当前位置： SCI文献检索 > CIRCULATION期刊下所有文献 > Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.

Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.

Abstract：

BACKGROUND:Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell proliferation. The X-box binding protein 1 (XBP1) is believed to be a signal transducer in the endoplasmic reticulum stress response. It is unknown whether there is crosstalk between vascular endothelial cell growth factor signaling and XBP1 pathway. METHODS AND RESULTS:We found that vascular endothelial cell growth factor induced the kinase insert domain receptor internalization and interaction through C-terminal domain with the unspliced XBP1 and the inositol requiring enzyme 1 α in the endoplasmic reticulum, leading to inositol requiring enzyme 1 α phosphorylation and XBP1 mRNA splicing, which was abolished by siRNA-mediated knockdown of kinase insert domain receptor. Spliced XBP1 regulated endothelial cell proliferation in a PI3K/Akt/GSK3β/β-catenin/E2F2-dependent manner and modulated the cell size increase in a PI3K/Akt/GSK3β/β-catenin/E2F2-independent manner. Knockdown of XBP1 or inositol requiring enzyme 1 α decreased endothelial cell proliferation via suppression of Akt/GSK3β phosphorylation, β-catenin nuclear translocation, and E2F2 expression. Endothelial cell-specific knockout of XBP1 (XBP1ecko) in mice retarded the retinal vasculogenesis in the first 2 postnatal weeks and impaired the angiogenesis triggered by ischemia. Reconstitution of XBP1 by Ad-XBP1s gene transfer significantly improved angiogenesis in ischemic tissue in XBP1ecko mice. Transplantation of bone marrow from wild-type o XBP1ecko mice could also slightly improve the foot blood reperfusion in ischemic XBP1ecko mice. CONCLUSIONS:These results suggest that XBP1 can function via growth factor signaling pathways to regulate endothelial proliferation and angiogenesis.

journal_name

Circulation

journal_title

Circulation

authors

Zeng L,Xiao Q,Chen M,Margariti A,Martin D,Ivetic A,Xu H,Mason J,Wang W,Cockerill G,Mori K,Li JY,Chien S,Hu Y,Xu Q

doi

10.1161/CIRCULATIONAHA.112.001337

subject

Has Abstract

pub_date

2013-04-23 00:00:00

pages

1712-22

issue

16

eissn

0009-7322

issn

1524-4539

pii

CIRCULATIONAHA.112.001337

journal_volume

127

pub_type

杂志文章

相关文献

CIRCULATION文献大全
  • NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation.

    abstract：UNLABELLED:BACKGROUND- Reactive oxygen species serve signaling functions in the vasculature, and hypoxia has been associated with increased reactive oxygen species production. NADPH oxidase 4 (Nox4) is a reactive oxygen species-producing enzyme that is highly expressed in the endothelium, yet its specific role is unkno...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.111.030775

    authors： Craige SM,Chen K,Pei Y,Li C,Huang X,Chen C,Shibata R,Sato K,Walsh K,Keaney JF Jr

    更新日期：2011-08-09 00:00:00

  • Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic lesions.

    abstract：BACKGROUND:A role for myeloperoxidase (MPO) as a mediator of coronary artery disease and acute coronary syndromes has recently received considerable attention. Although active MPO and hypochlorite-modified proteins and peptides have been detected in human atherosclerotic lesions, detection of novel chlorinated oxidized...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.CIR.0000104564.01539.6A

    authors： Thukkani AK,McHowat J,Hsu FF,Brennan ML,Hazen SL,Ford DA

    更新日期：2003-12-23 00:00:00

  • Anatomic features in victims of sudden coronary death. Coronary artery pathology.

    abstract：:Study of the detailed pathology of the myocardium and coronary arteries in ambulatory subjects dying suddenly of coronary heart disease shows that they can be divided into two groups. In one group, there is atherosclerosis with a new vascular event involving coronary thrombosis, which initiates acute myocardial ischem...

    journal_title：Circulation

    pub_type： 杂志文章,评审

    doi：

    authors： Davies MJ

    更新日期：1992-01-01 00:00:00

  • Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1.

    abstract：BACKGROUND:Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. On the cell surface, CathA, Neu1, and t...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.107.733212

    authors： Seyrantepe V,Hinek A,Peng J,Fedjaev M,Ernest S,Kadota Y,Canuel M,Itoh K,Morales CR,Lavoie J,Tremblay J,Pshezhetsky AV

    更新日期：2008-04-15 00:00:00

  • Perioperative myocardial infarction after coronary artery bypass surgery. Clinical significance and approach to risk stratification.

    abstract：:The clinical significance of perioperative myocardial infarction (MI) after coronary artery bypass surgery is not known. Therefore, strategies for the risk stratification of these patients do not exist. This study was undertaken to define the effect of perioperative MI on prognosis after discharge from the hospital an...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.82.3.903

    authors： Force T,Hibberd P,Weeks G,Kemper AJ,Bloomfield P,Tow D,Josa M,Khuri S,Parisi AF

    更新日期：1990-09-01 00:00:00

  • Evaluation of severity of heart failure using ventilatory gas analysis.

    abstract：:To evaluate the severity of heart failure, cardiopulmonary exercise testing was performed in 99 normal subjects and in 382 patients with cardiac disease. Anaerobic threshold, peak oxygen uptake, and the ratio of increase in oxygen uptake to work-rate increment were determined by ventilatory and gas exchange measuremen...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：

    authors： Itoh H,Taniguchi K,Koike A,Doi M

    更新日期：1990-01-01 00:00:00

  • Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients.

    abstract：BACKGROUND:There is evidence for increased formation of free radicals in patients with hypertension, raising the possibility that NO is inactivated by free radicals, which impairs coronary endothelial function. Therefore, we tested the hypothesis that the antioxidant vitamin C could improve abnormal endothelial functio...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章

    doi：10.1161/01.cir.96.5.1513

    authors： Solzbach U,Hornig B,Jeserich M,Just H

    更新日期：1997-09-02 00:00:00

  • Resuscitation Education Science: Educational Strategies to Improve Outcomes From Cardiac Arrest: A Scientific Statement From the American Heart Association.

    abstract：:The formula for survival in resuscitation describes educational efficiency and local implementation as key determinants in survival after cardiac arrest. Current educational offerings in the form of standardized online and face-to-face courses are falling short, with providers demonstrating a decay of skills over time...

    journal_title：Circulation

    pub_type： 共识发展会议,杂志文章,评审

    doi：10.1161/CIR.0000000000000583

    authors： Cheng A,Nadkarni VM,Mancini MB,Hunt EA,Sinz EH,Merchant RM,Donoghue A,Duff JP,Eppich W,Auerbach M,Bigham BL,Blewer AL,Chan PS,Bhanji F,American Heart Association Education Science Investigators; and on behalf of the American

    更新日期：2018-08-07 00:00:00

  • Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis.

    abstract：BACKGROUND:Cardiac allograft arteriosclerosis is a complex process of alloimmune response, chronic inflammation, and smooth muscle cell proliferation that includes cross talk between cytokines and growth factors. METHODS AND RESULTS:Our results in rat cardiac allografts established alloimmune response as an alternativ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.0000016821.76177.d2

    authors： Lemström KB,Krebs R,Nykänen AI,Tikkanen JM,Sihvola RK,Aaltola EM,Häyry PJ,Wood J,Alitalo K,Ylä-Herttuala S,Koskinen PK

    更新日期：2002-05-28 00:00:00

  • Preservation of myocardial function with mannitol reperfusate.

    abstract：:Reperfusion of the globally ischemic myocardium with mannitol has been shown to preserve myocardial function. However, it remains unclear whether the mechanism of mannitol protection relates to its hyperosmolar or free radical scavenging properties. Three groups of isolated, perfused rabbit hearts underwent 45 min of ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：

    authors： Ouriel K,Ginsburg ME,Patti CS,Pearce FJ,Hicks GL

    更新日期：1985-09-01 00:00:00

  • Impact of farnesylation inhibitors on survival in Hutchinson-Gilford progeria syndrome.

    abstract：BACKGROUND:Hutchinson-Gilford progeria syndrome is an ultrarare segmental premature aging disease resulting in early death from heart attack or stroke. There is no approved treatment, but starting in 2007, several recent single-arm clinical trials administered inhibitors of protein farnesylation aimed at reducing toxic...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.113.008285

    authors： Gordon LB,Massaro J,D'Agostino RB Sr,Campbell SE,Brazier J,Brown WT,Kleinman ME,Kieran MW,Progeria Clinical Trials Collaborative.

    更新日期：2014-07-01 00:00:00

  • Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women.

    abstract：BACKGROUND:Obesity is a risk factor for impaired cardiac performance, particularly in women. Animal studies suggest that alterations in myocardial fatty acid metabolism and efficiency in obesity can cause decreased cardiac performance. In the present study, we tested the hypothesis that myocardial fatty acid metabolism...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.CIR.0000127959.28627.F8

    authors： Peterson LR,Herrero P,Schechtman KB,Racette SB,Waggoner AD,Kisrieva-Ware Z,Dence C,Klein S,Marsala J,Meyer T,Gropler RJ

    更新日期：2004-05-11 00:00:00

  • Sex differences in medical care and early death after acute myocardial infarction.

    abstract：BACKGROUND:Women receive less evidence-based medical care than men and have higher rates of death after acute myocardial infarction (AMI). It is unclear whether efforts undertaken to improve AMI care have mitigated these sex disparities in the current era. METHODS AND RESULTS:Using the Get With the Guidelines-Coronary...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.108.789800

    authors： Jneid H,Fonarow GC,Cannon CP,Hernandez AF,Palacios IF,Maree AO,Wells Q,Bozkurt B,Labresh KA,Liang L,Hong Y,Newby LK,Fletcher G,Peterson E,Wexler L,Get With the Guidelines Steering Committee and Investigators.

    更新日期：2008-12-16 00:00:00

  • Tissue and serum angiogenic activity is associated with low prevalence of ischemic complications in patients with giant-cell arteritis.

    abstract：BACKGROUND:Vascular inflammatory lesions from patients with giant-cell arteritis show a remarkable amount of neovascularization, but its clinical implications have never been investigated. METHODS AND RESULTS:To assess the clinical relevance of neovascularization in giant-cell arteritis, angiogenesis was measured in t...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章

    doi：10.1161/01.cir.0000030185.67510.c0

    authors： Cid MC,Hernández-Rodríguez J,Esteban MJ,Cebrián M,Gho YS,Font C,Urbano-Márquez A,Grau JM,Kleinman HK

    更新日期：2002-09-24 00:00:00

  • Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators.

    abstract：BACKGROUND:We investigated the effects of candesartan (an angiotensin II antagonist) alone, enalapril alone, and their combination on exercise tolerance, ventricular function, quality of life (QOL), neurohormone levels, and tolerability in congestive heart failure (CHF). METHODS AND RESULTS:Seven hundred sixty-eight p...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1161/01.cir.100.10.1056

    authors： McKelvie RS,Yusuf S,Pericak D,Avezum A,Burns RJ,Probstfield J,Tsuyuki RT,White M,Rouleau J,Latini R,Maggioni A,Young J,Pogue J

    更新日期：1999-09-07 00:00:00

  • Cardiovascular and Ventilatory Consequences of Laparoscopic Surgery.

    abstract：:Although laparoscopic surgery accounts for >2 million surgical procedures every year, the current preoperative risk scores and guidelines do not adequately assess the risks of laparoscopy. In general, laparoscopic procedures have a lower risk of morbidity and mortality compared with operations requiring a midline lapa...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.116.023262

    authors： Atkinson TM,Giraud GD,Togioka BM,Jones DB,Cigarroa JE

    更新日期：2017-02-14 00:00:00

  • Plasma adenosine levels increase in patients with chronic heart failure.

    abstract：BACKGROUND:Adenosine is believed to be cardioprotective; however, it has not been elucidated whether the plasma adenosine level is increased in chronic heart failure. METHODS AND RESULTS:Seventy-one patients attending a specialized heart failure clinic during a 6-month period were grouped according to the cause of chr...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.95.6.1363

    authors： Funaya H,Kitakaze M,Node K,Minamino T,Komamura K,Hori M

    更新日期：1997-03-18 00:00:00

  • An enzyme histochemical study of human sinus node, coronary sinus, and mitral valve muscle.

    abstract：:An enzyme histochemical study of the sinoatrial node, the coronary sinus, and the atrial muscle extending into the anterior mitral valve was performed on human hearts. Investigation of the activity and localization of the structurally bound enzymes was performed by conventional histochemical techniques. Determination ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.72.1.205

    authors： Théry C,Krivosic I,Asseman P,Meijer AE

    更新日期：1985-07-01 00:00:00

  • Oral anti-CD3 antibody treatment induces regulatory T cells and inhibits the development of atherosclerosis in mice.

    abstract：BACKGROUND:Accumulating evidence suggests that several subsets of regulatory T cells that actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally administered anti-CD3 monoclonal antibody has been shown as an inducer of novel regulatory T cells expressing latency-associated peptide ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.109.863431

    authors： Sasaki N,Yamashita T,Takeda M,Shinohara M,Nakajima K,Tawa H,Usui T,Hirata K

    更新日期：2009-11-17 00:00:00

  • A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.

    abstract：BACKGROUND:Heart failure is a leading cause of death worldwide. Cyclic nucleotide phosphodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease. Our preliminary screening studies have revealed PDE10A upregulation in the diseased heart. However, the roles...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.119.042178

    authors： Chen S,Zhang Y,Lighthouse JK,Mickelsen DM,Wu J,Yao P,Small EM,Yan C

    更新日期：2020-01-21 00:00:00

  • Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men.

    abstract：BACKGROUND:The role of a cluster of risk factors characteristic for the insulin resistance syndrome as a predictor for coronary heart disease (CHD) has not been studied previously. METHODS AND RESULTS:Clustering of cardiovascular risk factors was analyzed by factor analysis to investigate whether these clusters (facto...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.100.2.123

    authors： Lempiäinen P,Mykkänen L,Pyörälä K,Laakso M,Kuusisto J

    更新日期：1999-07-13 00:00:00

  • Prevention of iatrogenic atrial tachycardia after ablation of atrial fibrillation: a prospective randomized study comparing circumferential pulmonary vein ablation with a modified approach.

    abstract：BACKGROUND:Circumferential pulmonary vein ablation (CPVA) is effective in curing atrial fibrillation (AF), but new-onset left atrial tachycardia (AT) is a potential complication. We evaluated whether a modified CPVA approach including additional ablation lines on posterior wall and the mitral isthmus would reduce the i...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1161/01.CIR.0000147186.83715.95

    authors： Pappone C,Manguso F,Vicedomini G,Gugliotta F,Santinelli O,Ferro A,Gulletta S,Sala S,Sora N,Paglino G,Augello G,Agricola E,Zangrillo A,Alfieri O,Santinelli V

    更新日期：2004-11-09 00:00:00

  • Multicentric origin of the atrial depolarization wave: the pacemaker complex. Relation to dynamics of atrial conduction, P-wave changes and heart rate control.

    abstract：:In studies to ascertain the basis of dynamic changes in the P wave, bipolar epicardial potentials were recorded from multiple atrial electrodes in dogs. One hundred to 120 activation times were displayed by a digital computer and used to construct atrial isotemporal activation sequence maps. Changes in heart rate or b...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.58.6.1036

    authors： Boineau JP,Schuessler RB,Mooney CR,Wylds AC,Miller CB,Hudson RD,Borremans JM,Brockus CW

    更新日期：1978-12-01 00:00:00

  • Effect of doxazosin gastrointestinal therapeutic system as third-line antihypertensive therapy on blood pressure and lipids in the Anglo-Scandinavian Cardiac Outcomes Trial.

    abstract：BACKGROUND:The role of doxazosin in treatment of hypertension remains controversial. METHODS AND RESULTS:We evaluated the effects on blood pressure (BP) and biochemical parameters of doxazosin GITS (gastrointestinal therapeutic system) as a third-line antihypertensive agent among 10,069 participants in the Anglo-Scand...

    journal_title：Circulation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1161/CIRCULATIONAHA.107.737957

    authors： Chapman N,Chang CL,Dahlöf B,Sever PS,Wedel H,Poulter NR,ASCOT Investigators.

    更新日期：2008-07-01 00:00:00

  • Thyroid hormone coordinates respiratory control maturation and adenine nucleotide translocator expression in heart in vivo.

    abstract：BACKGROUND:The signal transduction mechanism linking mitochondrial ATP synthesis with cytosolic ATP utilization in heart changes during postnatal development in vivo. This maturational process occurs in parallel with accumulation of mitochondrial adenine nucleotide translocator (ANT), which provides a possible site for...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.102.11.1323

    authors： Portman MA,Xiao Y,Qian K,Tucker RL,Parish SM,Ning XH

    更新日期：2000-09-12 00:00:00

  • Heat-shock protein 60-reactive CD4+CD28null T cells in patients with acute coronary syndromes.

    abstract：BACKGROUND:CD4+CD28null T cells are present in increased numbers in the peripheral blood of patients with acute coronary syndrome (ACS) compared with patients with chronic stable angina (CSA). The triggers of activation and expansion of these cells to date remain unclear. METHODS AND RESULTS:Twenty-one patients with A...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.CIR.0000118476.29352.2A

    authors： Zal B,Kaski JC,Arno G,Akiyu JP,Xu Q,Cole D,Whelan M,Russell N,Madrigal JA,Dodi IA,Baboonian C

    更新日期：2004-03-16 00:00:00

  • Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

    abstract：BACKGROUND:Cardiac hypertrophy and subsequent heart failure triggered by chronic hypertension represent major challenges for cardiovascular research. Beyond neurohormonal and myocyte signaling pathways, growing evidence suggests inflammatory signaling pathways as therapeutically targetable contributors to this process....

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.112.001357

    authors： Heymans S,Corsten MF,Verhesen W,Carai P,van Leeuwen RE,Custers K,Peters T,Hazebroek M,Stöger L,Wijnands E,Janssen BJ,Creemers EE,Pinto YM,Grimm D,Schürmann N,Vigorito E,Thum T,Stassen F,Yin X,Mayr M,de Windt LJ,

    更新日期：2013-09-24 00:00:00

  • Quantification of myocardial infarct size by thallium-201 single-photon emission computed tomography: experimental validation in the dog.

    abstract：:To evaluate the potential advantages of thallium-201 (201T1) single-photon emission computerized tomography (SPECT) to assess myocardial infarct size in the experimental animal, six normal dogs and 14 dogs with 6 to 8 hr closed-chest coronary occlusion (eight left anterior descending and six left circumflex) were stud...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.74.4.852

    authors： Prigent F,Maddahi J,Garcia EV,Satoh Y,Van Train K,Berman DS

    更新日期：1986-10-01 00:00:00

  • Cardiac Implantable Electronic Device Interrogation at Forensic Autopsy: An Underestimated Resource?

    abstract：BACKGROUND:Postmortem interrogations of cardiac implantable electronic devices (CIEDs), recommended at autopsy in suspected cases of sudden cardiac death, are rarely performed, and data on systematic postmortem CIED analysis in the forensic pathology are missing. The aim of the study was to determine whether nonselecti...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.117.032367

    authors： Lacour P,Buschmann C,Storm C,Nee J,Parwani AS,Huemer M,Attanasio P,Boldt LH,Rauch G,Kucher A,Pieske B,Haverkamp W,Blaschke F

    更新日期：2018-06-19 00:00:00

  • Pathological healing response of explanted MitraClip devices.

    abstract：BACKGROUND:The safety and effectiveness of the MitraClip device (Abbott Vascular, Menlo Park, CA) is being evaluated in the Endovascular Valve Edge-to-Edge Repair Study (EVEREST) clinical studies. The healing response after device implantation has not previously been characterized in humans. METHODS AND RESULTS:A tota...

    journal_title：Circulation

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/CIRCULATIONAHA.110.978130

    authors： Ladich E,Michaels MB,Jones RM,McDermott E,Coleman L,Komtebedde J,Glower D,Argenziano M,Feldman T,Nakano M,Virmani R,Endovascular Valve Edge-to-Edge Repair Study (EVEREST) Investigators.

    更新日期：2011-04-05 00:00:00