Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve.

abstract：:Multiple areas of concealed intraventricular conduction are deduced on the basis of aftereffects observed in His bundle recordings. Electrocardiograms and His bundle recordings are presented from two patients with unstable bilateral bundle branch block, the instability of which depended on the interval at which ventri...

journal_title：Circulation

authors： Cohen HC,D'Cruz I,Pick A

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND:Residual mural thrombus on severely damaged arterial wall is very thrombogenic. We tested the hypothesis that direct thrombin inhibition will block thrombus growth on fresh thrombus better than indirect thrombin inhibition, cyclooxygenase inhibition, or both. METHODS AND RESULTS:A fresh mural thrombus was f...

journal_title：Circulation

authors： Meyer BJ,Badimon JJ,Mailhac A,Fernández-Ortiz A,Chesebro JH,Fuster V,Badimon L

更新日期：1994-11-01 00:00:00

abstract：:Retrograde coronary artery flow was observed angiographically in 43 patients with aortic stenosis and/or regurgitation. In the 24 patients with pure or predominant aortic stenosis, retrograde flow was seen in all 24 during end-systole. In the eight patients with pure aortic regurgitation, retrograde flow was seen main...

journal_title：Circulation

authors： Carroll RJ,Falsetti HL

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:The relationships between childhood lifestyle risk factors and adulthood pulse wave velocity (PWV) have not been reported. We studied whether childhood and adulthood lifestyle risk factors are associated with PWV assessed in adulthood. METHODS AND RESULTS:The study cohort comprised 1622 subjects of the Card...

journal_title：Circulation

authors： Aatola H,Koivistoinen T,Hutri-Kähönen N,Juonala M,Mikkilä V,Lehtimäki T,Viikari JS,Raitakari OT,Kähönen M

更新日期：2010-12-14 00:00:00

abstract：:We studied regional myocardial perfusion by scintigraphic computer-assisted analysis of initial distribution, washout rates, and residual activity of 133Xe injected into the left coronary artery of four patients with normal arteriograms and 14 patients with coronary stenosis. At rest, residual activity in poststenotic...

journal_title：Circulation

authors： Maseri A,L'Abbate A,Pesola A,Michelassi C,Marzilli M,De Nes M

更新日期：1977-03-01 00:00:00

abstract：:We studied the inferior vena cava (IVC) as an index of right-heart function in 111 patients. A two-dimensional echocardiographic sector was used to visualize the IVC, and its M-mode cursor was used to generate a time-motion record of the IVC size and pulsation. Normal subjects had a small presystolic A wave (less than...

journal_title：Circulation

authors： Mintz GS,Kotler MN,Parry WR,Iskandrian AS,Kane SA

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND:Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell proliferation. The X-box binding protein 1 (XBP1) is believed to be a signal transducer in the endoplasmic reticulum stress response. It is unknown whether there is crosstalk between vascular endothel...

journal_title：Circulation

authors： Zeng L,Xiao Q,Chen M,Margariti A,Martin D,Ivetic A,Xu H,Mason J,Wang W,Cockerill G,Mori K,Li JY,Chien S,Hu Y,Xu Q

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a life-threatening disease, characterized by vascular smooth muscle cell hyperproliferation. The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation. METHODS AND RESULTS:We investigated the expres...

journal_title：Circulation

authors： Schermuly RT,Pullamsetti SS,Kwapiszewska G,Dumitrascu R,Tian X,Weissmann N,Ghofrani HA,Kaulen C,Dunkern T,Schudt C,Voswinckel R,Zhou J,Samidurai A,Klepetko W,Paddenberg R,Kummer W,Seeger W,Grimminger F

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Recent findings suggesting the involvement of adventitial cells in coronary repair have raised questions regarding the phenotypic "plasticity" of medial smooth muscle cells (SMCs). Accordingly, the aims of the present study were to examine the characteristics of coronary medial and adventitial cells and to c...

journal_title：Circulation

authors： Patel S,Shi Y,Niculescu R,Chung EH,Martin JL,Zalewski A

更新日期：2000-02-08 00:00:00

abstract：:The Beta-Blocker Heart Attack Trial was a multicenter, randomized, double-blind, placebo-controlled trial of propranolol therapy in 3837 men and women with acute myocardial infarction. The patients began their treatment 5-21 days after hospital admission (mean 13.8 days). During an average follow-up of 25 months, ther...

journal_title：Circulation

authors： Goldstein S

更新日期：1983-06-01 00:00:00

abstract：:Common conditions predisposing to atherosclerosis, such as hypercholesterolemia, hypertension, diabetes, and smoking, are associated with endothelial dysfunction. Endothelial function has largely been assessed as endothelium-dependent vasomotion, at least in part based on the assumption that impaired endothelium-depen...

journal_title：Circulation

authors： Landmesser U,Hornig B,Drexler H

更新日期：2004-06-01 00:00:00

abstract：:The effect of prolonged intense endurance exercise training on exertional hypotension was investigated in 16 patients with coronary artery disease who had a 10 mm Hg or greater fall in systolic blood pressure (SBP) during progressive exercise testing. Training consisted of walking, running, or cycling at 50% to 60% of...

journal_title：Circulation

authors： Martin WH 3rd,Ehsani AA

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:Heterogeneous electrophysiological properties, which may be due in part to autonomic innervation, are important in the maintenance of atrial fibrillation (AF). We hypothesized that heterogeneous sympathetic denervation with phenol would create a milieu for sustained AF. METHODS AND RESULTS:After the determi...

journal_title：Circulation

authors： Olgin JE,Sih HJ,Hanish S,Jayachandran JV,Wu J,Zheng QH,Winkle W,Mulholland GK,Zipes DP,Hutchins G

更新日期：1998-12-08 00:00:00

abstract：:In 526 patients undergoing a first percutaneous transluminal coronary angioplasty (PTCA) of a single native vessel, we studied the influence of length and eccentricity of the lesion on complications and primary success. Long stenoses (greater than or equal to 5 mm, n = 153) did not differ from short stenoses (less tha...

journal_title：Circulation

authors： Meier B,Gruentzig AR,Hollman J,Ischinger T,Bradford JM

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:The anti-inflammatory cytokine interleukin-10 (IL-10) has been detected in the plasma of patients with myocardial ischemia/reperfusion. The aim of our study was to investigate the role of endogenously produced IL-10 in myocardial ischemia/reperfusion. METHODS AND RESULTS:In the present study, we used wild-t...

journal_title：Circulation

authors： Yang Z,Zingarelli B,Szabó C

更新日期：2000-03-07 00:00:00

abstract：BACKGROUND:Household air pollution is the third largest risk factor for global disease burden, but direct links with cardiovascular disease mortality are limited. This study aimed to evaluate the relationship between household fuel use and cardiovascular disease mortality. METHODS AND RESULTS:The Golestan Cohort Study...

journal_title：Circulation

authors： Mitter SS,Vedanthan R,Islami F,Pourshams A,Khademi H,Kamangar F,Abnet CC,Dawsey SM,Pharoah PD,Brennan P,Fuster V,Boffetta P,Malekzadeh R

更新日期：2016-06-14 00:00:00

abstract：:In experimental animals, the calcium channel-blocking agents lessen the arrhythmogenic, ionic, metabolic, and electrical changes that occur during acute myocardial ischemia. To date, these effects have been studied separately, and the effects of these agents on local activation have not been correlated with ionic or m...

journal_title：Circulation

authors： Fleet WF,Johnson TA,Graebner CA,Engle CL,Gettes LS

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy (HCM) is characterized by myocardial hypertrophy of unknown etiology. Missense mutations of the cardiac beta-myosin-heavy-chain (beta-MHC) gene that may be responsible for cardiac hypertrophy have been detected in patients with HCM. On the other hand, gross structural abnormalitie...

journal_title：Circulation

authors： Nishi H,Kimura A,Harada H,Koga Y,Adachi K,Matsuyama K,Koyanagi T,Yasunaga S,Imaizumi T,Toshima H

更新日期：1995-06-15 00:00:00

abstract：:BACKGROUND-Catecholamine-induced apoptosis is mediated by activation of the beta-adrenergic signaling pathway. We tested the hypothesis that beta(1)- and beta(2)-adrenergic receptor (AR) subtypes differentially affect apoptosis in adult rat ventricular myocytes in vitro. METHODS AND RESULTS-Myocytes were first exposed...

journal_title：Circulation

authors： Zaugg M,Xu W,Lucchinetti E,Shafiq SA,Jamali NZ,Siddiqui MA

更新日期：2000-07-18 00:00:00

abstract：BACKGROUND:Mitral regurgitation (MR) due to mitral valve prolapse (MVP) is often treatable by surgical repair. However, the very long-term (>10-year) durability of repair in both anterior leaflet prolapse (AL-MVP) and posterior leaflet prolapse (PL-MVP) is unknown. METHODS AND RESULTS:In 917 patients (aged 65+/-13 yea...

journal_title：Circulation

authors： Mohty D,Orszulak TA,Schaff HV,Avierinos JF,Tajik JA,Enriquez-Sarano M

更新日期：2001-09-18 00:00:00

abstract：:Little is known of the functional capacity of coronary collaterals in humans without occlusive coronary artery disease. We, therefore, measured peripheral coronary pressure (PCP) and retrograde flow (RF) from coronary arteries at aortic valve replacement in seven patients without occlusive coronary artery disease. Usi...

journal_title：Circulation

authors： Goldstein RE,Michaelis LL,Morrow AG,Epstein SE

更新日期：1975-01-01 00:00:00

abstract：:End-systolic pressure (PES), volume (VES), wall tension (TES) and circumference (CES) of the human left ventricle were studied at cardiac catheterization in 24 subjects with varying degrees of left ventricular dysfunction. Acute alterations in systolic load consistently resulted in changes in VES and CES, with a small...

journal_title：Circulation

authors： Grossman W,Braunwald E,Mann T,McLaurin LP,Green LH

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:Myocardial necrosis can occur during percutaneous coronary intervention (PCI) despite optimal adjunctive pharmacology and careful technique. We investigated the mechanisms of procedural infarction using angiographic analysis, intravascular ultrasound, and delayed-enhancement magnetic resonance imaging. METH...

journal_title：Circulation

authors： Porto I,Selvanayagam JB,Van Gaal WJ,Prati F,Cheng A,Channon K,Neubauer S,Banning AP

更新日期：2006-08-15 00:00:00

abstract：:To determine whether alteration of intrinsic myocardial stiffness is responsible for the reduction of left ventricular filling pressure and volume by nifedipine in patients with impaired baseline ventricular function, we evaluated the hemodynamic responses in 32 patients undergoing diagnostic cardiac catheterization. ...

journal_title：Circulation

authors： Kurnik PB,Courtois MR,Ludbrook PA

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:NO has been advocated as an adjunct to cardioplegia solutions. However, NO undergoes a rapid biradical reaction with superoxide anions to produce peroxynitrite (ONOO(-)). ONOO(-) in crystalloid cardioplegia solution induces injury to coronary endothelium and to systolic function after cardioplegia and reperf...

journal_title：Circulation

authors： Nakamura M,Thourani VH,Ronson RS,Velez DA,Ma XL,Katzmark S,Robinson J,Schmarkey LS,Zhao ZQ,Wang NP,Guyton RA,Vinten-Johansen J

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into biliverdin, iron, and carbon monoxide (CO). Although HO-1 is induced in vascular smooth muscle cells (SMCs), the biological role of HO-1 in these cells has not been completely characterized. METHODS AND RESULTS:In the present study, we overexpre...

journal_title：Circulation

authors： Liu XM,Chapman GB,Wang H,Durante W

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) exhibit marked differences in atherosclerosis susceptibility. We sought to determine whether the difference in atherosclerosis susceptibility resides at the level of arterial walls. METHODS AND RESULTS:Thoracic aortic segments from 8-week-old female B6 an...

journal_title：Circulation

authors： Pei H,Wang Y,Miyoshi T,Zhang Z,Matsumoto AH,Helm GA,Tellides G,Shi W

更新日期：2006-11-28 00:00:00

abstract：BACKGROUND:Gaps of sufficient cross-sectional dimensions within linear radiofrequency (RF) lesions may allow conduction through the lesion. The purpose of this study was to examine the effects of different gap geometries on conduction through discontinuous RF lesions. METHODS AND RESULTS:Radiofrequency lesions were cr...

journal_title：Circulation

authors： Pérez FJ,Wood MA,Schubert CM

更新日期：2006-04-11 00:00:00

abstract：BACKGROUND:Mechanisms favoring the occurrence of paroxysmal atrial fibrillation (PAF) are complex and poorly defined. This study was designed to analyze dynamic changes in autonomic tone preceding the onset of PAF in a large group of patients. METHODS AND RESULTS:Holter tapes from 77 unselected consecutive patients (6...

journal_title：Circulation

authors： Bettoni M,Zimmermann M

更新日期：2002-06-11 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) remains a concern in patients with β-thalassemia major (TM) and intermedia (TI); however, studies evaluating its prevalence and risk factors using systematic confirmation on right heart catheterization are lacking. METHODS AND RESULTS:This was a multicenter cross-sectio...

journal_title：Circulation

authors： Derchi G,Galanello R,Bina P,Cappellini MD,Piga A,Lai ME,Quarta A,Casu G,Perrotta S,Pinto V,Musallam KM,Forni GL,Webthal Pulmonary Arterial Hypertension Group*.

更新日期：2014-01-21 00:00:00