Exercise-induced ST-segment depression in patients without restenosis after coronary angioplasty. Relation to preprocedural impaired left ventricular function.

abstract：:Preliminary clinical and laboratory observations suggest that nifedipine might prevent progression of threatened myocardial infarction by reversing coronary spasm or might limit necrosis during the course of acute myocardial infarction. We screened 3143 patients with ischemic pain of greater than 45 min duration and r...

journal_title：Circulation

authors： Muller JE,Morrison J,Stone PH,Rude RE,Rosner B,Roberts R,Pearle DL,Turi ZG,Schneider JF,Serfas DH

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:Combining 2 signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological and analytical limitations and thereby increase diagnostic accuracy for acute myocardial infarction with a single blood draw. We aimed to evaluate the diagnostic performance ...

journal_title：Circulation

authors： van der Linden N,Wildi K,Twerenbold R,Pickering JW,Than M,Cullen L,Greenslade J,Parsonage W,Nestelberger T,Boeddinghaus J,Badertscher P,Rubini Giménez M,Klinkenberg LJJ,Bekers O,Schöni A,Keller DI,Sabti Z,Puelacher C,

更新日期：2018-09-04 00:00:00

abstract：:Nine children ages 2--15 years have undergone mitral valve replacement (MVR) with Hancock porcine heterograft valves for severe mitral insufficiency. The etiology of the mitral valve disease was rheumatic in two patients, and congenital in seven. Porcine valve sizes ranged from 19--31 mm. Follow-up has been from 1.6 t...

journal_title：Circulation

authors： Kutsche LM,Oyer P,Shumway N,Baum D

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease. The pathways that govern titin-dependent cardiac growth and contribute to disease are diverse and difficult to dissect. METHOD...

journal_title：Circulation

authors： Radke MH,Polack C,Methawasin M,Fink C,Granzier HL,Gotthardt M

更新日期：2019-04-09 00:00:00

abstract：BACKGROUND:Patients with heart failure and systolic dysfunction may develop disordered breathing during sleep. Repeated episodes of apnea and hypopnea may result in desaturation and arousals, which could adversely affect left ventricular function. The purpose of this study was to determine the short-term effects of con...

journal_title：Circulation

authors： Javaheri S

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Children listed for heart transplantation face the highest waiting list mortality in solid-organ transplantation medicine. We examined waiting list mortality since the pediatric heart allocation system was revised in 1999 to determine whether the revised allocation system is prioritizing patients optimally a...

journal_title：Circulation

authors： Almond CSD,Thiagarajan RR,Piercey GE,Gauvreau K,Blume ED,Bastardi HJ,Fynn-Thompson F,Singh TP

更新日期：2009-02-10 00:00:00

abstract：:In seven patients who underwent Fontan procedures but in whom no valves were inserted, dynamics of right heart flow were evaluated with the use of a catheter-tipped velocity transducer, pulsed Doppler echocardiography, and angiocardiography. Right atrial (RA) contraction caused a forward flow to the pulmonary artery (...

journal_title：Circulation

authors： Nakazawa M,Nakanishi T,Okuda H,Satomi G,Nakae S,Imai Y,Takao A

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:A low ankle-arm index (AAI) is a strong predictor of mortality and cardiovascular events. A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population....

journal_title：Circulation

authors： O'Hare AM,Katz R,Shlipak MG,Cushman M,Newman AB

更新日期：2006-01-24 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) and diabetes are both associated with a high risk of ischemic events, but the role of intensive blood pressure control in PAD has not been established. METHODS AND RESULTS:The Appropriate Blood Pressure Control in Diabetes study followed 950 subjects with type 2 diabetes fo...

journal_title：Circulation

authors： Mehler PS,Coll JR,Estacio R,Esler A,Schrier RW,Hiatt WR

更新日期：2003-02-11 00:00:00

abstract：BACKGROUND:Trends in cardiovascular mortality across Europe demonstrate significant geographical variation, and an understanding of these trends has a central role in global public health. METHODS AND RESULTS:Ischemic heart disease and cerebrovascular disease age-standardized death rates (as per International Classifi...

journal_title：Circulation

authors： Hartley A,Marshall DC,Salciccioli JD,Sikkel MB,Maruthappu M,Shalhoub J

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:We postulated that the variability of the phase shift between blood pressure and heart rate fluctuation near the frequency of 0.10 Hz might be useful in assessing autonomic circulatory control. METHODS AND RESULTS:We tested this hypothesis in 4 groups of subjects: 28 young, healthy individuals; 13 elderly h...

journal_title：Circulation

authors： Halámek J,Kára T,Jurák P,Soucek M,Francis DP,Davies LC,Shen WK,Coats AJ,Novák M,Nováková Z,Panovský R,Toman J,Sumbera J,Somers VK

更新日期：2003-07-22 00:00:00

abstract：:The administration of hyaluronidase is a promising intervention to protect the ischemic myocardium in man, but evidence of the extent to which it may reduce the ultimate size of an infarct is not well-defined. Hence, open chest, anesthetized dogs were randomized into 10 control dogs which received saline and eight tre...

journal_title：Circulation

authors： Kloner RA,Braunwald E,Maroko PR

更新日期：1978-08-01 00:00:00

abstract：:One hundred four patients younger than 20 years of age underwent intracardiac xenograft valve replacement (n = 41) or extracardiac conduit implantation (n = 63). Long-term follow-up averaged 4.5 and 4.3 years, respectively, and cumulative follow-up totaled 344 patient-years (pt-yr). Thirty patients were followed more ...

journal_title：Circulation

authors： Miller DC,Stinson EB,Oyer PE,Billingham ME,Pitlick PT,Reitz BA,Jamieson SW,Baumgartner WA,Shumway NE

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Proliferation of smooth muscle cells (SMCs) plays an important role in vascular pathobiology, being involved in the development of coronary restenosis and atherosclerosis. The activation of nuclear proto-oncogenes appears to be a final common pathway onto which various mitogenic signals coverage. Accordingly...

journal_title：Circulation

authors： Shi Y,Hutchinson HG,Hall DJ,Zalewski A

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:In PTCA patients with multivessel coronary artery disease, incomplete revascularization (IR) is the result of both pre-PTCA strategy and initial lesion outcome. The unique contribution of these components on long-term patient outcome is uncertain. METHODS AND RESULTS:From the Bypass Angioplasty Revasculariz...

journal_title：Circulation

authors： Kip KE,Bourassa MG,Jacobs AK,Schwartz L,Feit F,Alderman EL,Weiner BH,Weiss MB,Kellett MA Jr,Sharaf BL,Dimas AP,Jones RH,Sopko G,Detre KM

更新日期：1999-08-31 00:00:00

abstract：:Scanning and transmission electron microscopic studies were made of: 1) 15 glutaraldehyde-treated porcine valvular heterografts that had been implanted in patients for periods of time ranging from 2 days to 76 months; 2) unimplanted, commercially processed porcine aortic valves; and 3) unprocessed porcine aortic valve...

journal_title：Circulation

authors： Ferrans VJ,Spray TL,Billingham ME,Roberts WC

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, including cancer and cardiovascular disease. Small-molecule BET protein inhibitors such as JQ1 have demo...

journal_title：Circulation

authors： Kim SY,Zhang X,Schiattarella GG,Altamirano F,Ramos TAR,French KM,Jiang N,Szweda PA,Evers BM,May HI,Luo X,Li H,Szweda LI,Maracaja-Coutinho V,Lavandero S,Gillette TG,Hill JA

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:The effect of the increasing prevalence of obesity on blood pressure (BP) secular trends is unclear. We analyzed BP and body mass index secular trends between 1998 and 2006 in children and adolescents of the Seychelles, a rapidly developing island state in the African region. METHODS AND RESULTS:School-base...

journal_title：Circulation

authors： Chiolero A,Paradis G,Madeleine G,Hanley JA,Paccaud F,Bovet P

更新日期：2009-02-03 00:00:00

abstract：BACKGROUND:Impaired endothelium-dependent vasodilation is an early sign of atherosclerosis in hypercholesterolemic patients. We hypothesized that lipid-lowering therapy can improve endothelial function and that this effect is mainly mediated by increased bioavailability of nitric oxide (NO). METHODS AND RESULTS:In a r...

journal_title：Circulation

authors： John S,Schlaich M,Langenfeld M,Weihprecht H,Schmitz G,Weidinger G,Schmieder RE

更新日期：1998-07-21 00:00:00

abstract：:The left anterior descending coronary artery of four dogs and the right common carotid artery of 15 rabbits were subjected to 40-60% reduction in transluminal diameter for 1 hour by partial ligation with suture thread. Scanning electron microscopic examination of the luminal surface of these vessels revealed endotheli...

journal_title：Circulation

authors： Gertz SD,Uretsky G,Wajnberg RS,Navot N,Gotsman MS

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) fatality rates are higher for women than for men, yet obstructive coronary artery disease (CAD) is less prevalent in women. Coronary flow reserve (CFR), an integrated measure of large- and small-vessel CAD and myocardial ischemia, identifies patients at risk for CVD death, but is...

journal_title：Circulation

authors： Taqueti VR,Shaw LJ,Cook NR,Murthy VL,Shah NR,Foster CR,Hainer J,Blankstein R,Dorbala S,Di Carli MF

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:Natural history of aortic dissection (AD) with intimal tear in the descending or abdominal aorta and retrograde extension into the ascending aorta (retrograde AD) remains unknown. The purpose of this study was to elucidate medium-term prognosis of patients with retrograde AD. METHODS AND RESULTS:Study popul...

journal_title：Circulation

authors： Kaji S,Akasaka T,Katayama M,Yamamuro A,Yamabe K,Tamita K,Akiyama M,Watanabe N,Tanemoto K,Morioka S,Yoshida K

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:In the preterm newborn, a patent ductus arteriosus is in large part a result of the increased sensitivity of the immature ductus to prostaglandin E2 (PGE2). PGE2 acts through 3 G protein-coupled receptors (EP2, EP3, and EP4) that activate both adenyl cyclase and K(ATP) channels. We explored these pathways to...

journal_title：Circulation

authors： Waleh N,Kajino H,Marrache AM,Ginzinger D,Roman C,Seidner SR,Moss TJ,Fouron JC,Vazquez-Tello A,Chemtob S,Clyman RI

更新日期：2004-10-19 00:00:00

abstract：BACKGROUND:The coronary artery collateral circulation may be beneficial in protecting against myocardial ischemia and necrosis. However, there is a tremendous interindividual variability in the degree of new collateral formation in patients with coronary artery disease. The basis for this interindividual heterogeneity ...

journal_title：Circulation

authors： Schultz A,Lavie L,Hochberg I,Beyar R,Stone T,Skorecki K,Lavie P,Roguin A,Levy AP

更新日期：1999-08-03 00:00:00

abstract：:A group of 916 apparently healthy men between the ages of 27 and 55 years (mean 37) were followed up with serial medical and exercise test evaluations for a period of 8 to 15 years (mean 12.7) to determine (1) the prevalence and specific types of new coronary events observed in subjects with and without abnormal ST se...

journal_title：Circulation

authors： McHenry PL,O'Donnell J,Morris SN,Jordan JJ

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:The atrioventricular (AV) node is insensitive to changes in extracellular potassium concentration, [K+]o, because of the absence of the inward rectifier potassium current (IK1). However, we propose that in the presence of adenosine, elevated [K+]o should increase the adenosine-activated inward rectifier pota...

journal_title：Circulation

authors： Martynyuk AE,Morey TE,Belardinelli L,Dennis DM

更新日期：1999-01-19 00:00:00

abstract：BACKGROUND:Insulin sensitivity and cardiovascular risk profile were examined in 20 healthy, nonobese, middle-aged men who were long-term users of nicotine-containing chewing gum and in 20 matched control subjects who did not use nicotine. METHODS AND RESULTS:Long-term use of nicotine-containing chewing gum was associa...

journal_title：Circulation

authors： Eliasson B,Taskinen MR,Smith U

更新日期：1996-09-01 00:00:00

abstract：:Intermittent aortic root infusion of a cold solution containing either potassium chloride (KCl) or diltiazem was performed in 32 dogs during a 2-hour aortic clamping. Half of the dogs in each group had a critical stenosis created on the circumflex artery before cardiopulmonary bypass. Global left ventricular (LV) func...

journal_title：Circulation

authors： Vouhé PR,Hélias J,Robert P,Grondin CM

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Little is known about the behavior with regard to restenosis of multiple lesions within the same patient treated with intracoronary stenting. Our objective was to test the hypothesis that there is an intrapatient dependence of restenosis between lesions. METHODS AND RESULTS:Quantitative analysis was carried...

journal_title：Circulation

authors： Kastrati A,Schömig A,Elezi S,Schühlen H,Wilhelm M,Dirschinger J

更新日期：1998-06-23 00:00:00

abstract：:Separate effects of perfusion hypothermia, potassium arrest, and procaine arrest were studied in 150 hearts using the isolated rat heart preparation. Aortic flow rate (AFR), coronary flow rate (CFR), and heart rate (HR) were measured before and after ischemic periods of 90 to 300 min. Prior to the ischemic period, the...

journal_title：Circulation

authors： Harlan BJ,Ross D,Macmanus Q,Knight R,Luber J,Starr A

更新日期：1978-09-01 00:00:00