknown. METHODS AND RESULTS:Activation of hypoxia-inducible factor-1 (HIF-1), t...

journal_title：Circulation

authors： Kempf VA,Lebiedziejewski M,Alitalo K,Wälzlein JH,Ehehalt U,Fiebig J,Huber S,Schütt B,Sander CA,Müller S,Grassl G,Yazdi AS,Brehm B,Autenrieth IB

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:The implantable left ventricular assist device (LVAD) was designed to provide circulatory support as an alternative to heart transplantation or to continued medical therapy of end-stage heart failure. Initial experience with the implantable LVAD used as a bridge to heart transplantation provides a clinical o...

journal_title：Circulation

authors： McCarthy PM,James KB,Savage RM,Vargo R,Kendall K,Harasaki H,Hobbs RE,Pashkow FJ

更新日期：1994-11-01 00:00:00