Effects of calcium entry blockade on hypertension-induced left ventricular hypertrophy.

abstract：:A lack in prostacyclin (PGI2) production due to atherosclerosis may play a role in the pathophysiology of some of the clinical manifestations of ischemic heart disease and in particular, of coronary vasospasm. We therefore evaluated the effects of i.v. PGI2 in nine patients with variant angina and six normal volunteer...

journal_title：Circulation

authors： Chierchia S,Patrono C,Crea F,Ciabattoni G,De Caterina R,Cinotti GA,Distante A,Maseri A

更新日期：1982-03-01 00:00:00

abstract：:The elimination of specific dietary cholesterol target recommendations in recent guidelines has raised questions about its role with respect to cardiovascular disease. This advisory was developed after a review of human studies on the relationship of dietary cholesterol with blood lipids, lipoproteins, and cardiovascu...

journal_title：Circulation

authors： Carson JAS,Lichtenstein AH,Anderson CAM,Appel LJ,Kris-Etherton PM,Meyer KA,Petersen K,Polonsky T,Van Horn L,American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclero

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Brugada syndrome (BrS) primarily associates with the loss of sodium channel function. Previous studies showed features consistent with sodium current (INa) deficit in patients carrying desmosomal mutations, diagnosed with arrhythmogenic cardiomyopathy (or arrhythmogenic right ventricular cardiomyopathy). Exp...

journal_title：Circulation

authors： Cerrone M,Lin X,Zhang M,Agullo-Pascual E,Pfenniger A,Chkourko Gusky H,Novelli V,Kim C,Tirasawadichai T,Judge DP,Rothenberg E,Chen HS,Napolitano C,Priori SG,Delmar M

更新日期：2014-03-11 00:00:00

abstract：BACKGROUND:Precise knowledge of the expected "normal" lumen diameter at a given coronary anatomic location is a first step toward developing a quantitative estimate of coronary disease severity that could be more useful than the traditional "percent stenosis." METHODS AND RESULTS:Eighty-three arteriograms were careful...

journal_title：Circulation

authors： Dodge JT Jr,Brown BG,Bolson EL,Dodge HT

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Supply of sulfhydryl groups with the administration of N-acetylcysteine (NAC) has been reported to reverse tolerance to nitroglycerin but not to isosorbide dinitrate (ISDN). Lack of interaction between NAC and ISDN was suggested as an explanation for these findings. The present study was therefore designed t...

journal_title：Circulation

authors： Mehra A,Shotan A,Ostrzega E,Hsueh W,Vasquez-Johnson J,Elkayam U

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:We investigated the feasibility and efficacy of polyethylenimine (PEI) based human vascular endothelial growth factor-165 (hVEGF165) gene transfer into human skeletal myoblasts (HSM) for cell based delivery to the infarcted myocardium. METHODS AND RESULTS:Based on optimized transfection procedure using enha...

journal_title：Circulation

authors： Ye L,Haider HKh,Tan R,Toh W,Law PK,Tan W,Su L,Zhang W,Ge R,Zhang Y,Lim Y,Sim EK

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:In individuals without known cardiovascular disease, elevated body mass index (BMI) (weight/height2) is associated with an increased risk of death. However, in patients with certain specific chronic diseases, including heart failure, low BMI has been associated with increased mortality. METHODS AND RESULTS:...

journal_title：Circulation

authors： Kenchaiah S,Pocock SJ,Wang D,Finn PV,Zornoff LA,Skali H,Pfeffer MA,Yusuf S,Swedberg K,Michelson EL,Granger CB,McMurray JJ,Solomon SD,CHARM Investigators.

更新日期：2007-08-07 00:00:00

abstract：BACKGROUND:Children awaiting heart transplantation have severe limitations in their ability to exercise. The purpose of this study was to assess exercise capacity after pediatric heart transplantation and to identify factors influencing exercise performance. METHODS AND RESULTS:Progressive cycle ergometry testing was ...

journal_title：Circulation

authors： Hsu DT,Garofano RP,Douglas JM,Michler RE,Quaegebeur JM,Gersony WM,Addonizio LJ

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that the oxygen-sensing pathway consisting of transcription factor hypoxia-inducible factor and prolyl hydroxylase domain proteins (PHDs) plays a critical role in glucose metabolism. However, the role of adipocyte PHD in the development of obesity has not been clarified. We examined wh...

journal_title：Circulation

authors： Matsuura H,Ichiki T,Inoue E,Nomura M,Miyazaki R,Hashimoto T,Ikeda J,Takayanagi R,Fong GH,Sunagawa K

更新日期：2013-05-28 00:00:00

abstract：BACKGROUND:Cellular rejection of an allograft is mediated in part by peripheral blood T cells. We tested the hypothesis that quantitative changes in T-cell subsets can be detected in the peripheral blood and that these changes correlate with rejection. METHODS AND RESULTS:T-cell subset analysis was performed by flow c...

journal_title：Circulation

authors： Carlquist JF,Hammond ME,Yowell RL,Holland C,Swanson S,Anderson JL

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The differentiation of hypertrophic cardiomyopathy (HCM) from hypertensive left ventricular hypertrophy (H-LVH) on the basis of morphological information obtained by conventional echocardiography is occasionally problematic. We investigated whether strain rate (SR) imaging derived from tissue Doppler imaging...

journal_title：Circulation

authors： Kato TS,Noda A,Izawa H,Yamada A,Obata K,Nagata K,Iwase M,Murohara T,Yokota M

更新日期：2004-12-21 00:00:00

abstract：:To investigate whether a fixed external reference system should be used to most accurately describe regional left ventricular wall motion, we used vectors to analyze a simple model of ventricular contraction. If measured in a fixed external reference system, motion of implanted radiopaque midwall markers may contain t...

journal_title：Circulation

authors： Clayton PD,Jeppson GM,Klausner SC

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:An effect of diet in determining blood pressure is suggested by epidemiological studies, but the role of specific nutrients is still unsettled. METHODS AND RESULTS:The relation of various nutritional factors with hypertension was examined prospectively among 30,681 predominantly white US male health profess...

journal_title：Circulation

authors： Ascherio A,Rimm EB,Giovannucci EL,Colditz GA,Rosner B,Willett WC,Sacks F,Stampfer MJ

更新日期：1992-11-01 00:00:00

abstract：:Coronal, horizontal, and sagittal sections through the mid-line are excellent ways of depicting the anatomical position of the aortic root and for studying its topographical relationship to the surrounding vascular structures. Minimal radiographic abnormalities or no abnormalities at all may be present with an enlarge...

journal_title：Circulation

authors： Viamote M,Camacho M,Cahill DR,Viamonte M,Mori K

更新日期：1975-02-01 00:00:00

abstract：:Malperfusion of the thoracoabdominal aorta or its branches is a common complication of aortic dissection, often with a fatal outcome. Since 1985 we saw thoracoabdominal malperfusion in 13 patients with aortic dissection. During repair of an acute type A aortic dissection, the intimal flap was fenestrated in three case...

journal_title：Circulation

authors： Laas J,Heinemann M,Schaefers HJ,Daniel W,Borst HG

更新日期：1991-11-01 00:00:00

abstract：:Between 1970 and 1987, 112 patients were diagnosed as having thromboangiitis obliterans (TAO). The age was 42 +/- 11 years (mean +/- SD; range, 20-75 years); 23% were women, and 7% were more than 60 years old when they were first diagnosed. Ischemic ulcerations were present in 85 (76%) patients: 24 (28%) patients with...

journal_title：Circulation

authors： Olin JW,Young JR,Graor RA,Ruschhaupt WF,Bartholomew JR

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Integrins are involved in structural remodeling and tissue repair. This study aimed to elucidate the role of the beta-integrins in cardiac remodeling after myocardial infarction (MI). METHODS AND RESULTS:The MI model was created by ligation of the left anterior descending coronary artery in rats. We detecte...

journal_title：Circulation

authors： Sun M,Opavsky MA,Stewart DJ,Rabinovitch M,Dawood F,Wen WH,Liu PP

更新日期：2003-02-25 00:00:00

abstract：:The echocardiograms of 46 patients with aortic insufficiency which manifested typical high frequency vibrations of the anterior mitral valve leaflet were reviewed. All patients had overt clinical evidence of aortic insufficiency which was confirmed by angiography in 17 cases. In 17 cases (eight of whom underwent cat...

journal_title：Circulation

authors： Cope GD,Kisslo JA,Johnson ML,Myers S

更新日期：1975-04-01 00:00:00

abstract：BACKGROUND:CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogen...

journal_title：Circulation

authors： Jansson AM,Aukrust P,Ueland T,Smith C,Omland T,Hartford M,Caidahl K

更新日期：2009-06-30 00:00:00

abstract：BACKGROUND:We have previously described two distinct mutations in the beta-myosin heavy chain gene with markedly different clinical presentations and outcome: The 908Leu-->Val mutation was associated with a low disease penetrance and a benign prognosis. In contrast, the 403Arg-->Gln mutation in a Caucasian kindred was ...

journal_title：Circulation

authors： Fananapazir L,Epstein ND

更新日期：1994-01-01 00:00:00

abstract：:Proarrhythmic effects of flecainide acetate have been reported during exercise, but the mechanism for the arrhythmogenic interaction between flecainide and exercise is unknown. We hypothesized that the sinus tachycardia of exercise may enhance flecainide-induced conduction slowing by increasing use-dependent sodium ch...

journal_title：Circulation

authors： Ranger S,Talajic M,Lemery R,Roy D,Nattel S

更新日期：1989-05-01 00:00:00

abstract：:The results of coronary bypass 5-10 years after operation at the Baylor College of Medicine are reported. The late results demonstrate that good relief of symptoms of angina pectoris persisted in 89% of patients at 10 years of follow-up. An overall annual attrition rate of 3% has been fairly constant through 10 years ...

journal_title：Circulation

authors： Lawrie GM,Morris GC Jr

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Single premature beats were introduced in the reentrant circuit during stable atrial flutter in the canine sterile pericarditis model to test the hypotheses that (1) despite the fact that the reentrant circuit is functionally determined, there is a fully excitable gap; (2) the excitable gap in the reentrant ...

journal_title：Circulation

authors： Niwano S,Ortiz J,Abe H,Gonzalez X,Rudy Y,Waldo AL

更新日期：1994-10-01 00:00:00

abstract：:The goal of the present study was to demonstrate that intracoronary platelet deposition may trigger intense vasoconstriction of large epicardial coronary arteries in vivo and that this is largely mediated by thromboxane A2 and serotonin released by activated platelets. Cyclic flow variations (progressive declines in b...

journal_title：Circulation

authors： Golino P,Ashton JH,Buja LM,Rosolowsky M,Taylor AL,McNatt J,Campbell WB,Willerson JT

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Studies have implicated a role for prostaglandin (PG) E(2)-dependent matrix metalloproteinase (MMP) biosynthesis in the rupture of atherosclerotic plaque. Cyclooxygenase-2 (COX-2) and PGE synthase (PGES) are coregulated in nucleated cells by inflammatory stimuli. The aim of this study was to characterize the...

journal_title：Circulation

authors： Cipollone F,Prontera C,Pini B,Marini M,Fazia M,De Cesare D,Iezzi A,Ucchino S,Boccoli G,Saba V,Chiarelli F,Cuccurullo F,Mezzetti A

更新日期：2001-08-21 00:00:00

abstract：BACKGROUND:Metabolic syndrome importantly accelerates the atherosclerotic process, the earliest event of which is endothelial dysfunction. Ghrelin, a gastric peptide with cardiovascular actions, has been shown to inhibit proatherogenic changes in experimental models. This study therefore investigated whether ghrelin ad...

journal_title：Circulation

authors： Tesauro M,Schinzari F,Iantorno M,Rizza S,Melina D,Lauro D,Cardillo C

更新日期：2005-11-08 00:00:00

abstract：BACKGROUND:The uptake of oxidized low-density lipoprotein (OxLDL) by macrophage scavenger receptors is thought to be a key process in the formation of foam cells, the hallmark of early atherosclerotic lesions. CXCL16/scavenger receptor for phosphatidylserine and OxLDL is a multifunctional chemokine that exhibits scaven...

journal_title：Circulation

authors： Aslanian AM,Charo IF

更新日期：2006-08-08 00:00:00

abstract：BACKGROUND:Data from single-center studies suggest that echocardiographic parameters of mechanical dyssynchrony may improve patient selection for cardiac resynchronization therapy (CRT). In a prospective, multicenter setting, the Predictors of Response to CRT (PROSPECT) study tested the performance of these parameters ...

journal_title：Circulation

authors： Chung ES,Leon AR,Tavazzi L,Sun JP,Nihoyannopoulos P,Merlino J,Abraham WT,Ghio S,Leclercq C,Bax JJ,Yu CM,Gorcsan J 3rd,St John Sutton M,De Sutter J,Murillo J

更新日期：2008-05-20 00:00:00

abstract：BACKGROUND:Intravascular irradiation with beta-emitters has been proposed for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. Previous studies have shown the effectiveness of gamma-radiation to prevent recurrent restenosis, even in the presence of an implanted stent. The l...

journal_title：Circulation

authors： Amols HI,Trichter F,Weinberger J

更新日期：1998-11-10 00:00:00

abstract：BACKGROUND:Despite intensive investigation, how DNA methylation influences endothelial function remains poorly understood. We used methyl-CpG-binding domain protein 2 (MBD2), an interpreter for DNA methylome-encoded information, to dissect the impact of DNA methylation on endothelial function in both physiological and ...

journal_title：Circulation

authors： Rao X,Zhong J,Zhang S,Zhang Y,Yu Q,Yang P,Wang MH,Fulton DJ,Shi H,Dong Z,Wang D,Wang CY

更新日期：2011-06-28 00:00:00