Abstract:
BACKGROUND:We postulated that the variability of the phase shift between blood pressure and heart rate fluctuation near the frequency of 0.10 Hz might be useful in assessing autonomic circulatory control. METHODS AND RESULTS:We tested this hypothesis in 4 groups of subjects: 28 young, healthy individuals; 13 elderly healthy individuals; 25 patients with coronary heart disease; and 19 patients with a planned or implanted cardioverter-defibrillator (ICD recipients). Data from 5 minutes of free breathing and at 2 different, controlled breathing frequencies (0.10 and 0.33 Hz) were used. Clear differences (P<0.001) in variability of phase were evident between the ICD recipients and all other groups. Furthermore, at a breathing frequency of 0.10 Hz, differences in baroreflex sensitivity (P<0.01) also became evident, even though these differences were not apparent at the 0.33-Hz breathing frequency. CONCLUSIONS:The frequency of 0.10 Hz represents a useful and potentially important one for controlled breathing, at which differences in blood pressure-RR interactions become evident. These interactions, whether computed as a variability of phase to define stability of the blood pressure-heart rate interaction or defined as the baroreflex sensitivity to define the gain in heart rate response to blood pressure changes, are significantly different in patients at risk for sudden arrhythmic death. In young versus older healthy individuals, only baroreflex gain is different, with the variability of phase being similar in both groups. These measurements of short-term circulatory control might help in risk stratification for sudden cardiac death.
journal_name
Circulationjournal_title
Circulationauthors
Halámek J,Kára T,Jurák P,Soucek M,Francis DP,Davies LC,Shen WK,Coats AJ,Novák M,Nováková Z,Panovský R,Toman J,Sumbera J,Somers VKdoi
10.1161/01.CIR.0000079222.91910.EEsubject
Has Abstractpub_date
2003-07-22 00:00:00pages
292-7issue
3eissn
0009-7322issn
1524-4539pii
01.CIR.0000079222.91910.EEjournal_volume
108pub_type
临床试验,杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:Because acute exercise increases systemic catecholamines, we sought to determine whether exercise training would alter daily or exercise-related catecholamine release and inactivation. METHODS AND RESULTS:In 24-hour urine collections, catecholamines and metabolites provided indexes of overall oxidative deam...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.6.2346
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Vasodilator drugs have variable effects on veins and arteries. However, direct measurements of their effects on the splanchnic veins, perhaps the most important volume reservoir, have not been reported. We assessed the effect of acute heart failure and the subsequent administration of hydralazine, enalaprila...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.4.1205
更新日期:1995-02-15 00:00:00
abstract:BACKGROUND:The fatty acid composition of the phospholipids in sarcolemma may significantly influence cell membrane functions. We evaluated the effects of dietary fat on the pharmacodynamics of the antiarrhythmic drug propafenone in isolated, perfused rabbit hearts. METHODS AND RESULTS:Three groups of weanling rabbits ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.4.1501
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Epidemiological findings suggest an association between low-for-age birth weight and the risk to develop coronary heart diseases in adulthood. During pregnancy, an imbalance between fetal demands and supply may result in permanent alterations of neuroendocrine development in the fetus. We evaluated whether c...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.23.2892
更新日期:2000-12-05 00:00:00
abstract::Diffuse coronary artery disease is frequently untreatable by coronary artery bypass or angioplasty. Many such "no-option" patients have been subjects for trials of angiogenesis using growth factor manipulation or laser injury. We think these novel revascularization strategies are limited by insufficient inflow to puta...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.21.2539
更新日期:2001-05-29 00:00:00
abstract::BACKGROUND. A pace mapping technique using body surface potential maps (BSPMs) was developed to guide the positioning of an ablation catheter at the ventricular insertion point of accessory pathways (AP) in patients with the Wolff-Parkinson-White syndrome (WPW). METHODS AND RESULTS. The study was performed on 30 WPW p...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.87.1.135
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Current methods of signal-averaged ECG analysis interrogate the terminal 40 msec of the QRS complex and/or the ST segment and have a low positive-predictive accuracy for detecting vulnerability to sustained ventricular tachycardia (VT). The extent to which abnormalities detected during these ECG intervals ar...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.6.1888
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that mutations in cardiac mitochondrial DNA (mtDNA) may contribute to the development of dilated cardiomyopathy. The mechanisms that regulate those mutations, however, remain undefined. Thus, we studied cardiac mtDNA repair mechanisms, mtDNA damage, and mitochondrial structure and func...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc4501.098944
更新日期:2001-11-13 00:00:00
abstract::An external cardiac pacemaker-monitor has been developed that provides safe, effective noninvasive ventricular stimulation that is well tolerated in conscious patients and allows clear recognition of electrocardiographic response. The noninvasive temporary pacemaker (NTP) has now been applied in 134 patients in five h...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.71.5.937
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Radiofrequency catheter ablation of concealed posteroseptal accessory pathways (APS) has been a relatively difficult task for electrophysiologists. Without a detailed mapping procedure, the left versus the right posteroseptal AP could not be distinguished. We investigated the electrophysiological characteris...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.93.5.982
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Poststroke angiogenesis contributes to long-term recovery after stroke. Signal transducer and activator of transcription-3 (Stat3) is a key regulator for various inflammatory signals and angiogenesis. It was the aim of this study to determine its function in poststroke outcome. METHODS AND RESULTS:We genera...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.013003
更新日期:2015-05-19 00:00:00
abstract::Trapidil (triazolopyrimidine) possesses activity against platelet-derived growth factor-induced cellular proliferation in vitro and intimal proliferation in vivo. The objective of this study was to determine if trapidil could prevent restenosis in experimentally induced atherosclerotic rabbits. New Zealand White rabbi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.81.3.1089
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Sudden cardiac death (SCD) is a major cause of mortality in adults with congenital heart disease (CHD). The aim of this study was to determine the adult CHD population at risk of SCD and the clinical parameters associated with SCD. METHODS AND RESULTS:We performed a multicenter case-control study. Patients ...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.112.104786
更新日期:2012-10-16 00:00:00
abstract:BACKGROUND:Ghrelin is a novel growth hormone-releasing peptide that has been shown to improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and metabolic disturbances in septic shock. Because cytokine-induced inflammation is critical in these pathological states and because the growth hormone s...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000127956.43874.F2
更新日期:2004-05-11 00:00:00
abstract::The effect of prolonged intense endurance exercise training on exertional hypotension was investigated in 16 patients with coronary artery disease who had a 10 mm Hg or greater fall in systolic blood pressure (SBP) during progressive exercise testing. Training consisted of walking, running, or cycling at 50% to 60% of...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.76.3.548
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:The Lewis-F344 rat cardiac transplantation model produces cardiac allografts with chronic rejection characterized by arteriosclerotic lesions composed of macrophages and smooth muscle cells. Modulation of the inflammatory response with a diet deficient in essential fatty acids protects against the developmen...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.3.457
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Intravascular ultrasound imaging was performed in 27 patients after coronary balloon angioplasty to quantify the lumen and atheroma cross-sectional areas. METHODS AND RESULTS:A 20-MHz ultrasound catheter was inserted through a 1.6-mm plastic introducer sheath across the dilated area to obtain real-time imag...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.83.3.913
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Distal embolization of debris during percutaneous carotid artery stenting may result in neurological deficit. Filter devices for cerebral protection potentially reduce the risk of embolization. METHODS AND RESULTS:Elective carotid stent implantation using 3 different types of distal filter protection device...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/hc2601.092495
更新日期:2001-07-03 00:00:00
abstract:BACKGROUND:The majority of infrarenal abdominal aortic aneurysm (AAA) repairs in the United States are performed with endovascular methods. Baseline aortoiliac arterial anatomic characteristics are fundamental criteria for appropriate patient selection for endovascular aortic repair (EVAR) and key determinants of long-...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.110.014902
更新日期:2011-06-21 00:00:00
abstract:BACKGROUND:Fibrinogen has been identified as an independent risk factor for cardiovascular disease and associated with traditional cardiovascular risk factors. Also, the role of elevated fibrinogen in thrombosis suggests that it may be on the causal pathway for certain risk factors to exert their effect. These associat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.14.1634
更新日期:2000-10-03 00:00:00
abstract:BACKGROUND:Autoantibodies against the beta 1-adrenoceptor have been detected in the sera of patients with idiopathic dilated cardiomyopathy (DCM). The mechanisms by which these autoantibodies can alter normal receptor function are investigated, and the results are interpreted in the light of the beneficial effects of b...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.6.2760
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:Early childhood introduction of nutritional habits aimed at atherosclerosis prevention reduces children's serum total cholesterol concentration, but its effect on vascular endothelial function is unknown. METHODS AND RESULTS:Between 1990 and 1992, we randomized healthy 7-month-old infants (n=1062) to interv...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.105.583195
更新日期:2005-12-13 00:00:00
abstract:BACKGROUND:The Ross procedure and aortic homografts have both been shown to have superior hemodynamic performance after valve replacement, but there have been few comparisons. METHODS:Sequential Doppler echocardiograms were performed up to 5 years after aortic valve replacement in 132 patients with the Ross procedure ...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:
更新日期:2002-09-24 00:00:00
abstract:BACKGROUND:Coxsackievirus-induced myocarditis can be a serious cause of heart failure. In the absence of a specific antiviral therapy, modulating the host immune response may be protective. Interferons (IFNs)-alpha and -beta perform a fundamental role in innate and adaptive antiviral responses, thereby presenting as ca...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000136824.73458.20
更新日期:2004-12-07 00:00:00
abstract:BACKGROUND:The mechanisms of increased neointimal hyperplasia after coronary interventions in diabetic patients are still unknown. METHODS AND RESULTS:Glucose and insulin effects on in vitro vascular smooth muscle cell (VSMC) proliferation and migration were assessed. The effect of balloon injury on neointimal hyperpl...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.24.2980
更新日期:2001-06-19 00:00:00
abstract:BACKGROUND:A key component of reperfusion of myocardial infarction is an immediate inflammatory response, which enhances tissue repair. Matrix turnover is crucial to tissue repair, and matrix metalloproteinases (MMPs) are key enzymes involved in matrix degradation. The hypothesis tested is that one inflammation-based e...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.17.2181
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:For patients with acute dilated cardiomyopathy, definition of prognosis and of clinical features predictive of outcome is particularly important due to the availability of cardiac transplantation and other innovative treatment strategies. METHODS AND RESULTS:We reviewed our experience with 24 children under...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.3.1310
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Rel/NF-kappaB, an oxidative stress-responsive transcription factor, participates transiently in the control of gene expression. The cellular mechanisms that mediate NF-kappaB activation during ischemia (and during reperfusion in the course of treating ischemia) are not known. METHODS AND RESULTS:To investig...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.suppl_2.ii-361
更新日期:1999-11-09 00:00:00
abstract:BACKGROUND:A number of parameters reflecting the effects of idiopathic dilated cardiomyopathy (IDC) on the structure and function of myosin from the human myocardium were analyzed. METHODS AND RESULTS:The content of the regulatory light chain, LC2, was reduced in myopathic heart myosin in contrast to the controls in w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.5.1720
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Biological pacemakers (BPM) implanted in canine left bundle branch function competitively with electronic pacemakers (EPM). We hypothesized that BPM engineered with the use of mE324A mutant murine HCN2 (mHCN2) genes would improve function over mHCN2 and that BPM/EPM tandems confer advantage over either appro...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.617613
更新日期:2006-09-05 00:00:00