Myocardial protection through cold cardioplegia with potassium or diltiazem. Experimental evidence that diltiazem provides better protection even when coronary flow is impaired by a critical stenosis.

abstract：:We studied the effects of experimentally induced emotional stress (mental arithmetic) on different hemodynamic parameters, catecholamine levels, and serum and platelet function tests in 25 postinfarction patients and in 10 apparently healthy, age-matched control subjects. Mental stress (10 minutes) induced significant...

journal_title：Circulation

authors： Grignani G,Soffiantino F,Zucchella M,Pacchiarini L,Tacconi F,Bonomi E,Pastoris A,Sbaffi A,Fratino P,Tavazzi L

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation in the diseased heart. However, the roles...

journal_title：Circulation

authors： Chen S,Zhang Y,Lighthouse JK,Mickelsen DM,Wu J,Yao P,Small EM,Yan C

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Long-term rapid atrial pacing may result in atrial fibrillation (AF) in dogs. Whether there is histological evidence for neural remodeling is unclear. METHOD AND RESULTS:We performed rapid right atrial pacing in 6 dogs for 111+/-76 days to induce sustained AF. Tissues from 6 healthy dogs were used as contro...

journal_title：Circulation

authors： Chang CM,Wu TJ,Zhou S,Doshi RN,Lee MH,Ohara T,Fishbein MC,Karagueuzian HS,Chen PS,Chen LS

更新日期：2001-01-02 00:00:00

abstract：BACKGROUND:Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction

journal_title：Circulation

authors： Levy WC,Lee KL,Hellkamp AS,Poole JE,Mozaffarian D,Linker DT,Maggioni AP,Anand I,Poole-Wilson PA,Fishbein DP,Johnson G,Anderson J,Mark DB,Bardy GH

更新日期：2009-09-08 00:00:00

abstract：BACKGROUND:Ischemia reperfusion injury (IRI) predisposes to the formation of donor-specific antibodies, a factor contributing to chronic rejection and late allograft loss. METHODS:We describe a mechanism underlying the correlative association between IRI and donor-specific antibodies by using humanized models and pati...

journal_title：Circulation

authors： Liu L,Fang C,Fu W,Jiang B,Li G,Qin L,Rosenbluth J,Gong G,Xie CB,Yoo P,Tellides G,Pober JS,Jane-Wit D

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:The goal of this study was to examine a possible association between systemic microinflammation, as reflected by C-reactive protein (CRP) serum levels, and coronary vasomotion in patients with coronary risk factors but with angiographically normal coronary arteries. METHODS AND RESULTS:Coronary vasomotor fu...

journal_title：Circulation

authors： Schindler TH,Nitzsche EU,Olschewski M,Magosaki N,Mix M,Prior JO,Facta AD,Solzbach U,Just H,Schelbert HR

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:We tested the hypothesis that long-term administration of the specific angiotensin II subtype 1 (AT1)-receptor blocker BMS-186295 will regress hypertrophy and modify left ventricular angiotensin converting enzyme (ACE) expression in rats with ascending aortic stenosis. METHODS AND RESULTS:Six weeks after su...

journal_title：Circulation

authors： Weinberg EO,Lee MA,Weigner M,Lindpaintner K,Bishop SP,Benedict CR,Ho KK,Douglas PS,Chafizadeh E,Lorell BH

更新日期：1997-03-18 00:00:00

abstract：BACKGROUND:Mendelian randomization studies have highlighted that lipoprotein(a) [Lp(a)] was associated with calcific aortic valve disease (CAVD). Lp(a) transports oxidized phospholipids with a high content in lysophosphatidylcholine. Autotaxin (ATX) transforms lysophosphatidylcholine into lysophosphatidic acid. We hypo...

journal_title：Circulation

authors： Bouchareb R,Mahmut A,Nsaibia MJ,Boulanger MC,Dahou A,Lépine JL,Laflamme MH,Hadji F,Couture C,Trahan S,Pagé S,Bossé Y,Pibarot P,Scipione CA,Romagnuolo R,Koschinsky ML,Arsenault BJ,Marette A,Mathieu P

更新日期：2015-08-25 00:00:00

abstract：:Exercise trials in cardiology are often hindered by inconsistent approaches to exercise testing. These inconsistencies include the choice of exercise protocol, exercise end points, points of analysis, and absence or misuse of gas exchange data. Gas exchange techniques greatly enhance the accuracy with which cardiopulm...

journal_title：Circulation

authors： Myers J,Froelicher VF

更新日期：1990-11-01 00:00:00

abstract：:Experimental studies of animals have previously demonstrated the validity of [1-11C]acetate as a tracer of oxidative metabolism for use with positron emission tomography. The present study was undertaken to define in normal human volunteers the relation between myocardial clearance kinetics of [1-11C]acetate, and the ...

journal_title：Circulation

authors： Armbrecht JJ,Buxton DB,Brunken RC,Phelps ME,Schelbert HR

更新日期：1989-10-01 00:00:00

abstract：:Increased ventricular volume is one of the most powerful predictors of reduced survival in patients with heart disease. Despite its well-documented prognostic significance, the magnitude of the progression of ventricular dilatation from the acute to the chronic phase of myocardial infarction has only recently been app...

journal_title：Circulation

authors： Pfeffer MA,Pfeffer JM

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:A line of block in the right atrium (RA) between the venae cavae is necessary to obtain classic atrial flutter (AFL). We tested the hypothesis that the location of that line of block would determine whether the AFL reentrant circuit would be due to single-loop reentry or figure-of-8 reentry. METHODS AND RES...

journal_title：Circulation

authors： Tomita Y,Matsuo K,Sahadevan J,Khrestian CM,Waldo AL

更新日期：2001-02-20 00:00:00

abstract：:Correlates of high-density lipoprotein (HDL) cholesterol levels were studied in 4756 white males and females ages 20-59 years examined during a population survey conducted by 10 North American Lipid Research Clinics. Multivariable analysis was used to assess the relation of social, demographic, physical and behavioral...

journal_title：Circulation

authors： Heiss G,Johnson NJ,Reiland S,Davis CE,Tyroler HA

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy for heart failure with left bundle branch block reduces left ventricular (LV) conduction delay, contraction asynchrony, and LV end-systolic volume ("reverse remodeling"). Up to one third of patients do not improve, and the electric requirements for reverse remodeling are unc...

journal_title：Circulation

authors： Sweeney MO,van Bommel RJ,Schalij MJ,Borleffs CJ,Hellkamp AS,Bax JJ

更新日期：2010-02-09 00:00:00

abstract：:Coronary arteriography was performed before and after the intracoronary injection of nitroglycerin to determine the presence or absence of spasm in patients within the first 12 hours of acute myocardial infarction. Coronary arterial spasm was demonstrated in six of fifteen (40%) acute myocardial infarctions associated...

journal_title：Circulation

authors： Oliva PB,Breckinridge JC

更新日期：1977-09-01 00:00:00

abstract：:Atherosclerotic coronary artery disease is the major cause of late cardiac transplant failure secondary to silent ischemia and infarction. To increase the longevity of cardiac homografts, we performed percutaneous transluminal coronary angioplasty (PTCA) in five male patients (aged 45 +/- 7 years, mean +/- SEM); 17 le...

journal_title：Circulation

authors： Vetrovec GW,Cowley MJ,Newton CM,Lewis SA,DiSciascio G,Thompson JA,Hastillo A,Lower R,Hess M

更新日期：1988-11-01 00:00:00

abstract：:A mathematical model to measure infarct size from serial estimates of CPK has been developed by Shell et al. Norris et al. have recently introduced a modification of this method by calculating an individualized disappearance rate parameter (Kd) from the uniformly monoexponential portion of the CPK vs time curve. This ...

journal_title：Circulation

authors： Slutsky AS

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:In PTCA patients with multivessel coronary artery disease, incomplete revascularization (IR) is the result of both pre-PTCA strategy and initial lesion outcome. The unique contribution of these components on long-term patient outcome is uncertain. METHODS AND RESULTS:From the Bypass Angioplasty Revasculariz...

journal_title：Circulation

authors： Kip KE,Bourassa MG,Jacobs AK,Schwartz L,Feit F,Alderman EL,Weiner BH,Weiss MB,Kellett MA Jr,Sharaf BL,Dimas AP,Jones RH,Sopko G,Detre KM

更新日期：1999-08-31 00:00:00

abstract：BACKGROUND:The development of selective atrial antiarrhythmic agents is a current strategy for suppression of atrial fibrillation (AF). METHODS AND RESULTS:Whole-cell patch clamp techniques were used to evaluate inactivation of peak sodium channel current (I(Na)) in myocytes isolated from canine atria and ventricles. ...

journal_title：Circulation

authors： Burashnikov A,Di Diego JM,Zygmunt AC,Belardinelli L,Antzelevitch C

更新日期：2007-09-25 00:00:00

abstract：BACKGROUND:The uptake of oxidized low-density lipoprotein (OxLDL) by macrophage scavenger receptors is thought to be a key process in the formation of foam cells, the hallmark of early atherosclerotic lesions. CXCL16/scavenger receptor for phosphatidylserine and OxLDL is a multifunctional chemokine that exhibits scaven...

journal_title：Circulation

authors： Aslanian AM,Charo IF

更新日期：2006-08-08 00:00:00

abstract：BACKGROUND:Lipoprotein oxidation plays an important part in atherogenesis. Autoantibodies to oxidation-specific epitopes of LDL occur in plasma and atherosclerotic lesions of humans and animals. The potential role of these autoantibodies in atherogenesis still remains unsolved. We studied the relationship between diffe...

journal_title：Circulation

authors： Karvonen J,Päivänsalo M,Kesäniemi YA,Hörkkö S

更新日期：2003-10-28 00:00:00

abstract：BACKGROUND:The renin-angiotensin system regulates blood pressure through its effects on vascular tone, renal hemodynamics, and renal sodium and fluid balance. METHODS AND RESULTS:Using data from a large population-based sample of 1488 siblings having a mean age of 14.8 years and belonging to the youngest generation of...

journal_title：Circulation

authors： Fornage M,Amos CI,Kardia S,Sing CF,Turner ST,Boerwinkle E

更新日期：1998-05-12 00:00:00

abstract：BACKGROUND:Plaque disruption and exposure of subendothelial procoagulants such as tissue factor (TF) to circulating factor VII/VIIa (FVII/VIIa) lead to intravascular thrombosis. Tissue factor pathway inhibitor (TFPI) is an endogenous inhibitor of TF-induced coagulation that binds to factor Xa and the TF-FVIIa catalytic...

journal_title：Circulation

authors： Caplice NM,Mueske CS,Kleppe LS,Simari RD

更新日期：1998-09-15 00:00:00

abstract：:Verapamil, a calcium antagonist, has been used extensively for treatment of cardiac arrhythmias. Concern persists, however, that it may seriously depress myocardial function in cardiac patients. To investigate this possibility, 20 patients with coronary artery disease (CAD) but no heart failure were given intravenous ...

journal_title：Circulation

authors： Ferlinz J,Easthope JL,Aronow WS

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:We previously demonstrated that ischemic postconditioning decreases creatine kinase release, a surrogate marker for infarct size, in patients with acute myocardial infarction. Our objective was to determine whether ischemic postconditioning could afford (1) a persistent infarct size limitation and (2) an imp...

journal_title：Circulation

authors： Thibault H,Piot C,Staat P,Bontemps L,Sportouch C,Rioufol G,Cung TT,Bonnefoy E,Angoulvant D,Aupetit JF,Finet G,André-Fouët X,Macia JC,Raczka F,Rossi R,Itti R,Kirkorian G,Derumeaux G,Ovize M

更新日期：2008-02-26 00:00:00

abstract：BACKGROUND:Exercise stimulates the vascular response in pathological conditions, including ischemia; however, the molecular mechanisms by which exercise improves the impaired hypoxia-induced factor (HIF)-1 alpha-mediated response to hypoxia associated with aging are poorly understood. Here, we report that swimming trai...

journal_title：Circulation

authors： Cheng XW,Kuzuya M,Kim W,Song H,Hu L,Inoue A,Nakamura K,Di Q,Sasaki T,Tsuzuki M,Shi GP,Okumura K,Murohara T

更新日期：2010-08-17 00:00:00

abstract：BACKGROUND:The aims of this study were to identify hibernating myocardium (hypocontractile, hypoperfused viable myocardium that regains contractility after revascularization) in the clinical setting and to predict functional outcome in patients with coronary artery disease after coronary revascularization. METHODS AND...

journal_title：Circulation

authors： Shivalkar B,Maes A,Borgers M,Ausma J,Scheys I,Nuyts J,Mortelmans L,Flameng W

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Chronic pulmonary regurgitation after repair of tetralogy of Fallot (TOF) may lead to right ventricular dilatation, which may be accompanied by ventricular tachycardia and sudden death. We aimed to examine the effects of pulmonary valve replacement (PVR) on (1) certain electrocardiographic markers predictive...

journal_title：Circulation

authors： Therrien J,Siu SC,Harris L,Dore A,Niwa K,Janousek J,Williams WG,Webb G,Gatzoulis MA

更新日期：2001-05-22 00:00:00

abstract：BACKGROUND:For patients with acute dilated cardiomyopathy, definition of prognosis and of clinical features predictive of outcome is particularly important due to the availability of cardiac transplantation and other innovative treatment strategies. METHODS AND RESULTS:We reviewed our experience with 24 children under...

journal_title：Circulation

authors： Matitiau A,Perez-Atayde A,Sanders SP,Sluysmans T,Parness IA,Spevak PJ,Colan SD

更新日期：1994-09-01 00:00:00

abstract：:In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with a first evolving myocardial infarction and with onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion of 100 mg recombinant tissue-type pla...

journal_title：Circulation

authors： O'Rourke M,Baron D,Keogh A,Kelly R,Nelson G,Barnes C,Raftos J,Graham K,Hillman K,Newman H

更新日期：1988-06-01 00:00:00